iiinova — where your digital self keeps evolving

Khaled_Selim Lab @selimlab.bsky.social · 19/09/2026

Our Collaborative Research Center MibiNet @mibinet.bsky.social @hhu.de was strongly present in #EMBOBacNet Best poster prize for Benita Lückel, a PhD student in Bott group @fz-juelich.de, sponsored by @natmicrobiol.nature.com Congrats🎉🎉everyone & organizers @lalouxlab.bsky.social @s-lab.bsky.social

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Khaled_Selim Lab @selimlab.bsky.social · 08/09/2026

So proud of Laís, a very talented PhD student @hhu.de & @ufpr.bsky.social, who won the best poster prize 🎉🎉 at the N2 Fixation conference Keep rocking Laís! #PII #Signaling @sfb1381.bsky.social

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Khaled_Selim Lab @selimlab.bsky.social · 07/09/2026

Simply, AMPylation increases the flexibility of the AMP-loop, disrupting a hydrogen-bond network that stabilizes the ATP substrate in an orientation required to position the ATP γ-phosphate in its catalytic conformation for efficient phosphoryl transfer to glutamate. 🙈

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Khaled_Selim Lab @selimlab.bsky.social · 01/09/2026

A press about our recent publication on Ca2+ signaling for controlling communication machinery in #cyano bacteria🦠 @hhu.de @cmfi.bsky.social @unituebingen.bsky.social Supposed by @spp2389.bsky.social @sfb1381.bsky.social @mibinet.bsky.social @ceplas.bsky.social www.eurekalert.org/news-release...

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Khaled_Selim Lab @selimlab.bsky.social · 01/09/2026

Thx a lot Alex @aharms485.bsky.social for the invitation to the Swiss Society for Microbiology Congress 2026 in Montreux. Amazing science & wonderful location! It was also awesome to get in touch with Swiss Microbiologist & thx🙏 for the organizers. I need this 1 day break to switch off for a moment

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Khaled_Selim Lab @selimlab.bsky.social · 13/08/2026

Finally, this work was done by amazing PhD student in my group "Teresa Müller", who recently defended her PhD @cmfi.bsky.social (deserving another post) & Wonderful collaboration w/ Murray Coles & Felicia Stahlecker at my time @mpi-bio-fml.bsky.social Supported @sfb1381.bsky.social & @embopress.org

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Khaled_Selim Lab @selimlab.bsky.social · 13/08/2026

Then we teamed up w/ @weiss-lab.bsky.social & his awesome student Karolina, who took some amazing tomograms, showing Δcse mutant "almost free from any junctions" #TeamTomo Some Add on, we also found that CSE likely interacting w/ an amidase that drills & builds up the #nanopores "explaining a lot"

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Khaled_Selim Lab @selimlab.bsky.social · 13/08/2026

To explain that communication phenotype mechanistically, we checked if the Δcse can drill the #nanopores, which are needed to build the #bacterial #junctions. Surprisingly, we found high heterogeneity with some cells almost free of nanopores, explaining why Δcse filaments can't communicate properly

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Khaled_Selim Lab @selimlab.bsky.social · 13/08/2026

With help of biophysical methods, like ITC, we concluded that CSE is a Ca2+-buffer protein that controls Ca2+ homeostasis in #Nostoc #cyanobacteria A striking phenotype of Δcse deletion mutant was a strong fragmentation, a hallmark feature of disturbing multicellularity and Cell-Cell communication

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Khaled_Selim Lab @selimlab.bsky.social · 07/07/2026

Happy to share our latest finding on ComFB, a new #cdiGMP receptor in bacteria Team effort w/ @freecyano.bsky.social at @sfb1381.bsky.social ComFB regulates type IV pilus-dependent functions via sequestering TFs (CRP1/2) @hhu.de @biologyunifreiburg.bsky.social www.sciencedirect.com/science/arti...

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Khaled_Selim Lab @selimlab.bsky.social · 02/07/2026

Plz spread the words: We have 2 opens for Full (W3) and Associate (W2) professorships @hhu.de Düsseldorf on Experimental Biophysics Come and join us to shape both physics & biology departments and let's make some great science together! berufungsportal.hhu.de

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Khaled_Selim Lab @selimlab.bsky.social · 06/06/2026

Join us for TPJ WEBINAR to feature our special issue on Plant structure biology @theplantjournal.bsky.social hosted by the amazing Editor-in-chief @katherinedenby.bsky.social Speakers: @cblikstad.bsky.social & @bjornppedersen.bsky.social & Clarisa Álvarez 30 June us02web.zoom.us/webinar/regi...

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Khaled_Selim Lab @selimlab.bsky.social · 03/06/2026

www.sfb1535.hhu.de/internationa... Come & join us @hhu.de For the international conference of CRC MibiNet @mibinet.bsky.social Topic: "Microbial Networking - from organelles to cross-kingdom communities"

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Khaled_Selim Lab @selimlab.bsky.social · 04/05/2026

As Lys is toxic in low uM, it was speculated to act as a potential killer for harmful #cyano #blooms But unfortunately, we observed that #cyano aquire resistance quite fast. Using #CRISPRi developed by #HudsonLab, we revealed different ways how cells become resistance with link to #cdiAMP signaling

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Khaled_Selim Lab @selimlab.bsky.social · 04/05/2026

The take home: Metabolic and physiological analysis indicated that Lys is mis-incorporated in the peptidoglycan by an stupid MurE enzyme, instead of mDAP (meso-diaminopimelate), causing a leaky cell wall and subsequent cell death of #cyanobacteria

