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Roger J. Lewis, MD, PhD

@rogerjlewis.bsky.social
299 followers 110 following 26 posts

Emergency physician and statistician; Bayesian adaptive and platform trial clinical trial design and implementation; Senior Statistical Editor at @jama.com.

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Reposted by Roger J. Lewis, MD, PhD
JAMA @jama.com · 15/10/2026
In an editorial, Roy H. Perlis, MD, MSc, Annette Flanagin, RN, MA, and Kirsten Bibbins-Domingo, PhD, MD, MAS discuss the launch of JAMA AI, a new JAMA Network journal dedicated to publishing rigorous, clinically focused research spanning AI, digital health, and computational health. ja.ma/4s34h7m
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Reposted by Roger J. Lewis, MD, PhD
Katie Spoon @kspoon.bsky.social · 14/10/2026
As a PhD student designing my first survey, I added what I thought was a throwaway question at the end. To my surprise, thousands of academics answered it! The paper is out today: doi.org/10.1093/pnas...
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Reposted by Roger J. Lewis, MD, PhD
Jeremy Berg @jeremymberg.bsky.social · 15/10/2026
A powerful companion to Jenny Grandis’s book with lots of interviews with women in medicine. jennifergrandis.com
jennifergrandis.com
Jennifer Rubin Grandis, MD | Author of Harsh Medicine
Official website of Jennifer Grandis, MD—author of Harsh Medicine, a critical examination of gender bias in medicine and scientific research.
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Reposted by Roger J. Lewis, MD, PhD
Deb Houry @drdebhoury.bsky.social · 13/10/2026
Heartbroken by Helen Branswell’s passing. I always enjoyed talking with her and reading her reporting. She sought the truth, lifted up science, and asked questions that mattered. Her loss leaves a tremendous void in journalism and public health. @statnews.com www.statnews.com/2026/10/13/h...
statnews.com
Helen Branswell, whose reporting on infectious diseases and public health drew acclaim, dies at 69
Helen Branswell, STAT's infectious disease reporter who earned the respect of experts and public health officials with her accessible, prescient dispatches, has died at age 69.
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Roger J. Lewis, MD, PhD @rogerjlewis.bsky.social · 09/09/2026
Trials Terminated Early jamanetwork.com/journals/jam...
jamanetwork.com
Trials Terminated Early
What does it mean to stop a clinical trial early? In the early days of the modern randomized trial, it meant the research had not gone according to plan.1 Trialists were expected to adhere to the sample sizes they originally proposed based on early assumptions about underlying event rates, loss to...
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Roger J. Lewis, MD, PhD @rogerjlewis.bsky.social · 17/08/2026
A storage-duration-finding trial is a natural extension of a dose-finding-trial design and addresses both efficacy and how to maximize the practical utility of the product. 
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Reposted by Roger J. Lewis, MD, PhD
JAMA Neurology @jamaneurology.com · 03/08/2026
📌 How can clinicians and researchers stay up to date on the most clinically relevant trials? Follow JAMA+ Trials to get curated access to the best of the JAMA Network’s trial research, commentaries, and educational resources: jamanetwork.com/channels/tri...
jamanetwork.com
JAMA+ Trials Research, Education and Commentary from JAMA Network
Find high-quality clinical trial research with JAMA+ Trials, offering curated studies, multimedia insights, and advanced search across the JAMA Network.
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Roger J. Lewis, MD, PhD @rogerjlewis.bsky.social · 31/07/2026
Fauci's Diary, the Origins of COVID, and Bad Headlines open.substack.com/pub/ninalewi...
open.substack.com
Fauci's Diary, the Origins of COVID, and Bad Headlines
The diary shows a scientist investigating and ruling out a remote possibility. Not one headline said so.
