Eight integrated mutational footprints collectively explain the mutational processes in 85% of primary prostate cancer genomes.

About OICR   OICR is Ontario’s cancer research institute. We bring together people from across the province and around the world to improve the lives of everyone affected by cancer. We take on the big...

This Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable environment...

Analysis of the somatic and transcriptomic profile of 123 acral melanoma samples from Mexican patients helps understand tumour origins and prognosis, and highlights the importance of including samples...

Lung cancer remains the leading cause of cancer-related deaths worldwide, with tumor recurrence a major contributor to its high mortality. The genetic and molecular mechanisms of recurrence remain poo...

Genetic interactions can reveal gene function and identify cancer-relevant synthetic lethals, but systematic mapping in human cells is constrained by inefficient reagents, vast combinatorial search sp...

Research from the Ontario Institute for Cancer Research associated a chemotherapy-related cellular process with genetic mutations and used it to identify novel cancer driver alterations. New research ...

Topoisomerases resolve topological DNA stress via double-strand breaks and are established targets of cancer chemotherapies. Here, the authors link genomic binding of TOP2B with localized mutational p...

Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein.  &nbs...

Discovery-based and/or translational research using model organism genetics and/or stem cell and organoid platforms to study paediatric cancer.

Fluid shear stress plays a role in medulloblastoma metastasis through a PIEZO2-actomyosin-GLUT1 signalling cascade.

Abstract. Oncogenesis, tumor progression and therapy response are shaped by somatic alterations in the cancer genome and features of the tumor immune microenvironment (TME). How interactions between t...

Synopsis. Social media has become widely used by the scientific community for a variety of professional uses, including networking and public outreach. For

RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource.

Integrative pathway enrichment analysis of multivariate omics data - reimandlab/ActivePathways

Nature - The Virtual Lab of AI agents designs new SARS-CoV-2 nanobodies

Radiation, the most effective treatment for medulloblastoma, induces an innate immune response and opens the blood-brain barrier, allowing for the intravasation of tumor cells into the blood circulati...

From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science.

In Alzheimer’s disease (AD), disruptions in myelin and axonal structures occur, although the underlying mechanisms remain unclear. Here the authors show that, at the myelin–axon interface, axon–glial ...

ALT: a man with a beard wearing a hat and glasses says ' hahahahahah ' on the screen

The incidence of prostate cancer is increasing. Screening with an assay of prostate-specific antigen (PSA) has a high rate for false positive results. Genomewide association studies have identified...

Genome sequencing results and single-cell transcriptomics continue to produce findings that challenge the idea that cancer is purely a ‘genetic disease’. This Essay delves into cancer omics data that ...

About OICR   OICR is Ontario’s cancer research institute. We bring together people from across the province and around the world to improve the lives of everyone affected by cancer. We take on the big...