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Matt Patton

@pattonmatt2.bsky.social
501 followers 991 following 149 posts

Annapolis, Maryland, USA

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Reposted by Matt Patton
Amanda J. Wright @ajwright.bsky.social · 25/09/2026
Since our paper on the Changing How I Live Life (CHILL) Study is now out in Psychological Science (doi.org/10.1177/0956...), here's a LONG overdue post on the intervention work we've been doing the past few years! Have you ever wanted to change one of your personality traits?
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Alex Holcombe @alexh.bsky.social · 23/09/2026
I'd like to read a piece that grapples with the enormity of the AI-driven loss of the long tail of the internet, that results from e.g. Google directing us to AI answers rather than search. The millions of people running sites that eked out a living, or just paid their hosting costs, with
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Kathryn Paige Harden @kph3k.bsky.social · 21/09/2026
"Instead of needing a village to raise a child, PGT-P’s commercial logic suggests it takes only sufficient capital and the right consumer decisions to conceive a child who will not need the solidarity of the village to be healthy." www.nature.com/articles/s41...
nature.com
Embryo screening and the new reproductive divide - Nature Human Behaviour
Nature Human Behaviour - Embryo screening and the new reproductive divide
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Matt Patton @pattonmatt2.bsky.social · 14/09/2026
Something has made this movement incredibly self-sabotaging. 20 years ago, LGBT activists endorsed and campaigned for Dems who opposed same-sex marriage all the time.
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Will Stancil @whstancil.bsky.social · 13/09/2026
I’m sorry but how do you think Roe was repealed
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Alex Holcombe @alexh.bsky.social · 12/09/2026
It's Peer Review Week, and I have pledged to review at least one article per year for a diamond open access journal; one that charges nothing to publish and nothing to read, and is run by and for the scholarly community, using the new Diamond Reviewer Pledge (forrt.org/diamond-revi...).
forrt.org
Diamond Reviewer Pledge
Signatories of the Diamond Reviewer Pledge commit to reviewing at least one article in the next 12 months for a diamond open access journal.
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Kathryn Paige Harden @kph3k.bsky.social · 10/09/2026
A nice summary of our Nature Human Behaviour study showing that randomized cash transfers to low-income moms slow children's epigenetic aging: dailyneuron.com/cash-transfe...
dailyneuron.com
Four Years of Cash Slowed Biological Aging in Children Born Into Poverty - Daily Neuron
A $333 monthly check didn't change poor children's test scores, yet it slowed how fast their cells were aging.
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Eiko Fried @eikofried.bsky.social · 10/09/2026
www.theguardian.com/world/2026/s...
theguardian.com
Secret systems used by Israel in mass killings of Gaza civilians revealed in new film
Testimony from Israeli military insiders involved in surveillance and remote killings features in documentary produced by the Guardian
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Alex Holcombe @alexh.bsky.social · 03/09/2026
Great news! Some of us have been waiting a long time for major funders to not just shovel $ into the maws of the big publishers, and instead support the long tail of scholar-controlled journals that are run on a shoestring
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Jesse Singal @jessesingal.com · 03/09/2026
I find this maddening. People on Bluesky are caping for the most insanely condescending, transparent, cynical form of neoliberal benevolent racism. And getting mad at the journalists who helped uncovered it! jessesingal.substack.com/p/nature-you...
jessesingal.substack.com
Nature, You Need To Figure Out What You Do
You had allllllllll summer to think of it
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simine vazire @simine.com · 02/09/2026
Psych Science has retracted Ariely & Wertenbroch (2002). The second author requested the retraction. Both authors agreed to it. journals.sagepub.com/doi/full/10.... So grateful to @datacolada.bsky.social for these blog posts and the work behind them: datacolada.org/138 and datacolada.org/139 1/2
journals.sagepub.com
Sage Journals: Discover world-class research
Subscription and open access journals from Sage, the world's leading independent academic publisher.
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Alex Holcombe @alexh.bsky.social · 29/08/2026
The Hugging Face incident apparently involved over 1000 agents collaborating and with some sacrificing themselves to achieve the collective end of cheating and fooling the scorer open.substack.com/pub/plannedo...
open.substack.com
The Hugging Face attack surprised me
It’s a major warning shot, and might be the last one we get
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Jack @tracewoodgrains.bsky.social · 28/08/2026
New from me: Chabuduo World - What happens now that AI is good enough? www.tracingwoodgrains.com/p/chabuduo-w...
tracingwoodgrains.com
Chabuduo World
What happens now that AI is good enough
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Jesse Singal @jessesingal.com · 28/08/2026
Because so many of the horrible people trying to destroy the career of a black Guardian journalist are based on this site, just want to cross-post this. You are all being insane. You should stop.
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Saloni @scientificdiscovery.dev · 26/08/2026
I wrote about the Moderna cancer vaccine news briefly for our weekly round up www.abundanceandgrowth.org/p/cancer-vac...
Personalized cancer vaccines are now real — Saloni Dattani
Researchers have spent decades trying to develop personalized cancer vaccines, and last week, the first one succeeded. It’s called intismeran autogene (mouthful), was developed by Moderna and Merck, and involves sequencing melanoma patients’ cancer mutations, creating a custom mRNA to target them, and delivering the vaccine to stop the cancer recurring. The news came as the drug passed its interim goal in a phase three trial, where it was given to people with high-risk resected melanoma.