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Reposted by Roger J. Lewis, MD, PhD
Jeremy Berg @jeremymberg.bsky.social · 30/07/2026
My thoughts about Tony Fauci. He was very demanding to work for because he was involved in so many things, but his staff deeply respected him and relished working with him, even with some challenges. They appreciated his demands for high standards in everything that they did. 1/2
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Reposted by Roger J. Lewis, MD, PhD
ATS Blue Journal @atsblueeditor.bsky.social · 09/07/2026
A statistical model for lung function trajectory and mortality in patients with fibrotic interstitial lung disease A new model for evaluating treatments in ILD holds promise for improving the accuracy and efficiency of clinical trials doi.org/10.1093/ajrc... @rogerjlewis.bsky.social
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Reposted by Roger J. Lewis, MD, PhD
NLew @ninalewis174247.substack.com · 23/06/2026
A summary of recent events where foreign leaders stopped rolling over when Trump publicly humiliates them. They are finding their spines. Too bad politicians in this country can't seem to find theirs. Yet.
open.substack.com
The World Is Done Playing Nice With Trump
Foreign leaders who try to appease him are learning that, to Trump, appeasement smells like prey. They are done being prey.
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Reposted by Roger J. Lewis, MD, PhD
NEJM.org @nejm.org · 19/06/2026
Although best practices are established for managing 𝘚𝘵𝘢𝘱𝘩𝘺𝘭𝘰𝘤𝘰𝘤𝘤𝘶𝘴 𝘢𝘶𝘳𝘦𝘶𝘴 bacteremia, the preferred antibiotic for methicillin-susceptible 𝘚. 𝘢𝘶𝘳𝘦𝘶𝘴 bacteremia is uncertain. Research findings from the SNAP trial are summarized in a new Quick Take video. nej.md/4uBjkVL
Illustration showing three vials labeled cefazolin, flucloxacillin, and cloxacillin. The words "vs." and "OR" are between them. A silhouette stands to the right, with Staphylococcus aureus bacteremia in the background.
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Reposted by Roger J. Lewis, MD, PhD
Jonathan Howard @joho.bsky.social · 18/06/2026
TLDR: Makary, Hoeg, and Prasad were incompetent political hacks and it will take years to undo their damage.
jamanetwork.com
Making the FDA Great Again
This JAMA Forum discusses staffing and policy changes at the US Food and Drug Administration (FDA) over the past year.
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Roger J. Lewis, MD, PhD @rogerjlewis.bsky.social · 18/06/2026
My sister is an expert in computer security and I'd like to encourage folks to explore her (free) substack posts exploring larger patterns in current events--helping us to see the forest even as we're being bombarded every day with leaves, branches, and sometimes trees. ninalewis174247.substack.com
ninalewis174247.substack.com
The Bigger Picture | Nina Lewis | Substack
I look for the big picture - patterns in the current and recent news events, patterns that might suggest future directions or provide insight into why things are the way they are. Click to read The Bi...
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Roger J. Lewis, MD, PhD @rogerjlewis.bsky.social · 18/06/2026
Congratulations to the entire international SNAP team! It is a pleasure for those of us at Berry Consultants to help in the design and conduct of this Bayesian adaptive platform trial. As a clinician, I look forward to getting answers to additional key questions about how to best treat S. aureus.
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Reposted by Roger J. Lewis, MD, PhD
Robert Califf @robcaliff.bsky.social · 10/06/2026
Good plain language summary of a very bad policy proposal. www.nytimes.com/2026/06/09/o...
nytimes.com
Opinion | Trump’s Assaults on Scientific Research Just Got Worse
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Reposted by Roger J. Lewis, MD, PhD
Don Moynihan @donmoyn.bsky.social · 23/05/2026
The push to cut funding from the National Academies of Science will involve illegally impounding funds on the claim that fringe Republican lawmakers understand what constitutes the “gold standard” for science better than the best scientists in America. www.aip.org/fyi/republic...
aip.org
Republican Lawmakers Suggest Cutting Off Funding for National Academies
A letter from 11 Republican representatives has caught the White House’s attention.
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Reposted by Roger J. Lewis, MD, PhD
NEJM.org @nejm.org · 24/04/2026
In children with septic shock, no significant difference was seen in the incidence of death, new renal-replacement therapy, or persistent kidney dysfunction with balanced fluid as compared with 0.9% saline for fluid resuscitation. Full PRoMPT BOLUS trial results: nej.md/4tvygVy #PAS2026
A forest plot for the subgroup analyses of the primary outcome.
