Paul Sheppard 🧠 @paulsheppard.bsky.social · 14/02/2026Near zero chance of any Olympic athlete found talking to a trash can, so... 🤷🏻♂️ 030
Reposted by Paul Sheppard 🧠emilyzelda.bsky.social @emilyzelda.bsky.social · 14/02/2026This is just to say I have eaten the runners that were in the forest And which you were probably tracking for inspo Forgive me they were delicious so sweet And so lost #BM100 #BM100fangirling 2476
Reposted by Paul Sheppard 🧠peepa0987.bsky.social @peepa0987.bsky.social · 14/02/2026#bm100 @keithdunn.bsky.social 071
Paul Sheppard 🧠 @paulsheppard.bsky.social · 14/02/2026I always have this cognitive dissonance as well 000
Paul Sheppard 🧠 @paulsheppard.bsky.social · 14/02/2026A quick search suggests it's about 5°C and sunny, so beautiful weather imo. Tomorrow looks like a lot of rain though... 120
Paul Sheppard 🧠 @paulsheppard.bsky.social · 14/02/2026Go for it! I just stuck words on a pic of Laz 🤷🏻♂️ 010
Paul Sheppard 🧠 @paulsheppard.bsky.social · 14/02/2026Valentine's Day? Family Day long weekend? Ah, you mean "the Barkley Marathons has started"! #bm100 19216
Reposted by Paul Sheppard 🧠thetemzreview.bsky.social @thetemzreview.bsky.social · 16/09/2025Don't miss @paulsheppard.bsky.social's visually innovative poem "a n y w a y (s)" in Issue 32! Excerpting doesn't do it justice; just click through to the poem: www.thetemzreview.com/sheppard-32.... 022
Paul Sheppard 🧠 @paulsheppard.bsky.social · 16/07/2025It's tragic, but I forgot to post this Good Meme when the touchscreen cognitive judgement bias paper came out. (paper link for context: www.nature.com/articles/s41...) 010
Paul Sheppard 🧠 @paulsheppard.bsky.social · 06/07/2025I ran my first ultra distance race today, an intense and technical 56km @limberlosttrailrun.bsky.social . It was HOT and I learned a lot of things that I'll do differently next time, but it was some great Type 2 Fun! 3200
Paul Sheppard 🧠 @paulsheppard.bsky.social · 21/06/2025It was hot, humid, then rainy; it was a lot. I wanted to go farther in the 4h but it wasn't in the cards today. But what a fun concept and a fun race! 000
Paul Sheppard 🧠 @paulsheppard.bsky.social · 21/06/2025Today I ran just shy of a marathon during a race called The Farthest put on by Persistence Racing. Everyone started from the same point and ran in whatever direction they wanted to get the farthest as the crow flies within 2, 4, or 8h. I did the 4h "Half-Farthest". 120
Paul Sheppard 🧠 @paulsheppard.bsky.social · 06/06/2025It must be really frustrating for those who were on search committees that had their searches cancelled to see this. It's a lot of work! 000
Paul Sheppard 🧠 @paulsheppard.bsky.social · 06/06/2025From canceled faculty hiring searches to this in <6 months... 👀 100
Paul Sheppard 🧠 @paulsheppard.bsky.social · 04/06/2025In case you were wondering (you 100% weren't): the mouse in the graphical abstract is "greyer mouse" because "grey mouse" just wasn't grey enough for certain co-authors who will go unnamed... 000
Reposted by Paul Sheppard 🧠Baptiste Lacoste @blacoste.bsky.social · 03/06/2025Happy to share the current version of our latest story, currently under peer review. Cool collab with @dablab.bsky.social @manickam-lab.bsky.social and others. We are not only understanding endothelial deficits in an #autism model, but now also capable of rescuing them! #16p11.2 #treatment #P2Y2biorxiv.orgPurinergic receptor activation rectifies autism-associated endothelial dysfunctionEarly cerebrovascular alterations affect brain maturation by impacting trophic support and energy supply. Recent evidence in a 16p11.2 deletion mouse model of autism spectrum disorder (ASD) revealed b... 0249
Paul Sheppard 🧠 @paulsheppard.bsky.social · 02/06/2025So check it out! And many thanks to the whole crew that worked on this! @westernubrainscan.bsky.social @timbussey.bsky.social @lisasaksida.bsky.social @maximoprado.bsky.social @touchscreencog.bsky.social @tcnlab.bsky.social 020
Paul Sheppard 🧠 @paulsheppard.bsky.social · 02/06/2025We also present some interesting data regarding a knock-in model often used as a control for this amyloidopathy model since they do not develop plaques. We found that despite this lack of plaque development, they show more profound decreases in cognitive flexibility across age compared to wildtypes. 110
Paul Sheppard 🧠 @paulsheppard.bsky.social · 02/06/2025We show herein that a mouse model of aggressive amyloidopathy can learn to discriminate visual cues, but, following learning, are deficit in reversing what they've learned (cognitive flexibility) and show perseverative responding. 110
