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Cecilia Blikstad

@cblikstad.bsky.social
236 followers 264 following 33 posts

Biochemist interested in biological CO2-fixation and CO2 concentration mechanisms mostly in cyanobacteria. Group leader at Uppsala University. UC Berkeley alumni. blikstadlab.org

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Reposted by Cecilia Blikstad
Ben Long @botbml.bsky.social · 27/07/2026
Machine learning-assisted directed evolution of plant Rubisco www.biorxiv.org/content/10.6...
biorxiv.org
Machine learning-assisted directed evolution of plant Rubisco
Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) is foundational to life on Earth, catalyzing carbon dioxide (CO2) fixation to generate biomass. However, Rubisco is a slow and inefficient enz...
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Reposted by Cecilia Blikstad
Ben Long @botbml.bsky.social · 05/07/2026
Engineering Modular Cargo Loading Strategies for Carboxysome-Derived Protein Particles | ACS Synthetic Biology @cellforganized.bsky.social
pubs.acs.org
Engineering Modular Cargo Loading Strategies for Carboxysome-Derived Protein Particles
Bacterial microcompartments (BMCs) are a diverse and widespread class of self-assembling protein-based organelles consisting of a semipermeable protein shell encapsulating an enzymatic core. Isolated ...
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Reposted by Cecilia Blikstad
ASM @asm.org · 06/07/2026
#MicrobiologyMonday: Many bacterial species contain specialized subcellular compartments that help organize and protect essential cellular functions. These structures may contribute to pathogen survival and virulence during infection. #mBio: asm.social/2ZP
Fig 1 Subcellular compartments found in bacterial pathogens. Representative micrographs, a summary of form and function, and a non-exhaustive list of pathogens containing bacterial microcompartments, encapsulins, and ferrosomes. Black triangles denote bacterial microcompartments. White arrows denote encapsulins. Black arrows denote ferrosomes. Asterisks denote unknown storage granules. Red and white triangles denote inner and outer membranes, respectively. Micrograph of bacterial microcompartments in S. Typhimurium (top) is adapted from reference 17. Micrograph of encapsulins in Mycobacterium marinum (middle) is adapted from reference 18. Micrograph of ferrosomes in C. difficile (bottom) is adapted from reference 19. Micrographs were modified from the originals by cropping and replacement or addition of arrows, triangles, asterisks, and scale bars.
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Ben Long @botbml.bsky.social · 20/06/2026
Chloroplast genome editing of Rubisco boosts photosynthesis and plant growth @utokyo-yamori.bsky.social ! www.nature.com/articles/s41...
nature.com
Chloroplast genome editing of Rubisco boosts photosynthesis and plant growth - Nature Communications
Rubisco has inherently low catalytic efficiency limiting crop productivity. Here the authors show that chloroplast genome editing can be used to generate substitutions in Arabidopsis rbcL that increas...
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Reposted by Cecilia Blikstad
Ben Long @botbml.bsky.social · 10/06/2026
Functional and structural insights into cyanobacterial CO2 concentrating mechanisms: from compartmentalization to regulation - Zimmer - 2026 - The Plant Journal - Wiley Online Library onlinelibrary.wiley.com/doi/epdf/10.... From @selimlab.bsky.social lab
onlinelibrary.wiley.com
Functional and structural insights into cyanobacterial CO2 concentrating mechanisms: from compartmentalization to regulation
Life on Earth depends on photosynthetic CO2 fixation via the Calvin–Benson–Bassham cycle to form organic carbon. This process evolved first in cyanobacteria and was later conveyed to eukaryotes, givi...
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Reposted by Cecilia Blikstad
C5 EU Project @c5-project.eu · 18/06/2026
Our coordinator, Maria Agustina Dominguez-Martin, will introduce our @horizoneu.bsky.social project at a knowledge transfer event for biotechnology Master students at @uco.es today! Hear from Tina at 17:00, Co working room, Campus Universitario de Rabanales. #EUInnovation #EarlyCareerResearchers
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Khaled_Selim Lab @selimlab.bsky.social · 15/06/2026
I'm sure that I'll be a great issue with a wonderful editor @botbml.bsky.social Consider this special issue if you are working on #CO2 metabolism and photosynthesis!