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Reposted by Roger J. Lewis, MD, PhD
JAMA @jama.com · 20/04/2026
US state-level policy responses to shifting federal guidance varied widely in 2025, with most states acting to preserve #COVID19 vaccination access through standing orders, insurance coverage, or clinician authority. ja.ma/4ckW8Fh
Map of US state actions related to COVID-19 vaccine infrastructure from April to December 2025. States are shaded to indicate action types: no action, strengthened, weakened, or both. The map includes notations like "text@0", "text@1", "text@2(1S/1W)", "text@3(2S/1W)", "text@4", and "text@5".
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Reposted by Roger J. Lewis, MD, PhD
Kerri Johannson MD MPH @kerrijohannson.bsky.social · 08/04/2026
The most impactful clinical ILD study in ages! 🌟 True multidisciplinary collaboration driving progress 🫁 @rogerjlewis.bsky.social @ipfdoc.bsky.social A Statistical Model for Lung Function Trajectory and Mortality in Patients with Fibrotic ILD academic.oup.com/ajrccm/advan... #OpenAccess
Screen shot of study title and authors
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Reposted by Roger J. Lewis, MD, PhD
Katie Mack @astrokatie.com · 07/04/2026
This is the face of a lunar scientist who has just been told that the #Artemis II crew saw SEVERAL impact flashes (the flashes when meteors hit the lunar surface) in real time 😃 🌓💥
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Reposted by Roger J. Lewis, MD, PhD
JAMA @jama.com · 03/04/2026
JAMA Statistical Editor @rogerjlewis.bsky.social MD, PhD, and Natalie Dean, PhD, discuss the test-negative study design, highlighting its role in analyzing effectiveness and minimizing bias in observational studies. 🎧 Listen now: ja.ma/4tl3MF9
JAMAevidence JAMA Guide to Statistics and Methods, video published April 2, 13 min, titled "Test-Negative Study Designs for Evaluating Vaccine..." with a play button.
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Roger J. Lewis, MD, PhD @rogerjlewis.bsky.social · 23/03/2026
So, I mentioned this to a manager, who calmly told me "yeah, the corporate office does that to fool people. They won't fix that if we complain." PS Yes, I know what they did wrong math-wise.
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Roger J. Lewis, MD, PhD @rogerjlewis.bsky.social · 23/03/2026
I stopped and stared at the price per ounce numbers for a few minutes trying to reproduce Kroger's / Ralph's math, especially since they are misleading in way that would make you buy a larger package that was actually more expensive per ounce.
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Reposted by Roger J. Lewis, MD, PhD
JAMA @jama.com · 05/03/2026
JAMA Statistical Editor @rogerjlewis.bsky.social, MD, PhD, and Steve Webb, MBBS, MPH, PhD, discuss the key features of platform trials, including adaptive structures, shared control groups, and domain-based randomization. 🎧 Listen now: ja.ma/3Pk33oU
JAMAevidence JAMA Guide to Statistics and Methods; March 5, 17 min; Platform Clinical Trials for the Efficient Evaluation of Multiple...; JAMAevidence JAMA Guide to...; Play Button.
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Roger J. Lewis, MD, PhD @rogerjlewis.bsky.social · 04/03/2026
I wonder what decision process or discussion initially led to this course of action, let alone the decision to perpetuate it. It's difficult for me to picture it.
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Reposted by Roger J. Lewis, MD, PhD
JAMA @jama.com · 06/02/2026
The updated PECARN rule reliably identified low-risk febrile infants, with no missed cases of bacterial meningitis, potentially reducing routine lumbar punctures. bit.ly/3Zkwf1a
JAMA | Original Investigation: "Prediction of Bacteremia and Bacterial Meningitis Among Febrile Infants Aged 28 Days or Younger." Key points discuss accuracy of clinical prediction rules based on lab results to identify risk in young infants.
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Reposted by Roger J. Lewis, MD, PhD
JAMA @jama.com · 06/02/2026
Among patients with acute ischemic #stroke due to non–large vessel occlusion, #tenecteplase administered 4.5 to 24 hours after symptom onset increased excellent outcomes but raised the risk of intracranial #hemorrhage. #ISC26 📽️ Watch the video & read the full study: bit.ly/4kgH1yQ
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Roger J. Lewis, MD, PhD @rogerjlewis.bsky.social · 04/02/2026
I do watch (and enjoy) it...
