What does it mean to stop a clinical trial early? In the early days of the modern randomized trial, it meant the research had not gone according to plan.1 Trialists were expected to adhere to the sample sizes they originally proposed based on early assumptions about underlying event rates, loss to...

Find high-quality clinical trial research with JAMA+ Trials, offering curated studies, multimedia insights, and advanced search across the JAMA Network.

The diary shows a scientist investigating and ruling out a remote possibility. Not one headline said so.

Foreign leaders who try to appease him are learning that, to Trump, appeasement smells like prey. They are done being prey.

This JAMA Forum discusses staffing and policy changes at the US Food and Drug Administration (FDA) over the past year.

I look for the big picture - patterns in the current and recent news events, patterns that might suggest future directions or provide insight into why things are the way they are. Click to read The Bi...

A letter from 11 Republican representatives has caught the White House’s attention.

But you probably should

On September 19, 2025, US Department of Health and Human Services (HHS) Secretary Robert F. Kennedy Jr and US Food and Drug Administration (FDA) Commissioner Martin Makary announced that HHS would be ...

This Perspective discusses how clinicians can navigate conflicting vaccination recommendations following revisions from the Advisory Committee on Immunization Practices and US Centers for Disease Cont...

"Things have not improved," writes Dr. Debra Houry. "They have worsened. And Congress has still failed to act."

Researchers at The Ohio State University Moritz College of Law and partner universities were recently awarded a grant from Arnold Ventures to support a multi-faceted research project, titled “A Princi...

The Trump administration has undermined the once bipartisan war on cancer and declined to approve a promising melanoma therapy.

Debra Houry speaks after testifying on eight months under Kennedy, who critics say shuns science and spreads falsehoods

This JAMA Medical News article discusses updated guidance on COVID-19 vaccination in pregnant people from the American College of Obstetricians and Gynecologists.