Paul Sheppard 🧠 @paulsheppard.bsky.social · 02/06/2025🚨 NEW PAPER ALERT 🚨 🚨 KLAXON KLAXON 🚨 Impaired Cognitive Flexibility With Preserved Learning in an Amyloid Precursor Protein Knock-In Mouse Model of Amyloidopathy onlinelibrary.wiley.com/doi/10.1111/...onlinelibrary.wiley.comImpaired Cognitive Flexibility With Preserved Learning in an Amyloid Precursor Protein Knock‐In Mouse Model of AmyloidopathyThe amyloid precursor protein knock-in mouse model of amyloidopathy (AppNL-G-F/NL-G-F) was assessed on touchscreen-based learning and cognitive flexibility tasks in comparison with both AppNL/NL and .... 3102
Reposted by Paul Sheppard 🧠Western BrainsCAN @westernubrainscan.bsky.social · 27/05/2025Well done to all of our affiliated presenters at this year's @canacn.bsky.social Meeting! Great work! 093
Reposted by Paul Sheppard 🧠Marco A. Maximo Prado @maximoprado.bsky.social · 23/05/2025This is finally out! Great collaboration with Andy Holmes @timbussey.bsky.social @lisasaksida.bsky.social and @touchscreencog.bsky.social @westernubrainscan.bsky.social trainees www.nature.com/articles/s41...nature.comIntegrating optical neuroscience tools into touchscreen operant systems - Nature ProtocolsThis protocol extension enables researchers to integrate optically based manipulation and measurement techniques into their touchscreen experimental systems, focusing on optogenetic manipulation, fibe... 11810
Reposted by Paul Sheppard 🧠Papouin Lab @ WashU @papouinlab.bsky.social · 16/05/2025Thought this would be a nice way to enter the bsky community👇Delighted for Katie (now in Chris Dulla's lab at Tufts). Thank you to our collaborators, to the reviewers and to Cagla Eroglu for the highlight! www.science.org/doi/10.1126/...science.orgNorepinephrine signals through astrocytes to modulate synapsesLocus ceruleus (LC)–derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit functional connectivity, but the underlying synapse-level... 45821
Reposted by Paul Sheppard 🧠CANGlia @canglia.bsky.social · 20/05/2025Dr. Adebiyi kicking off our second session with an exciting talk about demyelination and repair! #KeepSmyelin 052
Reposted by Paul Sheppard 🧠CANGlia @canglia.bsky.social · 20/05/2025We are back for our 2nd CANGlia meeting in beautiful Toronto for a day of exciting Glial science! #CANGlia2025 193
Reposted by Paul Sheppard 🧠Western BrainsCAN @westernubrainscan.bsky.social · 15/05/2025Come and work with the Translational Cognitive Neuroscience Lab! We are looking for a #labmanager who wants to understand the circuits and mechanisms underlying cognition. Search ID 39142 at: recruit.uwo.ca 024
Reposted by Paul Sheppard 🧠Ciaran Murphy-Royal @murphyroyallab.org · 15/05/2025Very nice series of papers showing the effects of noradrenaline on brain circuits and behaviour require astrocytes. Congrats to the three labs on this fantastic work! www.science.org/doi/10.1126/...science.orgAstrocytes, hidden puppet masters of the brainAstrocyte signaling pathways influence neuronal networks and behavioral responses to neuromodulators 2235
Paul Sheppard 🧠 @paulsheppard.bsky.social · 15/05/2025FINALLY a mnemonic that is legitimately helpful for this! 010
Paul Sheppard 🧠 @paulsheppard.bsky.social · 10/05/2025My poem "I Fix the Door Open with My Bones" appears in the premiere issue of Diceroll. Go show them some love! diceroll.pressdiceroll.pressdiceroll press 010
Paul Sheppard 🧠 @paulsheppard.bsky.social · 08/05/2025Many thanks to The Trinity Review for publishing my poem "Before the Grassfires Flew" in issue 137.1. You can check it, and others, out here: www.thetrinityreview.com/download 040
Paul Sheppard 🧠 @paulsheppard.bsky.social · 01/05/2025Stayed up late last night to register for my fall goal race! Running the 50km at The Bad Thing trail race 🤘🏻 020
Paul Sheppard 🧠 @paulsheppard.bsky.social · 27/04/2025This weekend is my first ever crack at @cv2magazine.bsky.social's 2 Day Poem Contest! I think I've got a whole fruit bowl of global melancholy cooking right now for my entry; so, yeah, it's a blast! #2DayPoem2025 071
Paul Sheppard 🧠 @paulsheppard.bsky.social · 27/04/2025I got to throw "Nanners" (for Bananas) into the mix as a result, so I feel you! 010
Paul Sheppard 🧠 @paulsheppard.bsky.social · 26/04/2025I'm immensely grateful to have poem "tiny sounds" published in The Spring Issue of @cv2magazine.bsky.social ❤️ Received my contributor copy last night. 140
Paul Sheppard 🧠 @paulsheppard.bsky.social · 24/04/2025Today at NOON! (...which I should know, as one of the co-hosts, but definitely thought was at 11am. No: NOON) 012
