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Gareth McVicker

@mcvickermicro.bsky.social
179 followers 223 following 36 posts

#TeamPlasmid PI. Bacterial plasmid genetics & TA systems in EAEC, Klebsiella & Yersinia (+ more) at NTU. Opinions my own, etc. He/him.

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Reposted by Gareth McVicker
Charlotte L Oxley @lotox.bsky.social · 23/06/2026
*glares at the sun* As I’m on the stay inside list, I am not physically present at #MGEWorkshop but I am available on here and via email to answer any questions from the presentation @mcvickermicro.bsky.social gave on my behalf today. #PhD #Heatwave #IS26 #transposon #ecoli #EAEC
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Charlotte L Oxley @lotox.bsky.social · 24/05/2026
One ancestor with diverging lineages in a state of emergency. #4thUKMGEWorkshop #MicroSky #PhDLife #2ndYearPhD #MolMicro #Plasmids #IS26 @mcvickermicro.bsky.social @mgeworkshop.bsky.social
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Kit Yates @kityates.bsky.social · 31/01/2026
Three UK research councils suspend funding opportunities “Temporary block on grant applications by MRC, BBSRC and EPSRC heightens concerns over funding cuts”
timeshighereducation.com
Three UK research councils suspend funding opportunities
Temporary block on grant applications by MRC, BBSRC and EPSRC heightens concerns over funding cuts
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Gareth McVicker @mcvickermicro.bsky.social · 22/01/2026
Can confirm, supervisory team is great ;) Excellent PhD project for your consideration - DM or email @dralhubb.bsky.social for more info!
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Alvaro San Millan @sanmillan.bsky.social · 11/07/2025
Plasmids are small, mobile DNA elements that enable bacteria to exchange genetic material, including genes for antibiotic resistance. We study these genetic vehicles with the aim to uncover how they facilitate the emergence and persistence of antibiotic-resistant pathogens. #AntibioticResistance
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Gareth McVicker @mcvickermicro.bsky.social · 16/06/2025
Thanks @fnobrega.bsky.social for an excellent first talk of talks at @mgeworkshop.bsky.social ... Very well-run event!
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Ben Vezina @bananabenana.bsky.social · 15/06/2025
Cool paper showing 🦠 recipient response to #plasmid conjugation Capsule blocks conjugation, preventing MPF between donor:recipient. However, conjugation exploits recipient strain heterogeneity of capsule thickness, conjugating to cells with less capsule #MicroSky 🧪 www.biorxiv.org/content/10.1...
Fluorescent microscopy image of donor cells (shown in green) and recipient cells (shown in dark blue). Light blue cells are transconjugants. Transconjugants are only next to donor cells.
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Gareth McVicker @mcvickermicro.bsky.social · 16/06/2025
On our way to @mgeworkshop.bsky.social for @lotox.bsky.social to present later. Looking forward to some amazing talks! @arom-ntu.bsky.social #mgeworkshop
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aurelianachilengue.bsky.social @aurelianachilengue.bsky.social · 11/06/2025
I am Honoured to have received the 2nd Prize at NTU's ⭐️ STAR (Science & Tech Annual Research) Conference! Special thanks to my supervisors @conmeehan.bsky.social @blackpassiflora.bsky.social and collaborators @danwhiley.bsky.social @Kate Cox for the incredible support. @arom-ntu.bsky.social
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Charlotte L Oxley @lotox.bsky.social · 07/06/2025
Almost ready for #MGEworkshop - my first time presenting, not just at an event but 𝘦𝘷𝘦𝘳 as I'm barely 9 months into my #PhD But I'm reminding myself of the words of my favourite fictional scientist #WalterBishop #Fringe #ADHD #WomeninSTEM #MolMicro
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Gareth McVicker @mcvickermicro.bsky.social · 12/05/2025
This is one of the coolest things I've seen in plasmid biology for a while. Excellent stuff.
