Reposted by Sander SmitsÁkos T Kovács @evolvedbiofilm.bsky.social · 11hAthanasios on developing a Ferrous iron sensor in Escherichia coli, Pseudomonas putida, and Corynebacterium glutamicum See their paper in ACS Sensors pubs.acs.org/ascefj/artic... #MibiNet 042
Reposted by Sander SmitscryoEM papers @cryoempapers.bsky.social · 20/09/2026Structure of the MurA-LpxC enzyme complex in modulating peptidoglycan and lipopolysaccharide biosynthesis pubmed.ncbi.nlm.nih.gov/42762934/ #cryoEM 022
Reposted by Sander SmitsMibiNet @mibinet.bsky.social · 18/09/2026MibiNet PI Eva Nowack (@hhu.de) has been awarded the 2026 Miescher-Ishida Award by the International Society of Endocytobiology! Honored for her work on how endosymbionts integrate into eukaryotic host cells. Huge congratulations! 👏 @evanowack.bsky.social #MibiNet www.hhu.de/news-einzela...hhu.deRenommierte Auszeichnung für HHU-BiologinDie Fachgesellschaft „International Society of Endobiology“ zeichnete am 15. September 2026 Prof. Dr. Eva Nowack, Leiterin des Instituts für Mikrobielle Zellbiologie der Heinrich-Heine-Universität Düs... 497
Reposted by Sander SmitsDaumann Lab @daumannl.bsky.social · 17/09/2026Come be our colleague at @hhu.de @chemiehhu.bsky.social ! We are currently looking for 2 Full Professors in Physical chemistry in our department! berufungsportal.hhu.de/VAADIN/dynam... berufungsportal.hhu.de/VAADIN/dynam... #chemsky #chemchat 🧪berufungsportal.hhu.de 159
Reposted by Sander SmitsMichael Feldbrügge @mfeldbruegge.bsky.social · 02/09/2026Two PhD positions in the Feldbrügge Lab at HHU Düsseldorf within nEXt-RNA: 🔬 DC1: Live-cell imaging of RNA transfer and function 📦 DC10: Mechanisms and applications of RNA delivery RNA biology, fungi, extracellular vesicles and advanced imaging. www.mikrobiologie.hhu.de/en/ 01423
Reposted by Sander SmitsSchmitt-Lab@HHU @schmitt-lab.bsky.social · 21/08/2026The pre-print is out! Ubp3 does not require its regulator for activity in vitro! Even the catalytic domain is sufficient. This raises the question about the function of the regulator Bre5 in vitro and in vivo! Thanks to everyone for this nice piece of work. And thanks to CRC 1531 for funding! 063
Reposted by Sander SmitsKedrov Lab @ HHU @kedrov-lab.bsky.social · 23/08/2026Thanks to all the folks on the project: Marius*, Cristian*, Julien* @hhu.de , but also @beckmannlab.bsky.social in @genecenter-lmu.bsky.social and, surely, Birgit Strodel @fz-juelich.de for all the expertise and guidance of the work in silico 🤩 041
Reposted by Sander SmitsKedrov Lab @ HHU @kedrov-lab.bsky.social · 23/08/2026And then - YES, we do see how the lipids under the ring slow down, even when far from the barrel of PelB. Abundant Arg's and Lys's of PelC "capture" those at the phosphates, and the slow-move area seen in simulations matches with cryo-EM data - but now with dynamics and real molecular resolution 131
Reposted by Sander SmitsKedrov Lab @ HHU @kedrov-lab.bsky.social · 23/08/2026Preprint🚨: Exopolysaccharide export complex PelBC of Pseudomonas aeruginosa attenuates the dynamics of the surrounding outer membrane. Longer in preparation than in actual making. Blame summer time and perfectionism 🫠 A brief tour, to keep the feed alive over the wknd www.biorxiv.org/content/10.6... 2259
Reposted by Sander SmitsbioRxivpreprint @biorxivpreprint.bsky.social · 22/08/2026Exopolysaccharide export complex PelBC of Pseudomonas aeruginosa attenuates the dynamics of the surrounding outer membrane www.biorxiv.org/content/10.64898/20… 0115