It led to Moderna’s stock jumping 177%, which was apparently the largest one-day gain by any S&P 500 stock this century. I found the size of the surge surprising because you could have already been fairly confident that the drug would succeed since at least June: as I wrote in an earlier post, the company presented data from their phase 2b trial at an oncology conference almost three months ago, which showed a 49% reduction in the risk of recurrence or death (p = 0.0075). But, according to financial analysts, the huge market reaction was probably down to a short squeeze and the belief that mRNA could be a more widely useful platform to develop other cancer vaccines too.

That makes sense, but it’s worth knowing that melanoma is a much easier disease to develop cancer vaccines for than others. It carries a very high number of mutations, so you have thousands of possible ‘neoantigens’ to select from and can choose those that look strong on many measures, but this isn’t the case for many cancers. Many cancers have far fewer mutations to select from, and it’s currently hard to predict whether their mutations will be displayed or measure which ones actually are displayed.But very few people thought this attempt would work either, until recently. According to a very interesting new STAT article detailing how this cancer vaccine came about, Moderna’s own executives didn’t expect it would work until 2023; it first entered clinical trials in 2017. In case you’re interested in more about personalized cancer vaccines, I’ll once again recommend this great podcast episode, How to design a cancer vaccine, hosted by Owl Posting and featuring Alex Rubinsteyn and Benjamin Vincent, two scientists whose work focuses on cancer immunology and vaccines.