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David Sünderhauf @davvi36.bsky.social · 12/05/2025
I *finally* get to share our work on plasmid competition– super proud to now have this on bioRxiv: CRISPR-Cas is beneficial in plasmid competition, but limited by competitor toxin-antitoxin activity when horizontally transferred www.biorxiv.org/content/10.1... 1/6 👇
pKJK5 vs RP4 cartoon sketch on plasmid competition
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David Sünderhauf @davvi36.bsky.social · 12/05/2025
cool preprint from a few months back: www.biorxiv.org/content/10.1... Really intriguing IS strategy to become fixed in plasmids, where the IS cuts up any plasmid that doesn't contain the insertion sequence
biorxiv.org
RNA-guided nucleases enable a gene drive of insertion sequences in plasmids
Mobile genetic elements (MGEs) and the interactions between them are a major source of evolutionary innovation. Insertion sequences, the simplest MGEs usually encoding only the necessary genes for tra...
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Gareth McVicker @mcvickermicro.bsky.social · 12/05/2025
www.biorxiv.org/content/10.1... New preprint on E. coli's intimin protein from Oslo, Tübingen & @arom-ntu.bsky.social
biorxiv.org
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Charlotte L Oxley @lotox.bsky.social · 01/05/2025
🧬 Thrilled to announce that I'll be speaking at the 3rd Annual MGE Workshop. If molecular mayhem is your jam, join me and explore "From Stability to Chaos: The Role of MGEs in an Enteroaggregative Escherichia coli Outbreak” #MGEWorkshop2025 #MGE #UKScience #PhDLife #MolMicro #FirstYearPhD
ukmgeworkshop.org
MGE Workshop
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Tatiana Dimitriu @tatianadimitriu.bsky.social · 31/03/2025
Preprint below has been a long time coming, here just in time for #microbio25 ! (if the train wifi lets me) With @andrewmatthews.bsky.social #MicroSky 🧵
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David Negus @davidnegus.bsky.social · 25/04/2025
🚨New publication🚨 We show that K. Pneumoniae bacteriophages can be incorporated into alginate to create an antibiofilm matrix effective against clinical K. pneumoniae strains academic.oup.com/jambio/artic...
academic.oup.com
Bacteriophage-embedded and coated alginate layers inhibit biofilm formation by clinical strains of Klebsiella pneumoniae
AbstractAims. This study aimed to determine the antibiofilm properties of Klebsiella pneumoniae phages previously isolated from Thai hospital sewage water.
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João Botelho @joaoftsbotelho.bsky.social · 24/04/2025
It's incredible that a resistance integrative and mobilizable element can spread while also holding back their helper plasmids with such a clever trick! From @vincentburrus.bsky.social lab www.biorxiv.org/content/10.1...
biorxiv.org
Conjugative transfer inhibition of IncA and IncC plasmids by pervasive SGI1-like elements via relaxosome assembly interference
Broad-host-range IncA and IncC conjugative plasmids propagate multidrug resistance in bacteria and mobilize chromosomal resistance islands, including Salmonella Genomic Island 1 (SGI1) across genera. ...
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Chris Thomas @chrismthomas.bsky.social · 04/04/2025
The second great paper concerns the discovery in Eva Top's group that an enigmatic protein encoded by IncP-1beta plasmids modulates the IncP-1 circuitry in E. coli to make the plasmid a burden in this host: Elg et al recently accepted in Molecular Biology and Evolution doi.org/10.1093/molb...
doi.org
pendingpublications
Pending Publication
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Chris Thomas @chrismthomas.bsky.social · 04/04/2025
It is a privilege to be an author on two great plasmid papers already this year. The first was McLean et al in Nature Microbiology focused on KorB and the discovery that it is a CTPase by Yung Le's group at the John Innes Institute in Norwich. www.nature.com/articles/s41...
nature.com
KorB switching from DNA-sliding clamp to repressor mediates long-range gene silencing in a multi-drug resistance plasmid - Nature Microbiology
Structural and single-molecule analyses show the CTPase, KorB, is a sliding DNA clamp that interacts with a clamp-locking protein KorA to inhibit gene expression over distances of more than 1 kb in th...
