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Sonja Schmid @scisonja.bsky.social · 30/09/2026

Right in time for #smFRET’s 30th anniversary, DyeCycling enables true single-molecule kinetic analysis, revealing hidden heterogeneities and even time-variant kinetic changes of individual molecules.

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Sonja Schmid @scisonja.bsky.social · 30/09/2026

The trick is to harness reversibly binding fluorescent probes – and their cumulative photon budgets – rather than single dyes whose bleaching terminates the observation immediately. High SNR is retained through efficient nanophotonic background suppression, demonstrated using DNA & protein systems.

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Sonja Schmid @scisonja.bsky.social · 30/09/2026

Glad to present #Nanophotonic DyeCycling – #BenjaminVermer’s magnum opus! 🎉 By breaking the longstanding photobleaching limitation in single-molecule #FRET, we achieve longterm observations of conformational #dynamics – gaining >1 order of magnitude more info. www.biorxiv.org/content/10.6...

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Sonja Schmid @scisonja.bsky.social · 20/04/2026

Don't miss the #GordonConference on 𝑺𝒊𝒏𝒈𝒍𝒆-𝒎𝒐𝒍𝒆𝒄𝒖𝒍𝒆 𝑨𝒑𝒑𝒓𝒐𝒂𝒄𝒉𝒆𝒔 𝒕𝒐 𝑩𝒊𝒐𝒍𝒐𝒈𝒚, organized by #KevinWelsher & me: ⏰ June 28 - July 3, 2026 🌍 in the Swiss Alpes (✈️ Geneva) ✅ APPLY now: deadline May 31. We're 75% booked: register today & be there! 🙌 🕳️ 🧬🧪🧫 🔬🟩🟥🟩🟥🏋️‍♀️💥🪤 🍩 ... you get it... 😁

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Sonja Schmid @scisonja.bsky.social · 12/02/2026

Where are you on the blueSky-map? bluesky-map.theo.io

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Sonja Schmid @scisonja.bsky.social · 12/02/2026

What a unique experience to lecture at #SeniorenUni @unibas.ch today – freely translated title: Molecules in gallop – getting 'personal' with the molecules of life. We filled the big aula 2x with 55+ers up to >80y-olds plus 100more online! All of them so genuinely curious! Truly touching! 🤝...

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Sonja Schmid @scisonja.bsky.social · 01/02/2026

We had a little celebration last week. 😊 #Already5y ...time flies!

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Sonja Schmid @scisonja.bsky.social · 12/01/2026

Good morning #FRET friends, Good news: #FRET is on track!

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Sonja Schmid @scisonja.bsky.social · 16/12/2025

Travelling back from #Paris 🚄, where #EllynRedheuil defended her PhD at @espciparispsl.bsky.social. Inspired by our #DyeCycling approach, Ellyn did impressive pioneer's work on single-biomarker detection using @quantum-si.bsky.social's protein sequencing platform!

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Sonja Schmid @scisonja.bsky.social · 12/12/2025

Thrilled to announce the successful import of the Dutch🇳🇱 Santa Claus tradition into Switzerland🇨🇭: So much fun with this creative team! 🎅😃 Sad to see team members leave – but also happy to welcome new ones: Bye Ben & David! Welcome Bastien, Antonella & Julius!!

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Sonja Schmid @scisonja.bsky.social · 11/12/2025

@dpgphysik.bsky.social are you kidding me? 😃 ...and the list goes on...🎓

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Sonja Schmid @scisonja.bsky.social · 10/11/2025

I recently wrote a 1page "Highlight" article for the Swiss Journal @chimiajournal.bsky.social about the #single-molecule perspective on biomolecular dynamics and experiments: Beyond 3D Structures: New Ways to Study Biomolecular Gymnastics www.chimia.ch/chimia/artic...

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Sonja Schmid @scisonja.bsky.social · 07/11/2025

Early rise for me today (3:45 😱) to get in time to our #Nanopore consortium meeting with #GiovanniMaglia & @ceesdekker.bsky.social groups at Amsterdam airport. So curious about their newest results! 🤩 We approached in style: ✈️ flying over Dutch (modern) windmills... Beautiful – even for train fans.

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Sonja Schmid @scisonja.bsky.social · 24/10/2025

"If it needs to be fast..." says this lift ad... 🤭 Have a good weekend you all! seen at: www.srf.ch/static/cms/i...

