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Maxim Igaev

@maxotubule.bsky.social
393 followers 1.2K following 11 posts

Computational Biophysicist and Royal Society University Research Fellow at Birkbeck, School of Natural Sciences 🇬🇧 Studying kinetochore-microtubule magic 🪄 Views are my own.

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Reposted by Maxim Igaev
Leah @hoxinsocks.bsky.social · 29/09/2026
#TubulinTuesday!!
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CompBioPhys @compbiophys.bsky.social · 24/09/2026
Great news! 🎉 Congrats to @maxotubule.bsky.social @maksimkalutskii.bsky.social @mpi-nat.bsky.social and Birkbeck, University of London! Happy reading!! 📜
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Maksim Kalutskii @maksimkalutskii.bsky.social · 23/09/2026
Excited to share our new preprint! 📜 Here, we used CALVADOS and ultra-CG models to show how the kinetochore establishes a robust attachment to the dynamic microtubule end. Spoiler: IDRs 🧵 1/n www.biorxiv.org/content/10.6...
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bioRxiv Biophysics @biorxiv-biophys.bsky.social · 23/09/2026
Dynamic microtubule-end structure governs multivalent kinetochore coupling by the Dam1c ring www.biorxiv.org/content/10.64898/20…
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CompBioPhys @compbiophys.bsky.social · 26/02/2026
🎉Just appeared online in #JCTC @pubs.acs.org "Improving Conformational Ensembles of Folded #Proteins in #GōMartini" @maksimkalutskii.bsky.social @maxotubule.bsky.social @carterjwilson.bsky.social pubs.acs.org/doi/10.1021/...
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Jose Jimenez-Luna @jjimenezluna.bsky.social · 10/07/2025
BioEmu is now on @science.org ! The revised version includes an upgraded model and makes a lot of MD simulation data internally generated at MSR available to the public. This took a lot of firepower from us in the last two years. www.science.org/doi/10.1126/...
science.org
Scalable emulation of protein equilibrium ensembles with generative deep learning
Following the sequence and structure revolutions, predicting functionally relevant protein structure changes at scale remains an outstanding challenge. We introduce BioEmu, a deep learning system that...
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Michal Kolář @mhko.bsky.social · 09/07/2025
New publication out on the evolution of protein-RNA interactions. Put together with Klára Hlouchová (@sciencecharles.bsky.social) during a lovely Czech spring. www.sciencedirect.com/science/arti...
A scheme of chemico-biological evolution of protein-RNA interactions. It started about 4.5 billion years ago with prebiotic monomers, went through peptides, oligonucleotides, and simple complexes, reaching proteins and RNA at about 4-3.7 billion years ago.
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CompBioPhys @compbiophys.bsky.social · 02/07/2025
📌Carter @carterjwilson.bsky.social‬ is presenting (P-2.44) "A Tale of Two #Aquaporins: Structural Mechanisms of Gating and Inhibition in Aqp3 and Aqp7" and + 📌Florian will explain (P-2.196) "How Loop #Dynamics Control Activity and Selectivity of a Short Chain #Reductase" Happy discussions! 👥
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CompBioPhys @compbiophys.bsky.social · 02/07/2025
Have a great D2@ #EBSA2025 in Rome🫠! Here are the posters of today's session: 📌Maksim @maksimkalutskii.bsky.social is presenting (P-2.195) his project addressing #Microtubule Dynamics Are Defined by Conformations and Stability of Clustered #Protofilaments 📜🔗 www.pnas.org/doi/10.1073/...
pnas.org
Microtubule dynamics are defined by conformations and stability of clustered protofilaments | PNAS
Microtubules are dynamic cytoskeletal polymers that add and lose tubulin dimers at their ends. Microtubule growth, shortening, and transitions betw...
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Derivery Lab - MRC LMB @deriverylab.bsky.social · 23/06/2025
🚨 JOB ALERT 🚨 We're hiring a Research Assistant – no PhD needed! Join us to explore the molecular mechanisms of receptor sorting in endosomes. Experience in protein expression/purification, cloning & cell culture desired 🧫🔬 Apply now 👉 www.nature.com/naturecareer... #STEMCareers #ResearchJobs
A picture of 3 rows of people on steps at the MRC LMB. From left to right - top row: Akaash, Vic, Lara - Middle row: Kerrie, Manu, Paddy - bottom row: Meg  and Julie
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Manuel Thery @manuelthery.bsky.social · 04/06/2025
the magic growing/shrinking GTP/GDP switch lies in the differential ability to bend out of plane and hold on neighbours. Alone you go faster, together we go further.
