Abstract. The genomes of all organisms encode diverse functional elements, including thousands of genes and essential noncoding regions for gene regulation

The relationship between parasite genotype and pathogenesis is largely unknown for Cryptosporidium, a leading cause of diarrheal disease in children. An array of parasites with similar genomes produce...

PhD conference, interact 2025, organised in Munich, Germany. Great opportunity for PhD candidates to network with fellow early career researchers and learn about their future career opportunities.

Transcription of protein coding genes in trypanosomatids is atypical and almost exclusively polycistronic. In Trypanosoma brucei, approximately 150 polycistrons, and 8000 genes, are constitutively tra...

A new study by Maria Colomé-Tatché and Nicolai Siegel shows how pathogens control changes in their cell surface to evade the immune system.

The MRE11-RAD50-NBS1 (MRN) complex is a central, multifunctional factor in the detection, signaling and nucleolytic processing of DNA double-strand breaks (DSBs). To clarify how human MRN binds generi...

The 2025 Gordon Research Conference on Epigenetics will be held in Castelldefels, Barcelona Spain. Apply today to reserve your spot.

Kinetoplastid parasites cause diseases that threaten human and animal health. To survive transitions between vertebrate hosts and insect vectors, these parasites rely on precise regulation of gene exp...

Plasmodium falciparum Snf2L is an ISWI-related ATPase that actively repositions P. falciparum nucleosomes in vivo.

PhD conference, interact 2025, organised in Munich, Germany. Great opportunity for PhD candidates to network with fellow early career researchers and learn about their future career opportunities.

PhD conference, interact 2025, organised in Munich, Germany. Great opportunity for PhD candidates to network with fellow early career researchers and learn about their future career opportunities.

In the life of a vertebrate embryo, gene expression is initiated for the first time at zygotic genome activation (ZGA). Maternally expressed transcription factors present in the embryo are essential f...

Decoding the role of inter-chromosomal DNA-DNA interactions remains challenging. Here, the authors use Micro-C to study the T. brucei genome architecture at high resolution and reveal an intricate net...