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Ryan Senne (he/him)

@ryguy.io
214 followers 482 following 27 posts

Computational Neuroscience Ph.D. Student @ Boston University. Labs of Dr. Brian DePasquale, Ben Scott, & Steve Ramirez. #JuliaLang stan.

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Ryan Senne (he/him) @ryguy.io · 16/09/2026
Check out my latest work from the Ramirez lab with co-author @rsuthard.bsky.social! It’s got astrocytes—what more do you need!?
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Nature @nature.com · 08/08/2026
Nature research paper: Amygdala astrocyte primary cilium mechanisms contribute to stress behaviours go.nature.com/3UiC3bT
go.nature.com
Amygdala astrocyte primary cilium mechanisms contribute to stress behaviours - Nature
Amygdala astrocyte primary cilia are disrupted during stress, and their restoration leads to improvements in stress-related behaviour in mice.
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Nadieh Bremer @nadiehbremer.com · 12/02/2026
📣 NEW! I’ve just released the BIGGEST and perhaps most creative project I’ve ever worked on! “Searching for Birds” searchingforbirds.visualcinnamon.com 🐤 A project, an article, an exploration that dives into the data that connects humans with birds, by looking at how we search for birds.
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PessoaBrain @pessoabrain.bsky.social · 03/08/2026
Harrison gives the state-space modeling tutorial at CNN
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Mark Histed @markhisted.org · 24/07/2026
I co-sign this great summary from @dereklowe.bsky.social . The goal is to destroy academic science, and these are the reasons. And all the “gold standard” and “needs reform” and “not high risk” stuff is transparent bullshit to hide the ball on what they are doing.
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Science
science. But let me make something clear right up front. When I talk to people about this subject (and that includes some journalists as well) and say what I'm about to at the end of this paragaph I am sometimes met with disbelief. But I mean what I say and I am trying my best to say what I mean: The Trump administration hates academic science funding, full stop. They hate where that money goes, and they hate who it goes to. They want to keep all that money for themselves, to hand out to favored cronies who can help them get elected and to steer yet more money and more power back into their hands.
That's it. That's the story. They are naturally not putting it in those words, but instead talking about "gold standard science" and the
"reproducibility crisis" and funding "bold inquiry" for "transformational
breakthroughs". This is all bullshit, and it's important to realize that. Shameless hand-waving bullshit, delivered in a how-dare-vou-
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Sean Marshall @seanyyz.bsky.social · 14/07/2026
Why I’m a fan of the Oxford comma.
TORONTO STAR
BOOK REVIEW
Sylvia Plath, a New York vigilante and Shah of Iran featured in latest historical fiction
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Hugo Spiers @hugospiers.bsky.social · 13/07/2026
Hippocampal engrams configure prefrontal context representations to guide flexible decisions Impressive combo of methods to manipulate and record this process: www.biorxiv.org/content/10.6...
biorxiv.org
Hippocampal engrams configure prefrontal context representations to guide flexible decisions
Flexible behavior requires using past experiences to configure cortical computations to suit current task demands. A central question in neuroscience is how memory representations control such reconfi...
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NY Times Pitchbot @nytpitchbot.bsky.social · 11/07/2026
Polls show that only 8% of Americans have a positive view of Adolf Hitler. But in this Palo Alto ketamine bar, that number feels much higher
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Michael "Shapes Dude" Betancourt @betanalpha.bsky.social · 09/07/2026
Today I learned that some of my nested quantile visualizations implemented for R and Python in github.com/betanalpha/m... have been implemented for Julia in the FlexiChains library, pysm.dev/FlexiChains..... Neat!
github.com
GitHub - betanalpha/mcmc_visualization_tools: Markov Chain Monte Carlo Visualization Tools
Markov Chain Monte Carlo Visualization Tools. Contribute to betanalpha/mcmc_visualization_tools development by creating an account on GitHub.
