AbstractAssigning causal function to post-translational modifications (PTMs) remains a central challenge in molecular biology, as most modification events

Lysine acylation is emerging as a fundamental mechanism linking cellular metabolism to protein regulation. Hintzen and Burslem synthesize the chemical biology, mechanistic principles, and unresolved questions that are redefining lysine acylation from an expanding catalog of modifications into a unifying framework for understanding metabolic regulation while outlining challenges.

Budinich et al. show that locally produced transcripts reinforce the nucleation of pathogenic condensates formed by mutant ENL at permissive target loci. This RNA-enhanced condensate nucleation in…

Traumatic experiences can cause memory problems, and estrogen may be a key factor that shapes the brain's resilience against such stressors, a mouse study finds.

Changes in nuclear architecture during cell state transitions remain poorly understood. Here, the authors use O-SNAP, a framework to analyze SMLM images of chromatin, to reveal chromatin remodelling i...

Maturing mouse sperm get loaded with full-length messenger RNAs that are transferred to fertilized egg, suggesting a new route for paternal influence

Abstract. The epididymis plays a critical role in promoting sperm maturation, including remodeling the sperm RNA payload. While small RNAs have been extens

Live molecular-scale imaging in fly embryos shows that a single RNA Polymerase II cluster stays bound to active genes during transcription. Cluster formation requires initiation, and intensity represe...

In eukaryotic nuclei, transcription is associated with the clustering of RNA Polymerase II (RNAPII) molecules. The mechanisms underlying cluster formation, their interactions with genes, and their imp...

The new toolkit, developed by Penn Medicine and Children’s Hospital of Philadelphia, allows researchers to test potential cancer targets directly in patient leukemia cells.

Penn biologists reveal how plants respond to seasonal flowering cues while protecting the stem cells at their growing tip, enabling continuous reproduction in changing environments.