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Gert Bange

@bangebalcony.bsky.social
283 followers 184 following 36 posts

Professor and Vice President for Research at University of Marburg. Proud member of SYNMIKRO. Fellow at the Max Planck Institute for terrestrial Microbiology. Interested in the response of organisms to stress. www.bangelab.org

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Gert Bange @bangebalcony.bsky.social · 30/03/2026
academic.oup.com/nar/article/...
academic.oup.com
Exploration of the proxiOME of large subunit ribosomal proteins reveals Acl1 and Bcl1 as cooperating dedicated chaperones of Rpl1
Abstract. In eukaryotes, most newly synthesized ribosomal proteins (r-proteins) need to rapidly and safely get into the nucleus to reach their assembly sit
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Reposted by Gert Bange
Jörg Stülke @joergstuelke.bsky.social · 05/03/2026
The #SubtiWiki paper of the month for February has been chosen. It reports about AppppA-mediated control of protein acetylation. Congrats to the groups of @bangebalcony.bsky.social and collaborstors! subtiwiki.uni-goettingen.de/wiki/index.p...
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Gert Bange @bangebalcony.bsky.social · 28/02/2026
Great collaboration with the labs of Axel Innis and @patrick-pausch.bsky.social on Typ I-F2 CRISPR-Cas. @synmikro.bsky.social @unimarburg.bsky.social @mpimicrobiomarburg.bsky.social
track.smtpsendmail.com
Structural basis of Cas8-independent Cas3 recruitment in Type I-F2 CRISPR–Cas
Abstract. CRISPR–Cas systems provide adaptive immunity in prokaryotes by targeting and degrading invasive genetic elements. Among them, the Type I-F2 syste
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Gert Bange @bangebalcony.bsky.social · 24/02/2026
AP4A functions as a regulatory switch of protein acetylation, connecting stress signaling to central metabolism. @synmikro.bsky.social @unimarburg.bsky.social @mpimicrobiomarburg.bsky.social Enjoy the reading: 
www.nature.com/articles/s41...
nature.com
A protein adaptor mediating Ap4A-dependent control of protein acetylation - Nature Communications
This study identifies AcuB as a conserved inhibitor of the deacetylase AcuC in bacteria. AcuB directly suppresses AcuC activity, and this inhibition is enhanced the alarmone diadenosine tetraphosphate...
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Gert Bange @bangebalcony.bsky.social · 24/02/2026
AP4A functions as a regulatory switch of protein acetylation, connecting stress signaling to central metabolism. @synmikro.bsky.social @unimarburg.bsky.social @mpimicrobiomarburg.bsky.social Enjoy the reading: 
www.nature.com/articles/s41...
nature.com
A protein adaptor mediating Ap4A-dependent control of protein acetylation - Nature Communications
This study identifies AcuB as a conserved inhibitor of the deacetylase AcuC in bacteria. AcuB directly suppresses AcuC activity, and this inhibition is enhanced the alarmone diadenosine tetraphosphate...
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Reposted by Gert Bange
Patrick Pausch @patrick-pausch.bsky.social · 19/02/2026
6/6) Big thanks and congrats to Monika Jasnauskaite et al. for their relentless work 🤜🤛! On Bluesky: @jjuozapaitis.bsky.social @mftorresj.bsky.social @evogytis.bsky.social @bangebalcony.bsky.social @ingasongailiene.bsky.social. Shout out to our funders @erc.europa.eu, @embo.org, @dfg.de, and LMT.
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Gert Bange @bangebalcony.bsky.social · 31/12/2025
journals.asm.org/doi/10.1128/...
journals.asm.org
Structural basis of quinone sensing by the MarR-type repressor MhqR in Staphylococcus aureus | mBio
Staphylococcus aureus is a major human pathogen that can cause life-threatening infections in humans. However, treatment options are limited due to the prevalence of antimicrobial-resistant isolates i...