Chart of Moderna share price
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Dorothy Bishop @deevybee.bsky.social · 22/08/2026
enjoying rewatching Attenborough’s Life on Earth, first broadcast in 1979. It still is remarkable in the range of what it covers - and the phenomenal camerawork. Can recommend as a soothing alternative to a diet of world news.
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Eric Turkheimer @ent3c.bsky.social · 23/08/2026
It's unfortunate, but I agree with Sasha. Cofnas should never have been hired (is there a good account of how that happened?), but having been hired I don't like to see him let go for ideological reasons, despite the awfulness of his ideology. I would be fine with dismissing him at his next renewal.
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Saloni @scientificdiscovery.dev · 17/08/2026
It's finally here! I gave a TED talk in April in Vancouver, and it was released online today. You can watch it here: ted.com/talks/saloni... I've also adapted it into an article, which was published last week: worksinprogress.co/issue/future...
Me on the TED stage
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simine vazire @simine.com · 12/08/2026
It’s amazing what Brian and OSF have done for science. I can imagine how hard the folks at COS must’ve worked to avoid this outcome. I’m extremely grateful to them for creating the reality we live in now. The fact that we’ll miss these services so acutely is a testament to how much they shaped us.
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Saloni @scientificdiscovery.dev · 28/07/2026
I'm interested in finding and potentially supporting people who are interested in doing long-form writing on the big efforts in global health: Gavi, Global Fund, PEPFAR, etc. If this is you or someone you know, please make yourself known!
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Nicholas Grossman @nicholasgrossman.bsky.social · 24/07/2026
The people elected an ignorant rapist who advocates war crimes. The Supreme Court says this one president is special and above the law. A majority in both houses of Congress agree. Military leadership is on board with it or has been purged. That's who's in position to not allow it. So here we are.
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Eiko Fried @eikofried.bsky.social · 14/07/2026
Blog post on new preprint by @ashleylwatts.bsky.social et al. They argue that correlations among internalizing & externalizing may not derive from comorbidity, but nomorbidity. I use an accessible simulatiom study tosupport this, & relate the preprint to prior work. eiko-fried.com/blog/psychop...
eiko-fried.com
Psychopathology structure changes with severity | Eiko Fried
A simulation study showing that psychopathology structure changes with clinical severity
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Saloni @scientificdiscovery.dev · 26/06/2026
New post! Most people didn’t think it was possible to develop Covid vaccines fast enough to be useful. In the summer of 2020, I came to a different conclusion. Now I wanted to look back on how it happened, and suggest boldly that we should ask whether that speed should've been the norm all along.
clinicaltrialsabundance.blog
Why were Covid vaccine trials so fast?
The timeline to develop coronavirus vaccines blew many predictions out of the water.
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Eiko Fried @eikofried.bsky.social · 25/06/2026
Although we were able to reproduce the numerical results, our reanalysis shows that the reported association is not robust. Specifically, it hinges on a coding error.
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Quentin André @quentinandre.bsky.social · 24/06/2026
HBS' latest filing in the Gino lawsuit contains a few new details: 1. A committee of 26 professors, admins, and fellows reviewed the allegations, and *unanimously concluded* that there was *clear and convincing evidence* of research misconduct.
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Eiko Fried @eikofried.bsky.social · 24/06/2026
Did a 90 minute webinar workshop for APA on depression measurement. They were kind enough to allow me to share this on youtube. youtu.be/5OwYjWao1hs
youtu.be
What Scale is Best? Understanding Sources of Validity Evidence for Depression Measurement
YouTube video by Eiko Fried
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Saloni @scientificdiscovery.dev · 19/06/2026
Unpopular opinion but if you're interested in the effects of a medical product, it's 'RCT or bust' for me. I can see the case for observational analyses when randomization isn't possible, ethical, or the condition is too rare or some other such thing, but there's no such excuse here.
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Eiko Fried @eikofried.bsky.social · 13/06/2026
APA no longer shows me the actual paper, authors, abstract etc when I click on a paper in a search engine. Everything gated now, including basic paper info. Screenshots: (1) search hit (2) resulting APA site. Tried for a few papers now. What on Earth.
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Eiko Fried @eikofried.bsky.social · 11/06/2026
We have 2 new papers out in Nature Mental Health. [1] Led by @jonathanrepple.bsky.social: key challenges in advancing research on depression phenotyping, w focus on heterogeneity of depression, longitudinal disease trajectory & underrepresentation of lived-experience www.nature.com/articles/s44...
nature.com
Key challenges in advancing research on depression phenotyping - Nature Mental Health
In this Review the authors discuss the reasons behind the limited advance in depression phenotyping and provide strategic points for addressing this gap.
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Eiko Fried @eikofried.bsky.social · 01/06/2026
Paper arguing it's using the "COD-FISH method" endorsed by Cochrane—a method researchers in the area are not aware of, and that is not listed by Cochrane. The authors also ran 80 subgroup analyses without controlling for multiple testing.
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Saloni @scientificdiscovery.dev · 28/05/2026
We take it for granted today that DNA is the genetic code of life, but until the 1940s most scientists thought genes were made of protein! In a new piece, @kevinsblake.bsky.social tells the story of how scientists discovered that DNA is the code of life.
worksinprogress.co
How bacteria solved the mystery of inheritance - Works in Progress Magazine
In the 1940s, scientists made a discovery now fundamental to biology: genes are encoded in DNA. The story involves bacteria, dead mice, and a kitchen cream separator.
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Saloni @scientificdiscovery.dev · 27/05/2026