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Martin Jonikas @mjonikas.bsky.social · 15/06/2026
Pyrenoid tubules are essential for supercharging CO₂ fixation, but they're hard to resolve by microscopy. So, we physically expanded cells to see where different proteins go (3 examples below). The central tubule region appears specialized for CO₂ delivery! www.biorxiv.org/content/10.6...
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Ben Long @botbml.bsky.social · 14/06/2026
A bifunctional coiled-coil protein generates the membrane-within-condensate architecture of the CO2-fixing pyrenoid @mjonikas.bsky.social lab www.biorxiv.org/content/10.6...
biorxiv.org
A bifunctional coiled-coil protein generates the membrane-within-condensate architecture of the CO2-fixing pyrenoid
How membranes are integrated into biomolecular condensates is a fundamental question in cell biology. In the algal pyrenoid, an organelle responsible for one-third of global carbon fixation, CO2-deliv...
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Cecilia Blikstad @cblikstad.bsky.social · 12/06/2026
Check out this great review on the bacterial CCM!
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Reposted by Cecilia Blikstad
Martin Jonikas @mjonikas.bsky.social · 11/06/2026
The algal pyrenoid fixes ~1/3 of global carbon, relying on a unique membrane-within-condensate architecture. How is this architecture built? We discovered that the protein MITH1 draws membranes into the pyrenoid condensate by promoting wetting! 🌿💧 www.biorxiv.org/content/10.6...
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Cecilia Blikstad @cblikstad.bsky.social · 11/06/2026
Watch @guillawme.eurosky.social great talk about our atomic resolution spinach rubisco structure which reveals both protons and dynamics.
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Reposted by Cecilia Blikstad
Guillaume Gaullier @guillawme.eurosky.social · 11/06/2026
I learned so much from watching past editions of @ccpem.bsky.social Spring Symposium, so I agreed to my talk being recorded even though this is stepping well out of my comfort zone (public speaking isn't my strongest skill). Anyway, here is the recording: www.youtube.com/watch?v=AKTf... #CCPEM
youtube.com
Atomic resolution structure of spinach rubisco reveals protons and dynamics | Guillaume Gaullier
YouTube video by CCP-EM
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Reposted by Cecilia Blikstad
Khaled_Selim Lab @selimlab.bsky.social · 11/06/2026
This is a wonderful talk by @guillawme.eurosky.social from @cblikstad.bsky.social Lab If you are interested in CO2 Fixation by RubisCO, then highly recommend to watch youtu.be/AKTfiUu720w?...
youtu.be
Atomic resolution structure of spinach rubisco reveals protons and dynamics | Guillaume Gaullier
YouTube video by CCP-EM
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Reposted by Cecilia Blikstad
Khaled_Selim Lab @selimlab.bsky.social · 06/06/2026
Join us for TPJ WEBINAR to feature our special issue on Plant structure biology @theplantjournal.bsky.social hosted by the amazing Editor-in-chief @katherinedenby.bsky.social Speakers: @cblikstad.bsky.social & @bjornppedersen.bsky.social & Clarisa Álvarez 30 June us02web.zoom.us/webinar/regi...
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Reposted by Cecilia Blikstad
The Plant Journal @theplantjournal.bsky.social · 06/06/2026
🔈 New TPJ webinar with the @globalplantgpc.bsky.social 🌱 New Insights from Plant Structural Biology🌱 Explore how structural biology is advancing plant science With Clarisa Ester Álvarez, @cblikstad.bsky.social & @bjornppedersen.bsky.social 🗓️ June 30 ⏰ 15:00 CEST us02web.zoom.us/webinar/regi...
