Sign in

Romit Bhattacharya

@romitb.bsky.social
826 followers 310 following 53 posts

Preventive Cardiologist at Mass General Hospital | Lifestyle, Genomics, Digital Health, South Asian CVD

PostsRepliesMedia
Reposted by Romit Bhattacharya
American College of Cardiology @accintouch.bsky.social · 05/12/2025
Front-of-package food labeling highlighting sodium, saturated fat & added sugars can serve as an effective catalyst for empowering consumers to make healthier food choices & improving ❤️ health. Learn more in the 🆕 ACC Concise Clinical Guidance ➡️ bit.ly/3McUHOJ #JACC #CardioSky #MedSky #cvPrev
032
Romit Bhattacharya @romitb.bsky.social · 20/08/2025
Was happy to join @boston25news.com 🎥for a discussion of alcohol and heart disease yesterday! Recent trends show Americans are drinking 🥃🍺 less - what does this mean for the heart? 🫀 www.boston25news.com/news/local/d... @massgeneralbrigham.bsky.social
boston25news.com
Dr. Romit Bhattacharya: Survey shows fewer adults drinking alcohol for health reasons
A new Gallup survey reveals that more Americans are choosing to abstain from alcohol.
1110
Reposted by Romit Bhattacharya
American Journal of Preventive Cardiology @ajpcardio.bsky.social · 23/07/2025
🆕 New in AJPC: High-Density Lipoproteins, Part 1 Explore HDL's role in CVD prevention—epidemiology, antiatherogenic effects & therapies to raise serum levels. 🔗 www.sciencedirect.com/science/arti... #HDL #Cardiology #LipidHealth #AJPC #PreventiveCardiology
044
Reposted by Romit Bhattacharya
Pradeep Natarajan @pnatarajanmd.bsky.social · 14/07/2025
An abs risk generalizable risk calculator is challenging. Led by @somijemmacho.bsky.social, evaluating AHA PREVENT across 4 academic health systems, we found similar discrimination but variable calibration. A universal abs risk threshold may not suitably guide www.sciencedirect.com/science/arti...
154
Romit Bhattacharya @romitb.bsky.social · 03/07/2025
Our combined model accounted for just shy of 85% of the risk of incident MI, but factors like diet and exercise underperformed. We wonder if healthy participant bias, or self report were to blame here? In a cohort with more lifestyle phenotyping would this improve? Criticism welcome
000
Romit Bhattacharya @romitb.bsky.social · 03/07/2025
Zooming in on the base of the graph yields further insights. While WHR has a lower R2 - in a society where obesity is increasingly common it accounts for a greater population risk Dyslipidemia is the opposite - greater R2, but decreasing burden Lp(a) and hsCRP are comparable!
110
Romit Bhattacharya @romitb.bsky.social · 03/07/2025
When we looked at population attributable risk, we found that PAR took the number one spot, with HTN at a close second, and comparing both R2 and PAR stand apart Perhaps HTN is a good integrator of the risk imparted by other risk factors Perhaps PRS is the primordial risk factor for all others
100
Romit Bhattacharya @romitb.bsky.social · 03/07/2025
We examined performance in 3 ways: by R2, C-statistic and PAR. In our R^2 leave-one-out approach, hypertension and a polygenic risk score (GPSmult @aniruddhpatelmd.bsky.social ) that integrated CVD risk factors performed better than all other risk factors. cc: @somijemmacho.bsky.social
110
Romit Bhattacharya @romitb.bsky.social · 03/07/2025
In the UKBB and MGBB we build a Clinical and Genetic/Biomarker model of disease. Traditional risk factors included: HTN, ApoB:ApoA1, T2D, EtOH, WHR, TDI, exercise and Diet Genetic/Biomarkers Added: PRS, HeFH variants, Lp(a) and hsCRP
100
Romit Bhattacharya @romitb.bsky.social · 03/07/2025
The statistic that 80-90% of all CVD risk is due to these factors is often cited, but this is at odds with what we see in the clinic. Many patients struggle more than others to control their risk factors - often due to polygenic risk, monogenic variants, or other risk factors. We integrated both
100
Romit Bhattacharya @romitb.bsky.social · 03/07/2025
INTERHEART & the Global Risk Factors Consortium showed that modifiable risk factors account for most risk www.nejm.org/doi/full/10.... So then how do genetic risk factors like Polygenic risk, Heterozygous FH variants, and novel biomarkers like Lp(a) [also genetic!] and hsCRP play a role?
nejm.org
Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality | NEJM
Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the ris...