Reposted by Sander SmitsKedrov Lab @ HHU @kedrov-lab.bsky.social · 11/07/2026OK, not a "tremendous breakthrough", but it is nice to have it completed - the first project in the group, started after moving to @hhu.de years ago, as a part of CRC 1208 (1st C is for "collaborative"). Thanks to all the co-authors for the joint effort and resilence ✊🤓 www.jbc.org/article/S002...jbc.orgConformational dynamics of the membrane-anchored foldase LipH from Pseudomonas aeruginosa governs recognition and release of its client lipaseThe lipase LipA from Pseudomonas aeruginosa is an extracellular enzyme that plays an important role in bacterial infections. Prior to its export via the type II secretion system, LipA requires the cog... 3157
Reposted by Sander SmitsPapadopoulos @ HHU @athanasios-ppdpls.bsky.social · 27/06/2026Excited to share our latest publication!🚀🙏🏼🤩 We present ATPLyzer, an advanced ratiometric biosensor that is a clear step forward in sensor-related ATP-research, opening new perspectives for future applications. 📄 advanced.onlinelibrary.wiley.com/doi/10.1002/...advanced.onlinelibrary.wiley.comATPLyzer—An Advanced Ratiometric Multi‐Color Biosensor for Long‐Term Monitoring of ATP DynamicsATPLyzer is a family of genetically encoded ratiometric biosensors developed for real-time monitoring of intracellular ATP dynamics in living cells. Using a Matryoshka design with single-wavelength e.... 196
Reposted by Sander SmitsSven Gould @turbokraken.bsky.social · 02/06/2026#Plastids appear to make use of the same protein as mitochondria to resolve #ribosome stalling by proline motifs. A fun project with great colleagues from @helsinki.fi Mitochondria and plastids really are best buddies that share everything.biorxiv.org 072
Reposted by Sander SmitsInformationsdienst Wissenschaft - idw @idw-online.de · 29/05/2026Neue Therapieansätze gegen aggressiven Brustkrebs Bundesforschungsministerium fördert KI-Forschungsprojekt TriNova Das Bundesministerium für Forschung, Technologie und Raumfahrt (BMFTR) fördert das Projekt „TriNova“ an der Heinrich-Hein... weiterlesen 012
Reposted by Sander SmitsHeinrich-Heine-Universität Düsseldorf @hhu.de · 21/04/2026Der Biologe Dr. Florian Altegoer vom Institut für Mikrobiologie der Heinrich-Heine-Universität Düsseldorf (HHU) erhält einen mit 210.000 Euro dotierten „Exploration Grant“ der Boehringer Ingelheim Stiftung (BIS). 2236
Reposted by Sander SmitsMibiNet @mibinet.bsky.social · 08/04/2026History in the making! 🎓 Huge congratulations to Nora Zöllner, who successfully defended her PhD - earning top honors! Nora is the very first graduate of our MibiNext cohort. We couldn’t be prouder! A massive achievement for her and a major milestone for the entire network. #MibiNet #MibiNext 055
Reposted by Sander SmitsUte Hellmich @hellmichgroup.bsky.social · 27/03/2026Standing ovations for an incredible Maya Schuldiner, who just received the Otto Warburg Metal at the #MosbacherKolloqium of the @gbmev.bsky.social and delivered the most impressive, passionate speeches one can imagine... beautiful oration by Christian Ungermann and many tears in the lecture hall 🧪💕 0195
Reposted by Sander SmitsGBM (Gesellschaft für Biochemie und Molekularbiologie) @gbmev.bsky.social · 27/03/2026This year‘s Lynen Lecture was held by Bruno Antonny (Valbonne, France). Robert Ernst gave the laudatio for Bruno‘s scientific achievements. 0113
