Philipp Niethammer @niethammerlab.bsky.social · 1hTo all hardworking scientists, by way of Hilde Domin: “Not grow weary instead, to the wonder quietly as if to a bird hold out your hand.” 000
Philipp Niethammer @niethammerlab.bsky.social · 09/10/2026Altogether, our work is a testimony to the unique evolutionary strengths of the zebrafish model system that reach beyond technical convenience such as ease of in vivo imaging. 010
Philipp Niethammer @niethammerlab.bsky.social · 07/10/2026And here the discovery story by Ian Demsky 🙏🙏🙏 www.mskcc.org/news/of-mice...mskcc.orgOf Mice and Zebrafish: How MSK Scientists Solved a Decades-Old Mystery and Uncovered New Insights About Inflammation | Memorial Sloan Kettering Cancer CenterA team of MSK researchers solved a decades-old scientific puzzle and revealed that a critical inflammatory signaling pathway doesn’t just summon immune cells to the place where they’re needed — it als... 110
Philipp Niethammer @niethammerlab.bsky.social · 07/10/2026How do cells sense tissue damage - and help their neighbors withstand it? Our new paper on the redox-sensitive 5-oxoETE lipid pathway shines light on this question. A huge THANK-YOU to all the colleagues and funding bodies that made this work possible! www.nature.com/articles/s41...nature.com5-oxoETE links redox control of epithelial damage detection and resilience - NatureThe DHRS7–OXER1 pathway links oxidative stress to immunity and tissue resilience by modulating 5-oxoETE via NADP+–NADPH, activating OXER1 to recruit antimicrobial cells and induce NUDIX enzymes t... 1319
Philipp Niethammer @niethammerlab.bsky.social · 05/10/2026👉Two fascinating, conceptually intertwined stories from my lab will finally be published this Wednesday. MASSIVE KUDOS to the two fearless postdoctoral scholars, Yanan Ma and Miklos Lengyel, whose ingenuity, resilience, and team spirit made all of this possible! A little reminder:👇🧵 030
Philipp Niethammer @niethammerlab.bsky.social · 28/09/2026👉 The Niethammer lab has two postdoctoral openings. We’re looking for researchers interested in how organelle mechanotransduction and redox signaling shape early responses to tissue injury. If interested, please reach out to me with a CV and letter of intent written in your own words (🚫 AI). 034
Reposted by Philipp NiethammerZebrafish Rock! 🎃 @zebrafishrock.bsky.social · 27/09/2026Electrochemical response triggers organ growth, following tail injury in a #zebrafish embryo. Credit to @ritamateus.bsky.social, @nerlielisa.bsky.social, & @liujinghui.bsky.social. #ZebrafishZunday 18419
Reposted by Philipp NiethammerJorge Ferreira @jorgeferreira.bsky.social · 25/09/2026Don´t know yet what you´ll be doing next April? Why not join us for a great meeting in Porto? Registration for Forces across scales is now open! meetings.embo.org/event/27-for...meetings.embo.orgForces across scalesThis EMBO Workshop on Forces Across Scales will provide an integrative perspective on mechanobiology, a rapidly advancing field that examines how mechanical forces shape biological systems across mol… 01921
Philipp Niethammer @niethammerlab.bsky.social · 20/09/2026Yeah, pretty and faithful must not be the same, sometimes the opposite. Faithful abstraction is the high skill. For me, drawing is just a pleasant, meditative activity. Because my drawing skills are very limited, I typically enjoy the process more than the result🙂. 010
Philipp Niethammer @niethammerlab.bsky.social · 20/09/2026Drawing by hand is not just a nostalgic/cute way to generate visuals. A good scientific drawing generates a faithful model of reality through careful observation and humble craftsmanship - it epitomizes good science. 110
Philipp Niethammer @niethammerlab.bsky.social · 17/09/2026Once in a while a student like Zaza comes along - so unafraid, and with so much skill, determination and pure, contagious joy for science and discovery, you remember that you also picked the job for meeting just such people. www.mskcc.org/news/2026-gs...mskcc.org2026 GSK Chairman’s Prize Recognizes Research on How Cells Sense Injury | Memorial Sloan Kettering Cancer CenterThis year's GSK Chairman’s Prize was awarded to Zaza Gelashvili for his research on how cells sense injury. 060
Reposted by Philipp NiethammerPhilipp Niethammer @niethammerlab.bsky.social · 20/08/2026👉1/3 We are looking for a research technician to join our lab at Sloan Kettering Institute in New York City. This is an ideal position for a recent college graduate (e.g., from the NYC area) interested in basic biology and gaining hands-on research experience before graduate or medical school. 167
Philipp Niethammer @niethammerlab.bsky.social · 09/09/2026Join us at the Gerstner Sloan Kettering Graduate School in one of the great cities of the world! www.sloankettering.edu/gerstner/wel... 000
Reposted by Philipp Niethammerc0nc0rdance @c0nc0rdance.bsky.social · 07/09/2026When threatened, a pufferfish fills its stomach with water (or air), reaching 3-4X their original size. That requires specialized adaptations. What you see below are the caltrop-shaped spines that change configuration with expanding skin. But these aren't the /bones/ of the fish. They're scales. 11169
