Reposted by Maxim IgaevCompBioPhys @compbiophys.bsky.social · 24/09/2026Great news! 🎉 Congrats to @maxotubule.bsky.social @maksimkalutskii.bsky.social @mpi-nat.bsky.social and Birkbeck, University of London! Happy reading!! 📜 031
Reposted by Maxim IgaevMaksim Kalutskii @maksimkalutskii.bsky.social · 23/09/2026Excited to share our new preprint! 📜 Here, we used CALVADOS and ultra-CG models to show how the kinetochore establishes a robust attachment to the dynamic microtubule end. Spoiler: IDRs 🧵 1/n www.biorxiv.org/content/10.6... 27436
Reposted by Maxim IgaevbioRxiv Biophysics @biorxiv-biophys.bsky.social · 23/09/2026Dynamic microtubule-end structure governs multivalent kinetochore coupling by the Dam1c ring www.biorxiv.org/content/10.64898/20… 032
Reposted by Maxim IgaevCompBioPhys @compbiophys.bsky.social · 26/02/2026🎉Just appeared online in #JCTC @pubs.acs.org "Improving Conformational Ensembles of Folded #Proteins in #GōMartini" @maksimkalutskii.bsky.social @maxotubule.bsky.social @carterjwilson.bsky.social pubs.acs.org/doi/10.1021/... 152
Reposted by Maxim IgaevJose Jimenez-Luna @jjimenezluna.bsky.social · 10/07/2025BioEmu is now on @science.org ! The revised version includes an upgraded model and makes a lot of MD simulation data internally generated at MSR available to the public. This took a lot of firepower from us in the last two years. www.science.org/doi/10.1126/...science.orgScalable emulation of protein equilibrium ensembles with generative deep learningFollowing the sequence and structure revolutions, predicting functionally relevant protein structure changes at scale remains an outstanding challenge. We introduce BioEmu, a deep learning system that... 14814
Reposted by Maxim IgaevMichal Kolář @mhko.bsky.social · 09/07/2025New publication out on the evolution of protein-RNA interactions. Put together with Klára Hlouchová (@sciencecharles.bsky.social) during a lovely Czech spring. www.sciencedirect.com/science/arti... 4134
Reposted by Maxim IgaevCompBioPhys @compbiophys.bsky.social · 02/07/2025📌Carter @carterjwilson.bsky.social is presenting (P-2.44) "A Tale of Two #Aquaporins: Structural Mechanisms of Gating and Inhibition in Aqp3 and Aqp7" and + 📌Florian will explain (P-2.196) "How Loop #Dynamics Control Activity and Selectivity of a Short Chain #Reductase" Happy discussions! 👥 122
Reposted by Maxim IgaevCompBioPhys @compbiophys.bsky.social · 02/07/2025Have a great D2@ #EBSA2025 in Rome🫠! Here are the posters of today's session: 📌Maksim @maksimkalutskii.bsky.social is presenting (P-2.195) his project addressing #Microtubule Dynamics Are Defined by Conformations and Stability of Clustered #Protofilaments 📜🔗 www.pnas.org/doi/10.1073/...pnas.orgMicrotubule dynamics are defined by conformations and stability of clustered protofilaments | PNASMicrotubules are dynamic cytoskeletal polymers that add and lose tubulin dimers at their ends. Microtubule growth, shortening, and transitions betw... 153
Reposted by Maxim IgaevDerivery Lab - MRC LMB @deriverylab.bsky.social · 23/06/2025🚨 JOB ALERT 🚨 We're hiring a Research Assistant – no PhD needed! Join us to explore the molecular mechanisms of receptor sorting in endosomes. Experience in protein expression/purification, cloning & cell culture desired 🧫🔬 Apply now 👉 www.nature.com/naturecareer... #STEMCareers #ResearchJobs 15033
Reposted by Maxim IgaevManuel Thery @manuelthery.bsky.social · 04/06/2025the magic growing/shrinking GTP/GDP switch lies in the differential ability to bend out of plane and hold on neighbours. Alone you go faster, together we go further. 0316
Reposted by Maxim IgaevVladimir Volkov 🇺🇦 @vladimirvolkov.bsky.social · 03/06/2025Happy to contribute to this fantastic work by @maksimkalutskii.bsky.social and @maxotubule.bsky.social! www.pnas.org/doi/abs/10.1...pnas.orgMicrotubule dynamics are defined by conformations and stability of clustered protofilaments | PNASMicrotubules are dynamic cytoskeletal polymers that add and lose tubulin dimers at their ends. Microtubule growth, shortening, and transitions betw... 04310
