Muscle needs to make serine from glucose to protect the fibers from mitochondrial disease. Read our story, a tour de force of Anastasiia Marmyleva and Christopher Jackson @SWAN @STEMM Helsinki University www.cell.com/cell-reports...
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De novo serine biosynthesis is protective in mitochondrial disease
Jackson et al. show that serine becomes an essential amino acid in mitochondrial muscle
disease, delaying disease progression. Blocking local biosynthesis of serine challenges
cellular phospholipid ho...