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Vladimir Volkov 🇺🇦 @vladimirvolkov.bsky.social · 03/06/2025
Happy to contribute to this fantastic work by @maksimkalutskii.bsky.social and @maxotubule.bsky.social! www.pnas.org/doi/abs/10.1...
pnas.org
Microtubule dynamics are defined by conformations and stability of clustered protofilaments | PNAS
Microtubules are dynamic cytoskeletal polymers that add and lose tubulin dimers at their ends. Microtubule growth, shortening, and transitions betw...
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Leah @hoxinsocks.bsky.social · 11/06/2025
( #TubulinTuesday! )
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Vladimir Volkov 🇺🇦 @vladimirvolkov.bsky.social · 08/06/2025
UK immigration policy is destabilising international academics’ careers. The effort of staying compliant with fluctuating regulations diminishes the mental space for teaching, research and building belonging, say Zahra Sharifonnasabu et al www.timeshighereducation.com/opinion/uk-i...
timeshighereducation.com
UK immigration policy is destabilising international academics’ careers
The effort of staying compliant with fluctuating regulations diminishes the mental space for teaching, research and building belonging, say Zahra Sharifonnasabi, Fleura Bardhi and Laetitia Mimoun
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CompBioPhys @compbiophys.bsky.social · 05/06/2025
📜 Great work by Maksim and Co-authors! Congratulations to this latest #microtubule #publication in @pnas.org 🍾 @maxotubule.bsky.social @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social
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Maxim Igaev @maxotubule.bsky.social · 03/06/2025
Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk.
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Matthieu Chavent @matthchavent.bsky.social · 27/05/2025
Our joint paper with Wonpil Im lab is now available as a preprint: "Dynamic Architecture of Mycobacterial Outer Membranes Revealed by All-Atom Simulations" www.biorxiv.org/content/10.1...
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Maxim Igaev @maxotubule.bsky.social · 03/06/2025
Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk.
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Rafael C. Bernardi @rcbernardi.bsky.social · 17/02/2025
🚀 First Bluesky Post! 🎉 VMD 2.0 Alpha is here! Released today at BPS 2025, this is the biggest update in 30 years—new UI, real-time ray tracing, fast surfaces, UHD & touchscreen support. Monthly updates coming in 2025! Try it now! #VMD #BPS2025 #MolecularVisualization www.ks.uiuc.edu/Research/vmd...
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rob.mechanochemistry.org @rob.mechanochemistry.org · 12/02/2025
Yean Ming Chew and I wrote doi.org/10.1042/BST2... about MT lattice switching. We discuss evidence that protofilament-level structural switching is ancient and fundamental and conserved; and that tubulation creates new allosteric interfaces that operate on essentially the same structural switch.
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CompBioPhys @compbiophys.bsky.social · 07/01/2025
The regular registration for on-site participation has been closed. However, it is still possible to join our workshop online! You find the link to the according registration on our workshop website 🔗https://www.mpinat.mpg.de/workshop/huenfeld #TheoryHünfeld2025 #biophysics
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Michal Kolář @mhko.bsky.social · 14/12/2024
We have a PhD position in Molecular chemical physics at UCT Prague, Czechia. It is closely related to our research of the evolution of #protein-RNA interactions. A pre-PhD #internship available from January 2025. Apply directly by email to positions@mhko.science.
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Martin Vögele @martinvoegele.bsky.social · 13/12/2024
The inside of a cell is incredibly crowded! With advancing computing power and smart algorithms, this complex world is becoming more accessible through simulations. This review summarizes the current state of modeling macromolecular crowding: pubs.acs.org/doi/10.1021/... #CompChem
pubs.acs.org
Recent Progress in Modeling and Simulation of Biomolecular Crowding and Condensation Inside Cells
Macromolecular crowding in the cellular cytoplasm can potentially impact diffusion rates of proteins, their intrinsic structural stability, binding of proteins to their corresponding partners as well ...
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Jess Ewald @ewaldlab.org · 13/12/2024
🎉 I'm starting my own lab at EMBL-EBI (Cambridge, UK; June 2025) 🎉 We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods. I am beginning the search for two postdocs now - stay tuned for more details! ewaldlab.org
ewaldlab.org
Ewald Lab
@ EMBL-EBI. We identify and characterize chemical hazards to both humans and ecosystems with cell profiling data, machine learning, and integrative data analysis.
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Max Planck Institute of Biophysics @mpibp.bsky.social · 12/12/2024
Do not miss our latest #cryoET work! 🕵️ Xing et al. present the dynamic architecture of TRiC in human cells! The study of this protein-folding chaperonin opens the door to understanding its dysfunction in diseases like cancer and neurodegeneration 🧠🧪 #teamTOMO @becklab.bsky.social
Chaperonin TRiC within human cells. The left panel displays a representative 3D map from a tomogram illustrating the spatial distribution of open and closed TRiC complexes in human cells. The top right panel highlights the interaction of PDCD5 with the CCT3-1-4 subunits of the open TRiC complex. The bottom right panel shows the closed TRiC complex forming clusters of two
particles.