120
Romit Bhattacharya @romitb.bsky.social · 03/07/2025
Thrilled that our work on integrating genetic, contemporary and traditional risk factors into acute MI models has been published in @CirculationGenomeandPrecisionMedicine @ahascience.bsky.social !! Are genetic and contemporary risk factors as powerful as traditional RFs? #CardioSky #cvPrev
162
Romit Bhattacharya @romitb.bsky.social · 04/06/2025
#JohnHawley tells us about Exercise Mimetics - A compound that increased skeletal muscle gene programs, did not have any effect in performance without at least some exercise. - he frames exercise mimetics more as augmentative therapies than therapies that replace exercise
010
Romit Bhattacharya @romitb.bsky.social · 04/06/2025
Using a multi-omics approach, changes in mitochondrial associated analytes were found across tissue types (particularly at the transcriptome level)
200
Romit Bhattacharya @romitb.bsky.social · 04/06/2025
@malenelindholm.bsky.social from Stanford shares about the molecular basis of exercise adaptations! - Describing the NIH-funded MoTrPAC study - OMics and the mitochondrial response to exercise - Sex differences in skeletal muscle responses!
110
Romit Bhattacharya @romitb.bsky.social · 04/06/2025
& Fascinating results of exercise slowing breast cancer metastases in mice
100
Romit Bhattacharya @romitb.bsky.social · 04/06/2025
#MarkFebbraio discussing how exercise can protect against the progression of #lifestyle diseases - Exercise protects against and reverses MASH - Integrin beta 5 as a key regulator of muscle-liver cross-talk - Purified EVs from exercising animals and reverse MASH
100
Romit Bhattacharya @romitb.bsky.social · 04/06/2025
EVs carrying an incredible diversity of proteins in the post-exercise individuals across a number of functional classes - including active kinases in particular AMPK Transferring exercise EVs from athletic mice to sedentary mice seems to reduce fat mass and markers of fatty liver!
110
Romit Bhattacharya @romitb.bsky.social · 04/06/2025
#MartinWhithamPhD from Birmingham tells us about techniques to decode exercise-responsive signaling networks, particularly those mediated by extracellular vesicles! Can EVs from exercising subjects confer benefits to sedentary individuals?
100
Romit Bhattacharya @romitb.bsky.social · 04/06/2025
While weight loss alone does not correct both of these deficits, but weight loss WITH exercise improves both!
100
Romit Bhattacharya @romitb.bsky.social · 04/06/2025
Lean subjects utilize fatty acid metabolism during a fast and quickly switch to carbohydrate metabolism with insulin. Whereas, insulin-resistant pts were inefficient oxidizers of fatty acids during fasting, and were less efficient in switching to carbohydrate metabolism when exposed to insulin.
100
Romit Bhattacharya @romitb.bsky.social · 04/06/2025
#BretGoodPasterPhD speaks to us about intramyocellular lipids and insulin resistance and a VERY fascinating concept of metabolic flexibility:
Intermuscular adipose tissue on CT, vs intromyocellular lipids on biopsy
100
Romit Bhattacharya @romitb.bsky.social · 04/06/2025
#MichaelSnyder from #StanfordGenetics gives the Blackburn Keynote and covers: - Ageotypes (people age in different patterns, in different organs) - 2 major aging timepoints at age 44 and 60 - The post-exercise compound Lac-Phe regulate appetite and obesity - Using Wearables for lifestyle monitoring
100
Romit Bhattacharya @romitb.bsky.social · 04/06/2025
100
Romit Bhattacharya @romitb.bsky.social · 04/06/2025
To learn more visit our Harvard NORCH website: dev.norch.org dev.norch.org/2025-muscle-...
dev.norch.org
Nutrition Obesity Research Center at Harvard | Promoting and Enhancing Nutrition Research Within the Greater Boston Community
111
Romit Bhattacharya @romitb.bsky.social · 04/06/2025
Huge thank you to Dr. Steve Grinspoon for inviting me to moderate the Harvard Nutrition Obesity Research Symposium at MGH! Watch this space for insights and work from our faculty! #CardioSky #EndoSky @mghcvrc.bsky.social @jsawallagusehmd.bsky.social @drprao.bsky.social @pnatarajanmd.bsky.social
193
Reposted by Romit Bhattacharya
Eric Topol @erictopol.bsky.social · 02/06/2025
Flavonoid food and beverage intake—quantity and diversity— is linked to reduced all-cause mortality, cancer, cardiovascular disease, Type 2 diabetes, and neurodegenerative disease www.nature.com/articles/s43...