Reposted by Sander SmitsMichael Feldbrügge @mfeldbruegge.bsky.social · 01/04/2026Breakthrough article 😊 Joint effort of teams Zarnack & König & Feldbrügge clarifies how multiple RNA-binding domains cooperate to identify functional important binding sites in vivo doi.org/10.1093/nar/... @zarnack-group.bsky.social @könig-lab.bsky.social @mibinet.bsky.social #EMBOrnaLocalizationdoi.orgDissecting the RNA-binding capacity of the multi-RRM protein Rrm4 essential for endosomal mRNA transportAbstract. RNA-binding proteins (RBPs) utilize multiple RNA-binding domains (RBDs) to engage with extensive messenger RNA (mRNA) networks. Understanding the 12516
Reposted by Sander SmitsSchmitt-Lab@HHU @schmitt-lab.bsky.social · 02/04/2026First conference of the newly founded interfaculty Center of Membrane Research at HHU. Two days of exciting talks about all areas of membrane research. Thanks to all speakers and participants for a great time. For sure worth to be repeated! 1124
Reposted by Sander SmitsDaumann Lab @daumannl.bsky.social · 24/02/2026Thanks for highlighting our work done at @hhu.de @chemiehhu.bsky.social published in @angewandtechemie.bsky.social , Aubrey @aubreyzerkle.bsky.social! Rare earth elements rock! doi.org/10.1002/anie...doi.orgInfluence of Rare Earth Elements on Prebiotic Reaction Networks Resembling the Biologically Relevant Krebs CycleRare earth elements can act as mediators in a prebiotic reaction network, producing various intermediates of the citric acid cycle starting from glyoxylate and pyruvate. The ionic radius and the resu... 1154
Reposted by Sander SmitsGert Bange @bangebalcony.bsky.social · 24/02/2026AP4A functions as a regulatory switch of protein acetylation, connecting stress signaling to central metabolism. @synmikro.bsky.social @unimarburg.bsky.social @mpimicrobiomarburg.bsky.social Enjoy the reading: www.nature.com/articles/s41...nature.comA protein adaptor mediating Ap4A-dependent control of protein acetylation - Nature CommunicationsThis study identifies AcuB as a conserved inhibitor of the deacetylase AcuC in bacteria. AcuB directly suppresses AcuC activity, and this inhibition is enhanced the alarmone diadenosine tetraphosphate... 0103
Reposted by Sander SmitsMichael Feldbrügge @mfeldbruegge.bsky.social · 19/02/2026Lasse presents our CRC1535 MibiNet project at the first RNA confluence meeting at the EMBL. @rhinelandrna.bsky.social @mibinet.bsky.social 073
Reposted by Sander SmitsJulia Frunzke @frunzkelab.bsky.social · 19/02/2026 Please RT: Looking forward to our International Symposium on "Microbial Networking - from organelles to cross-kingdom communities". Highlight of our first funding period of our Collaborative Researc Center @mibinet.bsky.social, @dfg.de www.sfb1535.hhu.de/mibinet @hhu.de , @fz-juelich.de 1109
Reposted by Sander SmitsDr. Bernd M. Schmidt @bmschmidtlab.bsky.social · 17/02/2026Super happy to share that our Chemical Science article ‘Structural control of dynamic covalent cages: kinetic vs. thermodynamic assembly and PFAS removal from water’ (pubs.rsc.org/doi/D5SC02247A) has been selected for the 2025 most popular supramolecular articles collection 🎉 052
Reposted by Sander SmitsMichael Feldbrügge @mfeldbruegge.bsky.social · 02/02/2026Happy to announce that our review article on vesicle-coupled mRNA trafficking is now availalbe @mibinet.bsky.social #EMBOrnaLocalization link.springer.com/article/10.1... 0138