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Khaled_Selim Lab @selimlab.bsky.social · 20/04/2026

It was a good pleasure to host Annegret Wilde @freecyano.bsky.social from @biologyunifreiburg.bsky.social and @sfb1381.bsky.social To our INSPIRE seminar series @hhu.de with a close interaction between @mibinet.bsky.social and @ceplas.bsky.social

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Khaled_Selim Lab @selimlab.bsky.social · 31/03/2026

A great team effort w/ @freecyano.bsky.social on c-di-NMP signaling via ComFB in #cyanobacteria ComFB sequesters TFs (CRP1/2) & keeps them inactive. High #c-di-GMP breaks the complexes & TFs become free to act on their targets @hhu.de @biologyunifreiburg.bsky.social www.biorxiv.org/content/10.6...

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Khaled_Selim Lab @selimlab.bsky.social · 09/12/2025

Come and join us at @ceplas.bsky.social for a structured #PhD program A new call for PhD students

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Khaled_Selim Lab @selimlab.bsky.social · 03/12/2025

Our regular Christmas Market routine 🙃 I had some fun with those amazing 🤩 guys from the Lab @hhu.de at @duesseldorf.bsky.social 🎄🎄 #Christmas 🌲🌲 Market 🎄🎄 ..... Thx for your enthusiasm, your support, your cool science & keep rocking! proud of all of you!

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Khaled_Selim Lab @selimlab.bsky.social · 01/12/2025

This CutA project is close to my heart as it was my first funded project. It was/still a highly risky project but ended quite well with a huge team effort from hard core chemistry to microbiology & biophysics Thanks @cmfi.bsky.social + Forchhammer for support & believing in us! @mibinet.bsky.social

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Khaled_Selim Lab @selimlab.bsky.social · 01/12/2025

With great help of Hughes & Petras group, pteridines were identified as natural ligands of CutA protein. Lumazine dehydroxyxanthopterin B2, a new pteridine, was found to bind CutA. Pteridines are involved in Redox biology, so we found that cutA mutants of #cyanobacteria & #E.coli have redox problems

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Khaled_Selim Lab @selimlab.bsky.social · 06/10/2025

He found another one of a bacterium with mitochondrial dysfunction I don't know if I should laugh 😂 or cry 😭 .... @mdpiopenaccess.bsky.social www.mdpi.com/2079-6382/14...

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Khaled_Selim Lab @selimlab.bsky.social · 06/10/2025

Bacterial 🦠 mitochondria 🙈 .... What a shit 😅 @sholtodavid.bsky.social pointed in X for an "unreviewed" article with status officially reviewed in @mdpiopenaccess.bsky.social Maybe it's AI generated with no efforts from authors, editors or reviewers to go through it? www.mdpi.com/2624-845X/5/...

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Khaled_Selim Lab @selimlab.bsky.social · 22/09/2025

It was a great pleasure hosting Prof. Edileusa Marques Gerhardt from Universidade Federal do Paraná, Brazil for our regular @mibinet.bsky.social seminar series @hhu.de She told us about the recent updates in #PII #Signaling in bacteria 🦠 .... What a beautiful system ;-)

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Khaled_Selim Lab @selimlab.bsky.social · 19/09/2025

We discovered a new family of c-di-NMP receptors, widespread in bacteria & regulating🦠motility @pnas.org A great collab. w/ @mygalperin.bsky.social @vikramalva.bsky.social @thethormannden.bsky.social www.pnas.org/doi/10.1073/... @hhu.de @cmfi.bsky.social @sfb1381.bsky.social @mibinet.bsky.social

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Khaled_Selim Lab @selimlab.bsky.social · 28/07/2025

A new doctor is born 😊🥳 Welcome with me Dr. Haffner, the first PhD student of the group after wonderful years @cmfi.bsky.social Michael published 8 articles & a review with 3 as 1st author.. www.science.org/doi/10.1126/... www.pnas.org/doi/10.1073/...

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Khaled_Selim Lab @selimlab.bsky.social · 11/04/2025

This CutA project is close to my heart as it was my first 3rd party funded project. It was/still a highly risky project but ended quite well with a huge team effort from hard core chemistry to microbiology & biophysics Thanks @cmfi.bsky.social + Forchhammer for financial support & believing in us!

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Khaled_Selim Lab @selimlab.bsky.social · 11/04/2025

With great help of Hughes & Petras groups, pteridines were identified as natural ligands of CutA protein. Lumazine dehydroxyxanthopterin B2, a new pteridine, was found to bind CutA. Pteridines are involved in Redox biology, so we found that cutA mutants of #cyanobacteria & E.coli have redox problems

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Khaled_Selim Lab @selimlab.bsky.social · 28/02/2025

It was a great pleasure having Ferran from @uarizona.bsky.social in our @mibinet.bsky.social seminar series @hhu.de He showed us how #cyano can attract friends in desert 🏜️ and how ugly friends can eat them from inside #Cyanoraptor www.nature.com/articles/s41...

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Khaled_Selim Lab @selimlab.bsky.social · 31/01/2025

Big News (a bit late 🙃): my group is moving to Düsseldorf @hhu.bsky.social Looking for next adventure w awesome colleagues @frunzkelab.bsky.social @kedrov-lab.bsky.social @apmweber.bsky.social Plz RT, positions available for #PhD & #postdoc w focus #CryoEM & #cdiAMP www.hhu.de/news-einzela...

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