1121463
Reposted by Romit Bhattacharya
JCI insight @insight.jci.org · 29/05/2025
Steffensen, Rasmussen, et al. show that deep whole-exome sequencing of human atherosclerotic plaques reveals that the expansion of large mutated clones within plaque tissue is an intrinsic feature of human atherosclerosis: buff.ly/zdEM0dm
041
Romit Bhattacharya @romitb.bsky.social · 28/05/2025
www.statnews.com/2025/05/23/n...
statnews.com
Scientists protest White House plan to put political appointees in charge of grant-making
Trump administration proposal is seen as a way to make NIH institute and center directors political appointees.
010
Romit Bhattacharya @romitb.bsky.social · 28/05/2025
Peer Review In Peril @aniloza.bsky.social "But now, “the Trump administration feels very strongly that the president’s agenda is the most important consideration for any government spending" www.statnews.com/2025/05/27/r... #Cardiosky
statnews.com
‘Corrupt’ medical journals have to change, RFK Jr. says, or the NIH will publish in-house
The criticism of The Lancet, NEJM and JAMA is not new, but the health secretary may use his position to influence research that journals publish.
150
Reposted by Romit Bhattacharya
American Journal of Preventive Cardiology @ajpcardio.bsky.social · 23/05/2025
📢 Just published! New insights on Lipoprotein(a): How it interacts with common cardiovascular risk factors to influence CVD risk — findings from the UK Biobank. www.sciencedirect.com/science/arti... #LipoproteinA #CVDprevention #CardioSky #PreventiveCardiology #ASPC #HeartHealth #UKBiobank
023
Romit Bhattacharya @romitb.bsky.social · 22/05/2025
CETP inhibitors revived? #CardioSky
011
Reposted by Romit Bhattacharya
Pradeep Natarajan @pnatarajanmd.bsky.social · 21/05/2025
Our study led by A. Flores & with @aniruddhpatelmd.bsky.social describes a new peripheral artery disease PRS. Predictive capability for incident PAD is comparable to CKD & DM2. Among those with PAD, it also associates with major adv limb events jamanetwork.com/journals/jam... @jama.com #JAMACardio
074
Reposted by Romit Bhattacharya
Vijay G. Sankaran @bloodgenes.bsky.social · 17/05/2025
Wow!!! These human genetic insights could enable the next generation of pain management therapies: rupress.org/jem/article/... Fascinating @jem.org article!
rupress.org
A pathological missense mutation in the deubiquitinase USP5 leads to insensitivity to pain | Journal of Experimental Medicine | Rockefeller University Press
The manuscript reports on patient with a USP5 mutation that gives rise to insensitivity to pain. The patient’s pathology is phenocopied in a knock-in mouse
0274
Reposted by Romit Bhattacharya
acscardiology.bsky.social @acscardiology.bsky.social · 16/05/2025
In stable patients with extensive noncalcified plaque volume at baseline, 18 months of evolocumab treatment was associated with a shift toward a lower risk quantitative plaque phenotype and reduction in microcalcification activity www.jacc.org/doi/10.1016/...
jacc.org
Effects of Evolocumab on Coronary Plaque Composition and Microcalcification Activity by Coronary PET and CT Angiography:
021
Romit Bhattacharya @romitb.bsky.social · 15/05/2025
www.nejm.org/doi/full/10....
nejm.org
Personalized Gene Editing to Treat an Inborn Error of Metabolism | NEJM
In this editorial, the authors describe the foundations of an N-of-1 gene-editing study to treat an infant with a urea-cycle disorder.
000
Romit Bhattacharya @romitb.bsky.social · 15/05/2025
@kiranmusunuru.bsky.social www.nejm.org/doi/full/10....
nejm.org
Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease | NEJM
Base editors can correct disease-causing genetic variants. After a neonate had received a diagnosis of severe carbamoyl-phosphate synthetase 1 deficiency, a disease with an estimated 50% mortality ...
100
Romit Bhattacharya @romitb.bsky.social · 15/05/2025
Here's the thing... pseudoscience can't do this. Only real science can. www.nytimes.com/2025/05/15/h...
nytimes.com
Baby Is Healed With World’s First Personalized Gene-Editing Treatment
120
Reposted by Romit Bhattacharya
Pradeep Natarajan @pnatarajanmd.bsky.social · 12/05/2025
Very excited to Chair this webinar on Cardiovascular Health May 21 7:30-8:30p ET hosted by @indiaspora.bsky.social with Opening Remarks from Vivek Murthy. Register us02web.zoom.us/meeting/regi... @drmarthagulati.bsky.social @mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social .