Philipp Niethammer @niethammerlab.bsky.social · 06/09/2026The past merging with the future. en.wikipedia.org/wiki/Idiocracyen.wikipedia.orgIdiocracy - Wikipedia 000
Philipp Niethammer @niethammerlab.bsky.social · 04/09/2026Adaptive motility enables neutrophils to rapidly navigate confined capillaries | Science Immunology www.science.org/doi/10.1126/...science.orgAdaptive motility enables neutrophils to rapidly navigate confined capillariesNeutrophils maintain migration speed in confined capillaries through adaptive actomyosin remodeling. 0177
Philipp Niethammer @niethammerlab.bsky.social · 31/08/2026The strongest "methods" of philosophy are those that throw you out of cozy "sureness" and the "well established". If you let this happen, you start philosophizing. No academic titles needed. 020
Philipp Niethammer @niethammerlab.bsky.social · 30/08/2026The question what philosophy is, and how you “do” it is one of the oldest in philosophy. it is neither resolved or “sure”, and there are different opinions that are neither “sure” but depend on certain schools or individuals. I was assuming you know that as a philosophy professor. 000
Philipp Niethammer @niethammerlab.bsky.social · 30/08/2026“If you are …. just being a facetious, condescending dick," is this suggestiveness part of your philosophical method of argumentation? Do you think this encourages engagement? I rather leave this type of argument to you. i am sure you will have lot of fans on social media. 110
Philipp Niethammer @niethammerlab.bsky.social · 29/08/2026Serious question: how do you “do” philosophy? 100
Reposted by Philipp NiethammerDavid Tobin @tobinlab.bsky.social · 28/08/2026New facets of eicosanoid signaling in TB: crosstalk with a specialized population of granuloma-associated fibroblasts. Happy to share new work led by Erika Hughes, with @charliejpyle.bsky.social and many other wonderful collaborators not on BlueSky.cell.comHost eicosanoid signals define a granuloma fibroblast population that coordinates mycobacterial containmentHughes et al. find that the TB susceptibility gene lta4h contributes to the recruitment and differentiation of a discrete set of fibroblasts that populate the periphery of mycobacterial granulomas in ... 3177
Philipp Niethammer @niethammerlab.bsky.social · 27/08/2026Philosophy is not about being "sure", it is exactly about the opposite 😜. 200
Reposted by Philipp NiethammerLaura Bianchi @laurafbianchi.bsky.social · 27/08/2026Ever wondered how epithelial cells clear apoptotic cells while maintaining tissue cohesion?🍝🔗 Check our new paper in which we show that E-cadherin plays a dual role in regulating basal cortex dynamics upon phagocytosis while maintaining connected tissue organization www.nature.com/articles/s41...nature.comDe novo E-cadherin/catenin complex formation controls basal epithelial mechanics and force transmission for apoptotic cell clearance - Nature CommunicationsEpithelial cells remodel their shape during phagocytosis while preserving tissue cohesion. Here, authors show that the E-cadherin/catenin adhesion complex is repurposed at phagocytic contacts, where i... 35019
Reposted by Philipp NiethammerJan Lammerding - Lab @lammerdinglab.bsky.social · 26/08/2026Interested in nuclear mechanobiology and want to know what some of the big open questions are in the field? Read our recent editorial with input from >15 leading experts in the field, along with a list of review articles on nuclear mechanobiology: www.tandfonline.com/doi/full/10....tandfonline.comNuclear mechanobiology: a brief history and five unresolved questionsPublished in Nucleus (Vol. 17, No. 1, 2026) 13120
Philipp Niethammer @niethammerlab.bsky.social · 23/08/2026The MPI-CBG in Dresden seems different- why was it never replicated? 110
Philipp Niethammer @niethammerlab.bsky.social · 20/08/20263/3 Applicants should be curious, reliable, fit into the team, and able to commit for at least two years. Some previous biology lab experience is helpful. Please contact me directly with your CV for more job details. Reposts are appreciated! 020
Philipp Niethammer @niethammerlab.bsky.social · 20/08/20262/3 Our lab studies how cells sense physical stress and tissue injury—and how they communicate with immune cells to coordinate healing. We investigate these questions using zebrafish, human cells, microscopy, genetics, and molecular biology. 120
Philipp Niethammer @niethammerlab.bsky.social · 20/08/2026👉1/3 We are looking for a research technician to join our lab at Sloan Kettering Institute in New York City. This is an ideal position for a recent college graduate (e.g., from the NYC area) interested in basic biology and gaining hands-on research experience before graduate or medical school. 167
Reposted by Philipp NiethammerStella Hurtley @smhsci.bsky.social · 12/08/2026Last week in @science.org A molecular switch for coordinating kinesin and dynein transport of mitochondrial cargo | Science www.science.org/doi/10.1126/...science.orgA molecular switch for coordinating kinesin and dynein transport of mitochondrial cargoThe cellular distribution of mitochondria in response to stress and local energy needs is governed by the relative activities of the microtubule-based molecular motors kinesin and dynein. The mechanis... 03010
