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Now: 🏆 Poster prizes just awarded to the top 4 posters - congratulations to all winners! 🎉 With so much excellent science on display, it was a very tough call for the poster committee. #CSSB25 #PosterPrize #ScienceInAction

And now: Morten Meldal - for me, THE highlight of the conference! 🧪 Host, organizer, and pioneer of click chemistry, he’s now taking the stage for an inspirational talk. A true icon shaping the future of chemical biology! #ClickChemistry @isbuc.bsky.social #CSSB25

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Next up: The last flashtalk from Céline Delaitre - presenting her work on fluorescent ligands for angiotensin II AT1 receptors! 🧪 A cutting-edge chemical biology tool to visualize and modulate signaling dynamics. #ChemicalBiology #GPCR #CSSB25

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Next up: Jin Zhang - illuminating the biochemical activity architecture of the cell! 🧬 She’s pioneering spatiotemporal biosensors and super-resolution imaging tools to track kinase, phosphatase, GPCR & second messenger activity in living cells. #CellBiology #SuperResolution #CSSB25

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Next up: Sonja Schmid @scisonja.bsky.social - presenting the broad-range dynamics of biomolecules uncovered by DyeCycling🌟! She’s using innovative single-molecule fluorescence & nanopore techniques to peer into protein dynamics. Fascinating! #SingleMolecule #ProteinDynamics #CSSB25

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Last speaker of this session is Nikos Hatzakis @hatzakislab.bsky.social - spotlighting his breakthroughs in 4D single-particle microscopy and machine‑learning analysis to decode enzyme function and cell biology one molecule at a time.🔬🧑‍💻 What a fantastic talk! #SingleMolecule #Biophysics #ML #CSSB25

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Next up: Ben Schuler - exploring how intrinsically disordered proteins behave in the crowded, dynamic environment of living cells. 🧬 Combining single-molecule spectroscopy with cellular complexity to decode protein folding and function in real time. #ProteinDynamics #SingleMolecule #CSSB25

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Up next: Keynote talk by Markus Sauer @sauer-lab.bsky.social - pushing the limits of live-cell imaging! He’s speaking about new strategies to achieve molecular resolution with super-resolution microscopy - in living cells! A breakthrough moment for the field! 🔬🍋 #Microscopy #SuperResolution #CSSB25

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Next up: Flashtalk by Mette Malle - unveiling strategies for programmable RNA loading into extracellular vesicles! 🧫 A powerful platform for targeted delivery and functional RNA transport. #RNA #ExtracellularVesicles #SyntheticBiology #CSSB25

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Next up: Christian Olsen — presenting on sulfur fluoride exchange (SuFEx) chemistry to target epigenetic regulators! 🔬 A powerful approach to probe and modulate chromatin biology with covalent precision. #ChemicalBiology #Epigenetics #CSSB25

Next up: Thomas Poulsen - diving into precision chemistry from the protein to the proteome! ⚗️ Powerful tools for covalent protein profiling. FANTASTIC work! #ChemBio #Proteomics #CSSB25

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Next up: Helma Wennemers - exploring the chemistry of the extracellular matrix! 🧬 Her work on collagen-targeting peptides reveals new ways to image, modulate, and understand ECM biology with precision. #PeptideChemistry #Collagen #ChemicalBiology #CSSB25

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Next up: Keynote talk by Ikuhiko Nakase — pioneering strategies for intracellular delivery! 🚀 From cell-penetrating peptides to exosomes and boron-based cancer therapies, his work is transforming how we get molecules where they need to go. Truly exciting! #DrugDelivery #Nanobiotech #CSSB25

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After a wonderful poster session, day 1 ends, but day 2 is just about to kick off! 🔬 A lot of structural biology, chemical biology, and super-resolution imaging ahead… here we go! 🚀 #CSSB25 #microscopy #chemistry

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Poster session time! 🧫🧠 So many brilliant ideas, creative experiments, and passionate scientists in one room. Come chat, exchange thoughts, and get inspired — this is where the magic happens! #CSSB25 #PosterSession #ScienceInAction

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Next flashtalk up: Ciara Pugh 🎤🔬 Excited to hear her latest work developing MAASTY to use at the interface of chemical biology and structural insights. Let’s see what molecular stories unfold! #CSSB25 #ChemicalBiology #StructuralBiology

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Knud Jensen on stage: "Selective Chemical Modification of Proteins: His-Tag Acylation" 🧪🔗 Smart strategies to precisely modify proteins using engineered His-tags — elegant and effective! #CSSB25 #ProteinChemistry

hatzakislab @hatzakislab.bsky.social · 12/06/2025

Now speaking: Kristian Strømgaard 🧠⚗️ Chemical probes & peptide engineering to dissect membrane proteins and synaptic signaling. Bridging chemistry and neuroscience with precision tools! #CSSB25 #Neurochemistry #ChemicalBiology

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Reposted by Gerti Beliu

Chemical solutions to structural biology kick off by #Nobel laureate Morten Meldal . So happy to organise and attend such a event Check the amazing line up of speakers isbuc.ku.dk/documents/CS...

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Keynote by Don Hilvert 🧪 Mastering enzyme design and evolution — from mechanistic insights to de novo biocatalysts. A true pioneer in protein engineering! #CSSB25 #EnzymeDesign #ProteinEngineering

Now it’s my turn! Excited to share our latest on GCE & click chemistry for live-cell and super-resolution microscopy 🧬🔬 From precise labeling to functional imaging — come by, join in, and let’s talk science! #CSSB25 #ClickChemistry #Bioimaging @uniregensburg.bsky.social @uni-wuerzburg.de

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Next up: Patricia Bassereau 🧫🧠 Exploring how membrane mechanics and curvature shape cellular trafficking and signaling. Physics meets biology at the membrane! #CSSB25 #MembraneBiophysics #CellMechanics

Now on stage - 2nd Keynote by Yamuna Krishnan 💡🧬 Pioneering DNA nanodevices for real-time imaging and intracellular sensing — decoding the cell from the inside out. Brilliant science! #CSSB25 #DNANanotech #ChemicalBiology

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First Flash Talk at #CSSB25 by Sara Mellemgaard: Microproteins to trigger cancer cell apoptosis 💥🧬 Smart design, functional evolution, therapeutic promise. #Microproteins #Apoptosis

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Next up: Nieng Yan – From Sugar Transporters to Glyco-Conjugate Ion Channels 🍬🧬 A deep dive into the structural transitions to ion channel gating. Wonderful membrane protein science! #CSSB25 #StructuralBiology #Transporters

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Annette Beck-Sickinger now on stage — exploring peptide signaling and GPCR pharmacology with a focus on chemerin and its receptor system. From biased agonism to receptor trafficking, unveiling how peptides fine-tune cellular responses. #CSSB25 #GPCRs #Chemerin #PeptideScience

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After Coffee Break Next up: Jörg Rademann, pioneering selective covalent inhibitors and fragment-based ligands for decoding enzyme function. Smart chemistry meets structural precision. #CSSB25 #MedicinalChemistry #FragmentBasedDesign

Now kicking off with Brian Kobilka — a legend in the field and nobel laureate — delivering the opening keynote. Straight into the heart of #GPCR biology: old lessons, new insights. A masterclass in receptor signaling begins. #CSSB25 #StructuralBiology #ChemicalBiology

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