Romit Bhattacharya @romitb.bsky.social · 03/07/2025Our combined model accounted for just shy of 85% of the risk of incident MI, but factors like diet and exercise underperformed. We wonder if healthy participant bias, or self report were to blame here? In a cohort with more lifestyle phenotyping would this improve? Criticism welcome 000
Romit Bhattacharya @romitb.bsky.social · 03/07/2025Zooming in on the base of the graph yields further insights. While WHR has a lower R2 - in a society where obesity is increasingly common it accounts for a greater population risk Dyslipidemia is the opposite - greater R2, but decreasing burden Lp(a) and hsCRP are comparable! 110
Romit Bhattacharya @romitb.bsky.social · 03/07/2025When we looked at population attributable risk, we found that PAR took the number one spot, with HTN at a close second, and comparing both R2 and PAR stand apart Perhaps HTN is a good integrator of the risk imparted by other risk factors Perhaps PRS is the primordial risk factor for all others 100
Romit Bhattacharya @romitb.bsky.social · 03/07/2025We examined performance in 3 ways: by R2, C-statistic and PAR. In our R^2 leave-one-out approach, hypertension and a polygenic risk score (GPSmult @aniruddhpatelmd.bsky.social ) that integrated CVD risk factors performed better than all other risk factors. cc: @somijemmacho.bsky.social 110
Romit Bhattacharya @romitb.bsky.social · 03/07/2025In the UKBB and MGBB we build a Clinical and Genetic/Biomarker model of disease. Traditional risk factors included: HTN, ApoB:ApoA1, T2D, EtOH, WHR, TDI, exercise and Diet Genetic/Biomarkers Added: PRS, HeFH variants, Lp(a) and hsCRP 100
Romit Bhattacharya @romitb.bsky.social · 04/06/2025#JohnHawley tells us about Exercise Mimetics - A compound that increased skeletal muscle gene programs, did not have any effect in performance without at least some exercise. - he frames exercise mimetics more as augmentative therapies than therapies that replace exercise 010
Romit Bhattacharya @romitb.bsky.social · 04/06/2025Using a multi-omics approach, changes in mitochondrial associated analytes were found across tissue types (particularly at the transcriptome level) 200
Romit Bhattacharya @romitb.bsky.social · 04/06/2025@malenelindholm.bsky.social from Stanford shares about the molecular basis of exercise adaptations! - Describing the NIH-funded MoTrPAC study - OMics and the mitochondrial response to exercise - Sex differences in skeletal muscle responses! 110
Romit Bhattacharya @romitb.bsky.social · 04/06/2025& Fascinating results of exercise slowing breast cancer metastases in mice 100
Romit Bhattacharya @romitb.bsky.social · 04/06/2025#MarkFebbraio discussing how exercise can protect against the progression of #lifestyle diseases - Exercise protects against and reverses MASH - Integrin beta 5 as a key regulator of muscle-liver cross-talk - Purified EVs from exercising animals and reverse MASH 100
Romit Bhattacharya @romitb.bsky.social · 04/06/2025EVs carrying an incredible diversity of proteins in the post-exercise individuals across a number of functional classes - including active kinases in particular AMPK Transferring exercise EVs from athletic mice to sedentary mice seems to reduce fat mass and markers of fatty liver! 110
Romit Bhattacharya @romitb.bsky.social · 04/06/2025#MartinWhithamPhD from Birmingham tells us about techniques to decode exercise-responsive signaling networks, particularly those mediated by extracellular vesicles! Can EVs from exercising subjects confer benefits to sedentary individuals? 100
Romit Bhattacharya @romitb.bsky.social · 04/06/2025While weight loss alone does not correct both of these deficits, but weight loss WITH exercise improves both! 100
Romit Bhattacharya @romitb.bsky.social · 04/06/2025Lean subjects utilize fatty acid metabolism during a fast and quickly switch to carbohydrate metabolism with insulin. Whereas, insulin-resistant pts were inefficient oxidizers of fatty acids during fasting, and were less efficient in switching to carbohydrate metabolism when exposed to insulin. 100
Romit Bhattacharya @romitb.bsky.social · 04/06/2025#BretGoodPasterPhD speaks to us about intramyocellular lipids and insulin resistance and a VERY fascinating concept of metabolic flexibility: 100
Romit Bhattacharya @romitb.bsky.social · 04/06/2025#MichaelSnyder from #StanfordGenetics gives the Blackburn Keynote and covers: - Ageotypes (people age in different patterns, in different organs) - 2 major aging timepoints at age 44 and 60 - The post-exercise compound Lac-Phe regulate appetite and obesity - Using Wearables for lifestyle monitoring 100
Romit Bhattacharya @romitb.bsky.social · 04/06/2025Huge thank you to Dr. Steve Grinspoon for inviting me to moderate the Harvard Nutrition Obesity Research Symposium at MGH! Watch this space for insights and work from our faculty! #CardioSky #EndoSky @mghcvrc.bsky.social @jsawallagusehmd.bsky.social @drprao.bsky.social @pnatarajanmd.bsky.social 193
Romit Bhattacharya @romitb.bsky.social · 31/03/2025Clever new study using #wearables data from from All Of Us Research Study and @medillschool.bsky.social The "Daily Heart Rate per Step" (DHRPS) ("Durpaz?") as a metric for health www.ahajournals.org/doi/epdf/10.... #cvPrev #CardioSky NYT: www.nytimes.com/2025/03/29/h... 042
Romit Bhattacharya @romitb.bsky.social · 29/03/2025Huge congrats to our clinical research coordinator Aarushi Bhatnagar on her oral presentation on the diversity of religious-language-regional groups in the OurHealthStudy (www.ourhealthstudy.org) @accintouch.bsky.social #ACC25 #SouthAsianCVD @aagarwalamd.bsky.social @pnatarajanmd.bsky.social 1197
Romit Bhattacharya @romitb.bsky.social · 10/03/2025The #NIH has been the most successful science funding mechanism in the world, with China's national funding rapidly rising. www.nature.com/articles/d41... 110
Romit Bhattacharya @romitb.bsky.social · 07/03/2025At the @hsph.harvard.edu today, #SouthAsianCVD “If you live past the age of 5 in Bangladesh, CV disease is the leading cause of death.” 010
Romit Bhattacharya @romitb.bsky.social · 06/03/2025Excited to talk to our @harvardmed.bsky.social students in the Integrated Human Physiology course today on #SouthAsianCVD @drmarthagulati.bsky.social @pnatarajanmd.bsky.social @rkwadhera.bsky.social @massgeneralbrigham.bsky.social 133