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Michael Galperin

@mygalperin.bsky.social
65 followers 54 following 8 posts

Lead Scientist at the Division of Intramural Research (formerly NCBI), NLM, NIH. Bacterial signaling, c-di-GMP, c-di-AMP, protein domains, COG database

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Reposted by Michael Galperin
EMBO Reports @emboreports.org · 15/06/2026
Philipp Rieche, Marten Exterkate, Arnold Driessen et al show that the #lipid divide between #bacteria and #archaea is not as strict as previously thought as bacterial lipid synthesizing enzymes can use both stereo-forms of glycerol-phosphate. #MembraneBiology -> link.springer.com/article/10.1...
link.springer.com
Bacterial lipid synthesizing enzymes PlsY and PlsC utilize both stereo-forms of glycerol-phosphate - EMBO Reports
The chemical composition of membrane lipids differs between eukarya, bacteria and archaea. The central dogma posits that the stereochemistry of phospholipids in bacteria is distinct from archaea. Bact...
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Reposted by Michael Galperin
Ken Timmis @kentimmis.bsky.social · 01/06/2026
Does unnecessary bureaucracy cause you frustration, affect your work? This paper outlines some root causes and actions needed to address them. If you wish to contribute to the solution, disseminate and engage: enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
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Reposted by Michael Galperin
Patricia Bernal @pbernalt6ss.eurosky.social · 31/05/2026
Excessive paperwork and inefficient systems are sabotaging scientific progress. Really proud to be part of this global manifesto spearheaded by @kentimmis.bsky.social. We need action at all levels to tackle the root causes. Our analysis & proposals @microbiotech.bsky.social: doi.org/10.1111/1751...
doi.org
Scientists' Warning to Humanity: Unnecessary Bureaucracy Is a Global Impediment to Productivity, Advancement of Human and Planetary Wellbeing, Science and Sustainability
Unnecessary bureaucracy is a global impediment to progress and productivity that increases stress and lowers workplace morale and motivation. In research it smothers creativity and innovation that ar....
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Reposted by Michael Galperin
Ákos T Kovács @evolvedbiofilm.bsky.social · 02/04/2026
Open Call for Editors at mBio, Microbiology Spectrum, mSphere, and mSystems at @asm.org journals.asm.org/editor-open-... [deadline: April 24 at 11:59 p.m. ET]
journals.asm.org
Open Call for Editors at mBio, Microbiology Spectrum, mSphere, and mSystems
ASM welcomes microbiologists globally to join the Boards of Editors for mBio, mSphere, mSystems, and Microbiology Spectrum.
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Michael Galperin @mygalperin.bsky.social · 22/03/2026
‪I am honored and humbled by being elected as a Fellow of the European Academy of Microbiology (particularly after being twice rejected by the American one )). Proud to be in such a good company!
fems-microbiology.org
Fellows
The European Academy of Microbiology (EAM) proudly brings together a distinguished community of leading scientists whose contributions have shaped and advanced the field of microbiology. Below, you wi...
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Reposted by Michael Galperin
Fusion Conferences @fusionconf.bsky.social · 16/10/2025
We’re excited to announce the incredible speaker line-up for the Prokaryotic Cell Biology Conference! Join the leading researchers as they explore the latest advances in Nanoimaging, Cell Growth and Cellular Structures. Join our speakers & register today! ➡️https://bit.ly/47rtkbw #ProkaryoticCellBio
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Reposted by Michael Galperin
SourjikLab @sourjik-lab.bsky.social · 15/10/2025
Everyone interested in bacterial signal transduction, environmental sensing and motility, don't miss this conference organised by Ariane Briegel @arianebriegel.bsky.social and myself! We have great invited speakers and a number of slots allocated to short talks: www.grc.org/sensory-tran...
grc.org
2026 Sensory Transduction in Microorganisms Conference GRC
The 2026 Gordon Research Conference on Sensory Transduction in Microorganisms will be held in Ventura, California. Apply today to reserve your spot.
