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annalisebond.bsky.social

@annalisebond.bsky.social
44 followers 53 following 0 posts

PhD in molecular and cellular biology from UC Santa Barbara 🔬👩🏼‍🔬

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Reposted by @annalisebond.bsky.social
Meghan Morrissey @mmorrissey.bsky.social · 10/02/2025
Excited to share @kirstin-rollins.bsky.social thesis project! 🥳Why do macrophages sometimes eat a whole cell, and sometimes just nibble off pieces? We found that if the target cell is stuck to a substrate or part of a 3D tissue, the macrophage nibbles instead of phagocytosing the whole cell.
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Reposted by @annalisebond.bsky.social
Meghan Morrissey @mmorrissey.bsky.social · 12/02/2025
Wyatt Miller's thesis project is on bioRxiv! We describe the signaling cascade that allows the 'Don't Eat Me' signal CD47 to inhibit phagocytosis. www.biorxiv.org/content/10.1...
biorxiv.org
CD47 prevents Rac-mediated phagocytosis through Vav1 dephosphorylation
CD47 is expressed by viable cells to protect against phagocytosis. CD47 is recognized by SIRPα, an inhibitory receptor expressed by macrophages and other myeloid cells. Activated SIRPα recruits SHP-1 ...
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Reposted by @annalisebond.bsky.social
Damon Runyon Cancer Research Foundation @damonrunyon.org · 28/01/2025
@mmorrissey.bsky.social is investigating how immune cells known as macrophages might be induced to “nibble” cancer cells to death through a process called trogocytosis.
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Reposted by @annalisebond.bsky.social
Journal of Cell Science @jcellsci.bsky.social · 13/01/2025
@annalisebond.bsky.social and @mmorrissey.bsky.social @ucsantabarbara.bsky.social review the biochemical and biophysical mechanisms that macrophages use to tune phagocytic appetite. journals.biologists.com/jcs/article/...
Cartoon showing that phagocytic receptor availability can be modulated through multiple mechanisms. Receptor availability can be modulated by (A) transcriptional changes affecting receptor expression levels, (B) receptor internalization, which reduces available ligand-binding sites, (C) ectodomain shedding, which can cause sequestration of ligands away from signalling domains, (D) post-translational modifications, such as conformational changes that affect ligand binding affinities, and (E) glycosylation that can affect receptor or ligand accessibility.
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