Do you want to conduct frontier research in an outstanding environment within evolutionary biology at Sweden’s largest faculty of science and technology? The Department of Ecology and Genetics at Up

GPN-Star, a genomic language model with a phylogeny-aware architecture for whole-genome alignment data, is shown to be a scalable and flexible tool for genetic variant effect prediction across species...

Abstract. Transcriptional adaptation (TA) is a regulatory process in which loss or disruption of gene function caused by protein-truncating variants (PTVs)

Abstract. Sexual selection may increase population fitness by favoring high-condition individuals and accelerating the purging of deleterious alleles. Howe

The capacity to adapt is essential for a population to avoid extinction in a changing world and is recognized as a global conservation priority. Ad...

Abstract. Many long-standing questions in population genomics can now be addressed through comparative analyses and by leveraging the vast amount of genomi

Abstract. Habitat loss contributes to extinction risk in multiple ways. Genetically, small populations can face an ‘extinction vortex’—a positive feedback

Author summary In 2006, we started a unique long-term experiment on the bank vole, a common European rodent. Our goal was to study how animals adapt to different challenges—a process known as adaptive...

An experiment with male-dimorphic mites shows long-lasting benefits of genetic rescue, regardless of type of male rescuer and despite introducing genetic load, in populations subjected to a thermal st...

The extent to which human adaptations have persisted throughout history despite strong eroding demographic events such as admixture, genetic drift,...

Abstract. Population-scale long-read DNA sequencing (PLRS) is rapidly reshaping our understanding of genomic variation in humans and non-model species. In

Abstract. Many mutations have detrimental effects. The mutation load in a population depends on the efficacy of purifying selection in removing deleterious

Olga Malinkiewicz i jej Saule Technologies i perowskitach po programie, jaki Krzysztof Stanowski zaproponował w Kanał Zero.

Abstract. The rate and chromosomal positioning of meiotic recombination significantly affects the distribution of the genetic diversity in eukaryotic genom

In the angiosperm mating system of heterodichogamy, two hermaphroditic morphs temporally alternate between male and female flowering phases, promoting…

The reshuffling of genomic variation from multiple origins is an important contributor to phenotypic diversification, yet insights into the evolutionary trajectories of this combinatorial process and ...

A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.

Recent Cell research covered by The Guardian, The New York Times, The Atlantic, and more.

Abstract. According to the “hologenome” theory of evolution natural selection and evolution can act through a conglomerate biological unit, the “holobiont”

Demographic history can shape the genetic load of populations by influencing the efficacy of selection, levels of heterozygosity, and by incorporation of new variants via gene flow. Understanding thes...

Measuring selection and dominance in fitness of the insecticide-resistant Ace alleles in Drosophila melanogaster, the authors show evidence for beneficial reversal of dominance, a mechanism that can s...