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Reposted by Michael Galperin
George O'Toole (he/him/his) @geiselbiofilm.bsky.social · 15/10/2025
I want to take a moment to say THANK YOU to Anke Becker and Conrad Mullineaux, our two Editors who retired this past summer. Please check out the article to see all they've done of JB! journals.asm.org/doi/10.1128/... @asm.org #JBacteriology
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Reposted by Michael Galperin
Lori L. Burrows @dr-lori-burrows.bsky.social · 13/10/2025
New paper alert! We used our fav technique, genetic suppression, to understand how FimX controls function of the T4P PilB motor ATPase in Pseudomonas aeruginosa. Great collab with the Ellison lab at U Georgia who helped with some fancy microscopy to capture pilus dynamics! doi.org/10.1371/jour...
doi.org
Twitching motility suppressors reveal a role for FimX in type IV pilus extension dynamics
Author summary Type IV pili enable Pseudomonas aeruginosa to attach to surfaces, move (twitch), and form biofilms. Pilus extension is powered by the motor protein PilB, which is regulated by other fac...
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Reposted by Michael Galperin
SourjikLab @sourjik-lab.bsky.social · 14/10/2025
Happy to share as my first Bluesky post: Our newest paper describing a beautiful example of surprizing evolutionary innovation: Control of flagellar gene expression by a chemotaxis receptor-like regulator in pathogenic Escherichia coli | The EMBO Journal www.embopress.org/doi/full/10....
embopress.org
Control of flagellar gene expression by a chemotaxis receptor-like regulator in pathogenic Escherichia coli | The EMBO Journal
imageimageChemotaxis receptors typically mediate biased movement of motile bacteria in environmental gradients by controlling rotation of the flagellar motor. This study identifies a chemotaxis recept...
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Reposted by Michael Galperin
Jörg Stülke @joergstuelke.bsky.social · 10/10/2025
Sneak preview of the next upcoming #SubtiWiki feature: All proteins are assigned to clusters sharing similar structures! Brought to you by Oskar Geissel and @c-elfmann.bsky.social . @imprsgs.bsky.social
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Reposted by Michael Galperin
Kranzusch Lab @kranzuschlab.bsky.social · 09/10/2025
Differential activation of cGAS in naked mole rats! An exciting addition to our understanding of species-specific mutations tailoring the cGAS-STING pathway in individual organisms www.science.org/doi/10.1126/...
science.org
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that na...
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Reposted by Michael Galperin
Kranzusch Lab @kranzuschlab.bsky.social · 09/10/2025
All science arises only because of the shared broader community. I want to especially recognize Rotem Sorek @soreklab.bsky.social Aude Bernheim @audeber.bsky.social our collaborators and the many wonderful labs and scientists in the field bringing together human and bacterial antiviral research!
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Reposted by Michael Galperin
Dana-Farber Cancer Institute @danafarber.bsky.social · 08/10/2025
Congratulations to Philip J. Kranzusch, Ph.D., Professor of Cancer Immunology and Virology, who was one of three scientists awarded top honors at the 2025 Blavatnik National Awards for Young Scientists. Watch to learn more about his work: bit.ly/4pZUDkF
Blavatnik National AwardsBlavatnik National AwardsBlavatnik National AwardsBlavatnik National Awards
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Reposted by Michael Galperin
Roni Odai @rodai.bsky.social · 02/10/2025
Viral AlphaFold Database (VAD) is live in Science Advances ~27,000 predicted viral protein monomers & homodimers Conserved folds across bacteria, archaea & eukaryotic viruses New toxin–antitoxin system KreTA uncovered Vast “functional darkness” remains uncharted www.science.org/doi/10.1126/...
science.org
The Viral AlphaFold Database of monomers and homodimers reveals conserved protein folds in viruses of bacteria, archaea, and eukaryotes
VAD is a Viral AlphaFold Database of protein monomers and homodimers from viruses infecting hosts across the tree of life.
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George O'Toole (he/him/his) @geiselbiofilm.bsky.social · 07/10/2025
Excited to be part of this collaboration with the Burrows lab exploring twitching and surface surface sensing by P. aeruginosa. This work further delineates a role for the T4P motor proteins and pili for surface sensing. journals.asm.org/doi/10.1128/... @asm.org
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Michael Galperin @mygalperin.bsky.social · 06/10/2025
Two fungal genera use two distinct pathways to synthesize psilocybin onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com
Dissimilar Reactions and Enzymes for Psilocybin Biosynthesis in Inocybe and Psilocybe Mushrooms
Mushrooms have learned twice independently how to make the iconic magic mushroom natural product psilocybin. This article introduces the enzymes of the second pathway, found in a fiber cap mushroom. ....
