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Jan Mašek

@maseklab.bsky.social
257 followers 202 following 52 posts

PI at CUNI Prague🇨🇿, Karolinska Institutet🇸🇪, Czexpat🌍, Junior Faculty chair. Notch & Wnt in development and disease 🔬🧫🐁. *All views my own; 🇪🇺🇺🇦 maseklab.org

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Jan Mašek @maseklab.bsky.social · 27/05/2026
Go Anna go!
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Jan Mašek @maseklab.bsky.social · 07/05/2026
Special thanks to @fabioturetti.bsky.social, one of my first PhD students, who drove this project with exceptional persistence and creativity, @harnoslab.bsky.social for their passion and scientific insight, and everyone else helping us along the way! #WNT, #NOTCH, #CellSignaling
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Jan Mašek @maseklab.bsky.social · 07/05/2026
By combining cell biology, structural modeling, NMR, mass spectrometry, and Xenopus in vivo assays, we show how CK1α activity supports assembly of the active NOTCH1 transcriptional complex.
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Jan Mašek @maseklab.bsky.social · 07/05/2026
Excited to share our new study, now out on bioRxiv: www.biorxiv.org/content/10.6... In this work, we identify CK1α as a novel positive regulator of NOTCH1 signaling and uncover a previously unknown phosphorylation-dependent regulatory mechanism centered on N1ICD residue S1970.
lnkd.in
LinkedIn
This link will take you to a page that’s not on LinkedIn
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Peter Fabian @fabianlab.bsky.social · 03/02/2026
Today at PI_Forum Brno we will discuss this graph. From 62% women at PhD level to 17% at professor level. Let’s talk about why this happens—and how to change it. 📍 CEITEC MU | 🕠 17:30 czexpats.org/en/udalost/p... @czexpats.bsky.social
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Jan Mašek @maseklab.bsky.social · 30/01/2026
Thanks for the kind words Alfonso! Very happy to discuss and learn from you if you would be interested.
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Jan Mašek @maseklab.bsky.social · 27/01/2026
Huge thanks to @fabioturetti.bsky.social, Marek Dokoupil, and the one and only Giovanna Collu, who worked on this review, and to @amartinezarias.bsky.social who pioneered this field pubmed.ncbi.nlm.nih.gov/22326376/ 🫶. #Wnt #Notch pubmed.ncbi.nlm.nih.gov/41558807/ #openbiology
pubmed.ncbi.nlm.nih.gov
Decoding 'Wntch': the intertwined Wnt and Notch pathways in development and disease - PubMed
Multicellularity emerges from the ability of cells to undergo functional differentiation. One of the key mechanisms that enables this coordination is cellular signalling-a series of molecular interactions within or between cells that induce changes in cell behaviour or gene expression. As the body p …
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Jan Mašek @maseklab.bsky.social · 27/01/2026
Together with @harnoslab.bsky.social, we compiled what is known about direct interactions of Wnt and Notch components, and advanced the testable framework of how the crosstalk could allow for a more polarized cellular response to one pathway or the other.
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Jan Mašek @maseklab.bsky.social · 27/01/2026
Paper alert! 🤓 Cells talk to one another all the time using cascades of protein interactions. Now, we know for quite some time that proteins from different cascades can interact with each other. It's called crosstalk. But doesn't it defy the logic of clear communication channels between cells? 🧐
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Jakub Tomek @jakubtomek.bsky.social · 09/12/2025
Author copies of our new book on statistics (mainly) for life scientists arrived recently. After three years of work, this is exciting, especially as we really hope it can help make a positive difference. What's so special about it? 🧵
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Jan Mašek @maseklab.bsky.social · 03/12/2025
Great article about starting a lab at @sciencecharles.bsky.social and the positive effect of supportive peer community from my colleague and co-chair of JF Vito @geohazards.group. For more context check also my article in @vedavyzkumcz.bsky.social - vedavyzkum.cz/nazory/nazor....
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Jan Mašek @maseklab.bsky.social · 02/12/2025
Big congratulations Jesse!!
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Jan Mašek @maseklab.bsky.social · 23/10/2025
Big thanks to all speakers (keynotes🤩), audience for discussions. Amazing job by organizers from PhD program Mehak Shaikh, Jonáš Vlasák, @annafrontino.bsky.social , @fabioturetti.bsky.social and Štěpánka Martiskova, and generous support from @nf-iocbtech.bsky.social and @sciencecharles.bsky.social !
