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Alasdair Hubbard

@dralhubb.bsky.social
1.7K followers 1.2K following 585 posts

Assistant Professor - research group works on the evolution of AMR and understanding cryptic mechanisms of resistance. All views my own. T1D

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Reposted by Alasdair Hubbard
Nature Communications @natcomms.nature.com · 20/09/2026
Micro-bladder model offers clues to stopping recurrent urinary tract infections (UTIs) The results indicate that phage therapy – using viruses to kill bacteria without harming people – could help to reduce recurrent infections @microberamon.bsky.social @jennyrohn.bsky.social #UTISky #UTI #IDSky
dlvr.it
Micro-bladder model offers clues to stopping recurrent UTIs
A lab-grown micro bladder may explain why urinary tract infections (UTIs) return so frequently, according to a study by researchers at UCL, the University of Oxford and the University of Leicester.
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Reposted by Alasdair Hubbard
Gabriele Pollara @gpollara.bsky.social · 21/09/2026
🚨 NEW RESEARCH TECHNICIAN POST 🚨 👉 Interested in understanding the biology of recurrent UTI? 👉 Keen to work in my own and @jennyrohn.bsky.social research groups at UCL? Then please do take a look at new position available 👇. Informal enquiries encouraged. #UTISky www.ucl.ac.uk/work-at-ucl/...
ucl.ac.uk
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
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Prof Jenny Rohn @jennyrohn.bsky.social · 21/09/2026
Please do consider applying for this exciting lab role with @gpollara.bsky.social and me - nice blend of advanced culture models, immunology, microbiology and ‘omics, in our friendly Central London labs. Closes 2 Oct, please amplify! Happy to chat informally #UTI #UTISky
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Alasdair Hubbard @dralhubb.bsky.social · 22/09/2026
Wonderful opportunity to work on the incredibly important but overlooked area of UTIs. Couldn't recommend this highly enough!
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Reposted by Alasdair Hubbard
Nature Communications @natcomms.nature.com · 18/09/2026
Micro-bladder model offers clues to stopping recurrent urinary tract infections (UTIs) The results indicate that phage therapy – using viruses to kill bacteria without harming people – could help to reduce recurrent infections @microberamon.bsky.social @jennyrohn.bsky.social #UTISky #UTI #IDSky
dlvr.it
Micro-bladder model offers clues to stopping recurrent UTIs
A lab-grown micro bladder may explain why urinary tract infections (UTIs) return so frequently, according to a study by researchers at UCL, the University of Oxford and the University of Leicester.
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Reposted by Alasdair Hubbard
Prof Jenny Rohn @jennyrohn.bsky.social · 15/09/2026
Our latest paper has been featured in Nature Comms' Editors’ Highlights page for Microbiology and Infection Diseases! Do check out the paper if you're interested in #UTI, #phage, #UPEC, advanced infection #models & treatment failure! #UTISky #MicroSky #IDSky www.nature.com/articles/s41...
Screenshot of this webpage - who knows how long our paper will last on it ;-) 

https://www.nature.com/collections/jedgcgeija
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Alasdair Hubbard @dralhubb.bsky.social · 10/09/2026
My poor boy has had surgery today to remove a lipoma. It was so big the nurse said it would make a perfect breast implant and they wished he had two... Proper zoned out now and uncomfortable, but so glad to have him hope. I've got a pic of the lipoma for those that want to see...
Dog in a cammo vest looking at a bowl of water trying to understand what it is
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Reposted by Alasdair Hubbard
Tatiana Dimitriu @tatianadimitriu.bsky.social · 20/08/2026
New paper led by Liam Shaw, with Arancha Peñil Celis, @aresarroyom.bsky.social, @adalijuanluo.bsky.social & Fernando de la Cruz. academic.oup.com/nar/article/... This is very much Liam’s story, but I loved playing a small part in it 🧵
academic.oup.com
The leading region of many plasmids is adapted for translational efficiency
Abstract. To successfully transfer, conjugative plasmids must overcome a recipient cell’s defence mechanisms. The leading region of many plasmids—the first
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Reposted by Alasdair Hubbard
Prof Jenny Rohn @jennyrohn.bsky.social · 04/09/2026
Thrilled our latest paper out @natureportfolio.nature.com Nature Comms, lead author @microberamon.bsky.social, who developed P-FLO, a urine-flowing human micro-bladder model in collab with Oxford & Leicester to understand #UTI biology & treatment failure 1/4 #UTISky www.nature.com/articles/s41...
nature.com
Effect of human urinary microenvironment and fluid flow on antibiotic and phage therapy efficacy against uropathogenic Escherichia coli - Nature Communications
Maset et al. show that bladder conditions strongly influence how urinary tract infections respond to antibiotics and bacteriophages, highlighting the need for more realistic lab models to improve diag...