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Alasdair Hubbard @dralhubb.bsky.social · 01/04/2025
And in a clash, we have @c-cornbill.bsky.social from Warwick (supervisor @friendlymicrobe.bsky.social) talking about the variability in AMR evolution in different host mimicking media in the "AMR - Mechanism and Regulation" (2/5)
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Alasdair Hubbard @dralhubb.bsky.social · 01/04/2025
And finally, last talk of the day is ... me! I'll be talking in the "Urogenetial Microbes in Health and Disease" at 17:00 where I will go through our preliminary project looking at where AMR genes/strains/species potentially come from during treatment (5/5) #microbio25. Come see them all!!
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Alasdair Hubbard @dralhubb.bsky.social · 01/04/2025
@danwhiley.bsky.social who will be speaking on Helicobacter suis in UK farmed pigs and retail meat products. Really interesting work! (15:30) (4/5)
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Alasdair Hubbard @dralhubb.bsky.social · 01/04/2025
Then later this afternoon we have a double bill in the "Exploring Hidden Threats" session with Kate Cox (MBiol student with @conmeehan.bsky.social) talking about creating a molecular epi framework for M. Leprae (15:15) followed by.. (3/5)
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Conor (Conchúr) Meehan @conmeehan.bsky.social · 01/04/2025
Come see @aurelianachilengue.bsky.social speak about doing molly epi for M. tuberculosis without the need for a reference genome (e.g. H37Rv) this afternoon at poster 049! #microsoc25
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Alasdair Hubbard @dralhubb.bsky.social · 01/04/2025
Today's the day for the majority of the @arom-ntu.bsky.social talks at #Microbio25. First up we have Chantelle Endley who will be talking about cell cycle control regulator cdc25 in yeast in the "Genetics and Genomics" forum (12:30). (1/5)
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Alasdair Hubbard @dralhubb.bsky.social · 01/04/2025
We ALSO have multiple @arom-ntu.bsky.social posters today at #microbio25 ! (1/3)
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 31/03/2025
Stealth plasmids: rapid evolution of deleted plasmids can displace antibiotic resistance plasmids under selection for horizontal transmission. www.biorxiv.org/content/10.1101/202…
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Antimicrobial Resistance, Omics & Microbiota (AROM) @ NTU @arom-ntu.bsky.social · 28/03/2025
Congratulations to PhD students Rachel and Lottie, and MRes student Martyna on their publication with @mcvickermicro.bsky.social! #microsky www.microbiologyresearch.org/content/jour...
microbiologyresearch.org
Genetic and phenotypic analysis of the virulence plasmid of a non-Shigatoxigenic enteroaggregative Escherichia coli O104:H4 outbreak strain
Enteroaggregative Escherichia coli O104:H4 is best known for causing a worldwide outbreak in 2011 due to the acquisition of a Shiga-like toxin alongside traditional enteroaggregative virulence traits;...
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apreston243.bsky.social @apreston243.bsky.social · 27/03/2025
New paper alert. Characterisation of ExPEC E. coli entering drinking water treatment plant, with potential for community-wide dissemination. @microbiologysociety.org www.microbiologyresearch.org/content/jour...
microbiologyresearch.org
Phylogenetic groups and extraintestinal virulence genes of inflow Escherichia coli entering a municipal drinking water treatment facility (St. Paul, MN, USA)
Extraintestinal pathogenic Escherichia coli (ExPEC), a leading cause of urinary tract infections, sepsis and neonatal meningitis, circulates between diverse hosts and the environment. Consequently, id...
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apreston243.bsky.social @apreston243.bsky.social · 25/03/2025
New paper alert! New paper alert! Insight, including genomic analyses, in to Staphylococcal diversity on NHP skin. @microbiologysociety.org @davidnegus.bsky.social www.microbiologyresearch.org/content/jour...
microbiologyresearch.org
Genomic and phenotypic characterization of staphylococci isolated from the skin of non-human primates
The growth of wildlife tourism coupled with continued deforestation has resulted in increased contact between non-human primates (NHPs) and humans. Such events may promote the transmission of potentia...