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Dr. Cate Peña @cate-cholamine.bsky.social · 06/07/2026
I’m so outrageously mad having realized a bunch of inane reviewer comments are probably AI. I’m also too busy and would rather be compen$ated for my reviews, but 1) who are we as academics if we don’t value reading and thinking about the literature and 2) dont waste my/student’s time with slop!!
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Alejandra Caraballo @esqueer.net · 02/07/2026
Really don't like how every person with a social security account now gets unsolicited political messages from the SSA.
A screenshot of an email in dark mode from Social Security. At the top is a dark blue header with the Social Security Administration logo, followed by a bright blue banner containing the text "Making Life More Affordable for America's Seniors".
​The body of the email reads: "This weekend, America celebrates its 250th birthday. For over 90 of those years, Social Security has provided financial freedom for America's seniors. President Donald J. Trump and the Trump Administration are not only protecting Social Security, but we are providing meaningful and immediate relief to older Americans who have spent decades contributing to our nation's economy.
​Just last year, on July 4, 2025, President Trump signed into law the Working Families Tax Cuts Act. This historic legislation included a tax cut that allows Americans 65 and older to keep more of their hard-earned Social Security benefits. Thanks to President Trump, over 35 million American seniors received an average of $7,500 in relief this tax season.
​If you did not take advantage of the President's signature tax cut for seniors, I encourage you to review eligibility requirements through the Internal Revenue Service (IRS) website for next year's tax filing season."
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Aki Vehtari @avehtari.bsky.social · 26/06/2026
@aloctavodia.bsky.social has been porting Bayesian Workflow book avehtari.github.io/Bayesian-Wor... case studies to Python using CmdStanPy, numpyro, ArviZ, Bambi, and kulprit arviz-devs.github.io/bayesian-wor... He is working on porting the rest of the case studies, too
arviz-devs.github.io
Bayesian Workflow book: Case studies in Python – Bayesian Workflow case studies in Python
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Grace Lindsay @neurograce.bsky.social · 19/06/2026
Love having data to show the students
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Ethan Mollick @emollick.bsky.social · 19/06/2026
More evidence, from a large-scale study in China, that using AI hurts learning if it undermines mental effort. When homework time drops due to AI use, so do test scores. Across studies, there is a clear theme: AI tutoring in support of classes is good, using AI to "help" with homework is bad.
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Brian DePasquale @briandepasquale.bsky.social · 17/06/2026
How can AI change theoretical neuroscience? Technologies separate us from the mechanics of computation. Are we liberated to focus on the big picture or abandoning the substrate of thought? Born from an ongoing experiment in my lab about balancing these technologies for research and training
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Dan Goodman @neural-reckoning.org · 16/06/2026
Interesting Transmitter article by Brian DePasquale on what will be the effect of the increasingly widespread use of LLMs to code up research ideas in neuroscience. Includes a somewhat sceptical commentary from me. 😉
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Ryan Senne (he/him) @ryguy.io · 11/06/2026
Check out the new work from the DePaq lab!
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Ryan Senne (he/him) @ryguy.io · 04/06/2026
The seemingly unlimited generosity of the current US funding landscape
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Matthijs Hollanders @matthollanders.bsky.social · 01/06/2026
Frequentists mogged by priormaxxing
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Karandeep(Singh) @kdpsingh.bsky.social · 01/06/2026
Statistics aka Likelihoodmaxxing
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Mark Histed @markhisted.org · 30/05/2026
In Jan 2029 a trifecta should pass a large bill package that overturns somewhere between 20 and 50 Roberts Court decisions of the last three decades. We can roll back what they did to legalize political bribery, enable fraud, empower white collar criminals, destroy the govt, etc.
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Mark Histed @markhisted.org · 30/05/2026
Russell Vought’s OMB published a rule today attacking peer review, which came along with a Murdoch NY Post article favorable to the rule- and attacking peer review. Which all makes the timing of yesterday’s Murdoch WSJ article attacking peer review seem much more suspicious!