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Alasdair Hubbard @dralhubb.bsky.social · 01/09/2026
Without saying your age, what was your favourite film that came out when you were 20 years old
static.klipy.com
Mean Girls: Lohan's Popularity Speech
ALT: Mean Girls: Lohan's Popularity Speech
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Alasdair Hubbard @dralhubb.bsky.social · 01/09/2026
Nothing better than being outside and having adventures with my boy..
Walking with marley on near empty sandy beach with bright blue skies
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Alasdair Hubbard @dralhubb.bsky.social · 24/08/2026
I think there needs to be a UK academic publishing server that provides permanent email addresses for researchers to use as corresponding authors. That way, people don't lose access when they move or leave an institution, and reviewer invitations can continue to be sent to a stable address #MicroSky
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Alasdair Hubbard @dralhubb.bsky.social · 19/08/2026
My mind is still blown by this, decades of using bunsen burners and teaching a wide range of students how to use them correctly and now.... we don't even need them. Crazy. #MicroSky journals.asm.org/doi/full/10....
journals.asm.org
As a component of aseptic technique, Bunsen burners do not universally decrease deposition of microbe-containing particles | Microbiology Spectrum
The ability to manipulate and control microbial presence in built environments is imperative to research and medicine. The lack of documented evidence relating Bunsen burner use and airborne contamina...
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Alasdair Hubbard @dralhubb.bsky.social · 17/08/2026
I grow chillis every year to make my own sauces, I love hot food. I've previous grown habaneros, Scotch bonnets, Jalapeños and sweet peppers. I've gone up a level and grew Carolina Reapers and used my first one tonight in a chilli... they are HOT. Literally sweating from the spice!
Super sweaty bald head after eating a super spicy chilli
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Alasdair Hubbard @dralhubb.bsky.social · 15/08/2026
I cant be the only to see the bigger problem with how Jason Arday has been treated? We have the media, public etc who support proven liars in politics and public life who consistently spread disinformation act as if they are right for pursing a story of an academic who *may* have plagiarised.
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Reposted by Alasdair Hubbard
Conor (Conchúr) Meehan @conmeehan.bsky.social · 11/08/2026
Last few days to register to attend our Biotic Control of Bacteria workshop in Nottingham, September 8th. We have some great talks on phage therapy, bacteria-bacteria warfare, microbiome augmentation and more! microbiologysociety.org/event/societ...?
microbiologysociety.org
Biotic Control of Bacteria
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Reposted by Alasdair Hubbard
Freya Harrison @friendlymicrobe.bsky.social · 06/08/2026
#MicroSky Pseudomonas people: does the Ausubel nr PA14 library really not have an insertion in lasR? Am I missing something when searching the spreadsheet?
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MERMan Research Group (University of Manchester) @mermanchester.bsky.social · 05/08/2026
Our keynote speaker Jasmine Ono (Nottingham): "Breaking a species barrier allows selection on recombinant hybrids in budding yeasts" #meehubs26 #meehubs2026
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Charles Mullon @charlesmullon.bsky.social · 03/08/2026
Looking for an Associate Prof position? Interested in behavioural ecology & cultural evolution? Come join us at the Dpt of Ecology and Evolution in Lausanne🇨🇭 @dee-unil.bsky.social @unil.bsky.social! Great department & great place to live. Pls RP. Apply here: wwwfbm.unil.ch/releve/appli...