Reposted by Sander SmitsPapadopoulos @ HHU @athanasios-ppdpls.bsky.social · 19/01/2026I feel very grateful that our recent publication on rapid biosensor creation has been announced by HHU (Heinrich Heine University Düsseldorf). 🍀🙏🏼🤩🧪🦠🧫🔬 www.hhu.de/news-einzela...hhu.deStrukturanalyse: Veröffentlichung in ACS SensorsUm Stoffwechselprozesse zu verstehen, ist es wichtig, einzelne wichtige Elemente in lebenden Organismen nachweisen zu können. Forschenden der Heinrich-Heine-Universität Düsseldorf (HHU) entwickelten n... 121
Reposted by Sander SmitsPapadopoulos @ HHU @athanasios-ppdpls.bsky.social · 12/01/2026✨ I am thrilled to share ✨ that our paper on computational biosensor design has just been published! Huge thanks to all co-authors and collaborators for the great teamwork and dedication throughout this journey! 🙌 📄 Read the paper here: pubs.acs.org/doi/10.1021/...pubs.acs.orgA Novel Biosensor for Ferrous Iron Developed via CoBiSe: A Computational Method for Rapid Biosensor DesignGenetically encoded biosensors enable the monitoring of metabolite dynamics in living organisms. We present CoBiSe, a computational biosensor design approach using Constraint Network Analysis to ident... 043
Sander Smits @sander1507.bsky.social · 12/01/2026We Are very happy that our Paper was published. Thank to everyone involved pubs.acs.org/doi/10.1021/... @mibinet.bsky.social @mfeldbruegge.bsky.social @frunzkelab.bsky.socialpubs.acs.orgA Novel Biosensor for Ferrous Iron Developed via CoBiSe: A Computational Method for Rapid Biosensor DesignGenetically encoded biosensors enable the monitoring of metabolite dynamics in living organisms. We present CoBiSe, a computational biosensor design approach using Constraint Network Analysis to ident... 1108
Reposted by Sander SmitsStephan Lab @stephanlab.bsky.social · 03/01/2026🔬 Job Alert! 🚨 Goethe University Frankfurt is hiring a Head of our new Imaging Facility at Campus Riedberg! Lead and support a vibrant imaging community, working with cutting-edge microscopes, e.g. a new Zeiss LSM 980, a Z1 Light Sheet, and a new Leica Stellaris. gerbi-gmb.de/resources/ca... 022
Reposted by Sander SmitsPatrick @paber.bsky.social · 19/12/2025Werde Teil des Teams @hhu.de: #Stellenangebot, scheinbar unbefristet. Grüße an #ichbinHanna & #ichbinReyhanjobs.zeit.deAbteilungsleitung (m/w/d) Forschungsmanagement und Transfer - Heinrich-Heine-Universität DüsseldorfHeinrich-Heine-Universität Düsseldorf bietet Stelle als Abteilungsleitung (m/w/d) Forschungsmanagement und Transfer in Düsseldorf - jetzt bewerben! 0104
Reposted by Sander SmitsSander Smits @sander1507.bsky.social · 16/12/2025Very happy to See This Published!!!! Thanks for the collaboration link.springer.com/article/10.1...link.springer.comVesicle-coupled mRNA transport and translation govern intracellular organelle networking - EMBO ReportsEukaryotic cells are highly compartmentalized, enabling sophisticated division of labour. For example, genetic information is stored in the nucleus while energy is produced in mitochondria. Despite th... 1116
Sander Smits @sander1507.bsky.social · 16/12/2025Very happy to See This Published!!!! Thanks for the collaboration link.springer.com/article/10.1...link.springer.comVesicle-coupled mRNA transport and translation govern intracellular organelle networking - EMBO ReportsEukaryotic cells are highly compartmentalized, enabling sophisticated division of labour. For example, genetic information is stored in the nucleus while energy is produced in mitochondria. Despite th... 1116
Reposted by Sander SmitsSchmitt-Lab@HHU @schmitt-lab.bsky.social · 05/12/2025Finally out – It is all about cholesterol Thanks to all for this excellent collaboration 053
