imageimageCertain E3 ligases have been found to ubiquitylate hydroxyl groups on free NAD+ and ADP-ribose in vitro, but the in vivo occurrence of this dual post-translational modification has remained ...

Cytoplasmic K63-linked polyubiquitin signals have well-established roles in endocytosis and selective autophagy. However, how these signals help to direct different cargos to different intracellular t...

In this Review, the authors highlight cancer cachexia as a complex and multifactorial disorder, and discuss the underlying host-driven and tumour-driven metabolic changes, therapeutic opportunities an...

imageimageUpon activation, STING traffics to the Golgi and induces NF-κB signaling through poorly understood mechanisms. This study shows that E3 ligase HOIP recruitment to STING-positive Golgi-relate...

imageimageDual regulation of Cell Death Receptor CD95 signalling by ER stress sensor IRE1. IRE1, a mediator of the unfolded protein response (UPR), governs CD95/Fas expression and CD95L-induced cell d...

Nature Communications - Dysregulation of the TNF receptor signaling complex (TNF-RSC) promotes the onset of autoinflammatory conditions. Here the authors show that two adapter proteins, TANK and...