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Reposted by Cecilia Blikstad
cryoEM papers @cryoempapers.bsky.social · 22/05/2026
Cryo-EM structure of ALC1 in an open conformation bound to a PARylated nucleosome pubmed.ncbi.nlm.nih.gov/42159202/ #cryoEM
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Cecilia Blikstad @cblikstad.bsky.social · 21/05/2026
Thanks for sharing our work and for providing excellent grids!
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Cecilia Blikstad @cblikstad.bsky.social · 21/05/2026
Our atomic resolution structure of Rubisco just got featured in @quantifoil.bsky.social newsletter. Check it out for a beautiful structure, visualized active site protons and novel mechanistic insights into one of the most important and abundant protein on Earth. doi.org/10.64898/2025.12.22.696010
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Reposted by Cecilia Blikstad
Lars-Anders Carlson @lacarlson.bsky.social · 14/05/2026
Just over a week left to apply to our postdoc position! Reposts appreciated.
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Plant Biotechnology Journal @plantbiotechj.bsky.social · 08/05/2026
📣 Call for Papers 📣 PBJ will be launching a special issue to coincide with Photosynthesis 2026, guest edited by Ben Long @botbml.bsky.social Watch this space for more information, but in the meantime don't miss your chance to present in-person at ICPR26 👇
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Laura T. Wey @lauratwey.bsky.social · 12/05/2026
Postdoc position available to join my team in Turku, Finland to explore light-activated extracellular electron uptake in microorganisms. Application open until end of June, position starts August-when suitable for best candidate. Please share/apply ats.talentadore.com/apply/tutkij...
ats.talentadore.com
Post-doctoral researcher, Molecular Plant Biology, at Turku, Finland
We are seeking a Postdoctoral Researcher to investigate extracellular electron uptake in photosynthetic bacteria (cyanobacteria), focusing on underlying molecular mechanisms and regulation, and with c...
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Reposted by Cecilia Blikstad
Ben Long @botbml.bsky.social · 06/05/2026
Carbon dioxide concentration alters cyanobacterial carboxysome encapsulation and redox state in Synechococcus sp. PCC 7002 rdcu.be/fhiaJ
rdcu.be
Carbon dioxide concentration alters cyanobacterial carboxysome encapsulation and redox state in Synechococcus sp. PCC 7002
Communications Biology - Single-cell timelapse fluorescence microscopy reveals dynamics of the carboxysomal redox state in cyanobacteria under high and low CO2concentration as a result of changing...
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Reposted by Cecilia Blikstad
Ryo Yokoyama @yokoyama-ryo.bsky.social · 07/05/2026
SAGA1 and SAGA2 localize the starch sheath to the pyrenoid in Chlamydomonas reinhardtii | PNAS www.pnas.org/doi/10.1073/... @pnas.org
pnas.org
SAGA1 and SAGA2 localize the starch sheath to the pyrenoid in Chlamydomonas reinhardtii | PNAS
Most algae enhance their CO2 assimilation by concentrating CO2 within the pyrenoid, a biomolecular condensate of the CO2-fixing enzyme Rubisco. Man...
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Reposted by Cecilia Blikstad
Martin Jonikas @mjonikas.bsky.social · 07/05/2026
Now published @PNASNews! SAGA1 and SAGA2 localize the starch sheath to the pyrenoid in Chlamydomonas reinhardtii www.pnas.org/doi/10.1073/...
pnas.org
SAGA1 and SAGA2 localize the starch sheath to the pyrenoid in Chlamydomonas reinhardtii | PNAS
Most algae enhance their CO2 assimilation by concentrating CO2 within the pyrenoid, a biomolecular condensate of the CO2-fixing enzyme Rubisco. Man...