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Jan Mašek @maseklab.bsky.social · 23/10/2025
We are closing the scientific program with talk from Ruslan Nyshchuck, who works on the Usher syndrome in minipig model.
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Jan Mašek @maseklab.bsky.social · 23/10/2025
Moving to brown adipose tissue to learn about function of VW8A function in lipid metabolism from Habib Hayat.
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Jan Mašek @maseklab.bsky.social · 23/10/2025
Next, we learn about the tumor-immune system interface in melanoma from Salim Abuhajiar.
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Jan Mašek @maseklab.bsky.social · 23/10/2025
Back to mitochondria biology with Michal Knězů and his cool talk on cytochrome C oxidase isoforms.
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Jan Mašek @maseklab.bsky.social · 23/10/2025
Starting the last session of today with Anastasiia Kolesnikova and her insight into Huntington disease from minipig model.
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Jan Mašek @maseklab.bsky.social · 23/10/2025
Now, closing the session 4 with Karolína Kowalska showing her cool work on Mical protein in axonal guidance.
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Jan Mašek @maseklab.bsky.social · 23/10/2025
Next, Adela Maraclikova takes us into development of sensitive sensors of bacterial proteases in priodontitis and Alzheimer's disease. (Apology here I forgot to take a picture)
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Jan Mašek @maseklab.bsky.social · 23/10/2025
We like to keep the audience on tip of their toes, and we jump into the story of finding the ideal NK cell donors for immunotherapies, presented by Eva Mašínová.
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Jan Mašek @maseklab.bsky.social · 23/10/2025
We take a sharp turn into the dark universe of possible protein structures that don't usually exist in biological system thanks to Tereza Neuwirthova.
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Jan Mašek @maseklab.bsky.social · 23/10/2025
Next speaker is our keynote neurobiologist from Norway, Giulia Quattrocolo @gquattrocolo.bsky.social, with an awesome talk on axonal cone biology! 🤩
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Jan Mašek @maseklab.bsky.social · 23/10/2025
First session of the day is closed by Yaroslav Nemesh who focuses on Dry AMD-related transcriptomic changes in the RPE cell model.
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Jan Mašek @maseklab.bsky.social · 23/10/2025
From mitochondria to homologous recombination! Matouš Palek reports his findings of how RAD18 directs DNA double-strand break repair by homologous recombination to post-replicative chromatin.
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Jan Mašek @maseklab.bsky.social · 23/10/2025
We continued with Maria Jose Saucedo-Rodriguez, studying the impact of SDHA Mutations on SDH Assembly and Function
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Jan Mašek @maseklab.bsky.social · 23/10/2025
Day of the DevCellBiol conference is here! Starting with Anna Macečková Brymová, working on human iPSC-derived RPE cell transplantation as a potential advanced medicinal therapy
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Jan Mašek @maseklab.bsky.social · 22/10/2025
And the final talk of today, Karel Fusek on recombination hot spots. After his talk we move to poster session of the 1st year PhD students.
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Jan Mašek @maseklab.bsky.social · 22/10/2025
Moving on to genome stability in oocytes and somatic cells, presented by Nataliia Dudko!
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Jan Mašek @maseklab.bsky.social · 22/10/2025
Now back to c. elegans with Allan Akandwanaho and his talk about chirality in actomyosin cortex.
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Jan Mašek @maseklab.bsky.social · 22/10/2025
Let's stick to nucleic acids with Jiří František Potužník's talk on mRNA capping.
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Jan Mašek @maseklab.bsky.social · 22/10/2025
Short break and we are back! Shreyas I Mazumder is taking us to the realm of telomeres.
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Jan Mašek @maseklab.bsky.social · 22/10/2025
Last speaker of the first session is Fatima J. Berro, taking us to the mRNA regulation in the oocyte.
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Jan Mašek @maseklab.bsky.social · 22/10/2025
Switching gears to c elegans early development with Subhadip Chakraborty!
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Jan Mašek @maseklab.bsky.social · 22/10/2025
Now straight, for an extra load of Notch-focused research from Fabio Turetti @fabioturetti.bsky.social !
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Jan Mašek @maseklab.bsky.social · 22/10/2025
Next is Miles Raishbrook, working on the Lratd2/FAM84b roles in mice.
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Jan Mašek @maseklab.bsky.social · 22/10/2025
And we continue with one of the organizers Štěpánka Martiskova, diving into the neuronal growth.
