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Mark Nichols, Ph.D.

@mnichols390.bsky.social
2.9K followers 5K following 38 posts

Research in molecular biology, pharmacology, cancer therapies, NIH grants, #aging, #mitochondria ❤️ 🧪 Science, sports, NASA 🚀🌎🌊⚾️ Cal, Opinions mine

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Reposted by Mark Nichols, Ph.D.
Pestilence @pestilence4all.bsky.social · 20/02/2026
More hope from mRNA vaccines. In this instance, individualized vaccines were given to women with triple negative breast cancer following surgery and adjuvant therapy. The results are quite remarkable. Despite cancer finding a ‘T cell-evading’ work-around in some patients. #Science 🧪
nature.com
Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC - Nature
In a phase 1 trial, personalized mRNA vaccines tailored to individual tumour mutations in triple-negative breast cancer induced robust, long-lasting T cell responses and improved prognosis.
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Reposted by Mark Nichols, Ph.D.
Nereide @drnereide.bsky.social · 12/07/2025
🧵 The Cosmic Microwave Background (CMB) is like a snapshot of the newborn universe, taken 380,000 years after the Big Bang. It is a key piece of evidence for the standard cosmological model (ΛCDM), but a new study suggests that part of this signal... ➡️ uni-bonn.de/en/news/087-... 🔭 🧪 #cosmology
This Hubble image depicts the massive elliptical galaxy ESO 325-G004. Located about 450 million light-years from Earth in the Abell 3574 supercluster, it is an example of early elliptical galaxies (ETGs), which, billions of years ago, were like "cosmic fires" thanks to intense bursts of star formation. Their light, absorbed and re-emitted by cosmic dust, may have mixed with the CMB, the "roar" of the Big Bang, influencing what we observe today

During their formation, these galaxies shone 10,000 times brighter than they do today, contributing to the cosmic microwave background. Imagine a vast, luminous cloud suspended in a dark void, like a giant lantern illuminating the silence of space. The main galaxy has an oval shape, with a central core emitting a bright light, like the warm glow of a fire. This light gradually fades towards the edges, as if the galaxy were shrouded in a soft mist fading into darkness. The hue is warm, similar to a pale yellow or pale white, conveying a sense of  calm, like a celestial object that witnessed the birth of the universe. There are no sharp details or irregularities, but a smooth, uniform surface, conveying an impression of order and stability. Surrounding the galaxy, the background is dark, like a moonless night sky, dotted with specks of light, resembling distant sparks. Other galaxies are visible, scattered like cosmic dust in a vast empty space.The stars marked by bright rays (diffraction spikes) belong to our galaxy, the Milky Way, and are foreground stars that appear in the field of view of the image taken by Hubble. The image evokes a sense of grandeur and mystery, as if we were mentally touching a remote corner of the early universe.
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Reposted by Mark Nichols, Ph.D.
Hao Yin @haoyin.bsky.social · 21/06/2025
#Fumarate update Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages & inflammation Dual role in Inflammation Anti- KEAP1-NRF2 GSDMD NLRP3 IL-10 Pro- mtDNA mtRNA➡️IFNβ #CellMetab 2025 www.sciencedirect.com/science/arti...
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Reposted by Mark Nichols, Ph.D.
Eric Topol @erictopol.bsky.social · 28/04/2025
Best lab assessment for coronary artery risk consists of ApoB particles and LP(a) academic.oup.com/eurheartj/ad...
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Reposted by Mark Nichols, Ph.D.
htw @heniek-htw.bsky.social · 14/04/2025
Improving #mitochondria associated endoplasmic reticulum membranes integrity as converging therapeutic strategy for rare neurodegenerative diseases and #cancer www.sciencedirect.com/science/arti...
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Reposted by Mark Nichols, Ph.D.
Voices for Vaccines @voices4vaccines.bsky.social · 05/04/2025
"The vaccine provides close to 100% protection against infections and pre-cancers caused by certain types of HPV. That is remarkable." Effective cancer prevention. www.voicesforvaccines.org/hpv-vaccine-...
voicesforvaccines.org
HPV Vaccine is Cancer Prevention
A couple of years ago I was waiting in a clinic to see my physician for a normal well check. When a nurse I had never met came in to check my vitals, she started with small talk. “How are you doing…
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Reposted by Mark Nichols, Ph.D.
Vaughn Smider, MD, PhD @vvsmider.bsky.social · 06/04/2025
“Science is not left or right. It’s reality.” 🧵🧪
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Reposted by Mark Nichols, Ph.D.
Eric Topol @erictopol.bsky.social · 06/04/2025
We've greatly underestimated the role of the gut microbiome in fatty liver disease (MASLD). This open-access outstanding review @jclinical-invest.bsky.social is illuminating www.jci.org/articles/vie...
