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Philipp Niethammer

@niethammerlab.bsky.social
543 followers 466 following 290 posts

Cell biologist interested in how tissues sense and adapt to physical and chemical stress. Wound healing and regeneration. Quantitative imaging approaches. Nuclear mechanotransduction, ROS signaling & metabolism. All opinions are my own.

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Philipp Niethammer @niethammerlab.bsky.social · 1h
To all hardworking scientists, by way of Hilde Domin: “Not grow weary instead, to the wonder quietly as if to a bird hold out your hand.”
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Philipp Niethammer @niethammerlab.bsky.social · 09/10/2026
Altogether, our work is a testimony to the unique evolutionary strengths of the zebrafish model system that reach beyond technical convenience such as ease of in vivo imaging.
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Philipp Niethammer @niethammerlab.bsky.social · 07/10/2026
And here the discovery story by Ian Demsky 🙏🙏🙏 www.mskcc.org/news/of-mice...
mskcc.org
Of Mice and Zebrafish: How MSK Scientists Solved a Decades-Old Mystery and Uncovered New Insights About Inflammation | Memorial Sloan Kettering Cancer Center
A team of MSK researchers solved a decades-old scientific puzzle and revealed that a critical inflammatory signaling pathway doesn’t just summon immune cells to the place where they’re needed — it als...
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Philipp Niethammer @niethammerlab.bsky.social · 07/10/2026
How do cells sense tissue damage - and help their neighbors withstand it? Our new paper on the redox-sensitive 5-oxoETE lipid pathway shines light on this question. A huge THANK-YOU to all the colleagues and funding bodies that made this work possible! www.nature.com/articles/s41...
nature.com
5-oxoETE links redox control of epithelial damage detection and resilience - Nature
The DHRS7–OXER1 pathway links oxidative stress to immunity and tissue resilience by modulating 5-oxoETE via NADP+–NADPH, activating OXER1 to recruit antimicrobial cells and induce NUDIX enzymes t...
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Philipp Niethammer @niethammerlab.bsky.social · 05/10/2026
👉Two fascinating, conceptually intertwined stories from my lab will finally be published this Wednesday. MASSIVE KUDOS to the two fearless postdoctoral scholars, Yanan Ma and Miklos Lengyel, whose ingenuity, resilience, and team spirit made all of this possible! A little reminder:👇🧵
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Philipp Niethammer @niethammerlab.bsky.social · 28/09/2026
👉 The Niethammer lab has two postdoctoral openings. We’re looking for researchers interested in how organelle mechanotransduction and redox signaling shape early responses to tissue injury. If interested, please reach out to me with a CV and letter of intent written in your own words (🚫 AI).
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Zebrafish Rock! 🎃 @zebrafishrock.bsky.social · 27/09/2026
Electrochemical response triggers organ growth, following tail injury in a #zebrafish embryo. Credit to @ritamateus.bsky.social, @nerlielisa.bsky.social, & @liujinghui.bsky.social. #ZebrafishZunday
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Jorge Ferreira @jorgeferreira.bsky.social · 25/09/2026
Don´t know yet what you´ll be doing next April? Why not join us for a great meeting in Porto? Registration for Forces across scales is now open! meetings.embo.org/event/27-for...
meetings.embo.org
Forces across scales
This EMBO Workshop on Forces Across Scales will provide an integrative perspective on mechanobiology, a rapidly advancing field that examines how mechanical forces shape biological systems across mol…
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Philipp Niethammer @niethammerlab.bsky.social · 20/09/2026
Yeah, pretty and faithful must not be the same, sometimes the opposite. Faithful abstraction is the high skill. For me, drawing is just a pleasant, meditative activity. Because my drawing skills are very limited, I typically enjoy the process more than the result🙂.
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Philipp Niethammer @niethammerlab.bsky.social · 20/09/2026
Drawing by hand is not just a nostalgic/cute way to generate visuals. A good scientific drawing generates a faithful model of reality through careful observation and humble craftsmanship - it epitomizes good science.
