Turning off checkpoint molecules freed microglia to attack plaques in brain, improved memory in mice.

Naderi and Kwak et al. developed IPAA, an integrated cellular/bioinformatics platform. IPAA derisks drug discovery by integrating Alzheimer’s brain gene expression with cellular model functional reado...

Background A significant proportion of individuals maintain healthy cognitive function despite having extensive Alzheimer’s disease (AD) pathology, known as cognitive resilience. Understanding the mol...

Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...

Using mouse and human plasma, Carver et al. identify factors that are altered with age and test which are reverted by a panel of genetic and pharmacological senolytic interventions in aged mice. They ...

A generative AI model, Orion, learns a robust and generalizable pattern of non-small cell lung cancer from cancer-specific circulating non-coding RNAs. Orion enhances the performance of liquid biopsy ...