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Reposted by Mark Nichols, Ph.D.
htw @heniek-htw.bsky.social · 25/03/2025
Molecular mechanism of #melatonin -mediated #mitophagy regulating proline production to ameliorate skin #aging 👇 www.sciencedirect.com/science/arti...
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Reposted by Mark Nichols, Ph.D.
htw @heniek-htw.bsky.social · 19/03/2025
SIRT2 alleviates pre-eclampsia via prompting mitochondrial biogenesis and function. www.sciencedirect.com/science/arti...
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Reposted by Mark Nichols, Ph.D.
Science Friday @scifri.bsky.social · 16/03/2025
90% of people diagnosed with pancreatic cancer die from the disease. That's why the medical community is excited about the results of a small trial in which nearly half of the pancreatic cancer patients who received an mRNA vaccine for the disease remained relapse-free three years later.
sciencefriday.com
A Vaccine For Pancreatic Cancer Continues To Show Promise
In a small trial, nearly half of pancreatic cancer patients who received an mRNA vaccine for the disease had no relapse three years later.
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Reposted by Mark Nichols, Ph.D.
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 10/03/2025
Supercharged T-Cells Hunt Down the Hardest-to-Treat Cancers scitechdaily.com/supercharged...
scitechdaily.com
Supercharged T-Cells Hunt Down the Hardest-to-Treat Cancers
Scientists have supercharged CAR-T therapy, making it more powerful against elusive cancer cells that usually escape detection. This innovation, called ALA-CART, helps the immune system better recogni...
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Reposted by Mark Nichols, Ph.D.
htw @heniek-htw.bsky.social · 09/03/2025
•SIRT3 deficiency exacerbated the progression of DED. •SIRT3 plays a significantly protective role in DED by enhancing autophagy. •The deacetylation and subsequent nuclear translocation of FOXO1 are mechanisms through which SIRT3 regulates autophagy in DED. www.sciencedirect.com/science/arti...
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Reposted by Mark Nichols, Ph.D.
htw @heniek-htw.bsky.social · 09/03/2025
•CPP can delay D-gal-induced liver aging •CPP can alleviate structural damage and functional impairment in aging liver & mitochondria •CPP can improve mitochondrial energy metabolism in aging liver of mice by regulating cAMP signaling pathway & other mechanisms www.sciencedirect.com/science/arti...
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Reposted by Mark Nichols, Ph.D.
htw @heniek-htw.bsky.social · 04/03/2025
Mechanism and application prospect of #magnesium -based materials in #cancer treatment www.sciencedirect.com/science/arti...
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Reposted by Mark Nichols, Ph.D.
htw @heniek-htw.bsky.social · 04/03/2025
#Mitochondrial dysfunction is a central hallmark of #aging and #energy transduction is a promising target for longevity interventions. New research suggests that interventions in how energy is transduced could benefit healthy longevity. www.cell.com/trends/bioch...
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Reposted by Mark Nichols, Ph.D.
htw @heniek-htw.bsky.social · 03/03/2025
The critical role of mitochondrial dysfunction in ADT-induced neurotoxicity www.nature.com/articles/s41...
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Reposted by Mark Nichols, Ph.D.
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 22/02/2025
Clonal driver neoantigen loss under EGFR TKI and immune selection pressures www.nature.com/articles/s41...
nature.com
Clonal driver neoantigen loss under EGFR TKI and immune selection pressures - Nature
We show the evolution of a case of EGFR mutant lung cancer treated with a combination of erlotinib, osimertinib, radiotherapy and a personalized neopeptide vaccine targeting somatic mutations, includi...
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Reposted by Mark Nichols, Ph.D.
htw @heniek-htw.bsky.social · 13/02/2025
Resveratrol protects neonatal rats from hyperoxia-induced kidney injury by promoting mitochondrial biogenesis, possibly in part through activation of the SIRT1/PGC-1α signaling pathway. www.sciencedirect.com/science/arti...
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Reposted by Mark Nichols, Ph.D.
Jason Koebler @jasonkoebler.bsky.social · 29/01/2025
Suddenly, out of nowhere, a declassified World War II-era CIA guide to sabotaging fascism in the workplace has become one of the most popular free ebooks on the internet: www.404media.co/declassified...
404media.co
Declassified CIA Guide to Sabotaging Fascism Is Suddenly Viral
The World War II-era "Simple Sabotage Field Manual" is full of steps that office workers can take to resist leadership.
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Reposted by Mark Nichols, Ph.D.
