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Romit Bhattacharya

@romitb.bsky.social
827 followers 310 following 53 posts

Preventive Cardiologist at Mass General Hospital | Lifestyle, Genomics, Digital Health, South Asian CVD

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Romit Bhattacharya @romitb.bsky.social · 03/07/2025
Our combined model accounted for just shy of 85% of the risk of incident MI, but factors like diet and exercise underperformed. We wonder if healthy participant bias, or self report were to blame here? In a cohort with more lifestyle phenotyping would this improve? Criticism welcome
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Romit Bhattacharya @romitb.bsky.social · 03/07/2025
Zooming in on the base of the graph yields further insights. While WHR has a lower R2 - in a society where obesity is increasingly common it accounts for a greater population risk Dyslipidemia is the opposite - greater R2, but decreasing burden Lp(a) and hsCRP are comparable!
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Romit Bhattacharya @romitb.bsky.social · 03/07/2025
When we looked at population attributable risk, we found that PAR took the number one spot, with HTN at a close second, and comparing both R2 and PAR stand apart Perhaps HTN is a good integrator of the risk imparted by other risk factors Perhaps PRS is the primordial risk factor for all others
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Romit Bhattacharya @romitb.bsky.social · 03/07/2025
We examined performance in 3 ways: by R2, C-statistic and PAR. In our R^2 leave-one-out approach, hypertension and a polygenic risk score (GPSmult @aniruddhpatelmd.bsky.social ) that integrated CVD risk factors performed better than all other risk factors. cc: @somijemmacho.bsky.social
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Romit Bhattacharya @romitb.bsky.social · 03/07/2025
In the UKBB and MGBB we build a Clinical and Genetic/Biomarker model of disease. Traditional risk factors included: HTN, ApoB:ApoA1, T2D, EtOH, WHR, TDI, exercise and Diet Genetic/Biomarkers Added: PRS, HeFH variants, Lp(a) and hsCRP
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Romit Bhattacharya @romitb.bsky.social · 04/06/2025
#JohnHawley tells us about Exercise Mimetics - A compound that increased skeletal muscle gene programs, did not have any effect in performance without at least some exercise. - he frames exercise mimetics more as augmentative therapies than therapies that replace exercise
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Romit Bhattacharya @romitb.bsky.social · 04/06/2025
Using a multi-omics approach, changes in mitochondrial associated analytes were found across tissue types (particularly at the transcriptome level)
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Romit Bhattacharya @romitb.bsky.social · 04/06/2025
@malenelindholm.bsky.social from Stanford shares about the molecular basis of exercise adaptations! - Describing the NIH-funded MoTrPAC study - OMics and the mitochondrial response to exercise - Sex differences in skeletal muscle responses!
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Romit Bhattacharya @romitb.bsky.social · 04/06/2025
& Fascinating results of exercise slowing breast cancer metastases in mice
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Romit Bhattacharya @romitb.bsky.social · 04/06/2025
#MarkFebbraio discussing how exercise can protect against the progression of #lifestyle diseases - Exercise protects against and reverses MASH - Integrin beta 5 as a key regulator of muscle-liver cross-talk - Purified EVs from exercising animals and reverse MASH
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Romit Bhattacharya @romitb.bsky.social · 04/06/2025
EVs carrying an incredible diversity of proteins in the post-exercise individuals across a number of functional classes - including active kinases in particular AMPK Transferring exercise EVs from athletic mice to sedentary mice seems to reduce fat mass and markers of fatty liver!
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Romit Bhattacharya @romitb.bsky.social · 04/06/2025
#MartinWhithamPhD from Birmingham tells us about techniques to decode exercise-responsive signaling networks, particularly those mediated by extracellular vesicles! Can EVs from exercising subjects confer benefits to sedentary individuals?
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Romit Bhattacharya @romitb.bsky.social · 04/06/2025
While weight loss alone does not correct both of these deficits, but weight loss WITH exercise improves both!
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Romit Bhattacharya @romitb.bsky.social · 04/06/2025
Lean subjects utilize fatty acid metabolism during a fast and quickly switch to carbohydrate metabolism with insulin. Whereas, insulin-resistant pts were inefficient oxidizers of fatty acids during fasting, and were less efficient in switching to carbohydrate metabolism when exposed to insulin.
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Romit Bhattacharya @romitb.bsky.social · 04/06/2025
#BretGoodPasterPhD speaks to us about intramyocellular lipids and insulin resistance and a VERY fascinating concept of metabolic flexibility:
Intermuscular adipose tissue on CT, vs intromyocellular lipids on biopsy
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Romit Bhattacharya @romitb.bsky.social · 04/06/2025
#MichaelSnyder from #StanfordGenetics gives the Blackburn Keynote and covers: - Ageotypes (people age in different patterns, in different organs) - 2 major aging timepoints at age 44 and 60 - The post-exercise compound Lac-Phe regulate appetite and obesity - Using Wearables for lifestyle monitoring
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Romit Bhattacharya @romitb.bsky.social · 04/06/2025
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Romit Bhattacharya @romitb.bsky.social · 04/06/2025
Huge thank you to Dr. Steve Grinspoon for inviting me to moderate the Harvard Nutrition Obesity Research Symposium at MGH! Watch this space for insights and work from our faculty! #CardioSky #EndoSky @mghcvrc.bsky.social @jsawallagusehmd.bsky.social @drprao.bsky.social @pnatarajanmd.bsky.social
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Romit Bhattacharya @romitb.bsky.social · 31/03/2025
Clever new study using #wearables data from from All Of Us Research Study and @medillschool.bsky.social The "Daily Heart Rate per Step" (DHRPS) ("Durpaz?") as a metric for health www.ahajournals.org/doi/epdf/10.... #cvPrev #CardioSky NYT: www.nytimes.com/2025/03/29/h...
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Romit Bhattacharya @romitb.bsky.social · 29/03/2025
Huge congrats to our clinical research coordinator Aarushi Bhatnagar on her oral presentation on the diversity of religious-language-regional groups in the OurHealthStudy (www.ourhealthstudy.org) @accintouch.bsky.social #ACC25 #SouthAsianCVD @aagarwalamd.bsky.social @pnatarajanmd.bsky.social
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Romit Bhattacharya @romitb.bsky.social · 10/03/2025
The #NIH has been the most successful science funding mechanism in the world, with China's national funding rapidly rising. www.nature.com/articles/d41...
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Romit Bhattacharya @romitb.bsky.social · 07/03/2025
At the @hsph.harvard.edu today, #SouthAsianCVD “If you live past the age of 5 in Bangladesh, CV disease is the leading cause of death.”
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Romit Bhattacharya @romitb.bsky.social · 07/03/2025
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Romit Bhattacharya @romitb.bsky.social · 06/03/2025
Excited to talk to our @harvardmed.bsky.social students in the Integrated Human Physiology course today on #SouthAsianCVD @drmarthagulati.bsky.social @pnatarajanmd.bsky.social @rkwadhera.bsky.social @massgeneralbrigham.bsky.social
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