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Reposted by Cecilia Blikstad
Ben Long @botbml.bsky.social · 03/05/2026
Hornwort pyrenoids: a terrestrial exception with engineering lessons. @tarobison.bsky.social @fernway.bsky.social @laura-gunn.bsky.social @jcarlosvillarreal.bsky.social academic.oup.com/plphys/advan...
academic.oup.com
Validate User
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Reposted by Cecilia Blikstad
Cyanotrans @cyanotrans.bsky.social · 27/04/2026
The small protein SbtC is a functional component of the CO2 concentrating mechanism in Synechocystis sp. PCC 6803 academic.oup.com/plphys/artic...
academic.oup.com
The small protein SbtC is a functional component of the CO2 concentrating mechanism in Synechocystis sp. PCC 6803
A previously non-annotated, CO2-controlled gene was identified in the cyanobacterium Synechocystis sp. PCC 6803 that encodes a small protein contributing t
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Reposted by Cecilia Blikstad
Cyanotrans @cyanotrans.bsky.social · 20/04/2026
Polyphosphate acts as an architectural regulator of carbon fixation and nucleoid structure in cyanobacteria www.biorxiv.org/content/10.6...
biorxiv.org
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ASM @asm.org · 15/04/2026
Cyanobacteria are an ancient clade of phototrophic prokaryotes. But out of all the cyanobacteria available, why did Synechocystis sp. PCC 6803 become the default laboratory model? This #JBacteriology review offers insights: asm.social/2TD
Overview of key research directions using Synechocystis sp. PCC 6803 as a model cyanobacterium. Summary of the main structural, physiological, genetic, and behavioral characteristics that have established Synechocystis sp. PCC 6803 as a leading model organism for cyanobacterial research. Core cellular functions include oxygenic photosynthesis, carbon, and nitrogen metabolism. Emerging research directions focus on primary metabolism and regulatory and adaptive processes, such as stress responses, circadian clock, behavior, and biotechnological applications.
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Lancaster Plant Biology @lancasterplantbio.bsky.social · 15/04/2026
Well done to PhD student Connor Nehls, @ecarmosilva.bsky.social and @doug-orr.bsky.social on new work out in @jxbotany.bsky.social on Rubisco dark inhibition. See the release here by @ripeproject.bsky.social www.linkedin.com/posts/ripepr...
linkedin.com
The RIPE team laser-focused on improving photosynthetic efficiency and new research sheds light on the complex regulation of Rubisco activity. In many plant species, Rubisco activity is inhibited… |...
The RIPE team laser-focused on improving photosynthetic efficiency and new research sheds light on the complex regulation of Rubisco activity. In many plant species, Rubisco activity is inhibited by...
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Reposted by Cecilia Blikstad
Ben Long @botbml.bsky.social · 13/04/2026
Polyphosphate acts as an architectural regulator of carbon fixation and nucleoid structure in cyanobacteria From the @cellforganized.bsky.social and @savagecatsonly.bsky.social labs www.biorxiv.org/content/10.6...
biorxiv.org
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New Phytologist @newphyt.bsky.social · 13/04/2026
The structure of intact and active Photosystem II from Arabidopsis thaliana at 2.44 Å resolution Forsman et al. nph.onlinelibrary.wiley.com/share/9CDHKF...
Water channels connecting the Mn-cluster to the protein exterior.
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Ella Sieradzki @sieravirus.bsky.social · 09/04/2026
Deadline is April 20th! Let’s get those viruses
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Ryo Yokoyama @yokoyama-ryo.bsky.social · 29/03/2026
Update: carbonic anhydrases in plants, algae, and cyanobacteria academic.oup.com/plphys/artic... @plantphys.bsky.social
academic.oup.com
Update: carbonic anhydrases in plants, algae, and cyanobacteria
Abstract. This update discusses the physiological roles of carbonic anhydrase (CA) in plants and algae. It examines some new observations about the functio
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Reposted by Cecilia Blikstad
Ryo Yokoyama @yokoyama-ryo.bsky.social · 03/04/2026
Using Cryogenic Electron Tomography (cryoET) to Determine Rubisco Polymerization Constants in α-Carboxysomes www.biorxiv.org/content/10.6...