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Gert Bange @bangebalcony.bsky.social · 08/12/2025
Bacterial swimming isn’t random - it’s engineered. 🦠 Discover how a conserved molecular switch (FlhF/FlhG) controls where and how many flagella bacteria build to navigate their world. @synmikro.bsky.social @unimarburg.bsky.social @mpimicrobiomarburg.bsky.social journals.asm.org/doi/10.1128/...
journals.asm.org
Where and how many: evolutionary diversification of a molecular switch regulating flagellar patterns | Journal of Bacteriology
The bacterial flagellum is a complex, rotary motor that powers bacterial motility. It consists of three main parts: the basal body, the hook, and the filament (Fig. 1A) (reviewed in: [1–3]). The basal...
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BIOspektrum @claudialudy.bsky.social · 19/11/2025
Nachgefragt: Prof. Dr. Gert Bange im Interview www.biospektrum.de/artikel/nach... @bangebalcony.bsky.social
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Gert Bange @bangebalcony.bsky.social · 13/11/2025
www.jbc.org/article/S002... @synmikro.bsky.social @unimarburg.bsky.social
jbc.org
Molecular Insights into the Substrate Recognition and quasi-unidirectional Catalysis of OpaE, an Atypical Fungal Enzyme from the Asp/Glu Racemase Family
Enzymes of the Asp/Glu racemase family, mostly found in bacteria, typically catalyze bidirectional reactions with similar rate due to their pseudo-symmetrical structure and minimal differences between...
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Gert Bange @bangebalcony.bsky.social · 26/09/2025
www.biorxiv.org/content/10.1...
biorxiv.org
Exploration of the proxiOME of large subunit ribosomal proteins reveals Acl1 and Bcl1 as cooperating dedicated chaperones of Rpl1
The eukaryotic ribosome consists of four ribosomal RNAs (rRNAs) and around 80 ribosomal proteins (r-proteins). Most r-proteins, due to their extensive interactions with rRNA, contain highly basic regi...
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Gert Bange @bangebalcony.bsky.social · 19/09/2025
In @elife.bsky.social: Membrane binding properties of the cytoskeletal protein bactofilin doi.org/10.7554/eLif...
doi.org
Membrane binding properties of the cytoskeletal protein bactofilin
A combination of cell biological, biochemical, and computational approaches characterizes the conserved membrane-targeting sequence of bactofilins and reveals a mutual influence of membrane binding an...
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Reposted by Gert Bange
Max Planck Institute for Terrestrial Microbiology @mpimicrobiomarburg.bsky.social · 27/08/2025
How do beneficial gut microbes 'read' their habitat? A study by Victor Sourjik`s lab together with @bangebalcony.bsky.social investigated the chemical preferences of gut microbes. The study highlights the important role of #microbes in #health and #ecosystems. 👉 s.academiccloud.de/zSKBRb
mpi-marburg.mpg.de
What Gut Bacteria Like
An international team of researchers has addressed a question that has received little attention to date: how do beneficial gut microorganisms perceive their environment? Led by Prof. Dr Victor Sourji...
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Ekaterina Jalomo @ekaterinajalomo.bsky.social · 26/08/2025
It is out now 🥳🥂 I am very happy to be part of this nice collaboration in which we were able to characterize different bacterial chemoreceptors and their ligand specificities. Amazing teamwork with Wenhao Xu, the Sourjik lab, @bangebalcony.bsky.social, et. al 🤩 👇👇👇 www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Gert Bange @bangebalcony.bsky.social · 26/08/2025
www.pnas.org/doi/10.1073/... @synmikro.bsky.social @unimarburg.bsky.social @mpimicrobiomarburg.bsky.social
pnas.org
Specificities of chemosensory receptors in the human gut microbiota | PNAS
The human gut is rich in metabolites and harbors a complex microbial community, yet surprisingly little is known about the spectrum of chemical sig...
