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Michal Kolář

@mhko.bsky.social
379 followers 402 following 84 posts

Biophysicist based in Prague, CZE. Interested in ribosomes, conformational disorder, and computation. Volunteer in @czexpats.bsky.social, Editorial Board Member of @commsbio.nature.com. Likes traveling by train, dislikes tomatoes. kolar.vscht.cz

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Reposted by Michal Kolář
Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 19/07/2026
It’s time for the World Cup final with one of the greatest footballers that may be playing his last cup So time for a short thread on a link between Messi and an intrinsically disordered protein. 1/n
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Stephen McLaughlin @lmbbiophysics.bsky.social · 29/06/2026
It will be our 10th Next Generation Biophysics Symposium @mrclmb.ac.uk on 16th September. Please join us in person or online and celebrate all things #biophysics www3.mrc-lmb.cam.ac.uk/sites/nextge...
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Reposted by Michal Kolář
Tomáš Pluskal @pluskal-lab.org · 26/06/2026
Do you have a bold, daring vision how to transform research in biology? Are you a young scientist within 7 years since your PhD? Submit your idea by July 31 to the Dream Biology Award competition and you can win the first prize of €10,000! More details at dreambiologyaward.org
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Michal Kolář @mhko.bsky.social · 25/06/2026
Our new contribution about #ribosomes. While preparing computer simulations for another project, we noticed that many r-protein parts were missing from the #cryoEM model. Surprisingly, we found this to be a general feature: a coat of #IDPs on the ribosome's surface. www.biorxiv.org/content/10.6...
biorxiv.org
Ribosomes are covered by a coat of flexible protein fragments
Ribosomal proteins contain flexible terminal regions that are averaged out during electron density reconstructions, rendering them absent from experimental models derived by X-ray crystallography or c...
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Reposted by Michal Kolář
Dr Zeinab Rekad 🔬🧬🧪 @zeinabrekad.bsky.social · 21/06/2026
#RNAsky .... Do we have to understand that Ribosomes are flufy sticky blobs rather than granulous dense gobs 🤔🤓
static.klipy.com
Om Nom Gets Sticky Shocked by Pizza Dough
ALT: Om Nom Gets Sticky Shocked by Pizza Dough
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Reposted by Michal Kolář
IOCB Prague @iocbprague.bsky.social · 10/04/2026
🔬 This tenure-track position is roughly comparable to an #assistantprofessor at a US university or to a #newinvestigator position at Max Planck Institutes in Germany. See more ► www.uochb.cz/en/open-posi... ⤵️ #openposition #iocbprague #iocb #compchem
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Reposted by Michal Kolář
Communications Biology @commsbio.nature.com · 08/05/2026
🌽🧬🐛 Together with @natcomms.nature.com and Scientific Reports, we invite articles in all areas of research investigating the roles of RNA in plant biotic interactions (including plant-microbe, plant-insect, and plant-plant interactions). www.nature.com/collections/...
nature.com
RNA biology in plant biotic interactions
The editors invite articles in all areas of research investigating the roles of RNA in plant biotic interactions.
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Reposted by Michal Kolář
Faculty of Science, University of South Bohemia @fscusb.bsky.social · 07/05/2026
New research shows bacteria can redefine stop codons by shortening tRNA anticodon stems. This "extended superwobble" proves tRNAs aren't passive—they're active drivers that can evolve entirely new genetic codes! doi.org/10.1093/nar/...
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Michal Kolář @mhko.bsky.social · 30/04/2026
We open up to two Junior PI positions at UCT Prague, Czechia @vschtpraha.bsky.social. Broadly defined chemistry-related projects will be considered. A support from any department must be negotiated prior application. Feel free to contact me for further info or visit www.vscht.cz/research/dag....
vscht.cz
Starting grants – Institutional Research Support - University of Chemistry and Technology, Prague
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Reposted by Michal Kolář
Communications Biology @commsbio.nature.com · 10/04/2026
🧬Linker histone H1 suppresses H4-acetylation–induced H3 N-tail acetylation by altering tail dynamics without affecting the nucleosome core, indicating that H1 restricts euchromatin formation. Find out more in this latest article at www.nature.com/articles/s42...
doi.org
Linker histone H1 represses H3 tail acetylation induced by H4 tail acetylation and alters its dynamics - Communications Biology
H1 suppresses H4-acetylation–induced H3 N-tail acetylation by altering tail dynamics without affecting the nucleosome core, indicating that H1 restricts euchromatin formation.
