Single-molecule imaging reveals diverse, megabase-scale heterochromatin domains in C. elegans. Some resemble TADs and depend on condensin I; others are independent of condensin and histone H3K9me, inc...

Cell-cycle remodeling is fundamental to pluripotency and lineage commitment, yet whether its transcriptional and post-transcriptional architecture is conserved across species and developmental states ...

With a bit of delay, I am delighted to share that I have started a new position as Full Professor at IE University. After more than 20 years building my scientific career across Europe, it is very sp...

Transcription by RNA polymerase II (Pol II) requires the ordered action of general transcription factors (GTFs) forming the pre-initiation complex (PIC). How these events unfold kinetically remains un...

Abstract. Enhancers play an essential role in developmental processes by regulating the spatiotemporal expression of genes. Characterizing their spatiotemp

YouTube video by Nikolai Slavov

The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing th...

Transcription factors (TFs) establish cell identity during development by binding regulatory DNA in a sequence-specific manner, often promoting local chromatin accessibility, and regulating gene expre...

ALT: a man with long hair and a mustache is wearing a pink unicorn shirt

Single-cell omics methods promise to revolutionize our understanding of gene regulatory processes during cell differentiation, but analysis of such data continues to pose a major challenge. Apart from...

By offering a significant support, the call for proposal "Recruiting international leaders in Oncology from USA" wishes to allow the implantation in France of new scientific leader that will establish...

Enteroendocrine cells (EECs) are rare intestinal epithelial cells producing multiple hormones that regulate essential aspects of digestion and energy. EEC subtypes, their hormone repertoire and differ...

The Institute of Genetics, Molecular and Cellular Biology (IGBMC) is seeking two outstanding group leaders to establish independent research teams.