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Brandon Sit

@sitbrandon.bsky.social
147 followers 204 following 2 posts

postdoc at MIT Bio | NIH/NIAID K99/R00 | interested in obligate intracellular bacterial pathogen-host interactions | can -> usa transplant

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Reposted by Brandon Sit
Andrew Savinov @biosavinov.bsky.social · 16/09/2026
Thrilled to announce that the Savinov lab is now live at UT Austin @utaustin.bsky.social! Our lab employs massively parallel experimental and AI methods to discover and design protein fragments as universal regulators of protein interactions in health and disease. www.savinovlab.com (1/n)
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I-75 Scientist @flscitriguy.bsky.social · 12/08/2026
Updates to NIH K awards starting with October 2027 deadlines. The individual K awards are being consolidated into 4 awards. 🧪 grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-26-098: Notice of NIH Updates to Career Development (K) Award Programs
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of NIH Updates to Career Development (K) Award Programs NOT-OD-26-098. OD
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Thomas P200 Burke @findmeinthelab.bsky.social · 15/06/2026
I'm excited to share our recent working using forward genetics to identify virulence determinants in Rickettsia. Check it out! www.biorxiv.org/content/10.6...
biorxiv.org
A genetic screen identifies O-antigen as essential for Rickettsia parkeri survival in macrophages by protecting from inflammasomes and interferon-stimulated genes
Lipopolysaccharide (LPS) is highly immunostimulatory, yet it is evolutionarily conserved among many obligate intracellular bacteria for unknown reasons. We report a forward genetic screen to identify ...
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Roberto Vázquez Núñez @robertovn.bsky.social · 29/05/2026
🚨 New preprint: GATO-seq did it again! ELOF1 is the missing promoter-proximal factor that confers RNA Pol II resistance to TFIIF. Including ELOF1, DSIF, and NELF in GATO-seq reactions recapitulates promoter-proximal pausing in vitro at physiological conditions for the 1st time. tinyurl.com/ELOF1
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Andrew Savinov @biosavinov.bsky.social · 13/05/2026
Interested in genetically encodable inhibitors of your favorite biomolecular condensate? Excited to announce our latest work, w/ Jibin Sadasivan, Gene-Wei Li, & Lindsay Case, on protein fragments as generalizable regulators of phase separation. (1/n) www.biorxiv.org/content/10.6...
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Matthew Welch @mattwelchlab.bsky.social · 28/04/2026
Our most recent paper "Divergent Rickettsia species exhibit distinct mechanisms of actin-based motility" is now out in @jcb.org! Check it out here: rupress.org/jcb/article/...
Image of Rickettsia bacteria in yellow, in an infected cell expressing fluorescent actin in blue.
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Thomas P200 Burke @findmeinthelab.bsky.social · 16/04/2026
I'm happy to share a review that our lab put together on innate immune responses to Rickettsia. One interesting tidbit - different Rickettsia species have distinct interactions with xenophagy, where some species co-opt ubiquitylation, while others avoid it! www.sciencedirect.com/science/arti...
sciencedirect.com
Innate immune responses to Rickettsia: emerging themes and contrasts between species
Over 10 species of Rickettsia cause serious human disease across the globe, including deadly spotted fever and typhus. These arthropod-borne microbes …
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A. Murat Eren (Meren) @merenbey.bsky.social · 16/04/2026
How every layer of science's "self-correcting machinery" failed when Iva Veseli and I simply wanted to reproduce the findings of a high-profile study on gut microbiome and autism: merenlab.org/2026/04/15/u...
merenlab.org
Unfalsifiable by Design: A Year of Trying and Failing to Reproduce a Human Microbiome and Autism Study
The myth of open data, reproducibility, responsibility, and accountability in science, and your role in it
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Becky Lamason @lamasonlab.bsky.social · 24/02/2026
Excited to share our latest work from first author Patrick Woida. Using a novel surface display platform for expression of split TurboID, we discovered that CYLD is recruited to the Listeria surface via the effector InlC and that it supports cell-to-cell spread www.biorxiv.org/content/10.6...
biorxiv.org
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Caulocon @caulocon.bsky.social · 21/02/2026
With CauloCon coming up in a few weeks, we are excited to share with you the schedule for the upcoming meeting! There will be 3 keynotes and 26 short talks over three days. You can see more information at caulocon.com
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I-75 Scientist @flscitriguy.bsky.social · 30/01/2026