Reposted by Sander SmitsEva Nowack @evanowack.bsky.social · 25/11/2025📢Postdoc position available!🧪🧫🧬 Our group is seeking a motivated researcher to investigate the molecular mechanisms driving host–endosymbiont interactions. Full details & application: karriere.hhu.de//index.php?a.... Please help us get the word out!karriere.hhu.dePostdoc (m/f/d) in Endosymbiosis Research 02435
Reposted by Sander SmitsDeutsche Forschungsgemeinschaft @dfg.de · 07/11/2025Die DFG fördert Projekte für ressourceneffizientere Großgerätenutzung in der Forschung mit insgesamt ca. 5,5 Mio €. Außerdem werden zusammen mit der GWK bis Ende 2025 Anträge unter dem üblichen Schwellenwert möglich, die eine längere Nutzung vorhandener Geräte erlauben. Details: sohub.io/r4kmsohub.ioDFG fördert Projekte für ressourceneffizientere Großgerätenutzung in der Forschung 0104
Reposted by Sander SmitsEva Nowack @evanowack.bsky.social · 01/11/2025✨X-ray crystallography reveals surprising twist in how proteins enter the unique photosynthetic organelles of Paulinella. The chromatophore targeting peptide (crTP) folds into a 3D structure, hinting that folded proteins cross peptidoglycan and inner membrane. (1/2) academic.oup.com/plphys/artic... 32610
Reposted by Sander SmitsSchmitt-Lab@HHU @schmitt-lab.bsky.social · 26/10/2025New publication in J Mol Biol New insights in to the function of the CLD and the entire hemolysin secretion machinery. Thanks to Holger Gohlke’s lab and CSS for the wonderful collaboration. Congrats to Sakshi and Cigdem! 062
Reposted by Sander SmitsKathrin Lang @klanglab.bsky.social · 16/10/2025🚨Our paper is out! 🥳 Hijacking a bacterial ABC transporter for efficient genetic code expansion. Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social www.nature.com/articles/s41... it all started years ago with a failed experiment 🧵👇 1/9nature.comHijacking a bacterial ABC transporter for genetic code expansion - NatureBacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins with novel func... 2021660
Reposted by Sander SmitsJulia Frunzke @frunzkelab.bsky.social · 08/10/2025Please RT: We have an opening for a junior group leader position in „Phage Biology & Biotechnology“. www.fz-juelich.de/de/karriere/... Interested candidates are encouraged to contact me via email for further details. @spp2330.bsky.social; @mibinet.bsky.socialfz-juelich.deJunior Group Leader - Phage Biology & BiotechnologyAs a leading research institution for microbial biotechnology the Institute of Bio- and Geosciences - Biotechnology (IBG-1, https://www.fz-juelich.de/de/ibg/ibg-1 ) at the Forschungszentrum Jülich foc... 03857
Reposted by Sander SmitsAltegoerlab @faltegoer.bsky.social · 01/10/2025Excited to share our latest work, spearheaded by @gabmrojas.bsky.social! GPCRs are central sensors in eukaryotes, but little is known about them in fungi. In Ustilago maydis, we now uncovered a host-dependent GPCR mechanism that promotes fungal infection. Gabriel nicely explains the full story👇 072
Reposted by Sander SmitsSven Gould @turbokraken.bsky.social · 25/09/2025The evolution of land plants involved a charge-based adaption in the targeting sequences for #mitochondria and #chloroplasts and the origin of their de/phosphorylation. #science 🧪 academic.oup.com/mbe/advance-...academic.oup.comEvolutionary refinement of mitochondrial and plastid targeting sequences coincides with the late diversification of land plantsAbstract. Plastids and mitochondria are key to plant survival and adaptation. The evolutionary progress of land plants (embryophytes) witnessed gene and ge 172
