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Marian Novotny

@majek.bsky.social
311 followers 225 following 37 posts

Proud dad, structural bioinformatician, cook, birdwatcher and skater

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Reposted by Marian Novotny
Pedro Beltrao @pedrobeltrao.bsky.social · 18/09/2026
Anthropic has used Claude to optimise structure prediction and design code to improve speed and memory efficiency. 2-3X speed improvements on AF3, 5X on OF3, 5X on BindCraft low memory modes to model large assemblies. All released as open source www.anthropic.com/research/cla...
anthropic.com
How Claude is uplifting biomolecular modeling
Anthropic is an AI safety and research company that's working to build reliable, interpretable, and steerable AI systems.
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Reposted by Marian Novotny
bioRxiv Bioinfo @biorxiv-bioinfo.bsky.social · 12/02/2026
Investigating Enzyme Function by Geometric Matching of Catalytic Motifs www.biorxiv.org/content/10.64898/20…
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Marian Novotny @majek.bsky.social · 19/12/2025
Krasny rozhovor! A krasna vzpominka - diky za ni!
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Marian Novotny @majek.bsky.social · 24/11/2025
Good luck, Vito!
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Marian Novotny @majek.bsky.social · 19/11/2025
Great work! Congratulations Ivan and Tomas!
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Reposted by Marian Novotny
Charles University, Faculty of Science @sciencecharles.bsky.social · 17/11/2025
Honoring Nov 17 🕯️🇨🇿 Faculty of Science, Charles University, led by Dean doc. Vladimír Krylov and Rector in spe prof. Jiří Zima, joined students & university reps 🤝 to pay tribute to those who defended freedom & democracy ✊📚.
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Marian Novotny @majek.bsky.social · 22/09/2025
Congratulations, Vaclav!
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Reposted by Marian Novotny
Alessandro Nascimento @asnascimento.bsky.social · 08/07/2025
👇🏾👇🏾👇🏾
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Reposted by Marian Novotny
Pedro Beltrao @pedrobeltrao.bsky.social · 05/07/2025
Great work from Horia Todor in Carol Gross's lab showing it's possible to predict complexes in "competition" pools in AF3 resulting in the first all-by-all prediction for a species. After length correcting the ipTM score predicts well known interactions and correlating ipTM vectors also has value.
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Marian Novotny @majek.bsky.social · 19/06/2025
Fantastic to work with so many talented people! today at departmental conference of cell biology department of @sciencecharles.bsky.social . Many thanks to our guests from Israel for joining us and sharing their results and time with us
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Marian Novotny @majek.bsky.social · 10/06/2025
@vaclav-veverka.bsky.social presents his phase seperation doubts #theconferencetoendallconferences #TCTeAC
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Marian Novotny @majek.bsky.social · 10/06/2025
P2Rank has a new version - you can even see a ligand bound to the identified pocket now - please , check it out and look at our NAR paper for a summary of the upgrades
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Reposted by Marian Novotny
Deník N @denikn.cz · 23/05/2025
„Hledání života ve vesmíru je pro mě asi největší vědecké dobrodružství,“ říká jedna z nejúspěšnějších českých vědkyň, biochemička a astrobioložka Klára Hlouchová. Zkoumá otázky původu a evoluce proteinů. Co ještě není, a co už je schopno života?
denikn.cz
Nález života ve vesmíru by s námi mohl pěkně zamávat, říká astrobioložka. Zkoumá vznik života i slepé uličky
Co ještě není, a co už je schopno života? A jak by mohl vypadat život ve vesmíru? Biochemička a astrobioložka Klára Hlouchová zkoumá otázky původu a evoluce proteinů. A otázky života, vesmíru a tak…
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Marian Novotny @majek.bsky.social · 23/04/2025
Jalview team strikes again! Congratulations!
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Marian Novotny @majek.bsky.social · 27/03/2025
We are grateful and fortunate to have Sameer Velankar, the head of @pdbeurope.bsky.social, to start first ever @elixircz.bsky.social phd conference. Thank you RSJ and @elixircz.bsky.social for general support!
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Marian Novotny @majek.bsky.social · 04/03/2025
@elixircz.bsky.social is celebrating 10th anniversary today! Jiri Vondrasek is in his summary acknowledging Janet Thornton and her contribution to founding of Elixir. Thank you!
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Marian Novotny @majek.bsky.social · 08/02/2025
Congratulations, i wonder whether the current tools can move ligands to right places…
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Marian Novotny @majek.bsky.social · 06/02/2025
Counterintuitive
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Marian Novotny @majek.bsky.social · 05/02/2025
Things are often obvious, but sometimes less so. It is true also for small things like ligand-binding sites. In this work, our @cusbg.bsky.social group presents a new dataset designed for cryptic-binding site predictons - happy, to be part of this: academic.oup.com/bioinformati...
academic.oup.com
CryptoBench: cryptic protein–ligand binding sites dataset and benchmark
AbstractMotivation. Structure-based methods for detecting protein–ligand binding sites play a crucial role in various domains, from fundamental research to
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Reposted by Marian Novotny
Česká společnost ornitologická @birdlife.cz · 31/01/2025
🪶Nečekané a vzácné pozorování pelikána bílého ve čtvrtek v ptačím parku Kosteliska na Hodonínsku. Pták byl v dobré kondici, bez chovatelských kroužků a často ladně přeletoval a kroužil. Jedná se již o 209. ptačí druh pozorovaný v ptačím parku ČSO Kosteliska. Foto: Ondřej Ryška
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Marian Novotny @majek.bsky.social · 24/01/2025
An important extension ofPyMOL by Rafi’s @rnajmanovich.bsky.social group
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Marian Novotny @majek.bsky.social · 19/01/2025
Two of our colleagues at the department of cell biology @sciencecharles.bsky.social just received Neuron prize. Congratulations, Klara Hlouchova and Jan Cerny. www.nadaceneuron.cz/ceny-neuron-...
nadaceneuron.cz
Ceny Neuron 2024
Nadace Neuron udělila prestižní vědecká ocenění excelentním vědkyním a vědcům
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Marian Novotny @majek.bsky.social · 16/01/2025
Welcome a new doctor! My student has successfuly defended his thesis on diversity of ligand binding sites today! Congratulations, Christos Feidakis!
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Reposted by Marian Novotny
Karel "CaCO3" Berka @krapnik.bsky.social · 03/12/2024
#CASP ligand #Alphafoldology - #AF3 wins over all other methods in baseline ligand prediction…
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Marian Novotny @majek.bsky.social · 03/12/2024
Congratulations, Klara! Look forward to our next project!
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Reposted by Marian Novotny
estella newcombe @estellaan.bsky.social · 27/11/2024
We did this crazy project where we tried to see if proteins could interact with their mirror image ligand. Seems impossible when proteins need to form 3D structures to interact. But what about if the interaction remains disordered??? www.nature.com/articles/s41...
nature.com
Stereochemistry in the disorder–order continuum of protein interactions - Nature
Studies on protein–protein interactions using proteins containing d- or l-amino acids show that stereoselectivity of binding varies with the degree of disorder within the complex.
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Marian Novotny @majek.bsky.social · 22/11/2024
Congratulations to Honza and his great team!
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Marian Novotny @majek.bsky.social · 20/11/2024
Happy to wait!
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Marian Novotny @majek.bsky.social · 19/11/2024
Highly recommended!
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Reposted by Marian Novotny
Radoslav Krivak @rdkbio.bsky.social · 19/11/2024
Trying to collect scientists in/from Czech Republic who are here. Let me know who should I add! go.bsky.app/Q4XavnF
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