Intrinsic timescale reflects the temporal window of neural processing, but how it matures across the human cortex during development remains unclear. This study shows that intrinsic timescale develops...

How does the human brain stop movements under realistic conditions? Using intracranial recordings and multi-variate EEG decoding, this study shows that a fronto-basal ganglia circuit featuring the sub...

Duration perception involves multiple brain regions, but how unimodal tuning across this network supports subjective timing remains unclear. This study shows that parietal, premotor, and caudal SMA en...

Perceived sleep depth is generally thought to reflect reduced brain activity. This study shows that this relationship weakens during dreaming, suggesting that dreaming helps sustain the subjective exp...

The role of the cerebellum in motor functions is well understood. But why is the same circuitry engaged in functions such as working memory, language, and social cognition? This Unsolved Mystery looks...

The complex organization of the brain's superficial white matter is a challenge for studying its contribution to cortico-cortical connectivity and large-scale brain function. This study reports a nove...

Infantile amnesia limits recall of early-life memories, but its cellular basis is unclear. This study reveals that transient microglial activity during postnatal development regulates infant memory pe...

Speech comprehension relies on predictive mechanisms, but models disagree on whether the brain prioritizes expected or unexpected information. This study shows that sharpening of sensory representatio...

Recent work has shown that TDP-43 loss in frontotemporal dementia (FTD) induces changes in alternative polyadenylation, but the functional consequences of this are unclear. This study reports that 3′U...

A no-fault compensation scheme may help balance innovation and patient protection

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How does our brain process interactions with an avatar compared to real human being? This study shows that feedback from an avatar increases risk-taking behavior in humans and is associated with lower...

Programming is essential for modern research in neuroscience and psychology, but it can quickly become a source of frustration and error. This Primer introduces ten practical principles guiding resear...

The role of the dorsal fan-shaped body in sleep regulation in Drosophila is contested. This study shows that cholinergic neurons in the dorsal fan-shaped body play a major role in sleep modulation in ...

Truly understanding the brain requires conditions we’re unlikely to meet: that knowledge of the brain is finite, accessible and understandable.

Many neuroscience students are steeped in an experiment-first style of thinking. Let’s not forget how theory can guide experiments.

Since its founding over twenty five years ago PLOS has been dedicated to advancing open science, ensuring that knowledge is accessible to…

Public sharing of neuroimaging data is becoming increasingly common for the advancement and validation of scientific research. However, this sharing poses challenges regarding privacy and data safety,...

The major pathological feature of Parkinson ‘s disease (PD), the second most common neurodegenerative disease and most common movement disorder, is the predominant degeneration of dopaminergic neurons...

How do the functional networks in the brain change at the beginning of human life? This longitudinal perinatal fMRI study of 140 babies reveals regionally specific changes in neural connectivity at th...