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Sonja Schmid @scisonja.bsky.social · 11/09/2025

Great times at the Annual Event of the @nanoscience.ch: What a place, what a crowd, what an interdisciplinarity! Fascinating...! 😀

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Sonja Schmid @scisonja.bsky.social · 01/08/2025

Happy Swiss National Day! 🇨🇭 with phenomenal fireworks above the Rhine in Basel. A day to be thankful for the unearned privilege of freedom, safety, welfare, and the stable democracy. 🤝🤝🤝

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Sonja Schmid @scisonja.bsky.social · 31/07/2025

#3: #PhD Position on Structure–Dynamics–Function Relationship of the #Chaperone #Hsp90: ➤ NMR spectroscopy for atomic-resolution ➤ Single-molecule FRET for time-resolved dynamics Collab.: @hillerlab.bsky.social & Schmid lab @unibas.ch More info & online application system: tinyurl.com/mr2em3nk

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Sonja Schmid @scisonja.bsky.social · 31/07/2025

#2: #PhD Position in Single-Molecule Biophysics using Fluorescence & DyeCycling/FRET ➤ Also for #Postdocs! ➤ Biomolecular dynamics, dynamic disorder & more ➤ with nano-photonic & fluorogenic DyeCycling/ #FRET. ⏰: submit by 30/9, 2025. More info & online application system: tinyurl.com/y9dnb38e

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Sonja Schmid @scisonja.bsky.social · 31/07/2025

#1: #PhD Position in Single-Molecule Biophysics using Nanopore Trapping: ➤ solid-state and biological #nanopores ➤ label-free protein fingerprinting, enzyme catalysis & more ⏰: submit by Sept. 20, 2025. More info & online application system: jobs.unibas.ch/offene-stell...

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Sonja Schmid @scisonja.bsky.social · 24/07/2025

Quick! 💣💥 Dont miss to sign up for the "Spreng-Vorlesung" @unibas.ch – the explosive lecture for all ages! #TheMagicOfChemistry 🌐: St. Johanns-Ring 19, 4056 #Basel ⏰: Fri or Sat Sept 12 or 13, at 11am and 2pm each (=4 shows!) RSVP: chemie.unibas.ch/en/sprengvor...

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Sonja Schmid @scisonja.bsky.social · 22/07/2025

Good morning, with impressions from our Dept white board: ex-cell-ent vibes, I'd say...: 🙃😅 ...and we have 1-2-3 openings coming up!

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Sonja Schmid @scisonja.bsky.social · 20/07/2025

What a special experience #EURO2025 #FRAGER: #Basel full of French & German ⚽ fans both claiming a 'home game' at the border triangle... All super passionate, yet a friendly atmosphere!👍 Also, well deserved AK Berger: player of the match! 110min numerical superiority by 🇫🇷 – how can they STILL lose?

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Sonja Schmid @scisonja.bsky.social · 14/07/2025

7(!) goals ⚽, a fun crowd and great company - this was a blast yesterday! #EURO2025 #ENGWAL

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Sonja Schmid @scisonja.bsky.social · 12/07/2025

Just wrote down my inside tips for friends visiting #Basel. Here they are - sharing is caring... (translatable German): docs.google.com/document/d/1... Feel free to comment yours!

https://www.basel.com/_Resources/Persistent/5a76774a48cdf1e2351e82741162d79fdf4f81b4/das-basler-muenster-bei-morgendaemmerung-the-basler-muenster-cathedral-at-dawn-1200x674.jpg

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Sonja Schmid @scisonja.bsky.social · 11/07/2025

Perks of living in🇨🇭: great lab outing options nearby... This time high above Solothurn with Aare & Bielersee in the back. Great fun with this awesome team – aka #thePotluckChampions!!

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Sonja Schmid @scisonja.bsky.social · 10/07/2025

20 years of #NanoScience studies @unibas.ch in general! Had lots of fun at the anniversary party organised by @nanoscience.ch for alumni and all involved – big THANKS! – so cool to catch up again after all the years, and hear old & new stories!

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Sonja Schmid @scisonja.bsky.social · 07/07/2025

Chemists' humour: onlinelibrary.wiley.com/doi/epdf/10.... On colleague Marcel Mayor's 60st birthday: he is known for wearing (and likely loving?) STRIPES – ALWAYS. Since my undergrad, as a dean, when awarding honorary doctorates – ALWAYS. 😀

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Sonja Schmid @scisonja.bsky.social · 04/07/2025

Next up #EURO2025 with #GERPOL and my sweet niece accompanying the Polish to the pitch in our "home stadium" in St.Gallen #FCSG1879. Such a cool experience for her 🤩. She's the one with the wrist cast 😳.