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Reposted by Michal Kolář
Communications Biology @commsbio.nature.com · 15/04/2026
🧬A new review article discusses the consequences of mutations in genes associated with rare hereditary diseases linked to #G-quadruplex -induced replisome stalling, as well as the molecular functions and cellular pathways of these G4-interacting proteins. doi.org/10.1038/s420...
doi.org
Rare genetic diseases associated with G-quadruplex-induced replication stress - Communications Biology
The authors review the consequences of mutations in genes linked to rare hereditary disorders associated with G-quadruplex (G4)-induced replisome stalling, as well as the molecular functions and cellu...
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Reposted by Michal Kolář
Martin Lulak @polarandycz.bsky.social · 27/04/2026
How can an ordinary clam (well, actually more than 1,600 of these shells) reveal what the fjords on Svalbard looked like thousands of years ago? 🧵👇
Beautiful left valve of Mya truncata from Svalbard, approximately 10,000 years old
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Michal Kolář @mhko.bsky.social · 25/04/2026
Hugo and his poster about the enormous flexibility of the ribosomal tunnel constriction. Preprint available here: www.biorxiv.org/content/10.6...
Hugo and his poster in shades of blue, showing results of molecular dynamics simulations of the bacterial ribosome.
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Michal Kolář @mhko.bsky.social · 25/04/2026
Huenfeld computational biophysics, 25th anniversary edition. Final slide of the final talk. I feel it the same.
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Fadel Fakih @fakih98.bsky.social · 20/04/2026
My first author paper is published in @narjournal.bsky.social , co-led with Satish Nandipati and Ambar Kachale. In this work, we build on the implications of the unusual genetic code features of Blastocrithidia nonstop... #RNAsky #RNA #evolution #molecular academic.oup.com/nar/article/...
academic.oup.com
Validate User
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Michal Kolář @mhko.bsky.social · 20/04/2026
Our latest contribution is out! In this highly collaborative paper, we show that tRNAs with a 4-base-pair anticodon stem are surprisingly frequent across organisms. Our atomistic MD simulations reveal the role of the 5th base pair. academic.oup.com/nar/article/...
academic.oup.com
Frequent occurrence and predicted functions of tRNAs with 4-base-pair anticodon stems in bacteria: extended superwobble hypothesis
Abstract. Recently, a tRNATrpCCA with a 4-base-pair (bp) anticodon stem (AS) was shown to efficiently recognize a near-cognate UGA codon in unicellular euk
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Reposted by Michal Kolář
Communications Biology @commsbio.nature.com · 01/04/2026
Thermus thermophilus forms two distinct type IV pili. Cryo-electron microscopy, mutagenesis, structural predictions and simulations reveal their structures, glycan flexibility, and a hypothetical model of pilus assembly. www.nature.com/articles/s42...
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Vojtech Spiwok @spiwokv.bsky.social · 29/03/2026
Analysis and Sampling of Molecular Simulations with Adversarial Autoencoders by @guted.bsky.social doi.org/10.1063/5.03...
doi.org
Analysis and sampling of molecular simulations with adversarial autoencoders
The design of good collective variables for analysis and the enhancement of sampling of molecular simulations is not a trivial task. It often relies on the know
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Michal Kolář @mhko.bsky.social · 23/03/2026
There is an unplanned power outage in Prague 6. It appears that the servers of the Czech Science Foundation GACR (including #GRIS) are affected and therefore currently unreachable.
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Michal Kolář @mhko.bsky.social · 12/03/2026
Our recent investigation of the constriction in the bacterial ribosomal tunnel is online. Unbiased all-atom MD simulations of the entire ribosome and PDB analysis show, how flexible the constriction is. The flexibility is modulated by short nascent polypetides.
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Reposted by Michal Kolář
Communications Biology @commsbio.nature.com · 05/12/2025
🧬Submissions are still open for our DNA repair and human disease Collection, a cross-journal Collection, highlighting new research and methodological advances. www.nature.com/collections/... ⚠️ Submission Deadline: 31 January 2026
nature.com
DNA repair and human disease
This cross-journal Collection between Nature Communications, Communications Biology and Scientific Reports welcomes submissions on the mechanisms of DNA ...
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Reposted by Michal Kolář
Communications Biology @commsbio.nature.com · 04/12/2025
💡Since November 2025, @springernature.com has introduced "Articles in Press", an initiative giving authors earlier visibility without compromising the quality or integrity of the final publication. ⌛Faster access to accepted research! For more information: support.springernature.com/en/support/s...