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apreston243.bsky.social @apreston243.bsky.social · 27/03/2025
New paper alert! New paper alert. Experimental determination of the traits conferred by the pAA virulence plasmid in an 0104:H4 enteroaggregative E. coli. @microbiologysociety.org @mcvickermicro.bsky.social www.microbiologyresearch.org/content/jour...
microbiologyresearch.org
Genetic and phenotypic analysis of the virulence plasmid of a non-Shigatoxigenic enteroaggregative Escherichia coli O104:H4 outbreak strain
Enteroaggregative Escherichia coli O104:H4 is best known for causing a worldwide outbreak in 2011 due to the acquisition of a Shiga-like toxin alongside traditional enteroaggregative virulence traits;...
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Gareth McVicker @mcvickermicro.bsky.social · 27/03/2025
Incredibly happy to see this paper come out! And first research paper for @lotox.bsky.social! Thanks also to all the collabs at @arom-ntu.bsky.social www.microbiologyresearch.org/content/jour...
microbiologyresearch.org
Genetic and phenotypic analysis of the virulence plasmid of a non-Shigatoxigenic enteroaggregative Escherichia coli O104:H4 outbreak strain
Enteroaggregative Escherichia coli O104:H4 is best known for causing a worldwide outbreak in 2011 due to the acquisition of a Shiga-like toxin alongside traditional enteroaggregative virulence traits;...
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Maureen Laroche 🇲🇶 @tattooed-bug.bsky.social · 19/03/2025
I'm hiring a microbiologist to support various projects related to the eco-epidemiology and virulence of neglected vector-borne bacteria. www.linkedin.com/posts/mauree...
linkedin.com
I'm hiring a microbiologist to support various projects related to the… | Maureen Laroche, M.Sc, Ph.D
I'm hiring a microbiologist to support various projects related to the eco-epidemiology and virulence of neglected vector-borne bacteria.
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Willem van Schaik @wvschaik.bsky.social · 13/02/2025
'Sanofi and Johnson & Johnson’s vaccine candidate for extraintestinal pathogenic E. coli was not sufficiently effective at preventing invasive E. coli disease (IED) compared to placebo. No safety signals related to the vaccine candidate were identified.'
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Applied Microbiology International @amiposts.bsky.social · 12/02/2025
In a new study, @mcvickermicro.bsky.social and @bugsinyourguts.bsky.social characterize the hipBA toxin-antitoxin system in Klebsiella michiganensis, demonstrating that it acts as a potent antibacterial toxin and significantly contributes to plasmid stability. academic.oup.com/jambio/artic...
academic.oup.com
The plasmid-borne hipBA operon of Klebsiella michiganensis encodes a potent plasmid stabilization system
AbstractAims. Klebsiella michiganensis is a medically important bacterium that has been subject to relatively little attention in the literature. Interroga
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Gareth McVicker @mcvickermicro.bsky.social · 11/02/2025
Apparently today is #WomenInScience #WomenInSTEM day and it's fitting that I'm deep-diving into all the groundbreaking work done in the field of microbial genetics by Esther Lederberg: en.wikipedia.org/wiki/Esther_... Some of her key citations at the bottom of schaechter.asmblog.org/schaechter/2...
en.wikipedia.org
Esther Lederberg - Wikipedia
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Antimicrobial Resistance, Omics & Microbiota (AROM) @ NTU @arom-ntu.bsky.social · 15/01/2025
Deadline to apply for this PhD is 14 February.
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Antimicrobial Resistance, Omics & Microbiota (AROM) @ NTU @arom-ntu.bsky.social · 15/01/2025
Deadline to apply for this PhD is 14 February.
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Antimicrobial Resistance, Omics & Microbiota (AROM) @ NTU @arom-ntu.bsky.social · 15/01/2025
Deadline to apply for this PhD is 14 February.