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Sonja Schmid @scisonja.bsky.social · 02/07/2025

#EURO2025 #SWINOR 10/n 2nd half: Let's go 🇨🇭🇨🇭🇨🇭! More of this please! Btw still 30,5°C in #Basel where they play...

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Sonja Schmid @scisonja.bsky.social · 02/07/2025

Fabulous new things start with an optical table... ...and 💎 are forever! ☺️

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Sonja Schmid @scisonja.bsky.social · 26/06/2025

#TomWard opening the #RepArtZymes conference @unibas.ch . Looking forward to getting to know the field of repurposed and artificial (metallo-)enzymes better! What a stellar line-up! rep.artzymes.info

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Sonja Schmid @scisonja.bsky.social · 13/06/2025

We had a fantastic conference dinner to close the #CSSB25 at Copenhagen: look at this! 😱 Huge thank you to the organizers Nikos Hatzakis, Morten Meldal, Karen Martinez, Claus Løland & Lucy Holt, as well as the two Deans giving their joint speech here. Had a phenomenal time at the Danish capital. 👌

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Sonja Schmid @scisonja.bsky.social · 13/06/2025

..and as a last treat at #CSSB25: #Nobel laureate #MortenMeldal's lecture about #clicking and its applications. Fig. caption: he distinguishes: everything ≠ all, since there's a bit of physics... 😉. Plus, a Nobel laureate's advice: get political, you scientists!

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Sonja Schmid @scisonja.bsky.social · 13/06/2025

@hatzakislab.bsky.social presenting new fast machine-learning based particle tracking tools to extract functional information from diffusion tracks. #deepSPT #CSSB25 www.nature.com/articles/s41...

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Sonja Schmid @scisonja.bsky.social · 13/06/2025

#BenSchuler with his elegant #IDP #smFRET work next up at #CSSB25 Copenhagen. Reminding everyone about the relevance of intrinsically disordered regions in proteins:

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Sonja Schmid @scisonja.bsky.social · 13/06/2025

Looking forward to hearing from #MarkusSauer about his probes and "Molecular resolution fluorescence imaging in cells" at the #CSSB25 Copenhagen.

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Sonja Schmid @scisonja.bsky.social · 12/06/2025

Can it get more Danish 🇩🇰 than this? #NielsineNielsen

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Sonja Schmid @scisonja.bsky.social · 12/06/2025

#DonHilvert @ethz.ch took us on a journey through the amazing progress in protein/enzyme evolution & de novo design. Wow! 🤩 Extra bonus: his personal summer project in the lab. ...sometimes you have to fly abroad to hear a speaker from 1h away. 🙃

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Sonja Schmid @scisonja.bsky.social · 11/06/2025

Fantastic 1st-ever www.grc.org/label-free-s..., initiated and organized by @reuven-gordon.bsky.social & #WarwickBowen . My loss to leave early and miss exciting label-free optics and nanopore sessions etc. But also looking forward to Hello-#Copenhagen! isbuc.ku.dk/chemical-sol...

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Sonja Schmid @scisonja.bsky.social · 02/05/2025

Delay luck... Fingers crossed... 🤞

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Sonja Schmid @scisonja.bsky.social · 30/04/2025

Fantastic to have #AleksandraRadenovic @radenoviclab.bsky.social as our guest today! Of course I forgot to take photo proof 🙃 over all the inspiring work she presented..., but find out yourself: www.epfl.ch/labs/lben/ I'm always so impressed by her elegant interdisciplinary cross-over experiments!🤩

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Sonja Schmid @scisonja.bsky.social · 30/04/2025

Summer in the city... 🎶 Greetings from #Basel. ...Soon the Rhine will be orange again from all the dry-bags of floating people. 😀

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Sonja Schmid @scisonja.bsky.social · 24/04/2025

What a treat to hear #UlrichLorenz' talk on µs-resolved cryo-EM, today at @biozentrum.unibas.ch . So many avenues to explore protein ensembles in an interesting spatiotemporal range... and other anecdotes... :) (funny colour effect from camera interference)

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Sonja Schmid @scisonja.bsky.social · 03/04/2025

...and the more colours the better ;) (veery interdisciplinary currently...)

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Sonja Schmid @scisonja.bsky.social · 23/03/2025

Thank you perplexity.ai for reminding me of the key points of #DyeCycling 😅:

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Sonja Schmid @scisonja.bsky.social · 20/03/2025

We were delighted to host #SebastianDeindl #UppsalaUniversity for a seminar at @unibas.ch yesterday. Thanks for the engaging seminar and inspiring discussions, Sebastian! It was great to have you. 👌

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