AbstractRationale. Hyponatremia is the most common electrolyte disorder found in hospitalized patients and is associated with an increased mortality. Urea

In randomized trials, finerenone, a nonsteroidal mineralocorticoid receptor antagonist, improved kidney and cardiovascular outcomes in patients with type 2 diabetes and chronic kidney disease (CKD)...

BACKGROUND: This secondary analysis of the CONFIDENCE (combination effect of fInerenone and empagliflozin in participants with chronic kidney disease and type 2 diabetes using a UACR endpoint) trial…

European regulators are also conducting a review of avacopan. The issue appears to involve data from the pivotal ADVOCATE trial and questions of liver safety.

Our beautiful baby has grown into a moody, hormonal teen.  That’s right, it’s year 14 of NephMadness!  Whether this is your first time or you are a seasoned veteran, we have all the inf…

FF 87 Can Fish Oil Knock the Crap out of Dialysis Associated CV Disease?

Day 3 of Kidney Week. Sibeprenlimab and Balcinrenone on NEJM and Lancet, plus a couple of other non-kidneywk studies.

Nature Reviews Nephrology, Published online: 23 September 2025; doi:10.1038/s41581-025-01006-4This Review provides a guide to metabolite retention in kidney disease and includes an overview of key uraemic toxins and the complex mechanisms underlying their toxicity, as well as a discussion of key strategies with the potential to prevent or mitigate their adverse effects.

This week, we will discuss the phosphate targets in dialysis. Are you aiming for HIgh or Low?

Limited evidence exists to support the simultaneous initiation of sodium–glucose cotransporter-2 inhibitors and finerenone, a nonsteroidal mineralocorticoid receptor antagonist, in persons with chr...

Submit your picks! |  @NephMadness |@nephmadness.bsky.social | NephMadness 2025 Over the next couple of weeks, NephMadness 2025 will be popping up on some great podcasts.  Keep your eyes and ears o…

ertain extent by systemic inflammatory toxicities affecting directly or indirectly the kidney. In the case of ICIs severe acute interstitial nephritis is the main adverse event and can lead to permane...