iiinova — where your digital self keeps evolving

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A/Prof Sam Stehbens PhD (She/Her) @samstehbens.bsky.social · 18/07/2026

Australian Grant assessors- can we please stop adding useless comments like ‘‘big papers from post doc in established international lab but has not proven themselves here yet”. It’s REALLY hard to move countries, set up an independent team, and produce high impact work in under 3 years.

static.klipy.com

Gru: Okay, That's Not Helping

ALT: Gru: Okay, That's Not Helping

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Edward T Eng @edwardteng.bsky.social · 20/03/2026

Day 5 @olibclarke.bsky.social did double duty talking about model building & validation and giving a Coot/chimeraX tutorial. Also Justin Flatt from the @rcsbpdb.bsky.social shared best practices for #cryoEM deposition & validation.

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Dr Rosemary Cater @rosemaryjcater.bsky.social · 18/12/2025

Congratulations to the Cater Lab's first ever graduate Parteek! Bachelor of Advanced Scince with First Class Honours - we are SO proud of you! Looking forward to another year of fun in the lab together in 2026! 🎓🔬🧪✨

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Josh Hardy @joshuamhardy.bsky.social · 28/09/2025

I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5) doi.org/10.1101/2025.09.24.678028 #proteindesign

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Australian Society for Biochemistry and Molecular Biology - 2025 @asbmbaus.bsky.social · 01/10/2025

Thank you to all of our plenary speakers for sharing your incredible research with us at #ASBMB2025! @nanigrotjahn.bsky.social @ajknights7.bsky.social Michelle Haber and Randal Halfmann. We have loved having you all in Brisbane and hearing about your labs awesome work! 🦠🧬🧪🧫🔬

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Australian Society for Biochemistry and Molecular Biology - 2025 @asbmbaus.bsky.social · 01/10/2025

And that's a wrap! A huge shout out goes to our conference chair Michael Landsberg @dr-berger.bsky.social and the rest of the organizing committee for putting together such a vibrant #ASBMB2025! See you all at #ComBio2026!

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Dr Rosemary Cater @rosemaryjcater.bsky.social · 18/09/2025

Lorne 2026 is set to be excellent! Especially with a Transporter Satellite Meeting!!

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Lorne Proteins @lorneproteins.bsky.social · 16/09/2025

👕✨ Design the next Lorne Protein Conference T-shirt! Entries close 17 Oct – don’t miss your chance to show off your creativity and cement your place in the history of Lorne Proteins 🤓 👉 Submit your design-see the link below... 📢 And don’t forget to submit your abstract by 24 Oct! #LorneProteins

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Australian Society for Biochemistry and Molecular Biology - 2025 @asbmbaus.bsky.social · 15/09/2025

DEADLINE extended till tomorrow!!! Decorate the ASBMB gelato cart with your cool microscopy image/favourite protein structure!!

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Australian Society for Biochemistry and Molecular Biology - 2025 @asbmbaus.bsky.social · 20/06/2025

Just over 1 week left for ASBMB 2025 abstract submission!!! Make sure you don't miss the deadline! WE want to hear the cool science YOU have to share! www.asbmb2025.com.au

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Dr Rosemary Cater @rosemaryjcater.bsky.social · 05/06/2025

Add it to your calendars! Register and submit your abstract for ASBMB this month! 🗓️📃🧬🧫🔬

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Australian Society for Biochemistry and Molecular Biology - 2025 @asbmbaus.bsky.social · 16/05/2025

The ASBMB 2025 Conference is coming to UQ Brisbane – and the official website is now LIVE! Explore the program, register early & submit your abstract now! www.asbmb2025.com.au #ASBMB2025 #UQ #biochemistry #molbio #academiclife #conferences

asbmb2025.com.au

Home - Australian Society of Biochemistry and Molecular Biology 2025 - University of Queensland

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André Nadler @nadlerlab.bsky.social · 06/05/2025

Why are biological membranes asymmetric, with different lipids in the two bilayer leaflets? Discovered in the 70s, lipid asymmetry is linked to many cellular processes, but why the cell needs it is largely unclear. @pavelbarahtjan.bsky.social addresses this question: www.biorxiv.org/content/10.1...