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Gert Bange @bangebalcony.bsky.social · 21/08/2025
In @elife.bsky.social: Membrane binding properties of the cytoskeletal protein bactofilin doi.org/10.7554/eLif... @synmikro.bsky.social @unimarburg.bsky.social
doi.org
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ProLOEWE @proloewe.bsky.social · 12/08/2025
👍🏼COOL🆕Christof Wegscheid-Gerlach @cwgmr.bsky.social (Koord. d. eh.LOEWE-GLUE) übernimmt Staffelstab🧪von Prof. Stefanie Dehnen (ehem.👩🏼‍🔬bei LOEWE-MOSLA, heute Direktorin des Instituts für Nanotechnologie am KIT in Karlsruhe).Wir gratulieren dem🆕Direktor des Chemikum #Marburg!!! @unimarburg.bsky.social
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Gert Bange @bangebalcony.bsky.social · 08/08/2025
From bacterial virulence to human disease, researchers gathered in Marburg exploring how Ap₄A and other dinucleoside polyphosphates are rewriting the rules of cellular signaling across life. 🚀 Huge thanks to all speakers, participants, and organizers. 🙌 @synmikro.bsky.social @unimarburg.bsky.social
onlinelibrary.wiley.com
Dinucleoside Polyphosphates in Cellular Signaling: Function and Evolution Across Life
Although discovered more than 50 years ago, the cellular functions of Ap4A and related dinucleotides remain largely enigmatic. To address this knowledge gap, we organized a conference showcasing rece....
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Gert Bange @bangebalcony.bsky.social · 08/08/2025
From bacterial virulence to human disease, researchers gathered in Marburg exploring how Ap₄A and other dinucleoside polyphosphates are rewriting the rules of cellular signaling across life. 🚀 Huge thanks to all speakers, participants, and organizers. 🙌 @synmikro.bsky.social @unimarburg.bsky.social
onlinelibrary.wiley.com
Dinucleoside Polyphosphates in Cellular Signaling: Function and Evolution Across Life
Although discovered more than 50 years ago, the cellular functions of Ap4A and related dinucleotides remain largely enigmatic. To address this knowledge gap, we organized a conference showcasing rece....
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Gert Bange @bangebalcony.bsky.social · 29/07/2025
www.uni-marburg.de/de/aktuelles... @unimarburg.bsky.social
uni-marburg.de
Antifeminismus verstehen – Demokratie stärken
LOEWE-Schwerpunkt „GenDem“ untersucht antifeministische Mobilisierungen in Europa und dem Südkaukasus
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ProLOEWE @proloewe.bsky.social · 29/07/2025
🍾 GOOD🆕s:➡️𝗗ü𝗿𝗿𝗲𝗮𝗻𝗽𝗮𝘀𝘀𝘂𝗻𝗴➡️𝗔𝗻𝘁𝗶𝗳𝗲𝗺𝗶𝗻𝗶𝘀𝗺𝗲𝗻➡️𝗽𝗲𝗿𝘀𝗼𝗻𝗮𝗹is. 𝗠𝗲𝗱𝗶𝘇𝗶𝗻𝘁𝗲𝗰𝗵𝗻𝗶𝗸: 38𝗠𝗶𝗼.€ 𝗳ü𝗿 hess.F𝗼𝗿𝘀𝗰𝗵𝘂𝗻𝗴:1️⃣𝗟𝗢𝗘𝗪𝗘-𝗭𝗲𝗻𝘁𝗿𝘂𝗺,4️⃣𝗦𝗰𝗵𝘄𝗲𝗿𝗽𝘂𝗻𝗸𝘁𝗲+🔟𝗟𝗢𝗘𝗪𝗘-𝗣𝗿𝗼𝗷𝗲𝗸𝘁𝗲-𝗪𝗶𝗿 🫶🏼 𝗴𝗿𝗮𝘁𝘂𝗹𝗶𝗲𝗿𝗲𝗻! @tuda.bsky.social @jlugiessen.bsky.social @goetheuni.bsky.social @unikassel.bsky.social @unimarburg.bsky.social ➡️ wissenschaft.hessen.de
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Reposted by Gert Bange
Ákos T Kovács @evolvedbiofilm.bsky.social · 18/06/2025
Rebekka is presenting their recent publication in #NAR academic.oup.com/nar/article/... Collaboration with @thanbichlerlab.bsky.social and also with @bangebalcony.bsky.social - thus beautiful crystal structures involved #BACELL2025
academic.oup.com
A conserved nuclease facilitates environmental DNA uptake
Abstract. Bacteria acquire new traits through the uptake of genetic material from the environment, a process requiring DNA processing. However, the molecul
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Gert Bange @bangebalcony.bsky.social · 06/06/2025
www.uni-marburg.de/de/aktuelles... @unimarburg.bsky.social
uni-marburg.de
2,3 Millionen Euro EU-Förderung für das Projekt „Von der Forschung zum Prototypen“ an der Philipps-Universität Marburg
EFRE-Mittel für innovatives Inkubator-Modell zur Stärkung von Gründung, Transfer und regionaler Innovationskraft
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Gert Bange @bangebalcony.bsky.social · 28/05/2025
academic.oup.com/nar/article/... @synmikro.bsky.social @unimarburg.bsky.social
academic.oup.com
A conserved nuclease facilitates environmental DNA uptake
Abstract. Bacteria acquire new traits through the uptake of genetic material from the environment, a process requiring DNA processing. However, the molecul
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Gert Bange @bangebalcony.bsky.social · 22/05/2025
www.uni-marburg.de/de/aktuelles...
