Nature Metabolism, Published online: 23 July 2026; doi:10.1038/s42255-026-01578-wMitochondrial oxidative metabolism is found to strongly affect the response of colorectal cancer (CRC) cells to the chemotherapeutic drug 5-fluorouracil (5FU). Targeting mitochondrial metabolism sensitizes CRC cells to 5FU.

Mapping the metabolic effects of drugs helps define their mode of action.

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Extracellular vesicles (EVs) are now recognized as powerful modulators of metabolism, and thus the new field of EV-mediated metabolic regulation is growing exponentially. Here, we discuss special experimental considerations for the study of EV function in metabolism.

The authors provide a comprehensive characterization of how glutamine uptake and utilization regulate macrophage function in atherosclerosis.

Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pathway analysis in metabolomics often yields misleading or nonsensical results.

This authoritative Perspective lays a foundation for the field of obesity research by comparing commonalities and differences between competing models of obesity pathogenesis and by defining terms that are at the core of this discussion.

Nature Nanotechnology, Published online: 01 October 2025; doi:10.1038/s41565-025-02017-9A spatiotemporally adaptive targeting strategy ensures sequentially reprogramming metabolism of inflammatory macrophages and senescent stem cells via intracellular NAD+ replenishment, accelerating bone and skin tissue regeneration.

Sharma et al. review the regulation and biological functions of apparently ‘futile’ dynamic lipid cycle in regulating whole-body metabolic homeostasis.

Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.

Lin et al. discover homocysitaconate, an anti-inflammatory metabolite formed during inflammation via AHCY-catalyzed adduction of homocysteine and itaconate. Homocysitaconate is recognized by MARS, ind...

Clustering and nesting (C&N) arise in many preclinical studies, such as when animals are group-housed or share litters, or in cell culture. Ignoring C&N undermines the validity of analyses. He...

This study, together with a companion manuscript, show that, in mice, weight loss as a result of GIP receptor antagonism requires, and potentiates, functional GLP-1 receptor signalling in the brain, e...

Arrays of silicon nanoneedles are used to generate molecular replicas of live brain tissue for longitudinal spatial lipidomic classification via desorption electrospray ionization mass spectrometry imaging of gliomas and to monitor the responses of the tumours to chemotherapy.

Nature Metabolism, Published online: 20 June 2025; doi:10.1038/s42255-025-01323-9Clustering and nesting (C&N) arise in many preclinical studies, such as when animals are group-housed or share litters, or in cell culture. Ignoring C&N undermines the validity of analyses. Here, we explain how C&N arise, as well as valid designs and analyses.

Abstract. The aging population is increasing worldwide, and there is also an increase in the aging population living with overweight and obesity, due to ch

In this Tutorial, we provide guidelines for the use of ML models to mine genomes and proteomes for the discovery of antimicrobial peptides, discussing the various stages of the ML workflow, recent advances in ML models and how to experimentally validate the computational predictions.

A Nature Metabolism study shows that, under acute stress, fatty acids liberated by lipolysis of white fat cells cause release from local macrophages of the growth-differentiation factor GDF15, which, in turn, binds to the receptor GFRAL in the brain, evoking anxiety.

Abstract. Macrophages are versatile innate immune cells that act as sentinels, warriors, and healers in virtually every tissue. This review synthesizes cur

Rodriguez et al. investigate the impact of biased signaling with a dual GLP-1R/GIPR agonist. Biased GLP-1R and GIPR agonism leads to better and prolonged glucose lowering, greater food intake reductio...

Diverse microbial exposures in early life reduce the risk of inflammatory conditions, including allergies and autoimmunity. Emerging data suggest that microbial diversity is as important as microbial ...

Rehabilitation after ischaemic stroke can promote only limited recovery for many patients with stroke. This Review discusses how the distinctly reparative environment of the subacute time window after stroke can inform the design of biology-driven biomaterial-based stroke therapies.

Plant-derived lipid nanoparticles (PDNPs) are nano-sized particles isolated from various edible plants that contain bioactive components involved in r…

Nature Metabolism, Published online: 23 May 2025; doi:10.1038/s42255-025-01310-0A new study reveals that the host-derived ketone body, β-hydroxybutyrate, protects against malaria in mice by inhibiting Plasmodium development. These findings highlight the anti-microbial potential of metabolic interventions.

Nature Nanotechnology, Published online: 21 May 2025; doi:10.1038/s41565-025-01909-0Mitochondrial nanoinducers that degrade mitochondria via autophagy enhance T cell activation and tumour cell susceptibility, improving immunotherapy.

Heo, Xu et al. used comprehensive plasma proteomics to identify 416 plasma proteins (294 new) associated with Alzheimer’s disease and applied machine learning to select 7 proteins that were highly pre...

Multi-drug nanotherapy consistently outperforms single-drug therapy, multi-drug combination therapy, and single-drug nanotherapy across different experimental settings, therapy strategies and cancer t...

Liver macrophages are a major obstacle to extrahepatic drug delivery. This study identifies the receptor–ligand interactions that they use to capture circulating nanoparticles and leverages this under...

Dysregulation of the dopamine-ACOD1 axis correlates with sepsis severity.

Integrons are bacterial genetic elements that capture, stockpile, and modulate the expression of genes encoded in integron cassettes. Mobile integrons (MIs) are borne on plasmids, acting as a vehicle ...

Experiments in mouse models show that proper recovery of the intestinal microbiota following depletion, with or without faecal microbiota transplant therapy, is dependent on syntrophic interactions th...