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Michal Kolář @mhko.bsky.social · 03/12/2025
Some thoughts on the chronic underfunding of the Czech Science Foundation. Much of this problem stems from the recent Ministry of Education’s sloppy implementation of funding for non-teaching staff at grammar schools. gacr.cz/informace-o-...
Czech Science Foundation budget as a function of time.
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Michal Kolář @mhko.bsky.social · 29/11/2025
Some facts about the Standard GACR grants awarded this year (in parentheses last year values): - grants funded: 336 (410) - budget: 3.0B CZK (3.4B) - women PI proportion: 25.6% (21.2%) - proportion of grants in social and humanities: 25.6% (27.3%)
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Michal Kolář @mhko.bsky.social · 29/11/2025
New publication about peptide transport through confined space with some implications for MD simulations of nascent polypeptides in the ribosomal exit tunnel. pubs.rsc.org/en/content/a...
pubs.rsc.org
Sensitivity of peptide conformational dynamics in carbon nanotubes to directional mechanical forces
In living organisms, proteins and peptides are often under the influence of mechanical forces, especially in confined spaces such as membrane channels, the ribosome exit tunnel, or the proteasome gate...
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Michal Kolář @mhko.bsky.social · 28/11/2025
The 14% success rate the main Czech funding scheme for fundamental research is simply a disaster. gacr.cz/en/next-year...
gacr.cz
Next Year, Czech Science Foundation to Fund 400+ New Projects Worth over CZK 3.7 Billion (€153 Million) - The Czech Science Foundation (GACR)
The Czech Science Foundation (GACR), as the most important provider of funding for basic research projects in the Czech Republic, will begin funding over
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Reposted by Michal Kolář
MDDB @mddbeu.bsky.social · 26/11/2025
Excited to share a fantastic set of sessions coming up at the MDDB Conference: Day 1: Large-scale MD simulations Day 2: MD kinetics and free energy / Industrial applications of MD Day 3: Innovative applications of MD to biological systems Explore more and register at ➡️ mddbr.eu/conference/ #MDDB
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Michal Kolář @mhko.bsky.social · 26/11/2025
Happy to take part in the workshop. Lots of inspiring discussions. The take-home message: there are many interesting research problems, but only some are truly important.
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Michal Kolář @mhko.bsky.social · 15/09/2025
Day 1 of the winter semester. Good luck to all of us @vschtpraha.bsky.social.
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Michal Kolář @mhko.bsky.social · 07/09/2025
At EMBL @events.embl.org , they know how to conclude a conference. #EMBLProtein
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Michal Kolář @mhko.bsky.social · 03/09/2025
It's 93. Come and chat on Thursday. #EMBLProtein
Research poster heading on yellow background featuring the poster number of 93.
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Michal Kolář @mhko.bsky.social · 23/07/2025
Hiking time with Hlouchova lab during our GACR project retreat in Jachymov. A lot of discussions on protein-RNA interactions under probiotic conditions🦠
A group of people walking on a path through meadows, with forests in the background. Hilly environment, gray clouds.
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Reposted by Michal Kolář
vschtpraha.bsky.social @vschtpraha.bsky.social · 15/07/2025
🥇 Václav Verner (PORG) won 2nd place in the world 🥈 Matěj Pěnička (Gymnázium Nad Alejí) 🥈 Ondřej Michal (Gymnázium Botičská) 🥉 Adam Horák (Gymnázium Hranice)
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Czexpats in Science @czexpats.bsky.social · 09/07/2025
🗣️ We are pleased to announce that our 2024 Annual Report is out and for the first time in English! ➡️ czexpats.org/en/about-us/...
czexpats.org
Annual reports - Czexpats in Science
Annual report 2024 2024 was a year of significant milestones for Czexpats in Science. We greatly expanded our community-building activities, including our largest Christmas Conference and six internat...
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Michal Kolář @mhko.bsky.social · 09/07/2025
New publication out on the evolution of protein-RNA interactions. Put together with Klára Hlouchová (@sciencecharles.bsky.social) during a lovely Czech spring. www.sciencedirect.com/science/arti...
A scheme of chemico-biological evolution of protein-RNA interactions. It started about 4.5 billion years ago with prebiotic monomers, went through peptides, oligonucleotides, and simple complexes, reaching proteins and RNA at about 4-3.7 billion years ago.