Reposted by Sander SmitsChemie_HHU @chemiehhu.bsky.social · 20/08/2025✨ Lust auf ein Studium mit bunten Farben, spannenden Apparaturen und mikroskopisch kleinen Stoffen? ✨👩🏼🔬👨🔬 🧪 Chemie oder Wirtschaftschemie könnten da genau das richtige für dich sein! 💡 Neu: Wirtschaftschemie ist ab sofort zulassungsfrei. 194
Reposted by Sander SmitsDirk Tischler @dirktischler.bsky.social · 07/07/2025Just moved online: Glutathione S-Transferase Mediated Epoxide Conversion: Functional and Structural Properties of an Enantioselective Catalyst | ACS Catalysis pubs.acs.org/doi/10.1021/...pubs.acs.orgGlutathione S-Transferase Mediated Epoxide Conversion: Functional and Structural Properties of an Enantioselective CatalystStyrene is a naturally occurring but mainly anthropogenically produced aromatic compound. It is degraded via different routes in nature but often activated to styrene oxide, predominantly to its (S)-e... 051
Reposted by Sander SmitsJohannes Rebelein @rebeleinlab.bsky.social · 03/07/2025I am honored and excited that our research on #nitrogenases and the conversion of #CO2 to hydrocarbons is highlighted in the Yearbook 2024 of the Max Planck Society, see page 29. An English and a German version of the Yearbook are available in www.mpg.de/13631298/yea....mpg.deYearbook HighlightsThe Yearbook Highlights of the Max Planck Society 0102
Reposted by Sander SmitsService-Center für gutes Lehren und Lernen (SeLL) @sell-hhu.bsky.social · 17/06/2025Fachliche Exzellenz und menschliche Nähe: diese Kombination beschreibt unseren heutigen #hhuLehrpreis2025-Nominierten Prof. Dr. Michael Schmitt @lasermichel.bsky.social aus der Chemie @hhu.de perfekt. In seinen Vorlesungen gibt er viel Raum für Diskussion. 🎓💬 0162
Reposted by Sander SmitsEva Nowack @evanowack.bsky.social · 02/06/2025Excited to share that our T7 RNA polymerase-based expression system brings a new level of versatility to Angomonas deanei as a model for studying endosymbiosis! doi.org/10.1371/jour...doi.orgT7 RNA polymerase-based gene expression from a transcriptionally silent rDNA spacer in the endosymbiont-harboring trypanosomatid Angomonas deaneiEukaryotic life has been shaped fundamentally by the integration of bacterial endosymbionts. The trypanosomatid Angomonas deanei that contains a β-proteobacterial endosymbiont, represents an emerging ... 1219
Reposted by Sander SmitsScheu Lab @scheu-immuno-lab.bsky.social · 30/05/2025🚨 Our new publication out now 🍄☠️“The mycotoxin Beauvericin is an uncompetitive inhibitor of Cathepsin B” 🔗 doi.org/10.1002/pro.... 👏Congrats to first authors Xiaoli Yang & Pablo Cea-Medina @dfg.de #RTG2158 & thnx to Holger Gohlke for the great collaboration! @hhu.de #RostockUniversityMedicalCenterdoi.orgThe mycotoxin Beauvericin is an uncompetitive inhibitor of Cathepsin BBeauvericin (BEA), a cyclic depsipeptide, is a mycotoxin of the enniatin family and the secondary metabolite of various toxigenic fungi. Multiple biological functions of BEA have been well investigat.... 152
Reposted by Sander SmitsService-Center für gutes Lehren und Lernen (SeLL) @sell-hhu.bsky.social · 30/05/2025Mit ihrem Modul „Bio110“ ermöglichen Prof. Dr. Petra Bauer @botanyhhu.bsky.social , Dr. Hans-Jörg Mai und Prof. Dr. Jürgen Zeier aus der Biologie @hhu.de Studierenden einen klaren Überblick über das weitläufige Fachgebiet. Das Trio ist für den #hhuLehrpreis2025 nominiert 🌿📖 0123
