Sam Morabito @sam-morabito.bsky.social · 18/11/2025A new comparative single-cell multi-omic study of two neurodegenerative disorders, Alzheimer's disease and Pick's disease. A long time in the making and finally published last week!! 🥳 030
Sam Morabito @sam-morabito.bsky.social · 20/03/2025🗞️ Genetic diversity has a profound impact on genomic annotations, and there is currently a massive European bias in widespread annotations like GRCh38 🤯 This paper is the result of the hard work and passion of @pclavell.bsky.social and @fairlie.bsky.social, congrats to the authors! 130
Reposted by Sam MorabitobioRxiv Genomics @biorxiv-genomic.bsky.social · 17/03/2025Long-read transcriptomics of a diverse human cohort reveals widespread ancestry bias in gene annotation www.biorxiv.org/content/10.1101/202… 0115
Reposted by Sam MorabitoJohn Skiles Skinner @skiles.blue · 01/03/2025I got laid off today, with the rest of 18F. 18F was an elite federal software shop. We made gov't websites work better, more efficiently for the American people. We saved taxpayers from getting screwed over by contractors. And were fired for it. We made this website to tell our story: 18f.org18f.orgWe're not done yet | 18F 31689271430856
Reposted by Sam MorabitoChenxin Li, PhD @chenxinli2.bsky.social · 25/02/2025“Assume that what you write will be read by malign foreign actors and tailor your response accordingly.” 082
Reposted by Sam MorabitoRosa Lafer-Sousa @rosalafersousa.bsky.social · 24/02/2025As a result of Trump’s slashes to research funding, dozens of graduate programs have announced reductions and cancellations of graduate admissions slots. If you are an impacted applicant, please fill out this survey: docs.google.com/forms/d/e/1F... 🧪🧠🧬🔬🥼👩🏼🔬🧑🔬docs.google.comGrad Admission Impacts SurveyIt is grad admissions season and many postbacs are feeling the chilling impacts of the Trump administration's recent executive orders freezing and slashing extramural research funding. Dozens of gradu... 8260266
Reposted by Sam MorabitoCNAG @cnag-eu.bsky.social · 19/02/2025🌟Great News: CNAG is now on BlueSky! 🚀From Barcelona to the world, we’re bringing you the latest in genomics! Stay tuned for breaking news, cutting-edge technologies, groundbreaking research, and upcoming events 🔗https://www.cnag.eu #Genomics #Innovation #Research #BlueSky #CNAGmedia.tenor.coma blue sky with a butterfly and the word bluesky on itALT: a blue sky with a butterfly and the word bluesky on it 0106
Reposted by Sam MorabitoCrystal Rogers, PhD @rogerslabucd.bsky.social · 19/02/2025Pretty sad. Just got the email that CZI is canceling the second round of Diversity Leadership Awards. Private industry will definitely not fill the hole that NIH and NSF are leaving. 😢💔 52717279
Reposted by Sam MorabitoAlessandro Rigolon @alerigolon.bsky.social · 10/02/2025I was just told that I have to remove “climate” from the title of an ongoing grant if I want to keep it. And publications from that grant cannot include “climate” and other forbidden words. I can’t believe I’m writing this from the United States of America. #AcademicSky 549129065481
Reposted by Sam MorabitoScience Magazine @science.org · 08/02/2025The National Institutes of Health plans to severely cut the percentage of its grant money that can be used for overhead costs rather than research.scim.agNIH slashes overhead payments for research, sparking outrageMove to cut indirect cost rate to 15% could cost universities billions of dollars 11181100
Reposted by Sam MorabitoCarl T. Bergstrom @carlbergstrom.com · 08/02/20251. Today the NIH director issued a new directive slashing overhead rates to 15%. I want to provide some context on what that means and why it matters. grants.nih.gov/grants/guide...grants.nih.govNOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost RatesNIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD 25470004078
Reposted by Sam MorabitoNiema Moshiri @niema.net · 04/02/2025Inspired by @charlesgaba.com's Herculean effort to post all Wayback URLs from the CDC website (including pages that have recently been deleted), I built this GitHub repo to share Wayback links to all CDC website pages, and will add more websites when I get a chance github.com/Niema-Lab/Go...github.comGitHub - Niema-Lab/Government-Wayback: Unofficial repository storing links to Wayback Machine for government pagesUnofficial repository storing links to Wayback Machine for government pages - Niema-Lab/Government-Wayback 711953
Reposted by Sam MorabitoPaula Nieto @paulanietog.bsky.social · 29/01/2025📢 SUPER EXCITED to share our latest preprint: Decoding the immune response in leptomeningeal disease through single-cell sequencing of cerebrospinal fluid Incredible work and collaboration from @jcnietos.bsky.social @piazeiner.bsky.social @hoheyn.bsky.social and others. biorxiv.org/content/10.110…biorxiv.org 1114
Reposted by Sam MorabitoJane Liebschutz, MD MPH (she/her) @liebschutz.bsky.social · 22/01/2025All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities. 583121984962
Sam Morabito @sam-morabito.bsky.social · 12/12/2024Overjoyed to share that I was selected for the EMBO #postdoc fellowship for my proposal titled "Charting immune cell signatures to tackle non-response to immunotherapy in colorectal cancer". Excited to work on this project over the next few years in #Barcelona! #EMBOFellows 140
