AbstractBackground:. Red meat consumption is a risk factor for colorectal cancer and has been linked to tumor alkylating DNA damage. rs16906252-T is a cis expression quantitative trait locus variant a...

Sex chromosome evolution is among the most dynamic genomic innovations in vertebrates, yet why some lineages evolve XY while others evolve ZW remains unclear. Using chromosome-level genomes from 19 ge...

Clonal hematopoiesis (CH), an aging-related expansion of hematopoietic stem cell (HSC) clones, is associated with hematologic malignancy, cardiovascular disease, and mortality. Most clonal expansions,...

The heart rarely develops cancer, and, at the same time, it lacks regenerative capacity, as cardiomyocytes stop proliferating after birth. This suggests that mechanisms limiting cardiac regeneration m...

Nature - Single-cell transcriptomics combined with morphological and ecological data show that the rapid evolutionary radiation of cichlid fishes in Lake Tanganyika was accompanied by dietary...

Ethylene oxide (EtO) is about 60 times more carcinogenic than believed in 2006, research finds

Clonal hematopoiesis, through the age-associated accumulation of somatic mutations in blood, is strongly associated with hematological malignancies and other chronic diseases. These mutations have lar...

The Department of Biology in the Faculty of Arts and Science at Concordia University invites applications for a tenure track faculty position and Tier II Canada Research Chair (CRC) in Applied Synthet...

Cell-extrinsic cues are key for neocortical cell identity and diversity.

Scientists in Svalbard in race to study polar microbes as global heating threatens fragile glacial ecosystems

A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early events during cancer development.

Ancient genomes reveal that a bacterial fever jumped from human-borne ticks to lice around the time wool textiles became common.

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Coffing et al. assemble a chromosome-level octopus genome assembly, revealing that the female octopus has just one sex chromosome (ZO karyotype), and males have two (ZZ karyotype). They conduct genomi...

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Despite appearing healthy at birth, neonates who later developed EOS already had distinct whole blood gene expression changes at birth, which enabled the development of a 4-gene predictive signature f...

Experiments in budding yeast reveal how the effects of mutations on phenotype and fitness vary across environments.

Proceedings of the 19th Machine Learning in Computational Biology meeting Held in Seattle, WA, USA on 05-06 September 2024 Published as Volume 261 by the Proceedings of Machine Learning Research on 17...

Pazokitoroudi et al. introduced a scalable method to estimate trait variance explained by gene-environment interactions across the genome and within specific genomic annotations. Application of the me...

Genotype × environment interactions (GxE) have long been recognized as a key mechanism underlying human phenotypic variation. Technological developments over the past 15 years have dramatically expand...