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Benedikt Zott

@bzottlab.bsky.social

Reposted by Benedikt Zott

PLOS Biology @plosbiology.org · 28/04/2025

The directed motion of #CerebrospinalFluid #CSF in the #brain is key for the distribution & removal of solutes, but how is this flux modulated? @bzottlab.bsky.social &co show that changes in total cerebral #blood volume drive the flow of CSF in humans @plosbiology.org 🧪 plos.io/4lOrHKm

Coupled neuronal activity, gGM, PFI, and CSF fMRI signals during burst-suppression anesthesia. Top left: Experimental design: fMRI recording under deep sevoflurane anesthesia in a Philips Achieva 3.0T scanner. Bottom left: Example scan positioning in a representative subject. Schematic depiction of the fMRI volume superimposed on a sagittal T1-weighted image with representative slice positions for the gGM and PFI masks and slice 1, which contains the CSF mask. Middle: Simultaneous recordings of the EEG with an MRI-compatible, 64-electrode cap with equidistantly arranged electrodes (Easycap) and of three fMRI masks, depicted in representative slices: gGM (white), PFI (blue), and CSF (red). Right: Simultaneously recorded signal time courses from one subject under burst-suppression anesthesia: EEG (green), gGM fMRI (black), PFI fMRI (blue), and CSF fMRI (red). Suppression and burst periods are indicated in light blue and light orange, respectively.

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Reposted by Benedikt Zott

PLOS Biology @plosbiology.org · 28/04/2025

The directed motion of #CerebrospinalFluid #CSF in the #brain is key for the distribution & removal of solutes, but how is this flux modulated? @bzottlab.bsky.social &co show that changes in total cerebral #blood volume drive the flow of CSF in humans @plosbiology.org 🧪 plos.io/4lOrHKm

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