Researchers have uncovered molecular differences that distinguish painful endometriosis.

This study investigated music processing in dementia using functional MRI. van ‘t Hooft et al. report that favourite music is processed differently in beha

ZMYND8 suppresses IL-2R–STAT5 signalling by inhibiting p300-mediated transcriptional activation of Il2ra to enforce CD8+ T cell terminal exhaustion, and its deletion boosts effector-lik...

Engaging core muscles—through movement, exercise or even coughing—may be a key regulator of blood flow in the brain. When the body moves, the contraction of abdominal muscles increases pressure in blo...

Voyaging gut-derived immune cells ‘remember’ past stomach infections in mice.

Plasma p-tau217 concentrations, considered together with APOE genotype, might help stratify risk and estimate the timing of future cognitive impairment in asymptomatic individuals who are at increased...

Studies in Asia, Africa, South America and the Middle East have consistently shown that tea or mate drunk at very high temperatures (~70°C) increases oesophageal cancer risk, but evidence is limited ...

The first arm bone fragment from these mysterious human relatives was found near cutting instruments and animal remains in southwestern China

Researchers identify more than 1,200 personality-linked genetic variants, with effects largely independent of family background.

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Heme is released from red blood cells during hemolytic uremic syndrome (HUS). Here, we investigated hemolysis-induced kallikrein-kinin system activation and the interaction between heme and clotting f...

Colorectal cancer often causes cachexia, a wasting syndrome that weakens muscles and bones. Here, the authors show that a tumor-liver signaling relay driven by FGF21 and IGFBP1 promotes this decline, ...

Previously collected fossils prove a treasure trove for understanding the origin of insects

This study identifies four antigenic sites on CCHFV NP, showing that protection is independent of head or stalk location. It maps the highly conserved binding epitope of mAb-9D5 in the head domain, en...

Models of how the brain changes over time could help researchers to understand how diseases affect the organ later in life.

Moderna’s newly approved vaccine could allow manufacturers to respond more rapidly to changing influenza strains.

Davidson et al. map the cellular and structural composition of developing joints and identify fibroblast populations that may predispose joints to inflammatory arthritis.

Study of mitochondria suggests new treatment strategy for Alzheimer’s and other diseases

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Huang et al. found that stressed neurons release DNA that activates the immune sensor cGAS, driving inflammatory responses that worsen seizures and mortality in Dravet syndrome. Blocking cGAS interrup...

“Huge” new study of Caribbean anole populations catches evolution in real time

Catfish melanomas are the first example of a transmissible cancer in fish, genetic studies reveal

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Researchers used artificial intelligence to design functional CRISPR enzymes not seen in nature.

Gargett and colleagues provide a molecular signature of human endometrial stem/progenitor cells by enriching 4 stem/progenitor populations from hysterectomies, using known markers, for scRNA-seq analy...

Cell Death & Disease - Impact of BECLIN1 haploinsufficiency on goblet cell function and susceptibility to colitis

Ongoing research provides evidence that readily available and sustainable oyster meat extract may have powerful anti-inflammatory effects on human intestinal cells.

Here, via analyses of pre-weaning and weaning infant gut microbiome (GM), as well as maternal GM in a mother-infant dyad cohort, the authors show that dual fibre and human milk oligosaccharide&nb...

CBX7 positively regulates cytokine expression by recruiting transcriptional activators and enhancing ERK1/2 activation in T cells.

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Two people were the first to receive the therapy for a condition that damages the spinal cord and optic nerve.

Neural maps reveal the specialized cells that produce speech.

HLA-DRB1*01:03 emerges as a genetic determinant of severe disease in both patients with Crohn's disease and patients with ulcerative colitis. Although further validation is needed, assessing HLA-DRB1*...

Softening of the cells on the outermost surface of the trap lets the plant move at a breakneck pace.

UC San Diego researchers have identified genetic drivers of cocaine addiction, uncovering a potential new treatment target in the liver. This large-scale study maps how metabolism influences addiction...

The therapy activates a protein that could stop pulmonary fibrosis from progressing.

Selpercatinib, a highly selective, potent, and central nervous system–penetrant rearranged during transfection (RET) inhibitor, is approved for RET fusion–positive advanced or metastatic non–small-...

l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and funct...