Early cerebrovascular alterations affect brain maturation by impacting trophic support and energy supply. Recent evidence in a 16p11.2 deletion mouse model of autism spectrum disorder (ASD) revealed b...

Background Alzheimer's disease (AD), the most common neurodegenerative condition, is characterized by significant cognitive decline. To detect these changes, diagnostic imaging approaches rely primari...

Lipid nanoparticles (LNPs) have transformed the delivery of nucleic acid therapeutics; however, their natural tropism favors the liver resulting in clearance by the reticuloendothelial system, with le...

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Sleep deprivation shifts metabolic resources and deprioritizes processes that support cognition.

🚨 Canada needs research that works for everyone! 🚨 Science shapes the policies that impact our daily lives—from healthcare to climate action to economic growth. But if our research doesn’t include di...

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Scientists have long recognized the brain’s need for energy, but groundbreaking research from the University of Kentucky’s Sanders-Brown Center on Aging has now illuminated how the brain’s energy uti...

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Traumatic brain injury (TBI) has emerged as a significant risk factor for Alzheimer’s disease (AD), a complex and devastating neurodegenerative disorder characterized by progressive cognitive decline ...

Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.