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Thanks a lot, Mike! Definitely DyeCycling can be realised with other reversible chemistries and we work on that. But for FRET resolution at the nanometer level, the linkers should be short. Hence, less sure about HaloTag & Co... May work in some cases. Curious to hear your ideas.

Thank you, Biswajit! Nice to hear. Likely some drift and variation of the local environment: fluorophore intensities are hardly fully constant over time.

My thanks for this inter-disciplinary collaboration go to all co-authors, all who commented and contributed in different ways, and the @nanoscience.ch for their support. 🙏

Right in time for #smFRET’s 30th anniversary, DyeCycling enables true single-molecule kinetic analysis, revealing hidden heterogeneities and even time-variant kinetic changes of individual molecules.

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The trick is to harness reversibly binding fluorescent probes – and their cumulative photon budgets – rather than single dyes whose bleaching terminates the observation immediately. High SNR is retained through efficient nanophotonic background suppression, demonstrated using DNA & protein systems.

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Swiss Nanoscience Institute, University of Basel @nanoscience.ch · 15/07/2026

Glad to present #Nanophotonic DyeCycling – #BenjaminVermer’s magnum opus! 🎉 By breaking the longstanding photobleaching limitation in single-molecule #FRET, we achieve longterm observations of conformational #dynamics – gaining >1 order of magnitude more info. www.biorxiv.org/content/10.6...

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🏊‍♀️💦Need to cool off? No problem with July’s “Tool of the Month": The swim bag. It holds a lot and everything stays dry when you jump into the Rhine after work or studying (don't forget to follow security advices). nanoscience.unibas.ch/en/news/deta... @unibas.ch @baselstadt.bsky.social #nanoscience

nanoscience.unibas.ch

Tool of the Month: The Swim Bag – Perfect for Basel’s Summer!

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GdR ImaBio 🔬 @gdrimabio.bsky.social · 16/06/2026

👏 Un grand merci à tou·te·s les intervenant·e·s pour leurs contributions inspirantes, notamment les conférenciers : @broichhagenj.bsky.social @fmp-berlin.de @glembockyte.bsky.social @mpi-mr.bsky.social Pablo Rivera Fuentes @chem.uzh.ch @scisonja.bsky.social @unibas.ch

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IDPSeminars @idpseminars.bsky.social · 06/05/2026

IDPSeminars is back TOMORROW (Thursday May 7th)! Come see Matt Parker and Maria Hondele speak! 1 pm EST / 7 pm EU - sign up with the link from our homepage idpseminars.com

IDPSeminar talks from two speakers:

1. Matt Parker (UTSW Medical Center); Rapid evolution of DNA replication origin selection mechanisms

2. Maria Hondele (University of Basel): DEAD-box ATPases as adaptive organizers of RNA condensates from bacteria to eukaryotes.

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Sonja Schmid @scisonja.bsky.social · 20/04/2026

PhD's & postdocs: dont miss the GRS partner conference, organized by @qmsmith.bsky.social & #AlbaGómez-Segalàs with lots of interaction opportunities and career mentorship: ⏰ June 27-28, 2026 🌍 Swiss Alpes (✈️ Geneva) ✅ APPLY now: deadline May 30. www.grc.org/single-molec...

grc.org

2026 Single Molecule Approaches to Biology (GRS) Seminar GRC

The 2026 Gordon Research Seminar on Single Molecule Approaches to Biology (GRS) will be held in Les Diablerets, Vaud (fr) Switzerland. Apply today to reserve your spot.

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Sonja Schmid @scisonja.bsky.social · 20/04/2026

Don't miss the #GordonConference on 𝑺𝒊𝒏𝒈𝒍𝒆-𝒎𝒐𝒍𝒆𝒄𝒖𝒍𝒆 𝑨𝒑𝒑𝒓𝒐𝒂𝒄𝒉𝒆𝒔 𝒕𝒐 𝑩𝒊𝒐𝒍𝒐𝒈𝒚, organized by #KevinWelsher & me: ⏰ June 28 - July 3, 2026 🌍 in the Swiss Alpes (✈️ Geneva) ✅ APPLY now: deadline May 31. We're 75% booked: register today & be there! 🙌 🕳️ 🧬🧪🧫 🔬🟩🟥🟩🟥🏋️‍♀️💥🪤 🍩 ... you get it... 😁

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Sonja Schmid @scisonja.bsky.social · 30/03/2026

Looking forward to your talk tomorrow :) 👍

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Sonja Schmid @scisonja.bsky.social · 10/03/2026

Last call for these 2 different #PhD positions in #nanopore tech: 🗓️ apply by March 15 to join our team at the nano-dynamics group at @unibas.ch Switzerland. Follow the guidelines online: schmid.chemie.unibas.ch/en/join-us-1/

schmid.chemie.unibas.ch

Join us! | Research Group Schmid | University of Basel

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meisterlab.bsky.social @meisterlab.bsky.social · 04/03/2026

Exciting news: Our RNA community in @uniregensburg.bsky.social is set to grow! We are opening a Junior Group Leader position in RNA biochemistry / ribonucleases / RNA stability. A great opportunity to start your own team within our collaborative RNA network. Details & application 👇

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meisterlab.bsky.social @meisterlab.bsky.social · 04/03/2026

karriere.uni-regensburg.de/jobposting/2...

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Johannes Hohlbein @hohlbeinlab.bsky.social · 26/02/2026

Coordinated call for applications for three (!) thematically related professorships (cell physiology, molecular genetics, and biochemistry) at BTU Cottbus-Senftenberg (Germany) (thread)

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Where are you on the blueSky-map? bluesky-map.theo.io

Karolin Luger @nucleosomepolice.bsky.social · 12/02/2026

Reposted by Sonja Schmid

#scientists, take a second to fully appreciate the @pdbeurope.bsky.social and @rcsbpdb.bsky.social and imagine live without them.

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...the molecules of life, how they feel in the cell, up to #single-molecule exp. & apps... Questions were also exciting😅 from: "how can you truly get single molecules?" to: "what metaphysical thoughts do you have?" All genuine questions. #sciComm – so rewarding – didnt expect that! 🤝 Thank you!

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...people hugely differing in age, backgrounds, education... A real challenge for me, but how eager they were to learn & how #grateful! Heartwarming to hear the metaphors (🍝,🍯,🐎,📻 for #FRET, 🐘&🐜 for #nanopores,...) helped them to understand, and even inspired them to think further. We discussed...

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