In this Editorial, Rebecca Grais outlines how COVID-19 transformed viral outbreak responses from a predominantly public health challenge into a political and security concern, highlighting the challen...

Chimeric antigen receptor (CAR)-expressing cells bear a great potential for the treatment of autoimmune diseases. In this Perspective, Jule Bachl, Melanie Hagen, and George Schett discuss the challeng...

Measles and other vaccine-preventable diseases are re-emerging worldwide in locations where they were once eliminated. In this Perspective, Chirag Kumar and Nathan Lo outline how and why targeted poli...

Despite public health strategies focusing on men’s mental health and suicide risk, rates of suicide among men remain concerningly high. In this Editorial, Seena Fazel outlines why targeted, specialize...

In this Perspective, Caitlin Ryus and colleagues discuss the NIH 2025 Public Access Policy, highlighting that while expanding who can read science, the policy risks creating new barriers to who can af...

Suppression of HIV with antiretrovirals eliminates HIV transmission risk, summarized as Undetectable = Untransmittable (U=U). However, U=U literacy remains unevenly understood and shared, and stigmas ...

In this Perspective, Silja Kosola outlines how social media disproportionately harms child and adolescent mental health, and argues that while recent policy changes aimed at protecting youth from soci...

In this Perspective, Sanjay Rajagopalan and colleagues discusses how climate change accelerates non-communicable diseases (NCDs) and exacerbates NCD-related mortality, and calls for greater visibility...

Why obesity increases cancer risk has long remained a biological mystery. In this Perspective, Steven Moore and Patrick Ryan discuss rapid advances in statistical and analytical methods that are now o...

In this Editorial, Nic Reitsam discusses how integrating spatial omics with artificial intelligence is likely to advance biomarker research and diagnostics, including the potentials and challenges of…

In this Perspective, Amanda Drury and colleagues outline how and why education, communication, and models of care for patients receiving oral systemic anti-cancer therapies must adapt to support…

In recognition of Endometriosis Awareness Month, this Editorial by Alexandra Tosun discusses why raising awareness and education of endometriosis, as well as increasing funding and research for this s...

In this Perspective, Tudor Groza and colleagues discuss how artificial intelligence (AI) can transform rare disease care when organized around the patient journey, outlining a patient-clinician-AI…

In recognition of International day of women and girls in STEM, this Editorial by Aparajita Chattopadhyay reflects on the gender gap in STEM in India, outlining socio-cultural and infrastructural…

This Collection of articles aims to shine a light on the many facets of immunometabolism, highlighting how molecular and cellular mechanisms impact diverse tissue and organismal functions and the exci...

In this Editorial, PLOS Medicine Editor-in-Chief Till Bärnighausen and Executive Editor Helen Lumbard outline how climate change and associated extreme weather events are threatening human health, and...

In this Perspective, Ariana Chao, Adam Gilden and Thomas Wadden discuss why alongside the rising popularity of glucagon-like peptide 1 (GLP-1)-based medications for obesity, there are also concerns ab...

Open research and data transparency are a bulwark against unethical activities, but can also introduce integrity risks. In this Perspective, Danny Maupin, Matt Spick and Nophar Geifman argue that…

Controlling transmission of the bacterial sexually transmitted infections (STIs) gonorrhoea, chlamydia and syphilis has proven difficult in recent years, and new solutions are needed. In this Perspect...

Large open health datasets present unique opportunities for studies that when well-designed, conducted, and reported, can offer valuable contributions to health and medicine. However, recent years hav...

Institutional partners Open access is not truly open without equitable opportunities to publish. To support authors from diverse research communities, funding backgrounds…

In recognition of World AIDS Day 2025, this Perspective by Gregory Folkers and Anthony Fauci reflects on the progress made in antiretroviral treatments and prevention of HIV/AIDS, highlighting promisi...

As PLOS Medicine enters a new chapter, its leadership sets out a bold editorial vision grounded in evidence, impact and equity. In a rapidly evolving global health landscape, the journal reaffirms its...

Open science often centers around publications and data transparency. This Perspective discusses how and why disseminating results to study participants is essential for maximizing the values and bene...

PLOS Medicine Executive Editor, Helen Lumbard, and Senior Editor, Front Section, Daniel Routledge, call for the scientific community to tackle research fraud and paper mills head on by creating robust...

Note: PLOS issued the following press release on Thursday, August 14th. SAN FRANCISCO, CA — Today, PLOS Biology announced a new agreement…

As PLOS Medicine enters a new chapter, its leadership sets out a bold editorial vision grounded in evidence, impact and equity. In a rapidly evolving global health landscape, the journal reaffirms its...

This collection focuses on how recent technological advancements in omics approaches (genomics, proteomics, metabolomics etc.) have enhanced our understanding of the mechanisms governing tumor progres...

The relationship between migraine aura and headache has been the subject of a long-standing debate. With insights from clinical, pharmaceutical, and in vivo animal studies, this Essay delves into the ...

Vaccines have saved millions of lives, yet their importance and safety is repeatedly in question. W e cannot let disinformation campaigns get in the way of global public health – it is not time to def...

Working for us We’re always looking for talented and motivated people to work as part of our close-knit team. Roles range from editorial to production, marketing to event co-ordination, HR to accounts...

Vaccines have saved millions of lives, yet their importance and safety is repeatedly in question. W e cannot let disinformation campaigns get in the way of global public health – it is not time to def...

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Can we ever have too much ecological field data? Are data sharing norms and the environmental costs of travel disincentivizing its collection? This Perspective advocates for proper funding and resourc...

Open science policies are rapidly evolving, but many researchers find them to be vague and difficult to navigate. These policies often lack clear, actionable guidelines for how researchers can respond...

The coming decade might see major cuts to US Government funding for biomedicine and the mainstreaming of pseudoscience. This Perspective highlights how your biosciences PhD gives you the problem-solvi...