Reposted by Paul NormanWaggoner Lab @labwaggoner.bsky.social · 28/09/2026@medrxivpreprint.bsky.social Decidual-Like NK Cells Are Enriched in Melanomas and Acquire CD9 Through Melanoma Cell Contact www.medrxiv.org/content/10.6... @pn0rmski.bsky.social 011 1
Paul Norman @pn0rmski.bsky.social · 05/08/2026academic.oup.com/jimmunol/art...academic.oup.comUnconventional functions of natural killer cells in homeostasis and diseaseAbstract. NK cells are classically defined by their rapid cytotoxicity against tumor cells and infected cells and by early inflammatory cytokine production 021 2
Paul Norman @pn0rmski.bsky.social · 27/06/2026journals.plos.org/plospathogen...journals.plos.orgLatent cytomegalovirus disrupts innate NK cell responses to P. falciparum and impairs parasite control in first infection in adultsAuthor summary How an individual’s immune system responds to infection is diverse, with multiple factors influencing the disease outcome. One such factor is individuals’ prior exposure to other pathog... 000 0
Paul Norman @pn0rmski.bsky.social · 09/06/20261 week left for early bird and abstract: sip-sassenheim.orgsip-sassenheim.orgSIP Symposium | 000 0
Paul Norman @pn0rmski.bsky.social · 16/05/2026academic.oup.com/gbe/advance-...academic.oup.comArchaic Introgression Shapes Genetic Variation at Loci Associated With DNA Virus Load in Modern HumansAbstract. Archaic introgression has shaped the modern human immune system, particularly components involved in RNA virus responses. In contrast, its contri 020 2
Paul Norman @pn0rmski.bsky.social · 04/05/2026www.cell.com/ajhg/fulltex...cell.comSignatures of pathogen-driven selection and Austronesian gene flow of Papua New Guinea HLA allelesPolymorphism of human leukocyte antigens (HLA) guides differential immune responses to infection. We analyze how HLA evolved across the distinct environments of Papua New Guinea. We find that HLA dive... 034 4
Paul Norman @pn0rmski.bsky.social · 22/03/2026Abstract submission and registration for the 3rd annual SIP in Sassenheim-The Netherlands is open. Take advantage of the early bird fee of only Euro 775 which does include 3 overnight hotel stay and all conference meals. sip-sassenheim.orgsip-sassenheim.orgSIP Symposium | 000 0
Paul Norman @pn0rmski.bsky.social · 05/03/2026haematologica.org/article/view...haematologica.org Integrating killer cell immunoglobulin-like receptor highresolution genotyping for predicting transplant outcomes in allogeneic hematopoietic stem cell transplantation | Haematologica 000 0
Paul Norman @pn0rmski.bsky.social · 30/10/2025www.oxforduniversitystores.co.uk/conferences-...oxforduniversitystores.co.ukOxford KIR Workshop 2026 | University of OxfordAn international gathering of scientists studying the killer-cell immunoglobulin-like receptors (KIR). It will cover topics such  evolution, immunogen 000 0
Paul Norman @pn0rmski.bsky.social · 17/10/2025www.youtube.com/watch?v=KALZ...youtube.comThe Genes That Encode T-Cell Receptors and B-Cell ReceptorsYouTube video by Society for Immune Polymorphism 010 1
Reposted by Paul NormanMalcolm Sim @mjwsim.bsky.social · 01/10/2025We're hiring! Come join our lab in Oxford as a research assistant and study peptide recognition of MHC molecules - please reach our for more details! www.jobs.ac.uk/job/DOW691/r...jobs.ac.ukResearch Assistant at University of OxfordAn opportunity for an academic position as a Research Assistant is available, as advertised on jobs.ac.uk. Apply now and explore other academic job openings. 001 1
Paul Norman @pn0rmski.bsky.social · 25/09/2025There are 4 places left at the SIP Symposium 2025. Hurry up and register before you miss your chance.. sip-sassenheim.org 010 1
Reposted by Paul NormanThiago Carvalho @cyrilpedia.bsky.social · 24/09/2025'Superresolution microscopy has revealed a nanoscale rearrangement of NK cell receptors at the cell surface upon cellular activation. An emerging idea is that the activation and inhibition of immune cells is influenced by the nanoscale proximities of receptor clusters' www.pnas.org/doi/10.1073/...pnas.orgNanoscale restructuring of the immune synapse with an engager enhances NK cell function | PNASEngagers are antibody-based therapies which bind immune cell receptors and a target cell ligand. Next-gen engagers typically bind two activating re... 0266 26