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Roger J. Lewis, MD, PhD @rogerjlewis.bsky.social · 02/02/2026
No, I Won't Watch 'The Pitt' www.medpagetoday.com/opinion/pres...
medpagetoday.com
Opinion | No, I Won't Watch 'The Pitt'
But you probably should
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Reposted by Roger J. Lewis, MD, PhD
JAMA @jama.com · 28/01/2026
📊 JAMA Guide to Statistics and Methods: The win ratio is a statistical method for hierarchical composite outcomes, offering a patient-centered summary of treatment effects by prioritizing more important clinical events in clinical trials. ja.ma/4qIidSJ
A JAMA article titled "Win Ratio Method for Hierarchical Composite Outcomes in Randomized Clinical Trials". Article discusses composite end points, win ratio, and time-to-event outcomes.
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Reposted by Roger J. Lewis, MD, PhD
Olga Nesterova @onestpress.onestnetwork.com · 23/01/2026
WHO removing Us Flag
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Reposted by Roger J. Lewis, MD, PhD
Dr. Jonathan N. Stea @jonathanstea.bsky.social · 14/01/2026
An announcement from Noah Wyle and the CDC:
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Roger J. Lewis, MD, PhD @rogerjlewis.bsky.social · 17/01/2026
jamanetwork.com/journals/jam...
jamanetwork.com
Mifepristone and the Future of FDA Drug Regulation
On September 19, 2025, US Department of Health and Human Services (HHS) Secretary Robert F. Kennedy Jr and US Food and Drug Administration (FDA) Commissioner Martin Makary announced that HHS would be ...
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Roger J. Lewis, MD, PhD @rogerjlewis.bsky.social · 17/01/2026
jamanetwork.com/journals/jam...
jamanetwork.com
Navigating Conflicting Vaccination Recommendations
This Perspective discusses how clinicians can navigate conflicting vaccination recommendations following revisions from the Advisory Committee on Immunization Practices and US Centers for Disease Cont...
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Reposted by Roger J. Lewis, MD, PhD
JAMA @jama.com · 10/01/2026
In this podcast, @rogerjlewis.bsky.social, MD, PhD, Senior Statistical Editor for JAMA, speaks with Kendra Sims, PhD, postdoctoral associate at @busph.bsky.social, about how tipping point analysis can help assess the robustness of study findings. Listen now: ja.ma/49fpFi5
JAMAevidence presents 'JAMA Guide to Statistics and Methods.' Tipping Point Analysis: Assessing the Potential Impact. A play button indicates video content from JAMAevidence JAMA Guide to...
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Reposted by Roger J. Lewis, MD, PhD
3 Wishes Program @3wishesprogram.bsky.social · 08/12/2025
Some beautiful keepsakes nurses made for a dying patient's family at Harbor-UCLA.
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Reposted by Roger J. Lewis, MD, PhD
Brandy Zadrozny @brandyzadrozny.bsky.social · 05/12/2025
“I did not resign to make a symbolic point. I resigned because staying silent would have made me complicit. I spoke up because the stakes for children, communities, and our preparedness are too high.” time.com/7338714/dr-d...
time.com
I Left the CDC 100 Days Ago. My Worst Fears About the Agency Are Coming True
"Things have not improved," writes Dr. Debra Houry. "They have worsened. And Congress has still failed to act."
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Reposted by Roger J. Lewis, MD, PhD
Holly Fernandez Lynch @hollylynchez.bsky.social · 07/12/2025
Here, here. "Congress must now also exercise its oversight responsibilities to ensure repairs to FDAs current and future capabilities, infrastructure, human resources, and reputation begin as soon as possible." Big deal coming from investors/companies. www.nopatientleftbehind.org/evidence-bas...
nopatientleftbehind.org
Supporting the Call for Evidence-Based Policy and Public Health Security — No Patient Left Behind
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Reposted by Roger J. Lewis, MD, PhD
Holly Fernandez Lynch @hollylynchez.bsky.social · 07/12/2025
Excited to work with @pzettler.bsky.social and @reshmagar.bsky.social on this new project supported by @arnoldventures.bsky.social with the goal of developing a principles-based approach to rebuilding and re-envisioning FDA. moritzlaw.osu.edu/ohio-state-a...
moritzlaw.osu.edu
Ohio State and Partners Secure Grant to Inform Future Vision of FDA
Researchers at The Ohio State University Moritz College of Law and partner universities were recently awarded a grant from Arnold Ventures to support a multi-faceted research project, titled “A Princi...