Notice of Temporary Extension of Eligibility for the NIH Pathway to Independence Award (K99/R00): for Individuals whose final due date was September-November 2025 and January-March 2026. As always, reach out to your PO/IC contact to discuss. grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-26-021: Notice of Temporary Extension of Eligibility for the NIH Pathway to Independence Award (K99/R00)
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Temporary Extension of Eligibility for the NIH Pathway to Independence Award (K99/R00) NOT-OD-26-021. OD
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Becky Lamason @lamasonlab.bsky.social · 06/01/2026
Check out our latest paper from first author Allison Scott using a powerful enrichment strategy to enable transcriptional profiling of the early stages of a rickettsial infection
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Brandon Sit @sitbrandon.bsky.social · 03/11/2025
First 🟦 post - my main postdoc work is out in the world! We designed a Cas12a-based genetic screen to identify host factors that contribute to infection by the tickborne pathogen Rickettsia parkeri, and stumbled across a really exciting direct interaction between host and bacterium🦠. Check it out!
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Andrew Savinov @biosavinov.bsky.social · 27/10/2025
Thrilled to contribute to this exciting work on protein binder design together w/ @hannes-stark.bsky.social , Felix Faltings, Regina Barzilay, Tommi Jaakkola, and co. We applied BoltzGen to design novel antimicrobial peptides targeting DNA gyrase based on inhibitory protein fragments. (1/n)
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Jordan Jastrab @jordanjastrab.bsky.social · 26/09/2025
Thrilled to share my work from the @jkagan1.bsky.social lab! TLDR: O-acetylation and wall teichoic acid compete for space on S. aureus peptidoglycan. This competition regulates DNA release, and thus immune receptor activation, during infection! www.biorxiv.org/content/10.1... #microsky #immunosky
biorxiv.org
Wall teichoic acid is required for DNA-triggered innate immune receptor activation by Staphylococcus aureus
Receptors that stimulate inflammation are commonly activated by ligands that are buried within microbial cells. The mechanisms that facilitate immunostimulatory ligand release from microbes during inf...
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Fabian Rivera-Chávez @fabianrchavez.bsky.social · 18/08/2025
1/ Excited to share the first preprint from my lab! 🎉 My postdoc Paz asked how cholera toxin (CT) helps Vibrio cholerae thrive in the gut. Turns out, CT rewires epithelial metabolism toward L-lactate production—fueling pathogen growth in the small intestine during disease
biorxiv.org
Cholera toxin-induced disease generates epithelial cell-derived L-lactate that promotes Vibrio cholerae growth in the small intestine
Cholera toxin (CT) promotes Vibrio cholerae colonization by altering gut metabolism to favor pathogen growth. We have previously found that CT-induced disease leads to increased concentrations of L-la...
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Maiko Kitaoka 北岡舞子, PhD @maikokitaoka.bsky.social · 01/07/2025
Are you an MIT postdoc in the life sciences? Come join my new initiative, the KendallSqBio Postdoc Symposium on Sept. 10, 2025! ✅ Present your science ✅ Connect with other postdocs ✅ Build your community Abstract deadline July 11th! forms.gle/iXMTYfqgLKWR...
Poster of diverse scientists chatting with each other and holding idea balloons representing various fields in the life sciences, such as DNA, cells, gears, and lightbulbs. More information is available through the QR code.
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Victor J. Torres @torreslab.bsky.social · 23/06/2025
Alert! The abstract deadline for the Microbial Pathogenesis & Host Response meeting has been extended to July 7 meetings.cshl.edu/meetings.asp...
meetings.cshl.edu
Microbial Pathogenesis & Host Response
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
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Lauren Bird @laurenbird.bsky.social · 25/04/2025
Excited to share this story from my PhD, out today in Nature Communications! We show that Coxiella removes cathepsin B to reduce lysosomal hostility and promote bacterial success. This depends on a vacuole established by effector CvpB. www.nature.com/articles/s41...
nature.com
Coxiella burnetii manipulates the lysosomal protease cathepsin B to facilitate intracellular success - Nature Communications
The zoonotic pathogen Coxiella burnetiiestablishes a unique intracellular niche within a lysosome-derived vacuole. Here Bird et al. undertook proteomic, cell biology and microbiology approaches to cha...
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Matt Barber @biobarber.bsky.social · 17/11/2024
Excited to see many in the bacterial pathogenesis community joining here in the last few weeks, so here's a Starter Pack to help make connections. Reply/DM to be added to this or future Packs. #Microsky go.bsky.app/VH64BaY
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Félix Ramos-León @felixrl.bsky.social · 10/11/2024
go.bsky.app/L3L2iFz
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