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Reposted by Michael Galperin
Ben Morehouse @benmorehouse.bsky.social · 01/10/2025
Our story describing the Panoptes bacterial immune defense system is now finally peer-reviewed and published today! www.nature.com/articles/s41...
nature.com
The Panoptes system uses decoy cyclic nucleotides to defend against phage - Nature
The Panoptes antiphage system defends bacteria by detecting phage-encoded counter-defences that sequester cyclic nucleotide signals, triggering membrane disruption and highlighting a broader strategy of sensing immune evasion through second-messenger surveillance.
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Reposted by Michael Galperin
Khaled_Selim Lab @selimlab.bsky.social · 30/09/2025
Also in Spanish ;-) larepublica.es/2025/09/27/d...
larepublica.es
Descubren nuevos mecanismos que regulan la motilidad y transferencia de ADN en bacterias
Investigaciones recientes realizadas por un equipo de científicos en colaboración con diversas universidades y centros de investigación han revelado nuevos mecanismos que regulan la motilidad bacteria...
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Reposted by Michael Galperin
Marie Joest @mariejoest.bsky.social · 17/09/2025
Thrilled to be a coauthor in this story 🚀 Check out our latest publication on the archaellum - spoiler: it's an archaellum in bacteria 😱 Who would have thought? Thank you to all the authors, and especially @sshamphavi.bsky.social for really keeping this paper rotating 😉
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Reposted by Michael Galperin
Sonja-Verena Albers @archaellum.bsky.social · 17/09/2025
Happy to share that our story on the bacterial archaellum was published today in @natmicrobiol.nature.com www.nature.com/articles/s41... Congrats to the authors: @sshamphavi.bsky.social @loumollat.bsky.social @mariejoest.bsky.social Najwa Taib and @sgribaldo.bsky.social
nature.com
Structure of a functional archaellum in Bacteria of the Chloroflexota phylum - Nature Microbiology
Bona fide gene clusters for archaella are widespread across a bacterial phylum and encode functional motility machinery.
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Reposted by Michael Galperin
Ákos T Kovács @evolvedbiofilm.bsky.social · 19/09/2025
And here is the published version of the work from @selimlab.bsky.social, @mygalperin.bsky.social, Dubnau labs and @thethormannden.bsky.social labs (superb collaboration) ComFB, a widespread family of c-di-NMP receptor proteins www.pnas.org/doi/10.1073/...
pnas.org
ComFB, a widespread family of c-di-NMP receptor proteins | PNAS
Cyclic dimeric-GMP (c-di-GMP) is a ubiquitous bacterial second messenger that regulates a variety of cellular processes, including motility, biofil...
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Reposted by Michael Galperin
Ariane Briegel @arianebriegel.bsky.social · 12/09/2025
Registration is open! Come join us at the sensory transduction in microorganisms GRC! Spread the word! www.grc.org/sensory-tran...
grc.org
2026 Sensory Transduction in Microorganisms Conference GRC
The 2026 Gordon Research Conference on Sensory Transduction in Microorganisms will be held in Ventura, California. Apply today to reserve your spot.
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Reposted by Michael Galperin
Jason Stajich @hyphaltip.bsky.social · 11/09/2025
asm.org/press-releas...
asm.org
ASM Launches New Food Microbiology Journal
ASM is launching ASM Food Microbiology, a new journal dedicated to advancing research on microbial safety, fermentation, spoilage and biotechnological innovations in food systems.
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Michael Galperin @mygalperin.bsky.social · 02/09/2025
Some thoughts on metabolism and metabolic pathway holes (PMID: 40892933) pnas.org/doi/10.1073/....
pnas.org
Using bioinformatics for identifying and plugging metabolic pathway holes | PNAS
Using bioinformatics for identifying and plugging metabolic pathway holes
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Reposted by Michael Galperin
Ákos T Kovács @evolvedbiofilm.bsky.social · 01/09/2025
Prioritising Microbiology in Secondary Education Addresses Emerging Scientific-Social-Educational Challenges and Competency Needs #MicrobialBiotech by Lara Amorim, Conceição Santos, and Kenneth Timmis enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
enviromicro-journals.onlinelibrary.wiley.com
Prioritising Microbiology in Secondary Education Addresses Emerging Scientific‐Social‐Educational Challenges and Competency Needs
This work highlights how microbiology education can empower secondary school students with critical and systems thinking, fostering STEM literacy, overcoming barriers and preparing informed, responsi...
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