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Reposted by Roger J. Lewis, MD, PhD
Seth Trueger @mdaware.org · 05/12/2025
thank you @drdebhoury.bsky.social !!
At the 100-day mark, we have enough data points to know this is not a series of isolated missteps. It is a purposeful reshaping of CDC away from evidence-based practice and toward ideology-driven governance. Today, I am asking again: Congress, governors, health systems, scientific societies, and the private sector must act. Not with statements, but with oversight, pressure, and protection for the.
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Roger J. Lewis, MD, PhD @rogerjlewis.bsky.social · 05/12/2025
Our new kitten was discovered alone and outside by a kind soul at approximately four weeks of age (first measured weight was 395 g). She appears to be settling into the household nicely. Our labradoodle is (very gently) trying to ignore her.
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Roger J. Lewis, MD, PhD @rogerjlewis.bsky.social · 25/11/2025
Thanks on behalf of the entire SNAP team--happy to have contributed to #3!
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Reposted by Roger J. Lewis, MD, PhD
The New York Times @nytimes.com · 12/11/2025
In @nytopinion.nytimes.com “Even as my own life is imperiled by the Trump administration’s actions, I understand the populist rage and institutional distrust that drive the Make America Healthy Again movement,” writes Sam Braslow, who has Stage IV melanoma.
nyti.ms
Opinion | MAHA Threatens My Life. I Understand Its Appeal.
The Trump administration has undermined the once bipartisan war on cancer and declined to approve a promising melanoma therapy.
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Roger J. Lewis, MD, PhD @rogerjlewis.bsky.social · 11/11/2025
Happy Veterans Day! This post is celebrating my mother's service as a WASP--Women Airforce Service Pilot--during WW II, flying P-52s, P-47s, etc. from the factory to bases for subsequent deployment. Flying newly built planes is risky; 38 of the 1074 women died, often due to mechanical failures.
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Reposted by Roger J. Lewis, MD, PhD
JAMA @jama.com · 03/11/2025
📢 JAMA Senior Statistical Editor @rogerjlewis.bsky.social, MD, PhD, @jamaotolaryngology.com EIC Jay Piccirillo, MD, & @jamaotolaryngology.com Statistics Editor Dorina Kallogjeri, MD, MPH, will be speakers at the 2nd Annual Midwest Critical Appraisal Workshop. See flyer for more details. ⬇️
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Reposted by Roger J. Lewis, MD, PhD
Deb Houry @drdebhoury.bsky.social · 31/10/2025
On halloween there’s nothing spookier than a future without CDC
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Roger J. Lewis, MD, PhD @rogerjlewis.bsky.social · 25/10/2025
Love this quote! Much of clinical trial design at statistical rigor is aimed at preventing this.
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Reposted by Roger J. Lewis, MD, PhD
JAMA @jama.com · 21/10/2025
In children 6 months after heart transplant, everolimus with low-dose tacrolimus was as effective as standard therapy in preventing major complications and showed potential benefits for kidney function and reduced CMV infection. ja.ma/4nWa63L
JAMA study showing that everolimus combined with low-dose tacrolimus is safe and effective for preventing rejection in children after heart transplant. 211 patients were randomized and the mean age was 8 years.
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Reposted by Roger J. Lewis, MD, PhD
JAMA @jama.com · 17/10/2025
Calling all early career researchers! Applications are open for the JAMA Editorial Fellowship Program. Individuals interested in becoming journal editors, as well as those looking to learn more about journal review processes, are invited to apply. 🔗 ja.ma/46ZoFMG
Call for Applications: JAMA Editorial Fellowship
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