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Michal Kolář @mhko.bsky.social · 03/07/2025
Poster is up and I've tried hard to match my t-shirt with the poster title. We're in the front hall, No. 24. Visit us, there's more air than around the posters in the side hall🫠 #EBSA
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Michal Kolář @mhko.bsky.social · 02/07/2025
My temporary office at #EBSA in Rome.
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Michal Kolář @mhko.bsky.social · 30/06/2025
My flight to Rome delayed by 12 hours. Saying goodbye to day 1 of the #EBSA conference and I'm hoping to make it for day 2!
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Michal Kolář @mhko.bsky.social · 30/06/2025
Heading to #EBSA in Roma and packing my poster to a luggage. Not a fan of poster tubes 🫣 Full text arxiv.org/abs/2503.21357
The same poster but cut in halves vertically, so when rolled down it fits to a luggage.A scientific poster about ribosome simulations. In a viridis colors scale from yellow through green and blue to dark violet.
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Michal Kolář @mhko.bsky.social · 26/05/2025
For Czech readers: The Prague administration has once again shown its incompetence - this time by failing to manage basic demographic data. As a result, young students are paying the price when trying to get into high schools. www.eduin.cz/clanky/nafou...
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Reposted by Michal Kolář
Czexpats in Science @czexpats.bsky.social · 18/05/2025
English-speaking colleagues welcome! Summer’s around the corner, and if you're in the mood for a break from the lab or the office, pop by Cafe Prostoru on June 10 to grab a beer and have a chat 😎 If you’re planning to join us, let us please know via the link above 🙏
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Michal Kolář @mhko.bsky.social · 18/05/2025
I'll be there😎
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Michal Kolář @mhko.bsky.social · 16/05/2025
For Czech readers: Some of the brightest Czech minds who made it to the finals of the @czexpats.bsky.social Award have short research summaries featured in the latest issue of @vesmir.bsky.social vesmir.cz/cz/casopis/s...
vesmir.cz
Ceny Czexpats in Science
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Claudia Alvarez Carreño @claudiaalcar.bsky.social · 01/05/2025
We are pleased to announce that the next speaker in the ProSE seminar series will be Dr. Klara Hlouchova with a talk on "Protein Structure Before LUCA" May 13, 4PM CET Registration link: tinyurl.com/prose-seminar4 Please share!
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Michal Kolář @mhko.bsky.social · 30/04/2025
Our research group studies #ribosomes. Our favorite region of interest is the ribosomal tunnel. We realized that it has been missing a Wikipedia page until now, so we decided to create one. Read, edit, enjoy👇 en.wikipedia.org/wiki/Ribosom...
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Czexpats in Science @czexpats.bsky.social · 30/04/2025
🌟 #PI_Forum Brno #5: Academic Leadership: The Big Picture is ahead! How does one lead a team vs. an institution? Join Irena Radová (MUNI) & Jiří Přibáň (Constitutional Court) to explore leadership in academia and beyond. 🗓️ 13 May 2025 📍CEITEC MU, room 211. Register: czexpats.org/en/udalost/p...
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Michal Kolář @mhko.bsky.social · 29/04/2025
12th PI forum by @czexpats.bsky.social, today about science communications with @pavlahubalkova.bsky.social.
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Michal Kolář @mhko.bsky.social · 20/04/2025
Sakuras in front of @vschtpraha.bsky.social Happy Easter!
Pink sakura trees in full bloom on front of VŠCHT Praha.
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Zeptej se vědce @zeptejsevedce.bsky.social · 12/04/2025
🌍 Proč vědci často zabalí kufry a frčí dělat vědu do zahraničí? Je to vůbec k něčemu dobré? ❓Na otázku od iniciativy Czexpats in Science * nám odpoví Radim👇
Zeptej se vědce Dotaz 1191 Pomáhá vědcům pobyt na jiném pracovišti?
🌍 Proč vědci často zabalí kufry a frčí dělat vědu do zahraničí? Je to vůbec k něčemu dobré? 
❓Na otázku od iniciativy Czexpats in Science * nám odpoví Radim👇
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vschtpraha.bsky.social @vschtpraha.bsky.social · 08/04/2025
Why does it matter? Uncovering ribosome origins might one day help us tackle antibiotic resistance. Fundamental science, fascinating questions, and a bit of time travel. 🌍🧬 📖 Read the full interview on the UCT Prague website: www.vscht.cz/press/interv...
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