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Philipp Niethammer @niethammerlab.bsky.social · 18/09/2026
sOrganellomics
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Philipp Niethammer @niethammerlab.bsky.social · 17/09/2026
Once in a while a student like Zaza comes along - so unafraid, and with so much skill, determination and pure, contagious joy for science and discovery, you remember that you also picked the job for meeting just such people. www.mskcc.org/news/2026-gs...
mskcc.org
2026 GSK Chairman’s Prize Recognizes Research on How Cells Sense Injury | Memorial Sloan Kettering Cancer Center
This year's GSK Chairman’s Prize was awarded to Zaza Gelashvili for his research on how cells sense injury.
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Philipp Niethammer @niethammerlab.bsky.social · 20/08/2026
👉1/3 We are looking for a research technician to join our lab at Sloan Kettering Institute in New York City. This is an ideal position for a recent college graduate (e.g., from the NYC area) interested in basic biology and gaining hands-on research experience before graduate or medical school.
https://www.mskcc.org/research/ski/labs/philipp-niethammer
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Philipp Niethammer @niethammerlab.bsky.social · 09/09/2026
Join us at the Gerstner Sloan Kettering Graduate School in one of the great cities of the world! www.sloankettering.edu/gerstner/wel...
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c0nc0rdance @c0nc0rdance.bsky.social · 07/09/2026
When threatened, a pufferfish fills its stomach with water (or air), reaching 3-4X their original size. That requires specialized adaptations. What you see below are the caltrop-shaped spines that change configuration with expanding skin. But these aren't the /bones/ of the fish. They're scales.
Deflated and inflated dermal scales in one of those fake taxidermy kits, showing the weird beak of the animal, big eye sockets, and lots of little caltrop spines that appear to intercalate together, then expand out.
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Philipp Niethammer @niethammerlab.bsky.social · 06/09/2026
human failure
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Philipp Niethammer @niethammerlab.bsky.social · 06/09/2026
The past merging with the future. en.wikipedia.org/wiki/Idiocracy
en.wikipedia.org
Idiocracy - Wikipedia
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Philipp Niethammer @niethammerlab.bsky.social · 15/03/2025
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Philipp Niethammer @niethammerlab.bsky.social · 04/09/2026
Adaptive motility enables neutrophils to rapidly navigate confined capillaries | Science Immunology www.science.org/doi/10.1126/...
science.org
Adaptive motility enables neutrophils to rapidly navigate confined capillaries
Neutrophils maintain migration speed in confined capillaries through adaptive actomyosin remodeling.
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Philipp Niethammer @niethammerlab.bsky.social · 31/08/2026
The strongest "methods" of philosophy are those that throw you out of cozy "sureness" and the "well established". If you let this happen, you start philosophizing. No academic titles needed.
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Philipp Niethammer @niethammerlab.bsky.social · 30/08/2026
The question what philosophy is, and how you “do” it is one of the oldest in philosophy. it is neither resolved or “sure”, and there are different opinions that are neither “sure” but depend on certain schools or individuals. I was assuming you know that as a philosophy professor.
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Philipp Niethammer @niethammerlab.bsky.social · 30/08/2026
“If you are …. just being a facetious, condescending dick," is this suggestiveness part of your philosophical method of argumentation? Do you think this encourages engagement? I rather leave this type of argument to you. i am sure you will have lot of fans on social media.
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Philipp Niethammer @niethammerlab.bsky.social · 29/08/2026
Serious question: how do you “do” philosophy?
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David Tobin @tobinlab.bsky.social · 28/08/2026
New facets of eicosanoid signaling in TB: crosstalk with a specialized population of granuloma-associated fibroblasts. Happy to share new work led by Erika Hughes, with @charliejpyle.bsky.social and many other wonderful collaborators not on BlueSky.
cell.com
Host eicosanoid signals define a granuloma fibroblast population that coordinates mycobacterial containment
Hughes et al. find that the TB susceptibility gene lta4h contributes to the recruitment and differentiation of a discrete set of fibroblasts that populate the periphery of mycobacterial granulomas in ...
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Philipp Niethammer @niethammerlab.bsky.social · 27/08/2026
Yes, and they disagree all the time ☺️
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Philipp Niethammer @niethammerlab.bsky.social · 27/08/2026
Philosophy is not about being "sure", it is exactly about the opposite 😜.