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Ryan Senne (he/him) @ryguy.io · 30/05/2026
Lastly a huge thanks to all the authors especially my advisors @briandepasquale.bsky.social and the bluesky-less Ben Scott!
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Ryan Senne (he/him) @ryguy.io · 30/05/2026
And the best part? Our new model was implemented fully in #JuliaLang. So check out our preprint and learn about the DDM-HMM; accumulating evidence suggests it’s the hottest new behavioral time series model!
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Ryan Senne (he/him) @ryguy.io · 30/05/2026
Our new model revealed “patient,” “impulsive,” and low-drift decision states that wax and wane across the light-dark cycle. We found that regardless of how good individual animals were, at the population level all animals accumulated evidence more effectively during the dark cycle!
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Ryan Senne (he/him) @ryguy.io · 30/05/2026
Move over, GLM-HMM—there’s a new hidden Markov model in town. In our new preprint, we introduce the DDM-HMM: a model that jointly infers latent decision states from reaction times and choices. Using 24-hour behavioral data from rats, we found that evidence accumulation changes with time of day!
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Gustavo A. Ballen @gaballench.bsky.social · 29/05/2026
And finally it was published! Massive thanks to my coauthors, the editor and reviewers, and the institutions that supported our research. journals.plos.org/plosone/arti...
journals.plos.org
What did the dove sing to Pope Gregory? Ancestral melody reconstruction in Gregorian chant using Bayesian phylogenetics
An attractive goal in the study of Gregorian chant melodies is reconstructing unobserved melodies as they may have been transmitted along their history, especially as early chant notation does not cap...
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Flatiron Institute @flatironinstitute.org · 30/04/2026
Congratulations to #FlatironCCN director @eerosim.bsky.social on his election to the National Academy of Sciences! bit.ly/42AEUhl #science #neuroscience
bit.ly
CCN Director Eero Simoncelli Elected to National Academy of Sciences
Eero Simoncelli, director of the Flatiron Institute’s Center for Computational Neuroscience (CCN), has been elected to the National Academy of Sciences.
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Kenji Lee @kenjilee.bsky.social · 27/04/2026
Super excited to (finally!) show our work on identifying cell types! Now in press www.nature.com/articles/s41.... We show how to identify cell types from ephys recordings *without* optotagging. This opens the study of not just individual cell types, but the interacting neural circuit during behavior
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Sam Gershman @gershbrain.bsky.social · 19/04/2026
There seems to be a broad perception across psychology and neuroscience that work shouldn't be "too technical" in order to reach the broadest possible audience. While I think we should strive for accessibility, I feel that this attitude can also be self-defeating: why are we dumbing down?
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allen institute @alleninstitute.org · 01/04/2026
The Orange Cat Brain Atlas is here. 🧠🐈 Today, we published the first comprehensive cellular map of the orange cat brain. The new atlas reveals a single, specialized neuron responsible for behaviors like staring at walls, knocking objects off tables, and the 3am "zoomies."
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Alex Williams @itsneuronal.bsky.social · 19/03/2026
Cosyne invited me to give a long tutorial (4 hours!) on methods to quantify differences high-d neural recordings across animals, brain regions, deep neural nets, etc. The recording is up on youtube. I hope it inspires more research on this fundamental topic! www.youtube.com/watch?v=n44x...
youtube.com
Cosyne 2026 - Cosyne Tutorial: Comparative Analysis of Neural Population Codes
YouTube video by Cosyne Talks
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ArviZ @arviz.bsky.social · 19/03/2026
ArviZ 1.0 is out! We have refactored it to be more modular, flexible & lightweight. For an overview of the changes, check the migration guide. python.arviz.org/en/stable/us...
python.arviz.org
Getting started — ArviZ 1.0.0 documentation
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Pynapple @pynapple.bsky.social · 27/02/2026
Checkout the notebook of this epic neuroscience dataset now on @dandiarchive.org and analyzed with pynapple!