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Alasdair Hubbard @dralhubb.bsky.social · 04/08/2026
Taking a little break between the #MEEHubs26 #MEEHubs2026 sessions to have a little down/thinking time! Some really excellent talks and posters so far, really getting my mind whirring on how to integrate in depth eco-evo into clinically focused research. #MicroSky
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Alasdair Hubbard @dralhubb.bsky.social · 30/07/2026
Am I being impatient or is this unreasonable? Submitted a manuscript in July 2025, 2 rounds of review then transferred to another of their journals with reviewers comments (R1 accepted, R2 minor comments). We made the changes and re-submitted ~3 months ago.. heard nothing since. #MicroSky
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Freya Harrison @friendlymicrobe.bsky.social · 29/07/2026
A novel stress response pathway mediates #biofilm architecture in Pseudomonas aeruginosa - delighted to see this super work out, led by Ainelen Piazza & Jake Malone @johninnescentre.bsky.social journals.plos.org/plospathogen... #MicroSky
journals.plos.org
A novel stress response pathway mediates biofilm architecture in Pseudomonas aeruginosa
Author summary Biofilm formation by the opportunistic pathogen Pseudomonas aeruginosa represents a major clinical challenge, with biofilms typically associated with chronic infection, increased antibi...
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Jason Nomburg @jnoms.bsky.social · 22/07/2026
Ad forthcoming, but I am hiring for a postdoc or staff scientist to advance related investigations of the virus-host conflict. This position is ~80-100% computational, but with opportunities for experimental work if desired. If interested, shoot me an email with your CV! Reposts appreciated! 15/15
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MEEhubs @meehubs.bsky.social · 23/07/2026
One week left to register for MEEHubs2026 taking place Aug 3-5!! Please join us in Montreal, Ann Arbor, Irvine, Morelia, Zurich, Manchester, Chernihiv, or online. Register here: meehubs.org
meehubs.org
Home
Abstract submission now closed but we now invite all poster presenters to upload their posters to our platform using the above link by July 31, 2026.
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Reposted by Alasdair Hubbard
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 23/07/2026
In vitro evolution of uropathogenic Escherichia coli to fosfomycin resistance in a 3D cultured human bladder microtissue model www.biorxiv.org/content/10.64898/20…
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Alasdair Hubbard @dralhubb.bsky.social · 23/07/2026
🚨New Pre-print Really excited to see this manuscript out. While short, this was a lot of work with troubleshooting and optimisation at all stages and will, hopefully, be the start out groups major focus. Microbial evolution studies..(1/7) #MicroSky #UTISky www.biorxiv.org/content/10.6...
biorxiv.org
In vitro evolution of uropathogenic Escherichia coli to fosfomycin resistance in a 3D cultured human bladder microtissue model
In vitro studies of antimicrobial resistance (AMR) using laboratory growth media produce important, fundamental information. However, their inability to more closely replicate the in vivo environment ...
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Reposted by Alasdair Hubbard
César de la Fuente @delafuentelab.bsky.social · 20/07/2026
Biology has plenty of data—the challenge is making it usable. AllTheBacteria transforms 2.44 million public bacterial and archaeal genomes into an open, uniformly processed, searchable, AI-ready resource. www.biorxiv.org/content/10.1...
biorxiv.org
AllTheBacteria: a community resource empowers biology and discovers novel peptide antibiotics
Public microbial genomes encode an immense record of biological diversity, evolution and molecular function, but much of this information remains difficult to reuse because raw sequencing data are not...
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Jessica Blair @jessicamablair.bsky.social · 20/07/2026
Applications are OPEN for the 2027 Gordon Research Conference on Multidrug Efflux Systems. 📅 When: March 21–26, 2027 📍 Where: Ventura, California 🔗 Apply here: www.grc.org/multi-drug-e... #GRC #MultidrugEfflux
grc.org
2027 Multi-Drug Efflux Systems Conference GRC
The 2027 Gordon Research Conference on Multi-Drug Efflux Systems will be held in Ventura, California. Apply today to reserve your spot.
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Gemma Clark 🧿🕯️ @gemmaclark.bsky.social · 15/07/2026
Resources and help for anyone, and it will be mostly women, affected by the increased risk of domestic abuse associated with football www.nhs.uk/live-well/ge...
nhs.uk
Getting help for domestic violence and abuse
Find out about the signs of domestic violence and abuse, and where to get help. Domestic violence and abuse can happen to anyone, and anyone can be an abuser.