Paul Norman @pn0rmski.bsky.social · 09/09/2025Society for Immune Polymorphism Memberships are now available through SquareUp. Join today and receive membership through end of 2026. We offer a range of membership types. Visit this storefront to join the society. immunepolymorphism.square.siteimmunepolymorphism.square.siteHome | Society for Immune Polymorphism 000 0
Paul Norman @pn0rmski.bsky.social · 19/08/2025Balking tradition, we will NOT be extending the abstract deadline for the Society for Immune Polymorphism Symposium, as we have lots of exciting abstracts to choose from already. If you would like to attend, there are still some spots available for registration: sip-sassenheim.org/registration/sip-sassenheim.orgRegistration | SIP Symposium 000 0
Paul Norman @pn0rmski.bsky.social · 09/08/2025news.cuanschutz.edu/dbmi/genome-...news.cuanschutz.eduCU Anschutz Researchers Help Build One of the Most Inclusive Human Genome Maps to DateCU Anschutz researchers contribute to one of the most inclusive human genome maps created, advancing disease research and precision medicine through groundbreaking genetic diversity insights. 000 0
Paul Norman @pn0rmski.bsky.social · 02/08/2025www.jbc.org/article/S002...jbc.orgMolecular characterization of the archaic HLA-B*73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2HLA class I alleles of archaic origin may have been retained in modern humans because they provide immunity against diseases to which archaic humans had evolved resistance. According to this model, ar... 000 0
Paul Norman @pn0rmski.bsky.social · 02/08/2025link.springer.com/article/10.1...link.springer.comMolecular Interactions Between NK Cells and Acute Leukemic Cells: KIR2DL5 Drastically Limits NK Cell Responses - Journal of Clinical ImmunologyNatural Killer (NK) cells naturally recognize and eliminate leukemic cells. However, the molecular interactions that govern these responses are diverse due to the large number of activating and inhibi... 011 1
Paul Norman @pn0rmski.bsky.social · 29/07/2025www.ashg.org/publications...ashg.orgASHG Announces 2025 Professional Award RecipientsFor Immediate Release: Tuesday, July 29, 2025, 10:00 a.m. U.S. Eastern Time Media Contact: Evelyn Mantegani, (301) 634-7300, press@ashg.org Rockville, Md. – The American Society of Human Genetics (ASH... 000 0
Reposted by Paul NormanNandita Garud @nanditagarud.bsky.social · 22/07/2025I am seeking a postdoc for my group at UCLA. We work at the intersection of population genetics x microbiome (garud.eeb.ucla.edu). If interested, please message me!garud.eeb.ucla.eduGarud Lab 18598 98
Paul Norman @pn0rmski.bsky.social · 24/07/2025www.nature.com/articles/s41...nature.comComplex genetic variation in nearly complete human genomes - NatureUsing sequencing and haplotype-resolved assembly of 65 diverse human genomes, complex regions including the major histocompatibility complex and centromeres are analysed. 000 0
Reposted by Paul NormanEd Chuong @edchuong.bsky.social · 17/07/2025Are you bravely deciding to do a postdoc in the US? And also interested in some combination of genomics, immunology, and transposons? If so, consider applying to my lab at the BioFrontiers Institute in Boulder, Colorado! jobs.colorado.edu/jobs/JobDeta... 🧪🧬 #TESky #interferosky 15436 54
Paul Norman @pn0rmski.bsky.social · 25/06/2025SIP 2025: Final line up of speakers announced today sip-sassenheim.org/speakers/sip-sassenheim.orgSpeakers | SIP Symposium 010 1
Paul Norman @pn0rmski.bsky.social · 25/06/2025Society for Immune Polymorphism annual meeting November 3-5 2025. Abstracts due August 15th. sip-sassenheim.org?_gl=1%2Ato8b...sip-sassenheim.orgSIP Symposium | 010 1
Reposted by Paul NormanWaggoner Lab @labwaggoner.bsky.social · 20/06/2025Florian Krammer lab looking for a postdoc in virology/immunology at the Ignaz Semmelweis Institute at the Medical University in Vienna. www.meduniwien.ac.at/web/karriere...meduniwien.ac.atNr24 Ignaz Semelweis Institut, Reference number 382/25 | MedUni Wien 044 4
Paul Norman @pn0rmski.bsky.social · 14/06/2025www.nature.com/articles/s41...nature.comRIFINs displayed on malaria-infected erythrocytes bind KIR2DL1 and KIR2DS1 - NatureCertain RIFINs from Plasmodium falciparum can bind to both inhibitory (KIR2DL1) and activating (KIR2DS1) immune receptors on natural killer cells, demonstrating the potential role of activating killer... 021 2