041
Reposted by Romit Bhattacharya
Parham Eshtehardi MD @cardioobdoc.bsky.social · 08/05/2025
Lp(a) & recurrent atherosclerotic CV events: US Family Heart Database #CardioSky academic.oup.com/eurheartj/ad... @hsbhatia.bsky.social @psatishmd.bsky.social @vietheartpa.bsky.social @anastasiasmihaili.bsky.social @michaeldshapiro.bsky.social @romitb.bsky.social @dlbhattmd.bsky.social
0119
Reposted by Romit Bhattacharya
Pradeep Natarajan @pnatarajanmd.bsky.social · 07/05/2025
Among N=2530 w HeFH or ASCVD on max tolerated LLT with insufficiently low LDL-C (mean 98mg/dl), obicetrapib (CETPi) 10mg po daily v placebo led to 33% lower LDL-C at 3mo www.nejm.org/doi/full/10.... @nejm.org #EAS2025
1104
Reposted by Romit Bhattacharya
Pradeep Natarajan @pnatarajanmd.bsky.social · 06/05/2025
The most math equations written on a whiteboard by a clinician I've seen - yet amazingly well delivered to a broad audience! S. Urbut's talk @broadinstitute.org A Practical Primer on Bayesian Statistics youtube.com/watch?v=jcFS... @mgbresearch.bsky.social @harvardmed.bsky.social
youtube.com
MPG Primer: A Practical Primer on Bayesian Statistics (2025)
YouTube video by Broad Institute
03818
Reposted by Romit Bhattacharya
Eric Topol @erictopol.bsky.social · 05/05/2025
Now the discovery of the 4th gene variant which promotes short sleep (4-6 hours) with full restfulness, potentially a path to a drug for sleep efficiency someday www.pnas.org/doi/10.1073/...
pnas.org
The SIK3-N783Y mutation is associated with the human natural short sleep trait | PNAS
Sleep is an essential component of our daily life. A mutation in human salt induced kinase 3 (hSIK3), which is critical for regulating sleep durati...
1327957
Romit Bhattacharya @romitb.bsky.social · 29/04/2025
Nice of @indiaspora.bsky.social to feature the OurHealth Study in their newsletter! #cvPrev #SouthAsianCVD #CardioSky
012
Romit Bhattacharya @romitb.bsky.social · 28/04/2025
Great study!
030
Romit Bhattacharya @romitb.bsky.social · 28/04/2025
Thrilled to join Ankur Kalra and Jaideep Patel on the Parallax Podcast to discuss South Asian Cardiometabolic Disease We get into: - Knowledge gaps - Lifestyle and Genetics - Common difficulties for the cardiologist in guiding South Asian patients #SouthAsianCVD bit.ly/4jVIuti
podcasts.apple.com
Ep 133: South Asian Heart Health: Unveiling Risk Patterns and Prevention Strategies
Podcast Episode · Parallax by Ankur Kalra · 04/28/2025 · 55m
222
Reposted by Romit Bhattacharya
Dr Martha Gulati @drmarthagulati.bsky.social · 23/04/2025
Our @aspcardio.bsky.social statement on South Asians & Cardiometabolic Health in @ajpcardio.bsky.social I had the honour of co-chairing this w/ the amazing Dr. Rohatji & @jaideeppatel.bsky.social 🙏🏽 to our entire talented team who brought this to life 📎 shorturl.at/4bJGz #CVPrev #Cardiosky
11310
Reposted by Romit Bhattacharya
Pradeep Natarajan @pnatarajanmd.bsky.social · 23/04/2025
Honored to contribute to the @aspcardio.bsky.social Clinical Practice Statement on optimizing cardiometabolic health among South Asian individuals spearheaded by A. Rohatgi @drmarthagulati.bsky.social J. Patel www.sciencedirect.com/science/arti...
1178
Reposted by Romit Bhattacharya
Pradeep Natarajan @pnatarajanmd.bsky.social · 23/04/2025
Very excited to share our preprint led by M. Levin @skoyama.bsky.social J. Woerner & with S. Damrauer assessing genome-wide pleiotropy of >1,000 clinical traits across ~1.7M individuals with nearly 30K locus-trait associations! www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social
34427
Reposted by Romit Bhattacharya
The Onion @theonion.com · 18/04/2025
“Studies of the past tell us that nitpicking the particular semantics of the term ‘concentration camp’ as they pertain to a place the government is actively sending people with no criminal history is highly associated with national stability,” said historian Kristen Boyd theonion.com/histori...
theonion.com
Historians: Quibbling Over Exact Definition Of Concentration Camp Sign Of Healthy Society
NEW HAVEN, CT—Calling such concern for linguistic precision a clear indicator of a thriving country, a panel of historians from Yale University issued a statement Thursday announcing that quibbling over the exact definition of a concentration camp was a sign of a healthy society. “Studies of the past tell us that nitpicking the particular semantics […]
202113350