biorxiv.org
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cryoEM papers @cryoempapers.bsky.social · 06/04/2026
Molecular mechanism of redox regulation of the alpha-carboxysomal carbonic anhydrase CsoSCA www.biorxiv.org/content/10.64898/2026.04.02.716132v1 #cryoEM
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bioRxivpreprint @biorxivpreprint.bsky.social · 06/04/2026
Molecular mechanism of redox regulation of the alpha-carboxysomal carbonic anhydrase CsoSCA www.biorxiv.org/content/10.64898/20…
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Cecilia Blikstad @cblikstad.bsky.social · 06/04/2026
Our new preprint on detailing the molecular mechanisms of how the carbonic anhydrase activates it's activity upon encapsulation into alpha-carboxysomes is now live. Congrats to Nikole and @guillawme.fediscience.org.ap.brid.gy !
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bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 06/04/2026
Molecular mechanism of redox regulation of the alpha-carboxysomal carbonic anhydrase CsoSCA www.biorxiv.org/content/10.64898/20…
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Ben Long @botbml.bsky.social · 06/04/2026
Molecular mechanism of redox regulation of the alpha-carboxysomal carbonic anhydrase CsoSCA From the incredible team of @cblikstad.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
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Ben Long @botbml.bsky.social · 01/04/2026
Update: carbonic anhydrases in plants, algae, and cyanobacteria Jim Moroney LSU. academic.oup.com/plphys/advan...
academic.oup.com
Update: carbonic anhydrases in plants, algae, and cyanobacteria
Abstract. This update discusses the physiological roles of carbonic anhydrase (CA) in plants and algae. It examines some new observations about the functio
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Evan Groover @evangroover.bsky.social · 31/03/2026
Excited to see the major chapter of my PhD in print! We present a massively-parallel approach for screening CRISPR edits in plants to speed up agricultural test cycles + benchmark genomic LMs. Thanks to my fantastic co-authors and advisors. Link below!
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Nature Biotechnology @natbiotech.nature.com · 11/03/2026
Engineered TnpB genome editors for plants and human cells identified by ribonucleoprotein mutational scanning - @savagecatsonly.bsky.social go.nature.com/4loaOGn
go.nature.com
Engineered TnpB genome editors for plants and human cells identified by ribonucleoprotein mutational scanning - Nature Biotechnology
TnpB endonucleases are engineered for improved genome editing.
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Savage Lab @savagecatsonly.bsky.social · 31/03/2026
Can CRISPR edits enable precise tuning of plant gene expression? We think: yes. In our newest manuscript, we measured the effects of >30,000 CRISPR-like promoter mutations in sorghum protoplasts.
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Nature Biotechnology @natbiotech.nature.com · 27/03/2026
Mapping cis-regulatory mutations at scale in sorghum enables modulation of gene expression - @savagecatsonly.bsky.social go.nature.com/3O7mDEN
go.nature.com
Mapping cis-regulatory mutations at scale in sorghum enables modulation of gene expression - Nature Biotechnology
Variant mapping of sorghum promoters identifies CRISPR-accessible mutations that upregulate gene expression.
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Innovative Genomics Institute @innovativegenomics.bsky.social · 27/03/2026
Out today in Nature Biotechnology — a team of IGI scientists including Brian Staskwicz, Kris Nyogi, Dave Savage (Savage Lab), Peggy Lemaux, & first author Evan Groover premier a cell-based method for understanding how #photosynthesis genes can be turned "up" or "down" ow.ly/KHWg50YyWbR
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Ben Long @botbml.bsky.social · 24/03/2026
Using Cryogenic Electron Tomography (cryoET) to Determine Rubisco Polymerization Constants in α-Carboxysomes www.biorxiv.org/content/10.6...
biorxiv.org
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Ben Long @botbml.bsky.social · 23/03/2026
CyanOperon: an operon building expansion for the CyanoGate MoClo toolkit www.biorxiv.org/content/10.6...
biorxiv.org
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