Paul Norman @pn0rmski.bsky.social · 28/05/2025MAIT cells exacerbate colonic inflammation in a genetically diverse murine model of spontaneous colitis www.sciencedirect.com/science/arti...sciencedirect.comMAIT cells exacerbate colonic inflammation in a genetically diverse murine model of spontaneous colitisIL-17-producing lymphocytes are involved in both tissue repair and the propagation of inflammation, with their effects highly context-dependent. Mucos… 000 0
Paul Norman @pn0rmski.bsky.social · 27/05/2025sip-sassenheim.org?_gl=1%2Ajqbh...sip-sassenheim.orgSIP Symposium |The Society for Immune Polymorphism is dedicated to understanding the genetic and functional variation of the vertebrate immune system, and the immune system’s role in evolutionary biology, disease and health. 000 0
Paul Norman @pn0rmski.bsky.social · 09/05/2025The one in which we finally lay the HLA vs mate selection debate to rest ...? www.biorxiv.org/content/10.1...biorxiv.orgNo evidence for disassortative mating based on HLA genotype in a natural fertility populationEvidence for disassortative mating based on the human-specific MHC, i.e. HLA, is equivocal1. Initial evidence for disassortative HLA-pairing in the European-descent Hutterites2 has tended not to repli... 010 1
Paul Norman @pn0rmski.bsky.social · 09/05/2025We are pleased to announce the availability of two Frans Claas Travel Awards, each valued at €1000, to support early-career researchers attending the 2nd annual SIP Symposium. The awards are offered by the TxMiller Foundation. sip-sassenheim.org/registration...sip-sassenheim.orgFrans Claas Travel Awards | SIP Symposium 000 0
Reposted by Paul NormanMalcolm Sim @mjwsim.bsky.social · 09/05/2025Delighted to be hosting the next KIR workshop in Oxford next year. Please save these dates if you're interested. More details to follow. 053 5
Paul Norman @pn0rmski.bsky.social · 08/05/2025sip-sassenheim.org/speakers/?_g...sip-sassenheim.orgSpeakers | SIP Symposium 000 0
Reposted by Paul NormanDenis Wirtz @deniswirtz.bsky.social · 28/04/2025A huge majority of Americans (77%) oppose the cuts to medical research that the current administration has made. (Source: Wash. Post/ABC/Ipsos poll) 310741 107
Reposted by Paul NormanThe American Association of Immunologists @aai.org · 28/04/2025Data in @jimmunol.bsky.social revealed the role of #malaria in Burkitt lymphoma, the most common childhood cancer in equatorial Africa and New Guinea. Reducing malaria could also reduce Burkitt #lymphoma said @rosemaryroch4d, who led the study @cuanschutz.bsky.social. Learn more: ow.ly/tTKg50VI6qR.ow.lyStudy Identifies How Malaria Can Lead to Childhood Cancer - AAI NewsNew data in The Journal of Immunology uncovered the role of malaria in the development of Burkitt lymphoma, the most common childhood cancer in equatorial Africa and New Guinea. 011 1
Reposted by Paul NormanMalcolm Sim @mjwsim.bsky.social · 18/04/2025Delighted that this review is now accepted and online. We review evidence from us and others that germline-encoded receptors of the innate immune system can detect peptides presented by MHC molecules, some with high peptide-specificity. t.co/9EKH2SpGEyt.cohttps://academic.oup.com/ooim/advance-article/doi/10.1093/oxfimm/iqaf003/8115587 1104 10
Paul Norman @pn0rmski.bsky.social · 18/04/2025Extremely honoured to host Prof. Josephine Pemberton FRS at the second annual #SocietyforImmunePolymorphism symposium Nov 3-5, 2025 000 0
Reposted by Paul NormanJerad Walker @jeradwalker.bsky.social · 16/04/202550 years ago the BBC filmed this incredible documentary about Shrewsbury Town FC’s ball boy who was a grown ass man named Fred who owned a tiny boat. 2540888 408
Paul Norman @pn0rmski.bsky.social · 11/04/2025And we are holding another one this year! sip-sassenheim.org #ImmunoSky #EvolSky 000 0
Paul Norman @pn0rmski.bsky.social · 11/04/2025Honored to announce that John Trowsdale will be giving the van Rood Prize lecture at this year's Society for Immune Polymorphism meeting sip-sassenheim.org/speakers/ November 3-5th 000 0
Paul Norman @pn0rmski.bsky.social · 03/04/2025Stunning show by Techno OGs Kraftwerk in Denver last night. 020 2
Reposted by Paul NormanMalcolm Sim @mjwsim.bsky.social · 26/03/2025academic.oup.com/jimmunol/adv...academic.oup.comPeptide selectivity of killer cell immunoglobulin-like receptors differs with allotypic variation in HLA class IAbstract. Natural killer (NK) cell activation is regulated by killer cell immunoglobulin-like receptors (KIRs) that recognize human leukocyte antigen (HLA) 042 4