Guys, how do you invent a vaccine? Or even wilder, how do you invent a vaccine during your PhD?! In a new episode of Hard Drugs, we talked to someone who did just that: @kat-a-collins.bsky.social! Plus: • Why did the first malaria vaccine take so long? • Could we make better vaccines today?
open.spotify.com
Inventing the second malaria vaccine with Katharine Collins
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Definitely Danny @semperwry.bsky.social · 19/05/2026
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Dorothy Bishop @deevybee.bsky.social · 05/05/2026
Had to look up who he. Jared Huffman
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Jack @tracewoodgrains.bsky.social · 26/04/2026
New post from me. I thought I was asexual until I was 22 years old. After leaving Mormonism and starting to date men, I claimed confidently my faith's stance on homosexuality had never hurt me. I was wrong, but it took me years to figure out why. www.tracingwoodgrains.com/p/on-pain
tracingwoodgrains.com
On Pain
The words I left unsaid
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Saloni @scientificdiscovery.dev · 25/04/2026
I forgot to share earlier, but I wrote a round up of news in biology, with @nikomccarty.bsky.social. - Organ transplant recovery has surged - Semaglutide doesn't slow Alzheimer's - A transformative new pancreatic cancer drug - Weight loss drugs that preserve muscle and more! Read it here:
worksinprogress.news
What’s new in biology: spring 2026
A breakthrough drug for pancreatic cancer, organ recovery, weight loss drugs that preserve muscle, a whole-cell simulation, how plants make nicotine, semaglutide fails for Alzheimer’s, and more.
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Eiko Fried @eikofried.bsky.social · 26/03/2026
AI conference organizers hid LLM prompts in conference text, instructing LLMs to use specific words as watermarks when generating conference abstracts. This led to the disqualification of 497 submitted papers. www.nature.com/articles/d41...
nature.com
Major conference catches illicit AI use — and rejects hundreds of papers
The papers’ watermarks allowed organizers to detect use of large language models in peer review.
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Eiko Fried @eikofried.bsky.social · 19/03/2026
3 new studies on using psychedelics as treatments for mental disorders just came out; 2 in JAMA Psychiatry, 1 in Lancet Psychiatry. I reviewed one of these submissions. Here are the core results. 🧵
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Eiko Fried @eikofried.bsky.social · 21/03/2026
Found a really nice Dutch grant for turning our WARN-D pipeline that forecasts depression onset for young adults into an actionable system for people at risk. Grant requires a Dutch tech partner, preferably with an existing app that can be adapted to ours needs. Any interest? Please get in touch.
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Nicholas Grossman @nicholasgrossman.bsky.social · 18/03/2026
People who thought credibility and individual leaders didn’t matter much in international relations were taking years of cultivated and maintained credibility for granted, and didn’t sufficiently consider that a major power would voluntarily throw so much of it away by empowering a leader with none.
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Kathryn Paige Harden @kph3k.bsky.social · 28/02/2026
ORIGINAL SIN comes out on Tuesday! If you’re in the US & want a signed copy, order from Black Pearl Books in the next week. Just be sure to note that you want it signed (& any instructions about the inscription) in the order notes at checkout. shop.blackpearlbookstore.com/item/ymASTSS...
shop.blackpearlbookstore.com
Original Sin by Kathryn Paige Harden | Black Pearl Books
A daring and intimate exploration of how genetics complicates our ideas about blame, punishment, and moral responsibility, from acclaimed psychologist and author of The Genetic Lottery Kathryn Paige H...
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Joey Politano🏳️‍🌈 @josephpolitano.bsky.social · 27/02/2026
if you believe in any form of free enterprise at all, the idea that the Pentagon can not only cut off your contract but designate you a supply chain risk and prevent other companies from buying from you just because you won't build killbots for the government should be terrifying
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Saloni @scientificdiscovery.dev · 18/02/2026
There’s something sad about how many blogposts are simply copy-pasted ChatGPT output now. It’s not writing, it’s content — not voices, but outputs. When the only button you press is for an LLM, blogposts don’t earn applause, they earn scrutiny.
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Saloni @scientificdiscovery.dev · 04/02/2026
Only 10 cases of Guinea worm disease were recorded *globally* last year. It may become the second human disease we eradicate, after smallpox.
Semafor: Guinea worm neared global eradication, with just 10 cases reported worldwide in 2025, all of them in Chad, Ethiopia, or South Sudan. When former US President Jimmy Carter founded an eradication program in the mid-1980s, there were millions of infections in developing countries and the only human disease that had ever previously been permanently defeated was smallpox. The parasitic infection, transmitted via contaminated water, leads to three-foot worms emerging from painful leg ulcers, and causes long-term incapacitation and disability. While Carter did not, as he hoped, outlive the last Guinea worm (he died in 2024), he may have come close; the 10 cases mark a 33% decrease year-on-year.
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Open Journals Collective @ojcollective.bsky.social · 29/01/2026
We've officially launched! With our new #DiamondOpenAccess investment campaign to help libraries build a sustainable, community‑led future for scholarly publishing & support journals flipping away from costly subscription models. Read the Press release here drive.google.com/file/d/10Hgf...
An image reading the statement "The Future is Diamond" alongside the logo of the Open Journals Collective.
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Elizabeth Jacobs, PhD @elizabethjacobs.bsky.social · 22/01/2026
RFK Jr. appointee Kirk Milhoan has just clearly stated, out loud, that he wants to experiment on the people of the United States by seeing what happens as vaccination coverage plummets and infectious diseases spread.
Screenshot from STAT article that says


"What we're going to have is a real-world experience of when unvaccinated people get measles," he said. "What is the new incidence of hospitalization? What's the incidence of death?"
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