Reposted by Maxim IgaevVladimir Volkov 🇺🇦 @vladimirvolkov.bsky.social · 08/06/2025UK immigration policy is destabilising international academics’ careers. The effort of staying compliant with fluctuating regulations diminishes the mental space for teaching, research and building belonging, say Zahra Sharifonnasabu et al www.timeshighereducation.com/opinion/uk-i...timeshighereducation.comUK immigration policy is destabilising international academics’ careersThe effort of staying compliant with fluctuating regulations diminishes the mental space for teaching, research and building belonging, say Zahra Sharifonnasabi, Fleura Bardhi and Laetitia Mimoun 052
Reposted by Maxim IgaevCompBioPhys @compbiophys.bsky.social · 05/06/2025📜 Great work by Maksim and Co-authors! Congratulations to this latest #microtubule #publication in @pnas.org 🍾 @maxotubule.bsky.social @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social 061
Reposted by Maxim IgaevMaxim Igaev @maxotubule.bsky.social · 03/06/2025Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk. 03411
Reposted by Maxim IgaevMatthieu Chavent @matthchavent.bsky.social · 27/05/2025Our joint paper with Wonpil Im lab is now available as a preprint: "Dynamic Architecture of Mycobacterial Outer Membranes Revealed by All-Atom Simulations" www.biorxiv.org/content/10.1... 13112
Maxim Igaev @maxotubule.bsky.social · 03/06/2025Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk. 03411
Reposted by Maxim IgaevRafael C. Bernardi @rcbernardi.bsky.social · 17/02/2025🚀 First Bluesky Post! 🎉 VMD 2.0 Alpha is here! Released today at BPS 2025, this is the biggest update in 30 years—new UI, real-time ray tracing, fast surfaces, UHD & touchscreen support. Monthly updates coming in 2025! Try it now! #VMD #BPS2025 #MolecularVisualization www.ks.uiuc.edu/Research/vmd... 311442
Reposted by Maxim Igaevrob.mechanochemistry.org @rob.mechanochemistry.org · 12/02/2025Yean Ming Chew and I wrote doi.org/10.1042/BST2... about MT lattice switching. We discuss evidence that protofilament-level structural switching is ancient and fundamental and conserved; and that tubulation creates new allosteric interfaces that operate on essentially the same structural switch. 095
Reposted by Maxim IgaevCompBioPhys @compbiophys.bsky.social · 07/01/2025The regular registration for on-site participation has been closed. However, it is still possible to join our workshop online! You find the link to the according registration on our workshop website 🔗https://www.mpinat.mpg.de/workshop/huenfeld #TheoryHünfeld2025 #biophysics 084
Reposted by Maxim IgaevMichal Kolář @mhko.bsky.social · 14/12/2024We have a PhD position in Molecular chemical physics at UCT Prague, Czechia. It is closely related to our research of the evolution of #protein-RNA interactions. A pre-PhD #internship available from January 2025. Apply directly by email to positions@mhko.science. 0118
Reposted by Maxim IgaevMartin Vögele @martinvoegele.bsky.social · 13/12/2024The inside of a cell is incredibly crowded! With advancing computing power and smart algorithms, this complex world is becoming more accessible through simulations. This review summarizes the current state of modeling macromolecular crowding: pubs.acs.org/doi/10.1021/... #CompChempubs.acs.orgRecent Progress in Modeling and Simulation of Biomolecular Crowding and Condensation Inside CellsMacromolecular crowding in the cellular cytoplasm can potentially impact diffusion rates of proteins, their intrinsic structural stability, binding of proteins to their corresponding partners as well ... 3419
Reposted by Maxim IgaevJess Ewald @ewaldlab.org · 13/12/2024🎉 I'm starting my own lab at EMBL-EBI (Cambridge, UK; June 2025) 🎉 We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods. I am beginning the search for two postdocs now - stay tuned for more details! ewaldlab.orgewaldlab.orgEwald Lab@ EMBL-EBI. We identify and characterize chemical hazards to both humans and ecosystems with cell profiling data, machine learning, and integrative data analysis. 916537
Reposted by Maxim IgaevMax Planck Institute of Biophysics @mpibp.bsky.social · 12/12/2024Do not miss our latest #cryoET work! 🕵️ Xing et al. present the dynamic architecture of TRiC in human cells! The study of this protein-folding chaperonin opens the door to understanding its dysfunction in diseases like cancer and neurodegeneration 🧠🧪 #teamTOMO @becklab.bsky.social 1289
Reposted by Maxim IgaevJorge Ferreira @jorgeferreira.bsky.social · 13/11/2024Want to engage with the #mechanobiology community? Why not join this group? Just drop me a DM and I´ll add you. go.bsky.app/G5cQqYT 517641