uni-marburg.de
Marburg feiert Doppelerfolg in der Exzellenzstrategie
Zwei Cluster erhalten Förderung im wichtigsten deutschen Forschungswettbewerb
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RobuCop @robucop.bsky.social · 22/05/2025
Thank you for being a part of RobuCop!@olallalab.bsky.social @bangebalcony.bsky.social @danielschindler.bsky.social @hoeferlab.bsky.social @schullerjm.bsky.social @georghochberg.bsky.social
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Gert Bange @bangebalcony.bsky.social · 19/05/2025
onlinelibrary.wiley.com/doi/10.1111/... @synmikro.bsky.social @unimarburg.bsky.social
onlinelibrary.wiley.com
FlhG Cooperates With the Cell Cycle Regulator GpsB to Confine Peritrichous Flagella in B. subtilis
FlhG (orange, with activator helix in green) regulates peritrichous flagellation in Bacillus subtilis by interacting with the C-ring protein FliY (gray, N-terminus in red) and the cell wall regulator....
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Reposted by Gert Bange
AndexerLab @andexerlab.bsky.social · 04/04/2025
If you want to know how to tell an N from an O, you can get some ideas in our new paper. This was a great team effort, introducing us to new methods: MD w/ Ferran Feixas & Marc Garcia Borràs (Girona) + HDX-MS w/ Wieland Steinchen & Gert Bange @bangebalcony.bsky.social pubs.acs.org/doi/10.1021/...
pubs.acs.org
How to Tell an N from an O: Controlling the Chemoselectivity of Methyltransferases
S-Adenosyl-l-methionine (SAM)-dependent methyltransferases (MTs) are important enzymes in numerous biological pathways. They share a common SN2 mechanism but act on different nucleophilic substrates i...
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Ákos T Kovács @evolvedbiofilm.bsky.social · 22/03/2025
Prophages in the infant gut are pervasively induced and may modulate the functionality of their hosts NPJ Biofilms and Microbiomes - from Copenhagen University Hospital and University of Copenhagen www.nature.com/articles/s41...
nature.com
Prophages in the infant gut are pervasively induced and may modulate the functionality of their hosts - npj Biofilms and Microbiomes
npj Biofilms and Microbiomes - Prophages in the infant gut are pervasively induced and may modulate the functionality of their hosts
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Gert Bange @bangebalcony.bsky.social · 17/03/2025
A doctor is born: congratulations Victor Zegarra!!! @synmikro.bsky.social @unimarburg.bsky.social
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Molecular Microbiology @molmicrounihoh.bsky.social · 17/03/2025
🫴 Mechanistic insights into the regulatory framework underlying acetyl-CoA biosynthesis from acetate in Bacillus subtilis: 👇👇👇 www.nature.com/articles/s41... @bangebalcony.bsky.social #subtiwiki #subtilis @naturecomms.bsky.social
nature.com
Regulation of acetyl-CoA biosynthesis via an intertwined acetyl-CoA synthetase/acetyltransferase complex - Nature Communications
Here the authors investigate the regulatory mechanisms of acetyl-CoA (Ac-CoA) biosynthesis in Bacillus subtilis, probing the interaction between acetyl-CoA synthetase (AcsA) and acetyltransferase (Acu...