Philipp Niethammer @niethammerlab.bsky.social · 06/08/2026H2O2 gradients, osmotic surveillance, nuclear membrane mechanotransduction & all the crucial, consolidating steps in-between. Now: metabolic redox signaling. A 15-year arc with lots of 🍾. When one chapter ends, a new one shall start. We are all ready for new sights! 🌅 020
Philipp Niethammer @niethammerlab.bsky.social · 05/08/2026A 15-year history of my lab in signed champagne bottles. We always find some reason to celebrate: papers, fellowships, prizes - 🙏 to all the good people in the lab. Yet we have never opened the BIG bottle - now it's time 😅. Hope it fits on the shelf. 171
Philipp Niethammer @niethammerlab.bsky.social · 05/08/2026Very interesting work! www.nature.com/articles/s41...nature.comScreening of amphipathic helices identifies features linked to inner nuclear membrane properties - Nature CommunicationsThe properties of the nuclear envelope and mechanisms of peripheral protein association are poorly understood. Here, authors show sensing lipid packing defects and a minor electrostatic contribution g... 000
Philipp Niethammer @niethammerlab.bsky.social · 04/08/2026I just updated LCS turbo adding a compatible Connector app at Zenodo. The Connector connects logical or marker/scRNAseq clusters across different experiments/data sources into Cytoscape compatible enrichment networks. Hope it is useful - I count downloads as ❤️. zenodo.org/records/2064... 032
Philipp Niethammer @niethammerlab.bsky.social · 21/07/2026Independent thinkers are rare, technically adept followers are plenty. Understanding/questioning what is closest to us -current concepts, life, reality, ourselves, etc- is the most difficult thing. It has never been different. No wonder that many people prefer to 👉 „shut up and calculate“ 😉 092
Philipp Niethammer @niethammerlab.bsky.social · 11/07/2026EZM2026 setting a very high bar for future social events 🍾🥂 020
Reposted by Philipp NiethammerCell Biology J-Club @cellclub.bsky.social · 06/07/2026www.nature.com/articles/s41...nature.comCD44 restricts EGFR mobility to polarize cytoskeletal signalling modules driving bleb-based migration - Nature Cell BiologyJha et al. show that the transmembrane protein CD44 restricts EGFR mobility to maintain an EGFR–PI3K–Rac gradient during bleb-based cell migration. 0125
Philipp Niethammer @niethammerlab.bsky.social · 05/07/2026gut.bmj.com/content/earl...gut.bmj.comPancreatic cancer fibrosis activates protumorigenic Schwann cells through a nuclear mechanosensing mechanismBackground Fibrosis and tumour innervation are two features of the tumour microenvironment (TME) that contribute directly to the lethality of pancreatic ductal adenocarcinoma (PDAC), but their potenti... 020
Philipp Niethammer @niethammerlab.bsky.social · 02/07/2026Next week - looking forward to see you there! www.ezm2026.orgezm2026.orgEuropean Zebrafish Meeting 2026 - July 7-11, 2026 - ViennaCreate a professional science website with Avada. Showcase research, highlight discoveries, and engage your audience with custom, informative designs. 020
Reposted by Philipp NiethammerPhil Abitua @ohnolog.bsky.social · 30/06/2026So proud of @sydsat.bsky.social, the lab’s first graduate student, for leading this work! Special thanks to the Searle Scholars Program and the Royalty Research Fund for making it possible. Check out the preprint here: www.biorxiv.org/content/10.6...biorxiv.orgEarly immune cell development precedes gastrulation in annual killifishDuring embryogenesis, cell types arise in a predictable order because developmental regulators act sequentially. But how evolutionary changes in morphogenesis reshape the signaling environments that a... 392
Reposted by Philipp NiethammerJournal of Cell Science @jcellsci.bsky.social · 01/07/2026Our Special Issue: Cell Biology of the Nucleus is complete Explore our Toc: journals.biologists.com/jcs/issue/13... Our cover image shows the posteriorly positioned nuclei (Nup50-mCherry - pink) of notochord cells in Ciona embryos. See article by Peng et al. journals.biologists.com/jcs/article/... 11411
Philipp Niethammer @niethammerlab.bsky.social · 30/06/2026Generating new pests by fighting pests. Brilliant idea, always works 👍as nature teaches us: "From effective biocontrol agent to successful invader: the harlequin ladybird (Harmonia axyridis) as an example of good ideas that could go wrong"peerj.com 110
Philipp Niethammer @niethammerlab.bsky.social · 30/06/2026We will have to get familiar with these type of legal texts. At least in Europe, there are some regulations: eur-lex.europa.eu/eli/dir/2019...eur-lex.europa.eu 000
Philipp Niethammer @niethammerlab.bsky.social · 29/06/2026What would be a license that precludes this type of usage? 120
Philipp Niethammer @niethammerlab.bsky.social · 29/06/2026We have posted there too. But I am not sure about their AI/bot security measures. This type of exploit seems to be quite new, and will only get worse in the future. Preprint servers, preferably the big ones, need to act now. 100