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Pharmacological blocking of spinal GABAA receptors in monkeys reduces sensory transmission to the spinal cord, thalamus, and cortex
Mahrous et al. examine the controversial role of GABAARs in sensory transmission in the monkey cervical spinal cord. They find that blocking spinal GABAARs reduces sensory input to both motoneurons and supraspinal centers. These findings suggest that GABAARs facilitate sensory transmission to modulate both movement and sensory perception in primates.