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Jan Mašek @maseklab.bsky.social · 22/10/2025
15th PhD Conference in Dev Cell biology just started and it looks like another year packed with great science, opening with brilliant @ruibenedito.bsky.social keynote!
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Emma R Andersson @anderssonlab.bsky.social · 27/09/2025
👩‍🔬👨‍💻 Postdoc recruitment! 👨‍🔬👩‍💻 Join us to use next generation single cell lineage tracing (de Haan & He et al Science 2025) to resolve dermis developmental dynamics & mechanisms. 🚨 Deadline Oct 1st!! 🚨 Please re-post and help us spread the word far and wide! ✈ ki.varbi.com/en/what:job/...
ki.varbi.com
Postdoctoral studies in next generation single cell lineage tracing of skin (scholarship)
Do you want to contribute to top quality medical research? A postdoctoral scholarship is available in the lab of Emma R Andersson at the Department of Cell and Molecular Biology, Karolinska Institutet
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Sofya Garushyants @garushyants.bsky.social · 15/09/2025
hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!
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Oded Rechavi @odedrechavi.bsky.social · 31/07/2025
🥂This was the highlight of my year. The "instigators", led by local master of the ceremony @svobodalab.bsky.social will never forget the privilege of organizing it and i think every participant will treasure the experience forever ❤️ @nature.com @josiegz.bsky.social www.nature.com/articles/d41...
nature.com
Scientific bedlam at the world’s weirdest and wildest research conference
Woodstock Bio2 + Night Science aimed to encourage collaborations through creativity. The walk-on music for presentations was fun, too.
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Lynn Chiu @drlynnchiu.bsky.social · 20/07/2025
Read all Elements in The Philosophy of Biology series for FREE during the ISHPSSB conference 20 - 25 July. You can find all of these Elements free to download and read here: cup.org/4kEgivL
cup.org
Philosophy of Biology
Welcome to Cambridge Core
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MwahahahahahadScientist @mads100tist.bsky.social · 17/07/2025
We should have the equivalent for PIs looking for students and/or postdocs
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John Wallingford @jbwallingford.bsky.social · 11/07/2025
Birth defects kill twice as many children as cancer. Animal model are crucial; no stem-cell or computer models can yet recapitulate the embryo's complexity. If you support birth defects research tell NIH that animal models are important! Click & scroll below to comment. tinyurl.com/mr3he6bx
tinyurl.com
FDA-NIH Workshop: Reducing Animal Testing
The FDA is hosting a workshop on reducing animal testing. The workshop is open to current FDA and NIH employees.
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Jan Mašek @maseklab.bsky.social · 09/07/2025
Big congrats!
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Czexpats in Science @czexpats.bsky.social · 06/07/2025
🍂 Podzimní London calling je opět tady! 🗣️ 🔗 czexpats.org/udalost/setk...
czexpats.org
Setkání českých vědkyň a vědců v Londýně 2025 - Czexpats in Science
V pořadí třetí setkání českých vědkyň a vědců působících ve Velké Británii se uskuteční v pátek 19. září v Londýně. Akce vzniká pod záštitou Czexpats in Science, ve spolupráci s Velvyslanectvím České ...
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paveltomancak.bsky.social @paveltomancak.bsky.social · 26/06/2025
Read this piece. It gives a great impression of #TCTeAC WoodstockBio2 & Night Science from one of the #Instigators. This is the next best thing to being there... I like the expression #BohemianFixers. Many thanks to them! Děkujeme. thenode.biologists.com/from-posters...
thenode.biologists.com
From Posters to Parades: Inside Woodstock.Bio² & Night Science Conference - the Node
A fever dream of science and spirit wrapped in the forests of Bohemia. Here’s an escalating list — starting with the standard (though nothing was standard
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Rui Benedito @ruibenedito.bsky.social · 26/06/2025
The new Department of Functional Genetics at the Max Planck Institute for Molecular Biomedicine is looking for scientists at any level. 👉 mpi-muenster.mpg.de/780013/profil
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Jan Mašek @maseklab.bsky.social · 25/06/2025
It was again a great event thanks to the organizer @majek.bsky.social, and all speakers, especially @pavlahubalkova.bsky.social for her keynote talk on science communication!
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Itai Yanai @itaiyanai.bsky.social · 16/06/2025
I am heartbroken about the loss of many labs at the Weizmann Institute yesterday in the missile attack. Dear scientists there: please know that you are not alone. Like many many others, I support you and am standing by to help you in any way I can.
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