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Channels, Receptors & Transporters Subgroup of BPS @bpscrt.bsky.social · 14/02/2025

One more sleep to the @biophysicalsoc.bsky.social CRT Symposium on tomorrow morning bright and early! Join us in Petree Hall C at 8.30am.

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Fiona Whelan @freewhelan.bsky.social · 09/02/2025

Our inspirational Leach Lecturer Frances Separovic. A champion of women in STEM. "A reluctant chemist". Croatia to Broken Hill. A peace lover. First in family to finish primary school. And one cool Professor 😎. #LorneProteins2025

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Lorne Proteins @lorneproteins.bsky.social · 11/02/2025

50 years of Lorne Proteins on one stage! Happy anniversary to us 😁 and the supportive and inclusive research culture we've built 🫶 #LorneProteins2025

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Lorne Proteins @lorneproteins.bsky.social · 11/02/2025

Session 9: Mitch O'Connell bacterial/bacteriophage arms race. Small RNAs to mount an adaptive MGE immune response. CRISPR RNA defence systems. How does Cas13 work as an enzyme to target RNA? Csx28 128 aa protein, TM, cyt. Co-opt membrane effectors? 👏 #LorneProteins2025

How does it enhance phage defence? Pfu/mL +/- Csx28. 10000x improvement in phage defence by small membrane protein. Bacterial growth with addition of phage. Bacteriostatic effect? Forms an octamerif forward in DDM, now nanodisc... ligand gating of channel? Depolarisation assay? Dye that is weakly fluorescent when cells are polarised, loss of polarisation increase fluor. DiBAC4. 40% depolarised with cas13b and csx28. No complex formation. Cleaved ssRNA to open this channel.

tRNA anticodon loop cleavage by target-activated CRISPR-Cas13a. Cleavage products from tRNAs. Pull down monomeric Csx28 no pulldown; Octomer- enrichment of ssRNA in pull-down. Pull downs on grids - 8 mol of tRNA degradation products bound to Csx28. Where is the tRNA cleaved? cmo5U? Xm5U? Keio collection - screened against tRNA modification enzyme kos. Modification of the wobble residue prevents the phage defence.

Csx27 4 TM protein next. Similar function to Csx28. Alphafold2 to identify similar RNA gated ion channels.

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Lorne Proteins @lorneproteins.bsky.social · 12/02/2025

Session 10 Ibrahim Cissé-Super-res imaging of transcription. Cooperativity in weak & transient biological interactions. PolII clustering in a cell nucleus w STORM. Limitations for weak and transient interactions. Lightsheet microscopy to follow polymerase condensates & gene bursts #LorneProteins2025

$High resolution in fixed cells, but temporal events - transient, sub diffraction clusters in live mammalian cells. -ve feedback - 4-5 polymerase load, clusters are released. Cells can hold clusters longer to increase transcriptional events. Dual colour super resolution. TcPALM. Measure active burst, estimate RNAs and correlate with cluster lifetime. Enhancer, mediator, PolII - Mediator and PolII in stem cells. Short lived 11 s. Subset large clusters 300-400 nm in size, long lived 10s of minutes. Lattice lightsheet. 3d, time lapse, 10s of minutes, a full nucleus every 15s or so. Some clusters fuse to merge content. In vivo condensates with liquid like properties. Condensate proximity to Sox2 promoter correlates to mRNA burst intensity. Du et al, Cell, 2024. Higher burst size, higher frequency of burst events. 1.5-2 fold higher proximal to a PolII condensate. Anticorrelation between distance and burst size. When condensate contacts enhancer and generates. If superenhancer is distal from condensate, then no burst. Mediator/PolII, Superenhancer DNA, nascent mRNA in 3 colours. Movie of condensate moving in to contact the superenhancer, Gene promoter active and mRNA increases. Is the condensate/superenhancer contact active? Yes, cohesion required to loop DNA - precise architecture of the DNA to achieve a burst. Cohesion loops DNA and stops at an enhancer element upstream of the promoter. Lee et al 2024, Condensates - complex, liquid droplets? Proximity mini turbo ID? Accumulate any cargo of interest to be concentrated in the condensate. Turn on blue light and generate condensate localisation? Light induced targeting of endogenous condensates. Cargo-miniturbo-ID-GFP blue light on, accumulates in condensate, biotinylation accumulating. LiTEC with BioID for proteomics on condensates. Some missing... Chimeric mining. Pass droplets through mass spec - often ignore low intensity peaks. Looked for background peaks. More to follow up..$