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Şuayb Üstün @suaybuestuen.bsky.social · 14/01/2025
Happy to share our latest @biorxiv-plants.bsky.social led by @manuelgonzalezfuen.bsky.social “Effector-triggered processing body formation attenuates host translation via ER stress responses and autophagy upon bacterial infection” #proteostasis #plantimmunity 🧵(1/16) www.biorxiv.org/content/10.1...
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Şuayb Üstün @suaybuestuen.bsky.social · 05/03/2025
Wow! The Proteasome generates antimicrobial peptides that directly affect bacterial membranes #proteostasis www.nature.com/articles/s41...
nature.com
Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature
Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...
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Reposted by Gert Bange
Christian Frezza @frezzalab.bsky.social · 14/03/2025
Structure of human PINK1 at a mitochondrial TOM-VDAC array | Science www.science.org/doi/10.1126/...
science.org
Structure of human PINK1 at a mitochondrial TOM-VDAC array
Mutations in the ubiquitin kinase PINK1 cause early onset Parkinson’s Disease, but how PINK1 is stabilized at depolarized mitochondrial translocase complexes has remained poorly understood. We determi...
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Reposted by Gert Bange
Jörg Stülke @joergstuelke.bsky.social · 16/03/2025
News on the regulation of acetyl-CoA synthesis! @naturecomms.bsky.social @bangebalcony.bsky.social #SubtiWiki www.nature.com/articles/s41...
nature.com
Regulation of acetyl-CoA biosynthesis via an intertwined acetyl-CoA synthetase/acetyltransferase complex - Nature Communications
Here the authors investigate the regulatory mechanisms of acetyl-CoA (Ac-CoA) biosynthesis in Bacillus subtilis, probing the interaction between acetyl-CoA synthetase (AcsA) and acetyltransferase (Acu...
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Reposted by Gert Bange
Max Planck Institute for Terrestrial Microbiology @mpimicrobiomarburg.bsky.social · 19/02/2025
Du interessierst Dich für #Forschung? Am 03.04. ist 𝗚𝗶𝗿𝗹`𝘀 𝗗𝗮𝘆 am Max-Planck Institut für terrestrische Mikrobiologie in #Marburg! Jetzt anmelden: s.gwdg.de/5na2yo
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Synmikro @Uni Marburg @synmikro.bsky.social · 18/02/2025
Invitation to our #Synmikro annual meeting in #Marburg, April 23rd, 2025 at the Cineplex Cinema: "Enzyme Design and Evolution - Unlocking a ustainable Future". Please register: www.eventbrite.de/e/enzyme-des... Participation is free
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Gert Bange @bangebalcony.bsky.social · 15/03/2025
www.nature.com/articles/s41... enjoy reading the latest work by Liu Zheng @synmikro.bsky.social @unimarburg.bsky.social @mpimicrobiomarburg.bsky.social
nature.com
Regulation of acetyl-CoA biosynthesis via an intertwined acetyl-CoA synthetase/acetyltransferase complex - Nature Communications
Here the authors investigate the regulatory mechanisms of acetyl-CoA (Ac-CoA) biosynthesis in Bacillus subtilis, probing the interaction between acetyl-CoA synthetase (AcsA) and acetyltransferase (Acu...
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Reposted by Gert Bange
Carsten Sachse @sachsegroup.bsky.social · 10/02/2025
Philipp's manuscript on our CryoVIA toolkit www.sciencedirect.com/science/arti... is out! For those interested in studying protein lipid interactions and high-throughput analysis of membrane structures (sizes, shapes, curvature etc.) - this could be your tool (github.com/philipp-scho...).
sciencedirect.com
CryoVIA: An image analysis toolkit for the quantification of membrane structures from cryo-EM micrographs
Imaging of lipid structures and associated protein complexes using cryoelectron microscopy (cryo-EM) is a common visualization and structure determina…
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Gert Bange @bangebalcony.bsky.social · 09/03/2025
Greetings from Marburg Botanical Garden @unimarburg.bsky.social @synmikro.bsky.social
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Gert Bange @bangebalcony.bsky.social · 05/03/2025
academic.oup.com/pnasnexus/ar... enjoy the read.