SARS‑CoV‑2 (COVID-19) @covid19disease.bsky.social · 29/01/2025
The situation keeps worsening. A single outbreak in Arizona has led to the loss of 316,000 egg-laying chickens. Bird flu is spreading faster than it can be contained.
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Reposted by Mark Nichols, Ph.D.
Amee Vanderpool @girlsreallyrule.bsky.social · 29/01/2025
Caroline Kennedy, cousin to the current pick for HHS secretary Robert F Kennedy Jr, has penned a scathing letter warning senators about her cousin, calling him a "predator." She also says her father and uncle would be "disgusted" by RFK, Jr. www.youtube.com/watch?v=YLLx...
youtube.com
Caroline Kennedy reads her letter to Senators denouncing her “predator” cousin Robert F. Kennedy Jr.
YouTube video by The Golden Circle
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Reposted by Mark Nichols, Ph.D.
Edward Z @edwardz65.bsky.social · 11/01/2025
How about those Buckeyes? What a game! #Buckeyes #GoBucks #CaptainJack #JackSawyer
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Reposted by Mark Nichols, Ph.D.
Christopher Webb @cwebbonline.com · 05/01/2025
In 1979, Jimmy Carter installed solar panels on the White House. In 1986, Ronald Reagan tore them down along w/Carter’s clean energy funding. This sums up the difference between the two men & political parties. Investing in solutions for the future vs canceling progress to score political points.
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Reposted by Mark Nichols, Ph.D.
Jon Cooper @joncooper-us.bsky.social · 05/01/2025
The Russian disinformation network “Matryoshka” has launched a new campaign on Bluesky. Eliot Higgins, founder of the investigative journalism group Bellingcat, has been one of the first researchers to detect its activity. So far, four Russian-made fake videos have been identified on the platform.
theins.ru
Russian disinfo network “Matryoshka” is migrating to Bluesky as exodus from X continues
The Russian disinformation network “Matryoshka” has launched a new campaign on the Bluesky social network. Eliot Higgins, founder of the investigative journalism group Bellingcat, has been one of the ...
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Reposted by Mark Nichols, Ph.D.
Andrea Love, PhD | Biomedical Scientist @drandrealove.bsky.social · 03/01/2025
In news that surprises no scientist in cancer research, alcohol is linked to several cancers. Alcohol has one of the strongest links to increased cancer risk of any modifiable risk factors. I wrote about cancer basics here, including modifiable risk factors: news.immunologic.org/p/cancer-hun...
news.immunologic.org
Cancer: hundreds of complex diseases that are plagued with misinformation
Lack of understanding of cancer underlies harmful pseudoscience that circulates rampantly
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Reposted by Mark Nichols, Ph.D.
htw @heniek-htw.bsky.social · 03/01/2025
This study highlights the significance of nanoengineered mitochondria as a promising and feasible tool for the replacement of dysfunctional mitochondria and the repair of mitochondrial function in mitochondrial disease therapies. www.sciencedirect.com/science/arti...
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Reposted by Mark Nichols, Ph.D.
Katie Scott @katiescott.bsky.social · 02/01/2025
youtube.com/watch?v=Fqsq...
youtube.com
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Reposted by Mark Nichols, Ph.D.
Chise @sailorrooscout.bsky.social · 02/01/2025
THIS IS HUGE! Researchers at Stanford Medicine have devised an influenza vaccine that prompts immunity to ALL four major flu subtypes AND shows potential against bird flu, indicating a significant advancement in flu prevention and a potential increase in vaccine efficacy. Let’s talk about that! 🧪🧵⬇️
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Reposted by Mark Nichols, Ph.D.
htw @heniek-htw.bsky.social · 01/01/2025
Mitochondrial-derived microproteins: from discovery to function www.cell.com/trends/genet...
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Reposted by Mark Nichols, Ph.D.
Bluesky @bsky.app · 30/12/2024
What a year! Bluesky opened its doors just last February. Since then, we opened federation, launched video, rolled out trending topics, and a whole lot more. Happy New Year, and here’s to a great year ahead! 🎉
bsky.social
2024 In Review - Bluesky
It’s been a big year for Bluesky! Let's take a look back at everything that’s happened in the past year.
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Reposted by Mark Nichols, Ph.D.
Jonathan Slater @jonathanslater.bsky.social · 04/12/2024
A soul saved.
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Reposted by Mark Nichols, Ph.D.
Rex Chapman @rexchapman.bsky.social · 23/12/2024
The Holidays and Hoops. Nothing better…
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Reposted by Mark Nichols, Ph.D.
Tom Nichols @radiofreetom.bsky.social · 21/12/2024
#AT40 You don't have to love Boston the way I do, but if you can't accept that this song is pretty much perfect* than you have a damaged soul. *Also better than most Led Zep songs
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Reposted by Mark Nichols, Ph.D.