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Antimicrobial Resistance, Omics & Microbiota (AROM) @ NTU @arom-ntu.bsky.social · 23/12/2024
2. Assessment of a light-curable hydrogel to be used for root canal obturation - Dr Sarah Kuehne
journals.sagepub.com
Sage Journals: Discover world-class research
Subscription and open access journals from Sage, the world's leading independent academic publisher.
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Antimicrobial Resistance, Omics & Microbiota (AROM) @ NTU @arom-ntu.bsky.social · 23/12/2024
Great end to the year for @arom-ntu.bsky.social, with three new publications out. 1. Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system - @mcvickermicro.bsky.social, Dr Jonathan Thomas
journals.asm.org
Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system | mBio
Our work addresses two processes, the maintenance of plasmids and antibiotic tolerance; both contribute to the development of antimicrobial resistance in bacteria that cause human disease. Here, we fo...
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Steph @stephy.bsky.social · 17/12/2024
I wish crypto was always short for cryptococcal meningitis
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Fiona J Whelan @whelanfj.bsky.social · 11/12/2024
🧪🎅 12 Days of Tools for Science Management 🦠🎄 Twas the weeks before Christmas when all through the lab, not a beaker was stirring, not even a culture-of-Pseudomonas. The meetings have lessened (kinda), the textbooks are closed.. & I found myself reflecting on how we get things done in academia (1/4)
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Gareth McVicker @mcvickermicro.bsky.social · 05/12/2024
Ah yes, my favourite artists: Placebo, AFI and *checks notes* the Buffy the Vampire Slayer cast from Once More With Feeling.
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Nazgul Sakenova @nazgulsakenova.bsky.social · 02/12/2024
My PhD work is now published in Nature Microbiology! Please, have a look!
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Willem van Schaik @wvschaik.bsky.social · 12/11/2024
JOB CLAXON! I am recruiting a post-doctoral researcher on a BBSRC-funded project (36 months) on the genetics and functional genomics of vancomycin resistance in enterococci. Further details here: edzz.fa.em3.oraclecloud.com/hcmUI/Candid... Please DM or email me if you want to discuss this post.
edzz.fa.em3.oraclecloud.com
Research Fellow - Department of Microbes, Infections and Microbiomes - 104864 - Grade 7
This exciting BBSRC-funded project aims to mechanistically characterise the fitness costs associated with vancomycin resistance in the Gram-positive opportunistic pathogens Enterococcus faecalis and E...
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Craig MacLean @craigmaclean.bsky.social · 27/11/2024
Plasmid afficionados: Does anybody know of any chromosomal genes that are required for plasmid conjugation? We have found a few by chance in a recent experiment and I would be really interested to know if there are other examples. #microsky #plasmid
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 25/11/2024
Delighted to see this out, after a 2-year-long review process that left @drsimonmcarthur.bsky.social and I wondering what we'd done to upset the reviewing gods. #microbiomesky #gutbrainaxis www.tandfonline.com/doi/full/10....
tandfonline.com
Cerebrovascular damage caused by the gut microbe/host co-metabolite p-cresol sulfate is prevented by blockade of the EGF receptor
The gut microbiota-brain axis has been associated with the pathogenesis of numerous disorders, but the mechanism(s) underlying these links are generally poorly understood. Accumulating evidence ind...
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MicrobesNG @microbesng.bsky.social · 20/11/2024
We're excited to be attending the 1st full East Midlands AMR Network conference TODAY!! Drop by our stand to enter the prize draw for petri dish themed coasters 🧫😍 We've also brought our famous BUZZ wire game, with prizes for the 3 fastest times ⚡🏆 #EastMidsAMR #MicroSky #AMR #WAAW
Promotional graphic featuring colorful images of petri dishes resembling bacterial cultures. The text reads: 'Limited Time Prize Draw. Visit our stand to find out how to enter our prize draw to win some petri dish themed coasters!' The design incorporates a blue banner overlay and bright, science-inspired visuals
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