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Jorge Ferreira @jorgeferreira.bsky.social · 13/11/2024
Want to engage with the #mechanobiology community? Why not join this group? Just drop me a DM and I´ll add you. go.bsky.app/G5cQqYT
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Kirsty Wan @micromotility.bsky.social · 13/11/2024
Couldn't find one so made a quick physics of life list, enjoy! go.bsky.app/EA2VsDN
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Sarah Rauscher @sarahrauscher.bsky.social · 11/12/2024
In this work, we use all-atom MD simulations to elucidate why human and rhesus macaque TRIM5α differ in their ability to restrict HIV. See our manuscript by Liam Haas-Neill, Deniz Meneksedag-Erol & Ibraheem Andeejani --
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Stuart Neil @tetherin.bsky.social · 11/12/2024
Extended until the 17th of Dec
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Chenxin Li, PhD @chenxinli2.bsky.social · 10/12/2024
Friends don't let friends make bad graphs repo has been updated! Friends don't let friends use boxplot for binomial (bimodal) data. Is your box plot hiding something from you? #DataVisualization github.com/cxli233/Frie...
A figure comparing box plot and showing all data points. 
Group1: normally distributed data.
Group2: bimodal data.
Group3: Data with 3 modes.
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Maxim Igaev @maxotubule.bsky.social · 08/12/2024
🚨 PLEASE REPOST 🚨 We're still looking for an enthusiastic PhD student 😉 Here are some potential projects: - mechanical stability of microtubules probed by computational force spectroscopy - mechanism of microtubule assembly studied by coarse-grained modeling www.mpinat.mpg.de/28-24?c=2501...
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BioExcel CoE @bioexcelcoe.bsky.social · 09/12/2024
The Spring School in Computational Chemistry 2025 is open for registration 🗓️ 23-25 April 2025 🌐 Espoo, Finland Further info and registration ➡️ bit.ly/41phwUJ #compchem #hpc #Training #moleculardynamics #machinelearning Organised together with CSC - IT Center for Science and @eurocc.bsky.social
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Maxim Igaev @maxotubule.bsky.social · 08/12/2024
Bluesky feels like the biggest speed dating event at a conference ever.
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Rosie Jackson @aramblingrosie.bsky.social · 20/11/2024
One week left to apply for this job!! I'm looking for a research tech to come and work on Alzheimers and ApoE! If you love cell culture, astrocytes, APOE or just fun science with fun people then come do science with us in beautiful Dundee! tinyurl.com/a33kjn49 Seriously the sunsets are on point!
Sunset over the tay bridge from The school of life sciences building in dundee
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Vladimir Volkov 🇺🇦 @vladimirvolkov.bsky.social · 04/12/2024
Very happy to receive a Wellcome CDA! The award will fund my lab for a whopping 8 years, allowing us to dissect force-sensing at the kinetochore-microtubule interface in depth using structural methods. We are currently looking for a postdoc: qmul-jobs.tal.net/vx/candidate... Please apply or repost
qmul-jobs.tal.net
Postdoctoral Research Assistant - QMUL Jobs
Description
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CompBioPhys @compbiophys.bsky.social · 04/12/2024
📢 It's our great pleasure to invite you all to our upcoming #Workshop on "Computer Simulation and #Theory of Macromolecules" in #Hünfeld on March 7-8, 2025 in #hybrid format! See you online or on-site! More details are provided here: www.mpinat.mpg.de/workshop/hue... #TheoryHünfeld2025 #biophysics
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Maxim Igaev @maxotubule.bsky.social · 08/12/2024
🚨 PLEASE REPOST 🚨 We're still looking for an enthusiastic PhD student 😉 Here are some potential projects: - mechanical stability of microtubules probed by computational force spectroscopy - mechanism of microtubule assembly studied by coarse-grained modeling www.mpinat.mpg.de/28-24?c=2501...
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Maxim Igaev @maxotubule.bsky.social · 07/12/2024
BTW we‘ve recently released an improved version of our manuscript uncovering the assembly mechanism of microtubules via intermediate clusters of protofilaments! @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social 👇👇👇 doi.org/10.1101/2024...
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Vladimir Volkov 🇺🇦 @vladimirvolkov.bsky.social · 07/11/2024
What is the difference between a growing and shortening microtubule end? I thought I knew the answer until I started talking to Maxim Igaev and Maksim Kalutskiy. Turns out the key are protofilament clusters - check out our new preprint for details www.biorxiv.org/content/10.1...
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Maxim Igaev @maxotubule.bsky.social · 07/12/2024
Open up and dance 🕺🏻
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Maxim Igaev @maxotubule.bsky.social · 07/12/2024
BTW we‘ve recently released an improved version of our manuscript uncovering the assembly mechanism of microtubules via intermediate clusters of protofilaments! @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social 👇👇👇 doi.org/10.1101/2024...
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