academic.oup.com
Mechanistic and structural insights into the itaconate-producing trans-aconitate decarboxylase Tad1
Abstract. Itaconic acid belongs to the high-value precursors for the production of biomass-based industrial compounds. It originates from the tricarboxylic
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Veronika Kivenson @kivenson.bsky.social · 08/11/2024
We discovered the first alternative genetic code in Archaea! www.biorxiv.org/content/10.1...
biorxiv.org
Sporadic distribution of a new archaeal genetic code with all TAG codons as pyrrolysine
Numerous genetic codes developed during the evolution of Eukaryotes and three are known in Bacteria, yet no alternative genetic code has been established for Archaea. Some bacterial and archaeal prote...
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René Ketting @reneketting.bsky.social · 14/12/2024
We are looking for new group leaders. If RNA is your thing, and/or computational biology and you want to start your own group, check out these links. Feel free to contact me about these! And, please help me spread this. Thanks! www.imb.de/jobs/jobdeta... www.imb.de/jobs/jobdeta...
imb.de
Jobdetail
IMB Mainz
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Kay Schink @kschink.bsky.social · 20/02/2025
Very proud to be part of that team - this was a really long term project with lots of amazing people!
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Kay Schink @kschink.bsky.social · 20/02/2025
nature.com/articles/s41467-025-57053-9 Finally this work is out - we show that short sequence motifs direct proteins to specific peroxisomal sub-domains. Fantastic collaboration with @bangebalcony.bsky.social , Johannes Freitag @unimarburg.bsky.social and many more! @uio.no @cancelluio.bsky.social
nature.com
Peroxisomal core structures segregate diverse metabolic pathways - Nature Communications
Peroxisomes contain detergent resistant core structures. Bäcker et al. show that these core structures contain diverse enzymes and serve to enable metabolic compartmentalization of the peroxisome lume...
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Gert Bange @bangebalcony.bsky.social · 20/02/2025
www.nature.com/articles/s41... Great Joint Venture with Johannes Freitag @synmikro.bsky.social @unimarburg.bsky.social
nature.com
Peroxisomal core structures segregate diverse metabolic pathways - Nature Communications
Peroxisomes contain detergent resistant core structures. Bäcker et al. show that these core structures contain diverse enzymes and serve to enable metabolic compartmentalization of the peroxisome lume...
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Gert Bange @bangebalcony.bsky.social · 19/02/2025
www.mdpi.com/2309-608X/11...
mdpi.com
Structural and Functional Analysis of the Lectin-like Protein Llp1 Secreted by Ustilago maydis upon Infection of Maize
The biotrophic fungus Ustilago maydis, which causes smut disease in maize, secretes numerous proteins upon plant colonization. Some of them, termed effectors, help to evade plant defenses and manipula...
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Gert Bange @bangebalcony.bsky.social · 14/02/2025
www.biorxiv.org/content/10.1... @synmikro.bsky.social @unimarburg.bsky.social
biorxiv.org
Specificities of Chemosensory Receptors in the Human Gut Microbiota
The human gut is rich in metabolites and harbors a complex microbial community, yet the sensory repertoire of its commensal bacteria remains largely uncharacterized. Here we systematically mapped liga...
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Gert Bange @bangebalcony.bsky.social · 14/02/2025
Please RT: Cool Meeting in Marburg at SYNMIKRO www.uni-marburg.de/en/synmikro/... @synmikro.bsky.social @unimarburg.bsky.social
uni-marburg.de
Enzyme Design and Evolution: Unlocking a Sustainable Future
The 12th annual Symposium of the Center of Microbiology will take place on 23 April 2025.
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Gert Bange @bangebalcony.bsky.social · 12/02/2025
febs.onlinelibrary.wiley.com/doi/10.1002/... @synmikro.bsky.social @unimarburg.bsky.social
febs.onlinelibrary.wiley.com
FEBS Press
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membra....
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