iiinova — where your digital self keeps evolving

Reposted by Dr. Natalie Tatum

Newcastle University Structural Biology Facility @nusbf.bsky.social · 07/11/2025

Next up is Robbie Burton from Newcastle University

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Dr. Natalie Tatum @nataliejtatum.bsky.social · 14/08/2025

Crystallography for the "dark proteome"? From @nudrugdiscovery.bsky.social and @chemistryncl.bsky.social : #FragLites map protein–protein interaction sites including regions with no previously known function. 🧵1/3 #DrugDiscovery #ChemBio 📖 www.sciencedirect.com/science/arti...

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Reposted by Dr. Natalie Tatum

Naomi Alderman @naomialderman.bsky.social · 14/08/2025

this is the thing. it's not nothing. in certain contexts it is really extraordinary, I am excited to be living to see what it does. it's also not erm <checks notes> going to be god-level general intelligence in two years time (or probably ever).

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Dr. Natalie Tatum @nataliejtatum.bsky.social · 14/08/2025

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Dr. Natalie Tatum @nataliejtatum.bsky.social · 02/07/2025

Today was one of those Good Days in Academia where (a) an experiment gave me a result I was hoping for, which is Super Cool, and (b) an undergrad emailed asking for advice and I could give them resources and context to point them on the next step of their journey. Little important wins 🩷

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Reposted by Dr. Natalie Tatum

Katie Mack @astrokatie.com · 19/06/2025

Chatbots — LLMs — do not know facts and are not designed to be able to accurately answer factual questions. They are designed to find and mimic patterns of words, probabilistically. When they’re “right” it’s because correct things are often written down, so those patterns are frequent. That’s all.

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Dr. Natalie Tatum @nataliejtatum.bsky.social · 03/06/2025

I'm at #DurhamHPCDays today to present in the Computational Biosciences workshop. Always lovely to come back to Durham, and this time to see a shiny new Maths+CompSci building!

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Reposted by Dr. Natalie Tatum

THIS ACCOUNT IS MOVING @xtaldave.xtaldave.net.ap.brid.gy · 01/04/2025

New Presidential executive order on proteins: All amino acids now to be right w̶i̶n̶g̶ handed. Leftist amino acids to be outlawed. (Also, Z-DNA is deemed to be Communist, and is prohibited.) Trans- and cis- peptide bonds to be banned. Non-binary amino acid Glycine to be banned. Proline is […]

xtaldave.net

Original post on xtaldave.net

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Dr. Natalie Tatum @nataliejtatum.bsky.social · 15/03/2025

Latest preprint out in the wild! This is some older work which lingered on our to-do lists; we published the crystal structure of the human IRF4 DNA-binding domain (6TD4) in 2020!

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Reposted by Dr. Natalie Tatum

Cole Group @colegroupncl.bsky.social · 08/03/2025

And thanks to the team at Newcastle for stepping up to the challenge!: @creechem.bsky.social, Rachael Pirie, @bieniekmat.bsky.social, @jthorton22.bsky.social, Ayaz Ahmad, Aaron Campbell, Kallie Friston, Natalie Roper, Roly Armstrong, Kate Harris, & @nataliejtatum.bsky.social

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Reposted by Dr. Natalie Tatum

Brendan @chemscrapes.bsky.social · 14/02/2025

My daughter messaged me after her chem class the other day and asked if i could do a cartoon about Trump and Musk as isomers. Dear followers, inspired by Amelia i present to you, unconstitutional arsomers. *insert applause here* #chemsky

Two isomers of hexane are shown - 2,2-dimethyl butane and 2,3-dimethyl butane. They are labelled as constitutional isomers.

Cartoon showing 2 x arsole molecules. The first looks like elon and is doing a nazi salute. It has a methyl group at the 3-position. The second arsole has a red tie, is gesticulating, is orange with a big combover. Face set with a scowel. It has a methl group at the 2-position. They are labelled as unconstitutional arsomers.