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KJ @kjgoh.bsky.social · 12/02/2025

Excellent talk, impressive techniques, definitely going to look into biomolecular condensates in prokaryotes

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Bronwyn Lucas @bronwynalucas.bsky.social · 15/01/2025

Exciting new position at UC Berkeley! Cal-Cryo is looking for a new scientific director! This is an ideal position for someone who is looking to continue doing science and collaborating with research teams at Berkeley. Come work with us! aprecruit.berkeley.edu/JPF04670

aprecruit.berkeley.edu

Scientific Director, Cal-Cryo@QB3, UC Berkeley’s Cryo-EM Facility

University of California, Berkeley is hiring. Apply now!

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Lorne Proteins @lorneproteins.bsky.social · 25/11/2024

As Lorne Protein Meeting approaches its 50th anniversary we’re excited to welcome the fantastic speakers coming in 2025 to celebrate. www.lorneproteins.org/speakers2025

lorneproteins.org

Invited Speakers — Lorne Proteins 2025

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Ute Hellmich @hellmichgroup.bsky.social · 16/11/2024

Ok, trying to bring my community back together... I created a starter pack for lipids and membrane protein aficionados! Feel free to share, add and distribute, so we can come together again! 😍 go.bsky.app/AEeXh86

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Coleman Lab @colemanlab.bsky.social · 25/11/2024

This week in Science Without Anguish: Who is driving our bus? The importance of controlling the controllables in research life. www.sciencewithoutanguish.com/blog/who-is-...

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ARC Tracker @arc-tracker.bsky.social · 25/11/2024

ARC says they’ll release the Discovery Projects 2025 outcomes tomorrow. Recently, outcomes announcements have tended to happen at/around 11am Canberra time. My bot will pick up the announcement in RMS’s database and post immediately. Good luck!

Screenshot of a tweet from the ARC saying they’ll announce DP25 grant outcomes tomorrow (Tuesday 26 Nov).

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Dr Rosemary Cater @rosemaryjcater.bsky.social · 08/11/2024

This week we had the pleasure of hosting cryo-EM guru @OliBClarke who gave the @UQ_News cryo-EM community a fantastic cryo-EM data-processing workshop. Thank you Oli for sharing your tricks with us, @FarrahBlades for wrangling the Bunya supercomputer, and all who attended! 🔬

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Dr Rosemary Cater @rosemaryjcater.bsky.social · 08/11/2024

Want to Structure, Function, Surf, Repeat?! @LorneProteins is renowned for being an outstanding international protein conference in a beautiful Aussie beach town. Have a read to get a feel and hope to see you all at the 50th anniversary meeting!...

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Dr Rosemary Cater @rosemaryjcater.bsky.social · 26/09/2024

Well done @FarrahBlades on an excellent talk @bmh2024Melb! The streamline #CryoEM data processing pipeline you've set up at @CMMUQ1 using the Bunya supercomputer is helping so many researchers @UQ_News to process data efficiently and answer important biological questions! 👏👏👏

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Dr Rosemary Cater @rosemaryjcater.bsky.social · 05/09/2024

Talk about a beautiful spot for a conference 😍 Big thank you to @_VanessaMorris_ and Michael Edmonds for putting together and inviting me to the spectacular Biomolecular Interactions satellite meeting for Queenstown Research Week!

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Dr Rosemary Cater @rosemaryjcater.bsky.social · 23/08/2024

It was my absolute pleasure to host @renaemryan1 for the Centre for Chemistry and Drug Discovery seminar @IMBatUQ this week! She shared such beautiful research and it was so fun to have my PhD advisor get to know my new academic home!

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Dr Rosemary Cater @rosemaryjcater.bsky.social · 27/07/2024

What a fantastic week at the #MembraneTransportProteins @GordonConf! So much excellent science being shared and so great to reconnect with my transporter family! Thanks to everyone who made it special, especially @renaemryan1 and @DrSusieLIngram1 for putting it all together.

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Dr Rosemary Cater @rosemaryjcater.bsky.social · 27/05/2024

Inaugural Cater Lab birthday cake! Happy 30th birthday to @FarrahBlades! #1 postdoc!