Reposted by Sam MorabitoShane Liddelow @liddelowsa.bsky.social · 11/12/20243 reviews on planning, execution, & validation of transcriptomic experiments in neuroscience published in @natureportfolio.bsky.social #NatureNeuroscience. A MUST READ if you're doing transcriptomics. 3 reviews, an amazing editorial, a beautiful cover – this is the issue of the year! (mini thread) 211844
Reposted by Sam MorabitoSarah Marzi @sj-marzi.bsky.social · 11/12/2024So excited that our work on predicting gene expression from histone modifications using deep learning is out in NAR today. Brilliant to work with lead author @al-murphy.bsky.social and collaborators Aydan Askarova, @borislenhard.bsky.social and Nathan Skene 🧬⭐️🙏 academic.oup.com/nar/advance-...academic.oup.comPredicting gene expression from histone marks using chromatin deep learning models depends on histone mark function, regulatory distance and cellular statesAbstract. To understand the complex relationship between histone mark activity and gene expression, recent advances have used in silico predictions based o 37029
Sam Morabito @sam-morabito.bsky.social · 11/12/2024A really nice summary on Alzforum of my recent paper where we used #SingleCell and #spatial #omics to investigate molecular and cellular abnormalities in the brains of individuals with Alzheimer's in Down Syndrome (DSAD). www.alzforum.org/news/researc...alzforum.orgIn Alzheimer’s Due to Down’s, Spatial Omics Spots Signs of Trouble | ALZFORUM 100
Reposted by Sam MorabitoSamuel Marsh Ph.D. @samuelmarsh.bsky.social · 03/12/2024Big day for single cell and neuroscience. Trio of single cell perspective pieces discussing applications, opportunities, challenges, and validation of single cell and spatial genomics in neuroscience are out now in Nature Neuroscience. Links in thread below.👇 1/n 27323
Reposted by Sam MorabitoHelena Lucia Crowell @helucro.bsky.social · 04/12/2024A little piece that's been in the works with former MSc, now PhD student, Jiayi Wang & @markrobinsonca.bsky.social in the multi-sample/-condition/-subpopulation theme: ... 1137
Reposted by Sam MorabitoFairlie Reese @fairlie.bsky.social · 03/12/2024Hi all! I'm a computational biologist studying the impact of variation on the functional genome at @bsc-cns.bsky.social. Consortium alumnus (ENCODE, LRGASP, IGVF @igvfconsortium.bsky.social); @ucirvine.bsky.social PhD; @ucsandiego.bsky.social BS; and recent transplant from California to Barcelona. 021
Sam Morabito @sam-morabito.bsky.social · 25/11/2024Our comparative spatial & single-nuc study of Alzheimer's, Down Syndrome in AD, and a genetic mouse model, just published in Nature Genetics. Massive effort of the 2nd half of my PhD, and a pleasure to work with co-first author Emily, my advisor Vivek, & many others at UC Irvine 🧠 🧬nature.comSpatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer’s disease - Nature GeneticsSpatial and single-nucleus analyses in human postmortem Alzheimer’s disease (AD) brain tissues at early and late stages from individuals with and without Down syndrome, as well as in AD mouse models, ... 081
Reposted by Sam MorabitoLuciano Martelotto @lgmartelotto.bsky.social · 24/11/2024STAMPing single cell like never before…at a ~0.25c/cell single cell-imaging is the new single cell-sequencing. www.biorxiv.org/content/10.1...biorxiv.orgSTAMP: Single-Cell Transcriptomics Analysis and Multimodal Profiling through ImagingWe introduce Single-Cell Transcriptomics Analysis and Multimodal Profiling (STAMP), a scalable profiling approach of individual cells. Leveraging transcriptomics and proteomics imaging platforms, STAM... 0358
Sam Morabito @sam-morabito.bsky.social · 20/11/2024👀 Working on a #StarterPack for early career researchers (PhD students & Postdocs) in #genomics & #bioinformatics 🧬🖥️ Please share! Happy to add those working in this area so please suggest. Seeing a lot of PIs on here but would love to see more students 🎓🚀 234123
Sam Morabito @sam-morabito.bsky.social · 20/11/2024Amazing new study led by my labmate Inés Sentís, leveraging #SingleCell 🖥️🧬 technologies to study the effects of #immunotherapy in #pediatric #cancer. Emphasis on #Tcell dynamics throughout treatment and comparing circulating vs. tumor-resident immune cells 🩸💪biorxiv.orgSpatio-temporal T cell tracking for personalized TCR-T designs in childhood cancerImmune checkpoint inhibition (ICI) has revolutionized oncology, offering extended survival and long-term remission in previously incurable cancers. While highly effective in tumors with high mutationa... 0115
Sam Morabito @sam-morabito.bsky.social · 19/11/2024Has anybody made a starter pack specifically for trainees #phd students & #postdocs in #genomics or #bioinformatics 👀 🖥️ 🧬 3140
Sam Morabito @sam-morabito.bsky.social · 12/11/2024"Single-cell atlas of the human immune system reveals sex-specific dynamics of immunosenescence" Interesting pre-print on immune cells dynamics throughout aging, from Marta Mele's group at Bacelona Supercomputing Center. www.biorxiv.org/content/10.1... #singlecell #immunology #agingbiorxiv.orgSingle-cell atlas of the human immune system reveals sex-specific dynamics of immunosenescenceImmunosenescence, the gradual deterioration of the immune system with age, leads to an increased susceptibility to a range of diseases associated with immune dysfunction. Notably, sex is an important ... 030
Sam Morabito @sam-morabito.bsky.social · 12/11/2024Hi BlueSky! I am a computational biologist 🖥️🧬 using -omics to study human diseases like cancer & Alzheimer's 🧠 Originally from southern #California, now in #Barcelona as a postdoc in the #singlecell #genomics group at the Centre Nacional d'Anàlisi Genòmica (CNAG). Happy to connect w/ others on here! 180