Mechanical forces are extensively involved in pregnancy and parturition, but their precise roles and mechanisms remain poorly understood. Here, we identify mechanically activated ion channels PIEZO1 a...

Interoception-the sensing and perception of the internal viscera-is widely cast as a transdiagnostic mechanism linking brain-body interaction to mental illness. Prevailing models propose that altered ...

The infant brain and gut microbiome both develop rapidly in early infancy. Growing evidence indicates that the gut microbiome plays a critical role in…

Subchronic variable stress, a paradigm shown to have divergent behavioral effects in males and females, induces shared and distinct physiological adaptations in the VTA. While both males and females ...

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This review explores the effects of early-life stress on brain development and cognitive function, highlighting gaps in understanding perceived stress, vulnerable developmental stages, underlying mole...

Competing political and economic goals on immigration are resulting in the loss of valuable skills and talent in the UK

Microglia have been implicated in the pathogenesis for several psychiatric disorders, yet comparatively little is known about their role in treatments for these conditions. Prior work showed that the ...

University of Glasgow College of Medical, Veterinary and Life Sciences  School of Psychology & Neuroscience Professor in Cognitive Neuroscience/Psy...

Move by US biomedical agency jeopardizes thousands of projects on infectious diseases, cancer and more.

This study, together with a companion manuscript, show that, in mice, weight loss as a result of GIP receptor antagonism requires, and potentiates, functional GLP-1 receptor signalling in the brain, e...

This study, together with a companion manuscript, shows that in mice, weight loss as a result of GIP receptor antagonism requires and potentiates functional GLP-1 receptor signalling in the brain, exp...

Ozempic and other similar drugs have dominated the headlines in the last year. Opinions on both sides are strong – on one hand claiming their power as a mi

Illness signals from the gut reactivate and strengthen flavour representations in the amygdala to support learning from delayed postingestive feedback.

This questionnaire will take approximately 15- 25 minutes to complete. Please answer in a safe environment and as truthfully as possible. As a neurodiverse research team, we prioritize the comfort an...

A pyramidal cell type and the 5-HT2A receptor in the medial frontal cortex have essential roles in psilocybin’s long-term drug action.

Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of...

Hedonic eating is defined as food consumption driven by palatability without physiological need. However, neural control of palatable food intake is poorly understood. We discovered that hedonic eatin...

This study maps the single-axon projections of 7,180 hypothalamic peptidergic neurons in male mice and uncovers extensive collateralization, topographic target innervation and modular intra-hypothalam...

Some early-career researchers report feeling pressure to use animal models to meet journal and grant requirements, even in disciplines and projects that don’t require them.

Single-cell profiling of vagal sensory neurons from seven organs in mice and calcium-imaging-guided spatial transcriptomics reveal that interoceptive signals are coded through three distinct dimension...