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Reposted by Alasdair Hubbard
Alasdair Hubbard @dralhubb.bsky.social · 14/07/2026
🧪🐍 New paper accepted! We screened 14 snake venoms for antimicrobial activity and identified candidate venom proteins with activity against E. coli, including phospholipases and neurotoxins. A cool example of looking for new antimicrobials in unexpected places. doi.org/10.1099/acmi... #MicroSky
doi.org
Screening the antimicrobial properties of snake venoms: an iterative fractionation approach
Antimicrobial resistance (AMR) increasingly poses a significant global health challenge. New antimicrobials are desperately needed, driving the need to explore novel sources of natural products. Snake...
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Reposted by Alasdair Hubbard
MEEhubs @meehubs.bsky.social · 07/07/2026
🚨The program for MEEHubs2026 is now online, as is more detailed information about the hubs! Check it out at meehubs.org and register‼️ Less than a month before the conference kicks off! 🦠
meehubs.org
Home
A hub-based conference on Microbial Ecology and Evolution
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Jessica Blair @jessicamablair.bsky.social · 14/07/2026
Fully Funded PhD alert!! Super interesting project with @overtonlab.bsky.social , Sara Jabbari and me!! 🤩
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Alasdair Hubbard @dralhubb.bsky.social · 14/07/2026
🧪🐍 New paper accepted! We screened 14 snake venoms for antimicrobial activity and identified candidate venom proteins with activity against E. coli, including phospholipases and neurotoxins. A cool example of looking for new antimicrobials in unexpected places. doi.org/10.1099/acmi... #MicroSky
doi.org
Screening the antimicrobial properties of snake venoms: an iterative fractionation approach
Antimicrobial resistance (AMR) increasingly poses a significant global health challenge. New antimicrobials are desperately needed, driving the need to explore novel sources of natural products. Snake...
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Alasdair Hubbard @dralhubb.bsky.social · 13/07/2026
Awesome to attend the APPG on UTIs today in the Houses of Parliament. Despite the incredibly warm weather (I cant handle heat), its always great as a scientist to listen to the people affected by UTIs and the clinicians that treated them, it really does shape the research we do! #UTISky #MicroSky
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Alasdair Hubbard @dralhubb.bsky.social · 08/07/2026
An interesting take on the impact of mutation heterogeneity in a population, the impact on growth rates (via birth/death rates), role of tolerance to facilitate resistance development and assessment of resistance. My opinion (not that anyone asked!) is that from a treatment approach mindset..(1/3)
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Freya Harrison @friendlymicrobe.bsky.social · 03/07/2026
Low concentrations of tetrasodium EDTA kill P. aeruginosa biofilm in some, but not all, chronic infection models. New paper proposed & designed by @tosinorababa.bsky.social, who led a team of PhD students to get this research done www.microbiologyresearch.org/content/jour... #MicroSky
microbiologyresearch.org
Low concentrations of tetrasodium EDTA cause significant killing of biofilm-associated Pseudomonas aeruginosa in high-validity models of chronic wound and cystic fibrosis lung infections – but not in ...
Pseudomonas aeruginosa is a pathogen notorious for its antimicrobial resistance and is currently classified as a high-priority pathogen for which new drugs are needed. Tetrasodium EDTA (tEDTA) is one ...
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Alasdair Hubbard @dralhubb.bsky.social · 03/07/2026
This is the key point for the UK as well. Due to the current "efficiencies" at many universities, research is being pushed more and more into the background and academics end up working more hours to write the grants, papers, etc but the Unis take the part of the credit when its successful
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Kate Clancy @kateclancy.bsky.social · 03/07/2026
What's baffling about how underfunded services are that help faculty get grants is that we bring money into the univ. They care about that overhead. But not enough, I guess, to fund the grant workers because they know faculty are workaholics & will just work more hours if we have less support.
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Marjon de Vos @lizscurious.bsky.social · 22/06/2026
Cross-study metagenomics analysis reveals distinct microbial signatures of urinary tract infections www.biorxiv.org/content/10.6... #UTISky
biorxiv.org
Cross-study metagenomics analysis reveals distinct microbial signatures of urinary tract infections
Background Urinary tract infections (UTIs) represent a major public health concern, increasingly complicated by rising antibiotic resistance, diminishing treatment efficacy, and increasing prevalence ...