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Laura Bianchi @laurafbianchi.bsky.social · 27/08/2026
Ever wondered how epithelial cells clear apoptotic cells while maintaining tissue cohesion?🍝🔗 Check our new paper in which we show that E-cadherin plays a dual role in regulating basal cortex dynamics upon phagocytosis while maintaining connected tissue organization www.nature.com/articles/s41...
nature.com
De novo E-cadherin/catenin complex formation controls basal epithelial mechanics and force transmission for apoptotic cell clearance - Nature Communications
Epithelial cells remodel their shape during phagocytosis while preserving tissue cohesion. Here, authors show that the E-cadherin/catenin adhesion complex is repurposed at phagocytic contacts, where i...
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Jan Lammerding - Lab @lammerdinglab.bsky.social · 26/08/2026
Interested in nuclear mechanobiology and want to know what some of the big open questions are in the field? Read our recent editorial with input from >15 leading experts in the field, along with a list of review articles on nuclear mechanobiology: www.tandfonline.com/doi/full/10....
tandfonline.com
Nuclear mechanobiology: a brief history and five unresolved questions
Published in Nucleus (Vol. 17, No. 1, 2026)
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Philipp Niethammer @niethammerlab.bsky.social · 23/08/2026
The MPI-CBG in Dresden seems different- why was it never replicated?
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Philipp Niethammer @niethammerlab.bsky.social · 20/08/2026
3/3 Applicants should be curious, reliable, fit into the team, and able to commit for at least two years. Some previous biology lab experience is helpful. Please contact me directly with your CV for more job details. Reposts are appreciated!
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Philipp Niethammer @niethammerlab.bsky.social · 20/08/2026
2/3 Our lab studies how cells sense physical stress and tissue injury—and how they communicate with immune cells to coordinate healing. We investigate these questions using zebrafish, human cells, microscopy, genetics, and molecular biology.
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Philipp Niethammer @niethammerlab.bsky.social · 20/08/2026
👉1/3 We are looking for a research technician to join our lab at Sloan Kettering Institute in New York City. This is an ideal position for a recent college graduate (e.g., from the NYC area) interested in basic biology and gaining hands-on research experience before graduate or medical school.
https://www.mskcc.org/research/ski/labs/philipp-niethammer
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Stella Hurtley @smhsci.bsky.social · 12/08/2026
Last week in @science.org A molecular switch for coordinating kinesin and dynein transport of mitochondrial cargo | Science www.science.org/doi/10.1126/...
science.org
A molecular switch for coordinating kinesin and dynein transport of mitochondrial cargo
The cellular distribution of mitochondria in response to stress and local energy needs is governed by the relative activities of the microtubule-based molecular motors kinesin and dynein. The mechanis...
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Philipp Niethammer @niethammerlab.bsky.social · 06/08/2026
H2O2 gradients, osmotic surveillance, nuclear membrane mechanotransduction & all the crucial, consolidating steps in-between. Now: metabolic redox signaling. A 15-year arc with lots of 🍾. When one chapter ends, a new one shall start. We are all ready for new sights! 🌅
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Philipp Niethammer @niethammerlab.bsky.social · 05/08/2026
A 15-year history of my lab in signed champagne bottles. We always find some reason to celebrate: papers, fellowships, prizes - 🙏 to all the good people in the lab. Yet we have never opened the BIG bottle - now it's time 😅. Hope it fits on the shelf.
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Philipp Niethammer @niethammerlab.bsky.social · 05/08/2026
Very interesting work! www.nature.com/articles/s41...
nature.com
Screening of amphipathic helices identifies features linked to inner nuclear membrane properties - Nature Communications
The properties of the nuclear envelope and mechanisms of peripheral protein association are poorly understood. Here, authors show sensing lipid packing defects and a minor electrostatic contribution g...
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Philipp Niethammer @niethammerlab.bsky.social · 04/08/2026
I just updated LCS turbo adding a compatible Connector app at Zenodo. The Connector connects logical or marker/scRNAseq clusters across different experiments/data sources into Cytoscape compatible enrichment networks. Hope it is useful - I count downloads as ❤️. zenodo.org/records/2064...
