ABSTRACTBackground. During the progression of immunoglobulin A nephropathy (IgAN), residual nephrons compensate for nephron loss by increasing single-nephr

ABSTRACTBackground and hypothesis. IgA nephropathy (IgAN) is the leading cause of primary glomerulonephritis; however, reported incidences and prevalences

ABSTRACTBackground. Finerenone has been proven to have cardiovascular and renal protective effects on chronic kidney disease associated with type 2 diabete

ABSTRACTBackground. Glomerular hyperfiltration is common in type 2 diabetes (T2D) and may reflect reduced nephron number and/or perturbed intrarenal hemody

ABSTRACTBackground. Obesity-associated nephropathy is becoming increasingly prevalent, yet the molecular mechanisms linking metabolic stress to renal dysfu

ABSTRACTBackground. The cardiovascular and renal benefits of sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonis

ABSTRACT. The 2026 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for Anemia in Chronic Kidney Disease represents a substant

To the Editor,

To the Editor,

To the Editor,

ABSTRACTBackground. Sodium–glucose co-transporter 2 inhibitors (SGLT2is) are emerging as an essential part of the standard of care for proteinuria in patie

ABSTRACTBackground and hypothesis. The complement system contributes to the progression of immunoglobulin A nephropathy (IgAN) and offers promising therape

ABSTRACTBackground. Despite treatment advances, there are limited data on the development of chronic kidney disease (CKD) in patients with lupus nephritis

ABSTRACTBackground and hypothesis. Defective hepatic alanine-glyoxylate aminotransferase (AGT) leads to oxalate overproduction in primary hyperoxaluria typ

ABSTRACTBackground. Ferroptosis is a key mechanism of tubular cell death in acute kidney injury (AKI), particularly in folic acid– and glycerol-induced mod

ABSTRACTBackground. Several studies have demonstrated the utility of urinary sediment (U-sed) examination in patients with glomerular diseases (GDs).In thi

ABSTRACTBackground. Children and young adults with nephrotic syndrome are commonly treated with steroid-sparing immunosuppressive medications. Rituximab is

ABSTRACTBackground. To investigate the efficacy and safety of telitacicept in adult immunoglobulin A vasculitis nephritis (IgAVN) patients with persistent

ABSTRACT. In 2025, the World Health Assembly of the World Health Organization (WHO) adopted a resolution on reducing the burden of noncommunicable diseases

To the Editor,

ABSTRACTBackground. Up to 20% of patients with antineutrophil cytoplasmic antibody–associated vasculitis (AAV) and kidney involvement progress to end-stage

ABSTRACTBackground and hypothesis. Glucagon-like peptide-1 receptor agonists (GLP1-RAs) are anti-hyperglycaemic agents, with cardioprotective effects, howe

ABSTRACTBackground and hypothesis. Strongyloides stercoralis is a neglected parasitic infection endemic to tropical regions, with rising prevalence in Euro

ABSTRACTBackground. Acute kidney injury (AKI) is a known immune-related adverse event of cancer immune checkpoint inhibitor (ICI) therapy. Further populati

ABSTRACT. Acute kidney injury (AKI) is a serious and common complication among patients undergoing major surgery. The underlying pathophysiologic mechanism

ABSTRACT. Despite advancements in obstetric care, pregnancy-associated acute kidney injury (PrAKI) continues to be a significant public health concern, con

ABSTRACT. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are incretin-based therapies with demonstrated efficacy in glycaemic control, weight reducti

ABSTRACT. Chronic kidney disease (CKD) affects >10% of the global adult population and is associated with substantial cardiovascular morbidity and morta

For many years and despite the best efforts of the community in optimizing dialysis adequacy, fluid management, blood pressure, anemia, and bone mineral di

The global adoption of sodium-glucose cotransporter 2 inhibitors (SGLT2i) as a novel kidney protective therapy that ameliorates glomerular hyperfiltration

ABSTRACT. Over the last 13 years, the use of immune checkpoint inhibitor (ICI) therapy has grown remarkably, owing to their unprecedented anti-tumor effica

ABSTRACT. The incidence and prevalence of atrial fibrillation (AF) in patients affected by kidney failure, i.e. glomerular filtration rate <15 ml/min/1.

ABSTRACT. Hyperkalemia is a common electrolyte disturbance in both inpatient and outpatient clinical practice. The severity and associated risk depends on

ABSTRACT. Anaemia is one of the most common complications of chronic kidney disease (CKD), having a significant impact on quality of life, and is also asso

ABSTRACT. Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are characterized by small-vessel necrotizing inflammation, and prior t

ABSTRACT. Among the broad spectrum of membranoproliferative glomerulonephritis (MPGN), immunofluorescence distinguishes C3 glomerulopathy (C3G), with predo

ABSTRACT. Immunoglobulin A nephropathy (IgAN) is the most common primary form of glomerular disease worldwide and carries a high lifetime risk of kidney fa

ABSTRACT. Sepsis is a host's deleterious response to infection, which could lead to life-threatening organ dysfunction. Sepsis-associated acute kidney inju

ABSTRACT. Hypertension is very common and remains often poorly controlled in patients with chronic kidney disease (CKD). Accurate blood pressure (BP) measu

ABSTRACT. The kidney is poised to defend against development of metabolic alkalosis through non-adaptive mechanisms in the proximal nephron and adaptive pr

ABSTRACT. Amyloidosis is a group of complex diseases caused by the misfolding and aggregation of proteins into amyloid fibrils. Light-chain (AL) amyloidosi

ABSTRACT. BK polyomavirus (BKPyV) is recognized as a significant viral complication of kidney transplantation. Prompt immunosuppression reduction reduces e

ABSTRACT. Antibody-mediated rejection (AMR) remains a major cause of graft failure, with significant health and economic burden. Despite being recognized &

ABSTRACT. The number of older people with chronic kidney disease (CKD) is increasing globally. The vast majority of these patients will die before they eve

ABSTRACT. Acute post-streptococcal glomerulonephritis (APSGN) is the leading cause of acute glomerulonephritis in children worldwide, owing to the high inc

ABSTRACT. Hemodialysis removes uremic toxins and excess water and sodium from the blood of patients with kidney failure. For the last 60 years, this techni