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Antimicrobial resistance #AMR @antimicrobial.bsky.social · 21/06/2026
Welcome for complicated UTIs w/ resistant bugs but oral carbapenem lower the last barrier protecting this important antibiotic class Convenience for patients must not become convenience for prescribers, otherwise we may pay with increased carbapenem resistance #AMR www.cidrap.umn.edu/antimicrobia...
cidrap.umn.edu
FDA approves new oral antibiotic for complicated urinary tract infections
Utebzi is the first oral carbapenem antibiotic approved in the US.
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Annie Joseph @anniejoseph.bsky.social · 16/06/2026
Interested in UTI prevention? Join the @esguti-studygroup.bsky.social webinar 'Expert Perspectives on Methenamine Hippurate' on Wednesday 24th June 13.00 Central Europe time. #UTIsky #IDsky Sign-up: gbr01.safelinks.protection.outlook.com?url=https%3A...
gbr01.safelinks.protection.outlook.com
ESGUTI webinar registration
ESGUTI will be hosting a webinar over Zoom on Wednesday 24th June 13:00 Central Europe time: "Expert perspectives on methenamine hippurate for UTI prevention". Please register using the form below, t...
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Ed Cunningham-Oakes @edcoakes.bsky.social · 11/06/2026
Our paper is now published in eBioMedicine and I'm genuinely thrilled it's out 🎉 🧵 www.thelancet.com/journals/EBI... Despite the fact that this is a 2026 paper (such is peer review!), I wanted to write something and take you back to 2023, where the story of this work began. (1/7)
thelancet.com
Implementing portable, real-time 16S rRNA sequencing in the healthcare sector enhances antimicrobial stewardship
The integration of ONT 16S sequencing into routine NHS diagnostics has enabled antimicrobial stewardship by offering a faster method with improved taxonomic resolution. Its earlier use in cases where ...
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Lara Krüger @lara-kruger.bsky.social · 09/06/2026
📢 We are looking for a Junior Group Leader to join us at @institutcurie.bsky.social! Having joined the department just over a year ago, I can honestly say that it is an exceptionally stimulating and supportive scientific environment, filled with outstanding colleagues — all in the heart of Paris.
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Madhu Pai, MD, PhD @madhupai.bsky.social · 04/06/2026
Karolinska Institutet KI is inviting applications for 21 Assistant Professor positions in medicine and health @ki.se ki.se/en/about-ki/...
ki.se
Assistant Professor recruitment programme 2026
Karolinska Institutet continues to grow a global community of excellence. In summer 2026, KI is inviting applications for 21 Assistant Professor positions in medicine and health. We are once again loo...
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Alasdair Hubbard @dralhubb.bsky.social · 05/06/2026
It was such a good talk @c-cornbill.bsky.social won the best talk prize! @friendlymicrobe.bsky.social 2 in 2 months, what a star! #MicroSky
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Alasdair Hubbard @dralhubb.bsky.social · 05/06/2026
Really cool talk from Sarah Mawer on identifying bacteriocins for treatment for UTIs. Some really strong candidates which could be an alternative to antibiotics. Great project led by @davidnegus.bsky.social. #MNGPopUp
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Alasdair Hubbard @dralhubb.bsky.social · 05/06/2026
Wonderful talk by @c-cornbill.bsky.social , PhD student with @friendlymicrobe.bsky.social and I on her work on the effect of media on P. aeruginosa evolution to meropenem at the #MNGPopUp. This work leads beautifully into her work using the ex vivo pig lung model!
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Marjon de Vos @lizscurious.bsky.social · 28/05/2026
Additive effects of environmental and demographic variation shape the repeatability of evolution across replicated experiments.
academic.oup.com
Additive effects of environmental and demographic variation shape the repeatability of evolution across replicated experiments
Abstract. The repeatability of evolution is fundamentally important for understanding the origin and diversification of life as well as for developing evol
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Freya Harrison @friendlymicrobe.bsky.social · 28/05/2026
Congratulations to @c-cornbill.bsky.social on her prize-winning talk at our Life Sciences & medical School postgrad symposium 🥂 Charlotte has just wrapped up some lovely selection experiments to look at AMR evolution in environments that mimic cystic fibrosis lungs #MicroSky
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Alasdair Hubbard @dralhubb.bsky.social · 19/05/2026
Rejection from the Wellcome Trust Genomics in Context award. Not unexpected as it was heavily applied to. The most disappointing thing is that we get no feedback. This is appalling from funders. How can they justify not giving any feedback with the amount of work they take to write? #MicroSky
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