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Dr Rosemary Cater @rosemaryjcater.bsky.social · 02/05/2024

(1/8) Do you eat enough choline? Have you even heard of it?? Choline is super important for the brain and must come from your diet 🐟🥚🥦 Here @Nature we show that FLVCR2 transports choline into the brain and use #cryoEM to show how! 🧠🔬...

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Dr Rosemary Cater @rosemaryjcater.bsky.social · 08/03/2024

When better to unleash a bit of girl power than International Women's Day! Introducing the Cater Lab's first postdoc: Dr. Farrah Blades @FarrahBlades. With expertise in #CryoEM, neurobiology, and algae, she's ready for any challenge! Let's get this show on the road! #IWD24💪✨

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Dr Rosemary Cater @rosemaryjcater.bsky.social · 11/12/2023

The time has come for me to farewell #ManciaLab, @ColumbiaPS and NYC! 🗽🍎 It's been an amazing ride, and I'm going to miss everyone so much, but excited for the next chapter for my own lab at @IMBatUQ! Thank you to everyone who made the last six years what they were - you rock!

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Dr Rosemary Cater @rosemaryjcater.bsky.social · 17/10/2023

Choline! We need it to make membranes and acetylcholine, & for DNA/protein methylation. Our brains need a LOT of it! 🧠 We show that FLVCR2 transports choline into the brain & solved its structure in the OFS & IFS with choline bound. 🐀🔬 Check it out!...

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Dr Rosemary Cater @rosemaryjcater.bsky.social · 24/06/2023

What a fantastic Mechanisms of Membrane Transport #GRC in Les Diablerets! It was fantastic to hear about all of the exciting transporter research being done, to catch up with old friends, make new friends, and all in this breathtaking part of the world 🏔️🇨🇭

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Dr Rosemary Cater @rosemaryjcater.bsky.social · 12/06/2023

Congratulations @renaemryan1 and all the other Honourees on being appointed as a Member of the Order of Australia! 🏅 You have lifted the careers of so many around you - so well earned!...

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Dr Rosemary Cater @rosemaryjcater.bsky.social · 09/06/2023

Check out our latest work on blood brain barrier #Omega3 transporter MFSD2A! 🐟➡️🧠 @NatureComms This work led by @GeorgeKhelashv1 reveals how substrate enters, occlusion occurs, and the role sodium plays in this! @pippomancia @ColumbiaPS @WeillCornell bit.ly/43xs2aP

bit.ly

Substrate binding-induced conformational transitions in t...

Molecular mechanisms of MFSD2A-mediated lysolipid transpo...

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Dr Rosemary Cater @rosemaryjcater.bsky.social · 20/02/2023

Three #BPS2023 cryo-EM postdoc co-chairs, three lipid transporter lovers @MeghnaG27 @CristinaSantar6

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Dr Rosemary Cater @rosemaryjcater.bsky.social · 15/11/2022

A huge thank you to @NYASciences for a fantastic Annual Gala! I'm so honoured to be a 2022 @BlavatnikAwards Finalist, and it was great to celebrate in style with the other honorees and a few of my nearest and dearest! 🏅💃🕺🥂

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Dr Rosemary Cater @rosemaryjcater.bsky.social · 06/10/2022

What an inspiring experience to attend the #stsforum2022 in Kyoto! When you bring scientists, politicians, and CEOs together to discuss issues in science and technology our society faces, it's incredible to see the walls come down and the ideas come out. We need more of this!

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Dr Rosemary Cater @rosemaryjcater.bsky.social · 26/06/2022

Thank you Wayne, @pippomancia & @OliBClarke for a top notch @comppaa 2022 meeting! Everything from the science to the kareoke was outstanding! Great to catch up and talk science with old friends, new friends, and meet some in 3D for the first time! What a special community 😊

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Dr Rosemary Cater @rosemaryjcater.bsky.social · 20/05/2022

Couldn't be more proud of my superstar undergrad 'Prof' Brendon Choy @brendon_choy on his commencement @Columbia! You have grown so much and excelled over the last 4 yrs in the #ManciaLab! Keep your scientific training in mind as you should @harvardmed what you're made of!! 👊🦁

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