Reposted by Maxim IgaevKirsty Wan @micromotility.bsky.social · 13/11/2024Couldn't find one so made a quick physics of life list, enjoy! go.bsky.app/EA2VsDN 7813077
Reposted by Maxim IgaevSarah Rauscher @sarahrauscher.bsky.social · 11/12/2024In this work, we use all-atom MD simulations to elucidate why human and rhesus macaque TRIM5α differ in their ability to restrict HIV. See our manuscript by Liam Haas-Neill, Deniz Meneksedag-Erol & Ibraheem Andeejani -- 0309
Reposted by Maxim IgaevStuart Neil @tetherin.bsky.social · 11/12/2024Extended until the 17th of Dec 1107
Reposted by Maxim IgaevChenxin Li, PhD @chenxinli2.bsky.social · 10/12/2024Friends don't let friends make bad graphs repo has been updated! Friends don't let friends use boxplot for binomial (bimodal) data. Is your box plot hiding something from you? #DataVisualization github.com/cxli233/Frie... 1130785
Reposted by Maxim IgaevMaxim Igaev @maxotubule.bsky.social · 08/12/2024🚨 PLEASE REPOST 🚨 We're still looking for an enthusiastic PhD student 😉 Here are some potential projects: - mechanical stability of microtubules probed by computational force spectroscopy - mechanism of microtubule assembly studied by coarse-grained modeling www.mpinat.mpg.de/28-24?c=2501... 01310
Reposted by Maxim IgaevBioExcel CoE @bioexcelcoe.bsky.social · 09/12/2024The Spring School in Computational Chemistry 2025 is open for registration 🗓️ 23-25 April 2025 🌐 Espoo, Finland Further info and registration ➡️ bit.ly/41phwUJ #compchem #hpc #Training #moleculardynamics #machinelearning Organised together with CSC - IT Center for Science and @eurocc.bsky.social 0178
Maxim Igaev @maxotubule.bsky.social · 08/12/2024Bluesky feels like the biggest speed dating event at a conference ever. 010
Reposted by Maxim IgaevRosie Jackson @aramblingrosie.bsky.social · 20/11/2024One week left to apply for this job!! I'm looking for a research tech to come and work on Alzheimers and ApoE! If you love cell culture, astrocytes, APOE or just fun science with fun people then come do science with us in beautiful Dundee! tinyurl.com/a33kjn49 Seriously the sunsets are on point! 02018
Reposted by Maxim IgaevVladimir Volkov 🇺🇦 @vladimirvolkov.bsky.social · 04/12/2024Very happy to receive a Wellcome CDA! The award will fund my lab for a whopping 8 years, allowing us to dissect force-sensing at the kinetochore-microtubule interface in depth using structural methods. We are currently looking for a postdoc: qmul-jobs.tal.net/vx/candidate... Please apply or repostqmul-jobs.tal.netPostdoctoral Research Assistant - QMUL JobsDescription 75112
Reposted by Maxim IgaevCompBioPhys @compbiophys.bsky.social · 04/12/2024📢 It's our great pleasure to invite you all to our upcoming #Workshop on "Computer Simulation and #Theory of Macromolecules" in #Hünfeld on March 7-8, 2025 in #hybrid format! See you online or on-site! More details are provided here: www.mpinat.mpg.de/workshop/hue... #TheoryHünfeld2025 #biophysics 12017
Maxim Igaev @maxotubule.bsky.social · 08/12/2024🚨 PLEASE REPOST 🚨 We're still looking for an enthusiastic PhD student 😉 Here are some potential projects: - mechanical stability of microtubules probed by computational force spectroscopy - mechanism of microtubule assembly studied by coarse-grained modeling www.mpinat.mpg.de/28-24?c=2501... 01310
Reposted by Maxim IgaevMaxim Igaev @maxotubule.bsky.social · 07/12/2024BTW we‘ve recently released an improved version of our manuscript uncovering the assembly mechanism of microtubules via intermediate clusters of protofilaments! @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social 👇👇👇 doi.org/10.1101/2024... 0214
Reposted by Maxim IgaevVladimir Volkov 🇺🇦 @vladimirvolkov.bsky.social · 07/11/2024What is the difference between a growing and shortening microtubule end? I thought I knew the answer until I started talking to Maxim Igaev and Maksim Kalutskiy. Turns out the key are protofilament clusters - check out our new preprint for details www.biorxiv.org/content/10.1... 1218
Maxim Igaev @maxotubule.bsky.social · 07/12/2024BTW we‘ve recently released an improved version of our manuscript uncovering the assembly mechanism of microtubules via intermediate clusters of protofilaments! @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social 👇👇👇 doi.org/10.1101/2024... 0214