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Reposted by Dr. Natalie Tatum

CRUK Newcastle Drug Discovery Group @nudrugdiscovery.bsky.social · 11/02/2025

🌍👩‍🔬 Celebrating International Women in Science Day! Thank you to all the women in our drug discovery team, their dedication, innovation and inspiration. Together we are pushing boundaries to discover novel anticancer drugs! @nucancer.bsky.social @crhorizons.bsky.social @newcastleuni.bsky.social

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Reposted by Dr. Natalie Tatum

Derek Lowe @dereklowe.bsky.social · 04/02/2025

A long post about what’s happening to the science funding agencies in the US and why. As mentioned, this one just kept getting longer even as I kept stripping curse words from it. www.science.org/content/blog...

science.org

What's Happening Inside the NIH and NSF

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CRUK Newcastle Drug Discovery Group @nudrugdiscovery.bsky.social · 27/12/2024

Read about our potential breakthrough in oncology - restoring wild type p53 function with ASTX295. This molecule was co-developed with Astex Pharmaceuticals, and is currently showing great phase I trial readout! #cancer #medchem #clinicaltrials www.linkedin.com/posts/cancer...

linkedin.com

Cancer Research Horizons on LinkedIn: #onmyhorizon #cancerresearch

2024 milestones worth celebrating 🧬🌟 Bravo to the incredible researchers at the Drug Discovery Unit at Newcastle University. They've unlocked a potential…

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Reposted by Dr. Natalie Tatum

CRUK Newcastle Drug Discovery Group @nudrugdiscovery.bsky.social · 19/12/2024

Our research is critically dependent on funding we receive from @cancerresearchuk.org and we are also willing to do our bit towards fundraising. In 2024: Funds Raised: £6,440 (+£1,031 gift aid) Online Donations: 283 Events: Great North Run, Race for Life, Shine Walk, Leeds Marathon, bake sale, quiz

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Dr. Natalie Tatum @nataliejtatum.bsky.social · 17/12/2024

Setting up some crystallisation plates today for a new year treat/Christmas miracle. First time setting up an in situ plate for some work with @diamondlightsource.bsky.social VMXi 💎

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Reposted by Dr. Natalie Tatum

Ash Jogalekar @ashjogalekar.bsky.social · 15/12/2024

In early phase drug discovery, biology and assays are make-or-break. I can remember very few programs I worked on which were hampered by the inability to make molecules, but plenty that were hampered by the inability to capture disease biology complexity on a chip or in an enzyme readout.

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Dr. Natalie Tatum @nataliejtatum.bsky.social · 13/12/2024

Been flying the @newcastleuni.bsky.social and @nudrugdiscovery.bsky.social flags recently, talking to @mosmedcdt.bsky.social Cohort 6 about applying computational methods appropriately + short talk at the Durham BSI bit.ly/4d7nlbB on our cyclin D3 work! bit.ly/3D6SwHF🧬🧶 #academicsky

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Reposted by Dr. Natalie Tatum

Christian Seitz @chemchristian.bsky.social · 10/12/2024

Per an email from Google DeepMind: Alphafold 3 is not licensed for academics to use for work that leads to a vaccine (pandemic preparations, anyone?). If structure prediction performance is comparable, people will leave AF3 for competitors with more permissive licenses

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Reposted by Dr. Natalie Tatum

Cole Group @colegroupncl.bsky.social · 06/12/2024

In case you missed it on the other site, we've written up some of our experiences from the CACHE2 hit finding challenge in this blog: cole-group.github.io/2024/09/10/c... Thanks to the organisers for a well-run challenge! @creechem.bsky.social @bieniekmat.bsky.social @nataliejtatum.bsky.social

cole-group.github.io

CACHE Challenge

Recently a team of us from Newcastle University were fortunate enough to enter the second Critical Assessment of Computational Hit-Finding Experiments (CACHE) Challenge. The full team comprised: Ben C...

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Reposted by Dr. Natalie Tatum

Jo Wolff @jowolff.bsky.social · 05/12/2024

Well, there’s a story.

When Nazi Germany invaded Denmark in World War II, the Hungarian chemist George de Hevesy dissolved the gold Nobel Prizes of Max von Laue and James Franck in aqua regia to prevent the Nazis from stealing them. He placed the resulting solution on a shelf in his laboratory at the Niels Bohr Institute. After the war, he returned to find the solution undisturbed and precipitated the gold out of the acid. The Nobel Society then recast the Nobel Prizes using the original gold.