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Nicole Carr @coleecarr.bsky.social · 18/02/2026
So happy to announce my first published paper: Neuropixels reveal laminar microcircuit organization in monkey V1 in vivo www.pnas.org/doi/epdf/10....
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Mel Andrews @bayesianboy.bsky.social · 17/02/2026
I am a pro-AI guy who often gets pigeonholed as an anti-AI guy. I am pro developing and using AI for things AI is good at. I am anti developing and using AI for things that will bring on another AI winter, a mild economic collapse, and make us all look like schmucks in ~5 years.
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Ryan Senne (he/him) @ryguy.io · 12/02/2026
As a proud Minnesotan, I second this
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Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 31/01/2026
nearly a thousand entries
Epstein files search for "Ed Boyden" returns 969 hits
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Winnie the Pooh (Official) @indianawalsh.bsky.social · 19/01/2026
Gary Larson: In my cartoon I invented Cow Tools as a cautionary tale Cows: At long last, we have created the Cow Tools from classic newspaper comic Cow Tools
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Aaron Rupar @atrupar.com · 15/01/2026
Walz: "What's happening in MN defies belief. News reports simply don't do justice to the level of chaos & disruption & trauma the federal govt is raining down... This long ago stopped being a matter of immigration enforcement. Instead, it's a campaign of organized brutality against the people of MN"
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Elizabeth Wrigley-Field @wrigleyfield.bsky.social · 13/01/2026
I really want ppl w/o Minneapolis connections to understand You might've heard that Mpls public schools went hybrid bc so many families are in hiding. Well, a coworker just told me that today, during his kid's hybrid class, a kid's apt building was raided onscreen *Everyone has stories like this*
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Taniel @taniel.bsky.social · 07/01/2026
The woman killed by ICE was Renee Nicole Good, a 37-year old who was the mother of a 4-year old child whose father already died a few years ago. The Star Tribune talked to her mother. www.startribune.com/she-was-an-a...
“Renee was one of the kindest people I’ve ever known,” she said. “She was extremely compassionate. She’s taken care of people all her life. She was loving, forgiving and affectionate. She was an amazing human being.”
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Elizabeth Cronise McLaughlin @ecmclaughlin.bsky.social · 07/01/2026
BBC is reporting that the same ICE officer who murdered Renee Good was involved in another violent incident in June.
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daviss @daviss.org · 07/01/2026
NOW: Crowd continues to grow in Minneapolis at a vigil where a federal agent shot and killed Renee Good this morning. “SAY HER NAME!” “RENEE GOOD!”
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Ken Klippenstein @kenklippenstein.bsky.social · 07/01/2026
If you knew Renee Nicole Good - the 37 year old killed by ICE in Minneapolis today - please text me at 202-510-1268. You can remain anonymous
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Matthias Nau @matthiasnau.bsky.social · 06/01/2026
A meta-analysis of studies using Tolman’s sunburst maze suggests poor replicability and little evidence for shortcutting. Ouch! Definitely relevant reading for anyone interested in cognitive maps! 👇
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Cian O'Donnell @cianodonnell.bsky.social · 05/01/2026
Given the popularity and centrality of neuronal calcium imaging to systems and cellular neuroscience, it is shockingly under-modelled. Makes me nervous about the conclusions from those studies. At least the fMRI BOLD interpretation gets routinely debated...
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Kate Nautiyal @katenautiyal.bsky.social · 21/12/2025
New paper drop! 🧠💊 Our new paper out in Molecular Psychiatry shows that the serotonin 1B receptor is important for the neural and antidepressant/anxiolytic behavioral responses to psilocybin in mice. www.nature.com/articles/s41...
nature.com
The serotonin 1B receptor is required for some of the behavioral effects of psilocybin in mice - Molecular Psychiatry
Molecular Psychiatry - The serotonin 1B receptor is required for some of the behavioral effects of psilocybin in mice
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Ryan Senne (he/him) @ryguy.io · 22/12/2025
The reviewer 2 special I see
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