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Philipp Niethammer @niethammerlab.bsky.social · 21/07/2026
Independent thinkers are rare, technically adept followers are plenty. Understanding/questioning what is closest to us -current concepts, life, reality, ourselves, etc- is the most difficult thing. It has never been different. No wonder that many people prefer to 👉 „shut up and calculate“ 😉
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Philipp Niethammer @niethammerlab.bsky.social · 11/07/2026
EZM2026 setting a very high bar for future social events 🍾🥂
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Philipp Niethammer @niethammerlab.bsky.social · 10/07/2026
My favorite summer tune!
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Cell Biology J-Club @cellclub.bsky.social · 06/07/2026
www.nature.com/articles/s41...
nature.com
CD44 restricts EGFR mobility to polarize cytoskeletal signalling modules driving bleb-based migration - Nature Cell Biology
Jha et al. show that the transmembrane protein CD44 restricts EGFR mobility to maintain an EGFR–PI3K–Rac gradient during bleb-based cell migration.
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Philipp Niethammer @niethammerlab.bsky.social · 05/07/2026
gut.bmj.com/content/earl...
gut.bmj.com
Pancreatic cancer fibrosis activates protumorigenic Schwann cells through a nuclear mechanosensing mechanism
Background Fibrosis and tumour innervation are two features of the tumour microenvironment (TME) that contribute directly to the lethality of pancreatic ductal adenocarcinoma (PDAC), but their potenti...
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Philipp Niethammer @niethammerlab.bsky.social · 02/07/2026
Next week - looking forward to see you there! www.ezm2026.org
ezm2026.org
European Zebrafish Meeting 2026 - July 7-11, 2026 - Vienna
Create a professional science website with Avada. Showcase research, highlight discoveries, and engage your audience with custom, informative designs.
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Phil Abitua @ohnolog.bsky.social · 30/06/2026
So proud of @sydsat.bsky.social, the lab’s first graduate student, for leading this work! Special thanks to the Searle Scholars Program and the Royalty Research Fund for making it possible. Check out the preprint here: www.biorxiv.org/content/10.6...
biorxiv.org
Early immune cell development precedes gastrulation in annual killifish
During embryogenesis, cell types arise in a predictable order because developmental regulators act sequentially. But how evolutionary changes in morphogenesis reshape the signaling environments that a...
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Journal of Cell Science @jcellsci.bsky.social · 01/07/2026
Our Special Issue: Cell Biology of the Nucleus is complete Explore our Toc: journals.biologists.com/jcs/issue/13... Our cover image shows the posteriorly positioned nuclei (Nup50-mCherry - pink) of notochord cells in Ciona embryos. See article by Peng et al. journals.biologists.com/jcs/article/...
JCS Cover: Posterior nucleus positioning in Ciona notochord cells. Co-expression of hCD4–eGFP (green, cell boundary) and Nup50–mCherry (pink, nuclei) in notochord cells in Ciona embryos. The cells and the nuclei are 3D reconstructed and highlighted by Imaris software. See article by H. Peng et al. (jcs264699).

Special Issue on Cell Biology of the Nucleus 
Guest Editor: Abby Buchwalter
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Philipp Niethammer @niethammerlab.bsky.social · 30/06/2026
Generating new pests by fighting pests. Brilliant idea, always works 👍as nature teaches us: "From effective biocontrol agent to successful invader: the harlequin ladybird (Harmonia axyridis) as an example of good ideas that could go wrong"
peerj.com
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Philipp Niethammer @niethammerlab.bsky.social · 30/06/2026
We will have to get familiar with these type of legal texts. At least in Europe, there are some regulations: eur-lex.europa.eu/eli/dir/2019...
eur-lex.europa.eu
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Philipp Niethammer @niethammerlab.bsky.social · 29/06/2026
What would be a license that precludes this type of usage?
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Philipp Niethammer @niethammerlab.bsky.social · 29/06/2026
We have posted there too. But I am not sure about their AI/bot security measures. This type of exploit seems to be quite new, and will only get worse in the future. Preprint servers, preferably the big ones, need to act now.
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Philipp Niethammer @niethammerlab.bsky.social · 29/06/2026
Whatever works!
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