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CRUK Newcastle Drug Discovery Group @nudrugdiscovery.bsky.social · 04/12/2024

Congratulations to Kenneth Tan who passed his PhD viva on Tuesday 🎉 Kenneth has also recently taken up a position as a Technical Specialist in our structural biology group. Many thanks to his examiners, @nucancer.bsky.social's Luke Gaughan and @universityofleeds.bsky.social's Richard Bayliss!

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Reposted by Dr. Natalie Tatum

Martin Pacesa @martinpacesa.bsky.social · 30/11/2024

#CASP16 results are in! Template-based VFold seems to be lead method for nucleic acid structure prediction! AlphaFold2 and 3 still seem to be best methods for protein monomer and complex prediction.

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Dr. Natalie Tatum @nataliejtatum.bsky.social · 29/11/2024

Pleasure to be on the judging panel for the @mosmedcdt.bsky.social Project Ideation session! An excellent showcase of ideas from all of the teams. Congratulations to our winners, who really emphasised patient need and presented a clear way forward to address it. 👏

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Dr. Natalie Tatum @nataliejtatum.bsky.social · 28/11/2024

Spent today with @newcastleuni.bsky.social development team on their new leadership induction course! Lots to take away and reflect upon 💪

A dark blue sign suspended from a office ceiling with text reading "Newcastle University Centre for Professional and Executive Development".

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Reposted by Dr. Natalie Tatum

Stuart Neil @tetherin.bsky.social · 27/11/2024

I am looking for 2 postdoctoral researchers to join my lab to work on the role of HIV-1 accessory proteins in the pathogenesis of HIV/AIDS and viral latency. Please contact me informally or ‘re-sky’ to anyone you think may be interested. Closing Dec 10th www.jobs.ac.uk/job/DKV639/p...

jobs.ac.uk

Postdoctoral Research Associate at King's College London

Discover an exciting academic career path as a Postdoctoral Research Associate at jobs.ac.uk. Don't miss out on this job opportunity - apply today!

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Reposted by Dr. Natalie Tatum

Dr. Natalie Tatum @nataliejtatum.bsky.social · 25/11/2024

The Newcastle Drug Discovery group are on BlueSky! Follow for updates and insights and probably photos of funrunners and cakes 🧬🧶 #chemsky 🧪 #academicsky #chembio #biophysics

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Reposted by Dr. Natalie Tatum

Stu Cantrill @stuartcantrill.com · 24/11/2024

Optimist: The cup is half full Pessimist: The cup is half empty Referee 1: Yeah, cups are fine, but can you do it with jars, mugs & glasses? Referee 2: You need to cite these 12 papers showing how to fill things (all ref. 2’s papers) Referee 3: You misspelled ‘container’ on page 6

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Dr. Natalie Tatum @nataliejtatum.bsky.social · 25/11/2024

The Newcastle Drug Discovery group are on BlueSky! Follow for updates and insights and probably photos of funrunners and cakes 🧬🧶 #chemsky 🧪 #academicsky #chembio #biophysics

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Reposted by Dr. Natalie Tatum

TJ McCorvie @allostericstate.bsky.social · 24/11/2024

Optimist: The cup is half full Pessimist: The cup is half empty Structural biologist: The cup requires further optimisation

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merr-itt came from outer space @merrittk.com · 20/11/2024

Look, do I regret betraying my siblings? Sure. Would I do it again for the great taste of Turkish delight? Of course I would

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Dr. Natalie Tatum @nataliejtatum.bsky.social · 20/11/2024

Done in the lab for today (multitasking a protein purification and setting up an SPR assay) so now I get to sit down, have a coffee, and start writing a fresh new talk for a symposium I'm speaking at in December! #ecrchat #academicsky 🧪 🧶🧬

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Reposted by Dr. Natalie Tatum

Max Fürst @maxfus.bsky.social · 20/11/2024

Very informative thread on hallucinations by AF3. Wonder whether we need another community assessment effort (as for AF2) probing its usefulness and limits. Given that hallucinated helices are much more difficult to identify as garbage than spaghetti structures, prob better sooner rather than later!

