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Sharpe Lab

@sharpe-lab.bsky.social
155 followers 119 following 1 posts

We investigate the functions of protein tyrosine phosphatases (PTPs) in redox signalling, cancer and immunology @babrahaminst.bsky.social #phosphatases #redox #kinases

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Reposted by Sharpe Lab
Waggoner Lab @labwaggoner.bsky.social · 20/01/2026
Pervanadate: So much more than a protein tyrosine phosphatase inhibitor @babrahaminst.bsky.social www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...
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Sharpe Lab @sharpe-lab.bsky.social · 21/01/2026
Pervanadate is more than just a phosphatase inhibitor! Read our paper just published in #sciencesignaling showing that pervanadate oxidises and activates SRC kinase too. Link: tinyurl.com/5ype7e2s Thanks for the 'focus' by: @nshahlab.bsky.social tinyurl.com/54fcjds3 @babrahaminst.bsky.social
science.org
Pervanadate-induced oxidation relieves autoinhibition of the protein tyrosine kinase SRC
A widely used tyrosine phosphatase inhibitor also oxidizes and activates the tyrosine kinase SRC.
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Reposted by Sharpe Lab
delladavid-lab.bsky.social @delladavid-lab.bsky.social · 04/07/2025
We are hiring a research assistant 👉 tinyurl.com/yxebtjbj to join our lab working on healthy #ageing and protein #aggregation in C. elegans 🪱. Deadline August 4th. 🙏 RT. #proteostasis @babrahaminst.bsky.social
tinyurl.com
hireful.
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Reposted by Sharpe Lab
Louise Fets @louisefets.bsky.social · 11/06/2025
We’re excited to share a new pre-print from the lab! Led by Carmen Ramirez Moncayo and a fantastic collaboration with several groups from across @mrc-lms.bsky.social & @imperialcollegeldn.bsky.social. Interested in #OvarianCancer, #PARPinhibitors or #DrugDistribution? please read on! bit.ly/45lpekS
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Reposted by Sharpe Lab
Babraham Institute @babrahaminst.bsky.social · 22/05/2025
'Rapper Rhodopsin' (AKA Ellie @trayon.bsky.social lab) and the Babraham Massive celebrating Ellie's victory in the first ever @eu-life.bsky.social Science Vision contest. We're so proud! Thanks @ceitec.eu - it was so much fun!
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Reposted by Sharpe Lab
Simon Cook @drsimoncook.bsky.social · 22/05/2025
The @babrahaminst.bsky.social rock steady crew in Brno at the @eu-life.bsky.social Communuty Meeting
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Reposted by Sharpe Lab
Babraham Institute @babrahaminst.bsky.social · 02/05/2025
That's the end of the Signalling Symposium and the end of an era. To quote Phill's closing words: "It's been a hell of a journey." Thank you to everyone for attending and making it such a fitting tribute.
Phill Hawkins and Len Stephens with Babraham Hall in the background
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Reposted by Sharpe Lab
Babraham Institute @babrahaminst.bsky.social · 12/02/2025
📢 Calling all Signallers! Join us for this celebratory smorgasbord of signalling research on 1-2 May with sessions on #proteostasis, #PI3K, #autophagy, #redox biology and #nuclear signalling. 🧪 Latest Institute research with special guests ⤵️ www.eventbrite.co.uk/e/cellular-s...
eventbrite.co.uk
Cellular signals for health & disease
A symposium marking the contributions of Len Stephens and Phillip Hawkins
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Adrian Saurin @adesaurin.bsky.social · 17/01/2025
If you’re thinking of what meeting to go to this year then check out the #phosphatase meeting in Würzburg. Lots of great speaking slots and events for junior researchers. It’s always a fun meeting meetings.embo.org/event/25-pho...
meetings.embo.org
Phosphatases: from basic research to translation
Phosphatases have been considered undruggable for decades. However, recent breakthroughs with the first small molecule phosphatase inhibitors for cancer immunotherapy now in clinical trials have resu…
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Ben Goult @bengoult.bsky.social · 18/12/2024
*Fully funded PhD position available in the lab* We will use structural proteomics to map the mechanosensitive interactions of talin in dendritic spines and how they change during long term potentiation. Please share, and email for details :) www.findaphd.com/phds/project...
findaphd.com
BBSRC NWD: Structural Proteomics to spatially resolve interactions with mechanosensitive synaptic scaffold proteins at University of Liverpool on FindAPhD.com
PhD Project - BBSRC NWD: Structural Proteomics to spatially resolve interactions with mechanosensitive synaptic scaffold proteins at University of Liverpool, listed on FindAPhD.com
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Maja Köhn @mkoehn.bsky.social · 11/12/2024
Join us in Würzburg, Germany, for the EMBO workshop “Phosphatases: From basic research to translation”! July 27-31 2025. Newest developments in the field, from academia and industry. Great networking opportunities! Short talk slots available. Hope to see you there! meetings.embo.org/event/25-pho...
meetings.embo.org
Phosphatases: from basic research to translation
Phosphatases have been considered undruggable for decades. However, recent breakthroughs with the first small molecule phosphatase inhibitors for cancer immunotherapy now in clinical trials have resu…
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Reposted by Sharpe Lab
Martin Turner @martint-babraham.bsky.social · 09/12/2024
www.nature.com/naturecareer...
nature.com
Principal Investigators in Immunology - Babraham, Cambridge job with Babraham Institute | 12832167
The Babraham Institute in Cambridge, UK, invites applications for tenure-track and tenured group leader positions in the Immunology Programme. We w...
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Martin Turner @martint-babraham.bsky.social · 30/11/2024
New science leadership opportunities at the Babraham Institute
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