#TuckFrump @realtuckfrumper.bsky.social · 21/12/2024
thehill.com
These 20 GOP senators voted against the Social Security bill
Twenty GOP senators voted against legislation approved by the Senate late Friday that would bolster Social Security benefits for over 2 million American citizens working in a range of occupations.  The legislation, dubbed the Social Security Fairness Act,…
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Reposted by Mark Nichols, Ph.D.
The Ferrari Lab @theferrarilab.bsky.social · 21/12/2024
This is a devastating article highlighting the contortions in logic (and humanity) that our manufacturing and legal system will go through to achieve efficiencies that will only serve to make the very rich very much richer.
nytimes.com
Undocumented Workers Take on Dangerous Jobs to Feed America (Gift Article)
Undocumented workers help feed America’s hunger for prepared foods, but some take jobs with staffing agencies that expose them to hazardous conditions.
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Reposted by Mark Nichols, Ph.D.
Fionna O’Leary @fascinatorfun.bsky.social · 18/12/2024
Goldman Sachs analysts : The money men saying the quiet part out loud Curing patients may not be a sufficiently profitable enterprise for biotech companies. Chronic disease is a far more beneficial business model www.cnbc.com/2018/04/11/g...
cnbc.com
Goldman Sachs asks in biotech research report: 'Is curing patients a sustainable business model?'
Goldman Sachs warns sales from the most successful disease treatments are difficult to maintain.
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Reposted by Mark Nichols, Ph.D.
Miguel Godinho Ferreira @miguelgf.bsky.social · 30/11/2024
“In this Review, we discuss #telomere protection, maintenance and damage. We highlight the differences between #human and #mouse telomere biology that may contribute to discrepancies between human #diseases and mouse models.” #telomerase #aging www.nature.com/articles/s41...
nature.com
Telomere function and regulation from mouse models to human ageing and disease - Nature Reviews Molecular Cell Biology
Telomere dysfunction, usually owing to shortening, activates cellular senescence and can contribute to age-associated diseases and cancer. Mouse models are crucial for telomere research, but human and...
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Reposted by Mark Nichols, Ph.D.
Colwyn "CoCo" Headley, PhD @mitococo.bsky.social · 10/12/2024
- Come listen to me yap about #Mitochondria 😂 ⚛️🧬 And stay for the other amazing talks/discussions on how to stabilize Healthspan with aging 🫡🔥 #Aging #HealthSpan #Immunology #Cardiovascular
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Reposted by Mark Nichols, Ph.D.
Booming Encore @boomingencore.bsky.social · 18/12/2024
Here's something to consider - have a great one everyone! #aging #longevity #retirement #exercise #health #motivation #inspiration
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Anna Baxter 💙🇺🇸 @msannabaxter.bsky.social · 18/12/2024
And in-depth on the Idiot of the Year from Aaron Rupar, who we all should support since we’re off cable news. www.publicnotice.co/p/trump-time...
publicnotice.co
Trump's Time interview provides a sobering reminder
He's staggeringly unfit. Always has been. Always will be.
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Reposted by Mark Nichols, Ph.D.
Common Sense @cmmnsensedspnsr.bsky.social · 18/12/2024
Some folks are pretty good seeing things coming.
Passage from Carl Sagan’s A demon-haunted world book.
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Peter Stefanovic @peterstefanovic.bsky.social · 18/12/2024
This needs to be taken very seriously. All donations that originate from abroad, no matter who is the final donor, should be banned. Only UK citizens should be allowed to donate to British political organisations
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Reposted by Mark Nichols, Ph.D.
Patti Olivier 💙VOTE BLUE @patti3333.bsky.social · 15/12/2024
💯💯
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Helen @helenmaryme.bsky.social · 15/12/2024
Neuschwanstein Castle, Germany
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Prof. Emily Nordmann @emilynordmann.bsky.social · 15/12/2024
If you would like to teach your students useful data skills, the entire PsyTeachR suite is available with a creative commons licence to reuse and adapt. We teach stats but our focus is on working with real data, wrangling, visualisation and reproducibility using R psyteachr.github.io #AcademicSky
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Jesse Eisinger @jeisinger.bsky.social · 11/12/2024
Excellent piece from my buddy Paul Kiel on an obscure loophole that allows billionaires to avoid Medicare tax: www.propublica.org/article/medi...
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htw @heniek-htw.bsky.social · 11/12/2024
It Is Not Just About Storing #Energy: The Multifaceted Role of #Creatine #Metabolism on #Cancer Biology and Immunology www.mdpi.com/3081778
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