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Reposted by Dr. Natalie Tatum

Protein Data Bank in Europe (PDBe) @pdbeurope.bsky.social · 19/11/2024

Want more biological database resources & tools in your feed? Welcome EMBL-EBI (@ebi.embl.org) to 🦋💙 Bluesky 🦋💙! PDBe is part of EMBL-EBI & behind various resources: - founding partner of the wwPDB, - community-led PDBe-KB resource - AlphaFold Protein Structure Database (with Google DeepMind)

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Ute Jungwirth @utejungwirth.bsky.social · 19/11/2024

Our Newcastle University Centre for Cancer has its own account @nucancer.bsky.social Follow us to hear from our 100+ cancer researchers & how they translate their research into the clinic. For example our Drug Discovery group developed the clinically approved Rucaparib (PARPi) & Erdafitinib (FGFRi)

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Reposted by Dr. Natalie Tatum

Harmit Singh Malik @harmitmalik.bsky.social · 19/11/2024

Since @markhamillofficial.bsky.social has joined Bluesky I think it totally appropriate to call ourselves Skywalkers instead of Twitterati

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Cole Group @colegroupncl.bsky.social · 19/11/2024

Newcastle Chemistry @chemistryncl.bsky.social is on BlueSky! Give them a follow for research and teaching news from colleagues at @newcastleuni.bsky.social

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Reposted by Dr. Natalie Tatum

Shayan Sardarizadeh @shayan86.bsky.social · 19/11/2024

Beware, this "BBC Breaking News" account is fake. It's not an official BBC News account. If BBC News ever joins this platform, it'll be publicised via official BBC platforms.

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Pat Walters @wpwalters.bsky.social · 18/11/2024

There’s a new Practical Cheminformatics post, “Some Thoughts on Dataset Splitting,” (with code and a robot cartoon) at practicalcheminformatics.blogspot.com/2024/11/some... .

A cartoon robot using a chainsaw on a log

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Angie Rasmussen @angierasmussen.bsky.social · 17/11/2024

This is a great thread about the potential impact of some of the mutations found in the H5N1 virus from the patient in BC. A lot of people want to know what this means for pandemic risk and the answer is a very complex but unsatisfying “we don’t know”. Host adaptation is complicated.

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Dr. Natalie Tatum @nataliejtatum.bsky.social · 17/11/2024

Revisiting this post because while I did finish Northanger Abbey, I recently failed to beat my all time Pride and Prejudice record (25% 😅). I'm just not a Victorian prose girly.

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Reposted by Dr. Natalie Tatum

Razvan Borza @rborza.bsky.social · 17/11/2024

⚠️THREAD OF ALL SCIENCE-RELATED STARTER PACKS! ⚠️ 🔄Share to help people finding its topic/field - STRUCTURAL BIOLOGY Structural Biology 1: bsky.app/starter-pack... Structural Biology 2: bsky.app/starter-pack... Crystallography: bsky.app/starter-pack... Synchrotron&CryoEM: bsky.app/starter-pack...

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Dr. Natalie Tatum @nataliejtatum.bsky.social · 17/11/2024

Latest paper on CDK structural biology from the Endicott & Noble labs is in press at Structure! Good old fashioned mutational studies and fun newfangled AlphaFold modelling to characterise the interaction of CRABP2 with CDK4/6-Cyclin D3. 🧶🧬 #biophysics www.cell.com/structure/fu...

cell.com

Structural requirements for the specific binding of CRABP2 to cyclin D3

Using purified proteins, Pastok et al. confirm CRABP2 binding to cyclin D3. Their mutational study, supported by crystal structures of CRABP2 mutants and AlphaFold modeling, identifies a protein-prote...

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Dr. Natalie Tatum @nataliejtatum.bsky.social · 17/11/2024

I've been riding the high of a positive experimental result on Friday morning all through the weekend. One of those ones you weren't getting your hopes up about, but then you see something binds something else and the mutants don't and you do an involuntary little dance and maybe swear a bit. 🧶🧬

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Dorian Lynskey @dorianlynskey.bsky.social · 16/11/2024

Discussing Bluesky migration in terms of liberal flight misses the simple fact that most people use social media for fun not influence and this platform, unlike X and cruddified Facebook, doesn’t feel like you’re wading through shit to reach your friends. It’s not that deep.

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Jess Foster 🏳️‍🌈 🌱 🧪 she/her @jfplantstuff.bsky.social · 16/11/2024

one of my labmates is a genius, behold her tiny arabidopsis farm made from a 96-well plate and pcr strip lids 🤩😆

rows of tiny seedlings only millimeters tall

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