Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 8hBut an earlier, similar talk is available here: www.youtube.com/watch?v=3kTy...youtube.comPCI Webinar Series - Richard McElreath - A Guerrilla Approach to Scientific WorkflowYouTube video by Peer Community In 110
Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 8hUnfortunately not, @kupferdieb.bsky.social. 😓 110
Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 8hAnd the Internet rabbit hole goes deeper, as I found that LEAN is actually the name of the director for "Lawrence of Arabia". It might seem unrelated, but it's all there in @rmcelreath.bsky.social's talk. 😅 010
Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 22hAbsolutely engaging talk from @rmcelreath.bsky.social at the Workshop for Data Management at the @unibonn.bsky.social! Data insurgents, unite! (epidemiologists and economists are also welcome 😂) 3121
Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 13/05/2026Great advance for the inflammasome field! www.pnas.org/doi/10.1073/...pnas.orgInflammasome adaptor protein ASC is a mechanistic checkpoint in IL-1β maturation | PNASInflammasome activation triggers caspase-1-dependent maturation of pro-interleukin-1β (pro-IL-1β) in an apoptosis-associated speck-like protein con... 000
Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 26/01/2026Interesting work from Niels Olsen Camara´s team, on the divergence of responses upon the NLPR1 inflammasome activation between human and mouse sources! Very interesting and highly needed approach! @agenciafapesp.bsky.socialbiorxiv.org 000
Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 12/01/2026“‘The Secret Agent’ is a film about memory — or the lack of memory — and generational trauma. I think that if trauma can be passed along generations, values can too. So this is to the ones that are sticking with their values in difficult moments.” Words to follow and live by! Wagner Moura, BRAVO! 020
Reposted by Lucas Secchim RibeiroDZNE research center @dzne.science · 17/12/2025Congrats dear Lucas Ribeiro! Lucas has taken up a prestigious position in his home country of Brazil. Alongside his work at DZNE Bonn, the immunologist and bioinformatician is now a Visiting Research Fellow at his alma mater, the Federal University of Minas Gerais. 181
Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 01/12/2025Very cool talk on Tips and Tricks on Spectral Flow Cytometry by Dr. Oliver Burton (@labliston.bsky.social) in the ThemeNight of the Flow Cytometry Core Facility of the @unibonn.bsky.social! 0131
Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 04/11/2025Finally somebody out there asking the important questions! www.pnas.org/doi/10.1073/...pnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans... 000
Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 30/09/2025AI-screened inhibitor for GSDMD pores! What a cool finding!! www.nature.com/articles/s41...nature.comDelaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response - Nature ImmunologyWang and colleagues show that an AI-assisted designed peptide obstructs GSDMD pores and inhibits IL-1β and IL-18 release and pyroptosis. 010
Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 01/09/2025Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA | Science www.science.org/doi/10.1126/...science.orgPlatelets sequester extracellular DNA, capturing tumor-derived and free fetal DNAPlatelets are anucleate blood cells vital for hemostasis and immunity. During cell death and aberrant mitosis, nucleated cells release DNA, resulting in “cell-free” DNA in plasma (cfDNA). An excess of... 010
Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 17/08/2025The #IUIS2025 is on!! The @dgfi-org.bsky.social is kicking off the Satellite Symposium in great style at the Austria Center Vienna! #Immunology #Science 051
Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 16/08/2025Arriving in #Vienna for the #IUIS2025! It is going to be a fantastic conference and if you are around, make sure to reach out, let's talk and build the #Immunology of the future! 020
Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 28/05/2025Just finished reading the original #Mistborn trilogy and I am amazed with the truly engaging storytelling and character development! I can really recommend the reading, as I am already looking very much forward to starting the next book from @brandonsanderson.bsky.social! 020
Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 21/04/2025An interesting (and multi-species) short text on the immune senses of organisms! @cellpress.bsky.social www.cell.com/trends/immun...cell.comThe five senses of immunityA genealogy of immunity reveals increasingly complex systems for pathogen response, organism homeostasis, and multispecies interaction. New studies show how the five senses can all contribute to behav... 020
Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 21/03/2025It was a pleasure to host the @sawitzkilab.bsky.social for the First Symposium on #SwarmLearning for Precision Medicine! Our team from the @dzne.science is always glad to engage with such outstanding researchers for important collaborations! Really excited with our plans for the future! 040
Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 25/02/2025Great example of how to make good use of #Olink and #SomaScan #proteomics in a population-level study! www.nature.com/articles/s41...nature.comComparative studies of 2168 plasma proteins measured by two affinity-based platforms in 4000 Chinese adults - Nature CommunicationsMany recent proteomics studies use either Olink or SomaScan platforms to quantify proteins in high-throughput, but the consistency between the two is unclear. Here, the authors measure proteins in the... 010
Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 17/02/2025Very interesting pre-print from the group of Vishva Dixit in California! The @genentech.bsky.social team found the small-molecule inhibitors of caspase activity can be delivered using GSDMD pores as an entry point! #Inflammasome #Immunology www.biorxiv.org/content/10.1...biorxiv.orgDelivery of caspase inhibitors through GSDMD pores to inhibit pyroptosisCaspase-1, -4, -5, and -11 activate Gasdermin D (GSDMD) to form pores in the plasma membrane. In addition to releasing interleukin (IL)-1β and IL-18, GSDMD pores cause a lytic, proinflammatory form of... 051
Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 11/02/2025Another fantastic shot from @roisinmcmanus.bsky.social at the mechanisms of activation and modulation of the #NLRP3 inflammasome! Congratulations to the McManus team at the @dzne.science and my dear friends at the iii @unibonn.bsky.social! Fantastic work! www.cell.com/immunity/ful...cell.comNLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progressionHow NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3 is located at mitochondria where it regulates microglial metabolism. Depletion or chronic pharmacological inhibiti... 061
Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 11/02/2025As it turns out, Mars will not be kind to our immune system! Very interesting work from @dlr-spaceagency.bsky.social, @radboudumc.bsky.social and @unibonn.bsky.social! www.biorxiv.org/content/10.1...biorxiv.orgImmune responses to human pathogens exposed to simulated Mars conditionsThe identification of health risks associated with long-term crewed missions to Mars is critical for mission planning and crew safety. Human-associated pathogens can be part of the microbiome and are ... 022
Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 23/01/2025It has been a while since I worked with microbiome, but it is nice to see such as amazing effort out there! Great work on @cellpress.bsky.social by the group of @blekhman.bsky.social! www.cell.com/cell/fulltex...cell.comIntegration of 168,000 samples reveals global patterns of the human gut microbiomeThe Human Microbiome Compendium is a unified database of publicly available human gut microbiome 16S samples, built with the integrated data from hundreds of independent projects. The compendium is us... 010
Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 15/01/2025In this very interesting publication on @cp-immunity.bsky.social, Saller and the team of Olaf Gross unveiled the complexity of #NLRP3 activators, highlighting mitochondria’s roles in switching #apoptosis to NLRP3 #inflammasome activation! www.cell.com/immunity/ful...cell.comAcute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activationMitochondria control metabolism, cell death, and innate immunity, yet their reciprocal mechanistic connections are elusive, as is the conserved physiological function of the NLRP3 inflammasome. Saller... 000
Reposted by Lucas Secchim RibeiroCNN @cnn.com · 06/01/2025Fernanda Torres was a surprise win, taking home her first Golden Globe for best female actor in a drama motion picture for “I’m Still Here.” She told the red carpet ahead of the awards that she was the second Brazilian to be nominated, her mother Fernanda Montenegro being the first. cnn.it/3DIPxFO 961550217
Reposted by Lucas Secchim RibeiroEric Topol @erictopol.bsky.social · 03/01/2025Suppression of the inflammation that occurs with aging ("inflammaging") by blocking thrombospondin-1 (Thbs1), prevented age-related blood stem cell defects and expanded lifespan in the mouse model (KO-knockout) www.science.org/doi/10.1126/... 215230
Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 03/01/2025With a great comment of @petterbrodin.bsky.social in the same edition! Check it out! #TeamPlatelets www.nature.com/articles/s41...nature.comPlatelet partnerships and lasting memories - Nature ImmunologyPulendran and colleagues define a molecular signature that can be used to predict the durability of antibody responses to vaccination and reveal important insights into the mechanisms by which vaccine... 010
Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 03/01/2025Amazing read to start the year! The team of Bali Pulendran, our #SwarmLearning partner, just published a great article, highlighting the role of #platelet factors and TPO-mediated activation as an important mechanism to enhance the durability of #vaccine responses! www.nature.com/articles/s41...nature.comSystem vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans - Nature ImmunologyPulendran and colleagues define a molecular signature that can be used to predict the durability of antibody responses to vaccination and reveal important insights into the mechanisms by which vaccine... 100
Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 02/01/2025Not only ASC specks and inflammatory cytokines, but gasdermin pores are found to be shared during pyroptosis! #Inflammasome #Immunology www.cell.com/cell/fulltex...cell.comTransplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cellsExpanding the consequences of pyroptosis, this study reveals that GSDMD pore-laden pyroptotic EVs transplant GSDMD pores on neighboring cell surfaces and propagate cell death to bystander cells. 042
Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 20/12/2024The infamous article that stated the fallacious positive effect of hydroxychloroquine and azithromycin for COVID is now retracted, i.e., the results are made up and cannot be reproduced (of course). Let's hope that good science can prevail - faster - whenever needed the most. 010
